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ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Ting Zhang, Chaoran Yin, А. И. Федоров et al. · Nature
Open access |
25 May 2022 |
428 |
| 2 |
Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review
SIDNEY J. STOHS, Oliver Chen, Sidhartha D. Ray et al. · Molecules
Open access |
19 Mar 2020 |
379 |
| 3 |
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity
Stefan Henrich, Angus Robert Cameron, Gleb P. Bourenkov et al. · Nature Structural & Molecular Biology
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6 Jun 2003 |
352 |
| 4 |
Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization
Kiyoshi Okamoto, Megumi Ikemori‐Kawada, A. Jestel et al. · ACS Medicinal Chemistry Letters
Open access |
17 Nov 2014 |
285 |
| 5 |
Z-DNA and Z-RNA in human disease
Alan G. Herbert · Communications Biology
Open access |
27 Dec 2018 |
258 |
| 6 |
Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells
Mohammad Rashidian, Jessica R. Ingram, Michael Lawrence Dougan et al. · The Journal of Experimental Medicine
Open access |
30 Jun 2017 |
256 |
| 7 |
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Laura M. Raffield et al. · PROTEOMICS
Open access |
9 May 2020 |
195 |
| 8 |
Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials
Joan B. Mannick, Grace Sock Leng Teo, Bernardo Patti et al. · The Lancet Healthy Longevity
Open access |
May 2021 |
122 |
| 9 |
Phyloproteomics: species identification of Enterobacteriaceae using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
G C Conway, Sandra Smole, D A Sarracino et al. · PubMed
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2001 |
113 |
| 10 |
The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of ( S )-2-((2-(1-Isopropyl-1 H -1,2,4-triazol-5-yl)-5,6-dihydrobenzo[ f ]imidazo[1,2- d ][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Timothy P. Heffron et al. · Journal of Medicinal Chemistry
Open access |
7 Jan 2016 |
109 |
| 11 |
Conditioned Medium of Mesenchymal Stromal Cells: A New Class of Therapeutics
Natalia V. Bogatcheva, Michael Coleman · Biochemistry (Moscow)
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Nov 2019 |
107 |
| 12 |
ADAR and Immune Silencing in Cancer
Alan G. Herbert · Trends in cancer
Review |
May 2019 |
103 |
| 13 |
Hybrid AC/DC Transmission Expansion Planning
Azim Lotfjou, Yong Ming Fu, Mohammad Shahidehpour · IEEE Transactions on Power Delivery
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30 May 2012 |
96 |
| 14 |
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors
Qinglin Pu et al. · ACS Medicinal Chemistry Letters
Open access |
15 Jul 2020 |
91 |
| 15 |
Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults
Lynne S. Cox, Ilaria Bellantuono, Janet M. Lord et al. · The Lancet Healthy Longevity
Open access |
Nov 2020 |
85 |
| 16 |
Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells
Michael F. T. Koehler, Philippe Bergeron, Elizabeth M. Blackwood et al. · ACS Medicinal Chemistry Letters
Open access |
6 Jan 2016 |
85 |
| 17 |
The protein interaction map of bacteriophage lambda
Seesandra Venkatappa Rajagopala, Sherwood Casjens, Peter H Uetz · BMC Microbiology
Open access |
2011 |
85 |
| 18 |
Mendelian disease caused by variants affecting recognition of Z-DNA and Z-RNA by the Zα domain of the double-stranded RNA editing enzyme ADAR
Alan G. Herbert · European Journal of Human Genetics
Open access |
18 Jul 2019 |
75 |
| 19 |
Antioxidant and Anti-Diabetic Functions of a Polyphenol-Rich Sugarcane Extract
Jin Ji, Xin Yang, Matthew Flavel et al. · Journal of the American College of Nutrition
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22 Apr 2019 |
75 |
| 20 |
Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8
Philippe Bergeron, Michael F. T. Koehler, Elizabeth M. Blackwood et al. · ACS Medicinal Chemistry Letters
Open access |
5 Apr 2016 |
64 |
| 21 |
A Second-generation Protein–Protein Interaction Network of Helicobacter pylori
Roman Häuser, Arnaud Gerard Michel Ceol, Seesandra V. Rajagopala et al. · Molecular & Cellular Proteomics
Open access |
13 Mar 2014 |
64 |
| 22 |
ALU non-B-DNA conformations, flipons, binary codes and evolution
Alan G. Herbert · Royal Society Open Science
Open access |
Jun 2020 |
59 |
| 23 |
A Genetic Instruction Code Based on DNA Conformation
Alan G. Herbert · Trends in Genetics
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25 Oct 2019 |
53 |
| 24 |
Gene Therapy Developments for Pompe Disease
Zeenath Unnisa, John K. Yoon, Jeffrey W. Schindler et al. · Biomedicines
Open access |
28 Jan 2022 |
51 |
| 25 |
HTS Reporter Displacement Assay for Fragment Screening and Fragment Evolution Toward Leads with Optimized Binding Kinetics, Binding Selectivity, and Thermodynamic Signature
Lars Neumann, Konstanze von König, Dirk Ullmann · Methods in enzymology on CD-ROM/Methods in enzymology
Book chapter |
2011 |
51 |
| 26 |
On-rate based optimization of structure–kinetic relationship – surfing the kinetic map
Andreas Schoop, Fabian Dey · Drug Discovery Today Technologies
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19 Sep 2015 |
47 |
| 27 |
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry
John P. Guilinger et al. · Bioorganic & Medicinal Chemistry
Open access |
19 May 2021 |
46 |
| 28 |
To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase
Alan G. Herbert · PLoS Genetics
Open access |
13 May 2021 |
45 |
| 29 |
Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1
Carina C. de Oliveira Mann, Reiner A. Kiefersauer, Gregor Witte et al. · Scientific Reports
Open access |
8 Jun 2016 |
43 |
| 30 |
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo
Edwige Lorthiois et al. · Journal of Medicinal Chemistry
Open access |
16 Jun 2017 |
39 |
| 31 |
Targeting XPO1 and PAK4 in 8505C Anaplastic Thyroid Cancer Cells: Putative Implications for Overcoming Lenvatinib Therapy Resistance
Husain Yar Khan, James Ge, Misako Nagasaka et al. · International Journal of Molecular Sciences
Open access |
29 Dec 2019 |
37 |
| 32 |
Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications
Vania Lo Presti, Annelisa M. Cornel, Maud Plantinga et al. · Molecular Therapy — Methods & Clinical Development
Open access |
23 Mar 2021 |
35 |
| 33 |
Two-colour single-molecule photoinduced electron transfer fluorescence imaging microscopy of chaperone dynamics
Jonathan Schubert, Andrea Schulze, Chrisostomos Prodromou et al. · Nature Communications
Open access |
29 Nov 2021 |
34 |
| 34 |
Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies
Jung‐Hoon Lee, Daniel Bollschweiler, Tillman Schäfer et al. · Science Advances
Open access |
8 Jan 2021 |
34 |
| 35 |
ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing
Xinfeng Guo, Silvia Liu, Sheng Yi et al. · Cell Reports
Open access |
Jul 2023 |
33 |
| 36 |
Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: walking the razor's edge
Carly DeAntoneo, Alan G. Herbert, Siddharth Balachandran · Current Opinion in Immunology
ReviewOpen access |
3 Jun 2023 |
33 |
| 37 |
The fallacy of enzymatic hydrolysis for the determination of bioactive curcumin in plasma samples as an indication of bioavailability: a comparative study
SIDNEY J. STOHS, C. Y. O. Chen, Harry G. Preuss et al. · BMC Complementary and Alternative Medicine
Open access |
4 Nov 2019 |
32 |
| 38 |
Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis?
Felix Wei et al. · Stroke
Open access |
23 Mar 2016 |
30 |
| 39 |
Host cell Z-RNAs activate ZBP1 during virus infections
Chaoran Yin et al. · Nature
Open access |
13 Oct 2025 |
29 |
| 40 |
Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and disease
Dmitriy Umerenkov, Alan G. Herbert, Dmitrii Konovalov et al. · Life Science Alliance
Open access |
10 May 2023 |
29 |
| 41 |
A polyphenol rich sugarcane extract as a modulator for inflammation and neurological disorders
Jin Ji, Matthew Flavel, Xin Yang et al. · PharmaNutrition
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12 Mar 2020 |
29 |
| 42 |
Simple Repeats as Building Blocks for Genetic Computers
Alan G. Herbert · Trends in Genetics
Review |
18 Jul 2020 |
28 |
| 43 |
Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers
Luc Négroni, Saı̈d Taouji, Daniela Arma et al. · Molecular & Cellular Proteomics
Open access |
16 Sep 2014 |
26 |
| 44 |
BioTIME 2.0: Expanding and Improving a Database of Biodiversity Time Series
María Dornelas et al. · Global Ecology and Biogeography
Open access485 authors |
May 2025 |
23 |
| 45 |
Production of aggregation prone human interferon gamma and its mutant in highly soluble and biologically active form by SUMO fusion technology
Milena Tileva, Elena Krachmarova, Iván Ivanov et al. · Protein Expression and Purification
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25 Sep 2015 |
23 |
| 46 |
Structural analysis of free and enzyme-bound amaranth α-amylase inhibitor: classification within the knottin fold superfamily and analysis of its functional flexibility
Oliviero Carugo, Shanyun Lu, Jingchu Luo et al. · Protein Engineering Design and Selection
Open access |
Sep 2001 |
23 |
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Structure and evolution of the genetic code viewed from the perspective of the experimentally expanded amino acid repertoire in vivo
Nediljko Budiša, Luis Moroder, Robert Huber · Cellular and Molecular Life Sciences
Open access |
2 Oct 1999 |
22 |
| 48 |
The ancient Z-DNA and Z-RNA specific Zα fold has evolved modern roles in immunity and transcription through the natural selection of flipons
Alan G. Herbert · Royal Society Open Science
Open access |
Jun 2024 |
21 |
| 49 |
Untangling the Gordian knot—further resolving the super-species complex of 300-million-year-old xiphosurids by reconstructing their ontogeny
Carolin Haug, Joachim T. Haug · Development Genes and Evolution
Open access |
2020 |
21 |
| 50 |
Development of a Generic Anti-PEG Antibody Assay Using BioScale’s Acoustic Membrane MicroParticle Technology
Huijin Dong, Johanna R. Mora, Catherine Brockus et al. · The AAPS Journal
Open access |
2 Jul 2015 |
21 |