| 1 |
Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery
Marta M. Kijanka, Frank-Jan Warnders, Mohamed El Khattabi et al. · European Journal of Nuclear Medicine and Molecular Imaging
|
18 Jun 2013 |
147 |
| 2 |
Recent trends in molecular diagnostics of yeast infections: from PCR to NGS
Amir A. Arastehfar et al. · FEMS Microbiology Reviews
Open access |
31 May 2019 |
134 |
| 3 |
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform
Alex Klarenbeek, Khalil El Mazouari, Aline Desmyter et al. · mAbs
Open access |
27 May 2015 |
95 |
| 4 |
A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition
D. Lutje Hulsik et al. · PLoS Pathogens
Open access |
7 Mar 2013 |
92 |
| 5 |
Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists
Ali Işbilir, Jan Møller, Marta Arimont et al. · Proceedings of the National Academy of Sciences
Open access |
4 Nov 2020 |
81 |
| 6 |
Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans
Selene Mogavero, Frank M. Sauer, Sascha Brunke et al. · Cellular Microbiology
Open access |
10 Jul 2021 |
73 |
| 7 |
Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs
Timo W.M. De Groof, Vladimir Bobkov, Raimond Heukers et al. · Molecular and Cellular Endocrinology
Open access |
26 Jan 2019 |
66 |
| 8 |
Hypoxia-Targeting Fluorescent Nanobodies for Optical Molecular Imaging of Pre-Invasive Breast Cancer
Aram S. A. van Brussel, Arthur L.L. Adams, Sabrina Oliveira et al. · Molecular Imaging and Biology
Open access |
20 Nov 2015 |
63 |
| 9 |
Nanobodies that Neutralize HIV
Robin A. Weiss, C. Theo Verrips · Vaccines
Open access |
31 Jul 2019 |
60 |
| 10 |
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry
Anneleen Van Hout, Alex Klarenbeek, Vladimir Bobkov et al. · Biochemical Pharmacology
Open access |
17 Oct 2018 |
60 |
| 11 |
Towards an ultra-rapid smartphone- connected test for infectious diseases
Valérian Turbé, Eleanor Ruth Gray, Victoria E. Lawson et al. · Scientific Reports
Open access |
14 Sep 2017 |
56 |
| 12 |
Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights
Eleanor Ruth Gray, Jennifer C. Brookes, Christophe Caillat et al. · ACS Infectious Diseases
Open access |
7 Jun 2017 |
50 |
| 13 |
Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
Nika M. Strokappe, M. Benjamin Hock, Lucy Rutten et al. · Antibodies
Open access |
18 Jun 2019 |
48 |
| 14 |
Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1
Laura E. McCoy, Lucy Rutten, Dan Frampton et al. · PLoS Pathogens
Open access |
18 Dec 2014 |
47 |
| 15 |
Legomedicine─A Versatile Chemo-Enzymatic Approach for the Preparation of Targeted Dual-Labeled Llama Antibody–Nanoparticle Conjugates
Sanne A. M. van Lith, Sander M. J. van Duijnhoven, Anna C. Navis et al. · Bioconjugate Chemistry
Open access |
3 Jan 2017 |
44 |
| 16 |
Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells
Leilei Zhong, Xiaobin Huang, Emilie Dooms Rodrigues et al. · Stem Cells and Development
Open access |
12 Oct 2016 |
42 |
| 17 |
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies
Timo W.M. De Groof, Nick D. Bergkamp, Raimond Heukers et al. · Nature Communications
Open access |
16 Jul 2021 |
39 |
| 18 |
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis
Marisa Valentine, Paul Rudolph, Axel Dietschmann et al. · mBio
Open access |
13 Feb 2024 |
38 |
| 19 |
VHH-Photosensitizer Conjugates for Targeted Photodynamic Therapy of Met-Overexpressing Tumor Cells
Raimond Heukers, Vida Mashayekhi, M. Ramirez-Escudero et al. · Antibodies
Open access |
4 Apr 2019 |
38 |
| 20 |
Neutralisation of HIV-1 cell-cell spread by human and llama antibodies
Laura E. McCoy, Elisabetta Groppelli, Christophe Blanchetot et al. · Retrovirology
Open access |
Oct 2014 |
38 |
| 21 |
Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design
Alla Amcheslavsky, Aaron Wallace, Monir Ejemel et al. · Scientific Reports
Open access |
2 Feb 2021 |
37 |
| 22 |
Candidalysin Is the Hemolytic Factor of Candida albicans
Selene Mogavero, Sarah Höfs, Alexa N. Lauer et al. · Toxins
Open access |
15 Dec 2022 |
34 |
| 23 |
Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D
Ravian L. van Ineveld, Michiel Kleinnijenhuis, María Alieva et al. · Nature Biotechnology
Open access |
3 Jun 2021 |
34 |
| 24 |
Viral G Protein–Coupled Receptors: Attractive Targets for Herpesvirus-Associated Diseases
Timo W.M. De Groof, Elizabeth Elder, Marco H. Siderius et al. · Pharmacological Reviews
Open access |
10 Mar 2021 |
34 |
| 25 |
A novel immuno-gold labeling protocol for nanobody-based detection of HER2 in breast cancer cells using immuno-electron microscopy
Marta M. Kijanka, Elly G. van Donselaar, Wally H. Müller et al. · Journal of Structural Biology
Open access |
25 May 2017 |
34 |
| 26 |
Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas
Hannah J. Barbian et al. · mBio
Open access |
22 Apr 2015 |
34 |
| 27 |
Expression of VHHs in Saccharomyces cerevisiae
Andrea Gorlani, Hans de Haard, Theo C. Verrips · Methods in molecular biology
Book chapter |
2012 |
32 |
| 28 |
Anti-HIV-1 Nanobody-IgG1 Constructs With Improved Neutralization Potency and the Ability to Mediate Fc Effector Functions
Angela I. Schriek, Marlies M. van Haaren, Meliawati Poniman et al. · Frontiers in Immunology
Open access |
16 May 2022 |
31 |
| 29 |
Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies
Mark Soave, Raimond Heukers, Barrie Kellam et al. · Cell chemical biology
Open access |
30 Jun 2020 |
29 |
| 30 |
Camelid heavy chain only antibody fragment domain against β‐site of amyloid precursor protein cleaving enzyme 1 inhibits β‐secretase activity in vitro and in vivo
Bram Dorresteijn, Maarten Rotman, Dorien Faber et al. · FEBS Journal
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6 Jul 2015 |
17 |
| 31 |
NanoB2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET
Jelle van den Bor, Nick D. Bergkamp, Stephanie M. Anbuhl et al. · Cell Reports Methods
Open access |
Mar 2023 |
16 |
| 32 |
Nanobody-liposomes as novel cancer vaccine platform to efficiently stimulate T cell immunity
Rianne G. Bouma, Maarten K. Nijen Twilhaar, Hendrik J. Brink et al. · International Journal of Pharmaceutics
Open access |
23 May 2024 |
15 |
| 33 |
Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies
Eva M. Struijf, Karla I. De la O Becerra, Maartje Ruyken et al. · Journal of Biological Chemistry
Open access |
24 Jun 2023 |
14 |
| 34 |
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Gamal Anton Wakileh, Philipp Bierholz, Mara Kotthoff et al. · Experimental Hematology and Oncology
Open access |
23 Nov 2023 |
13 |
| 35 |
Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism
Stephanie M. Anbuhl, Xavier Dervillez, Saskia Neubacher et al. · Biochemical Pharmacology
Open access |
2 Aug 2024 |
12 |
| 36 |
Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single‐Domain Llama‐Derived Antibody
Maurits R. Hollander, Matthijs F. Jansen, Luuk H G A Hopman et al. · Journal of the American Heart Association
Open access |
9 Oct 2019 |
12 |
| 37 |
Extremely thin layer plastification for focused‐ion beam scanning electron microscopy: an improved method to study cell surfaces and organelles of cultured cells
Elly G. van Donselaar, Bram Dorresteijn, Dušan Popov‐Čeleketić et al. · Journal of Microscopy
Open access |
25 Mar 2018 |
10 |
| 38 |
Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells
Dehan Çömez, Jacqueline R. Glenn, Stephanie M. Anbuhl et al. · Frontiers in Immunology
Open access |
23 Nov 2022 |
9 |
| 39 |
Performance evaluation of InfectID-BSI: A rapid quantitative PCR assay for detecting sepsis-associated organisms directly from whole blood
Lisa A. Simms, C. Davies, Nadeesha Jayasundara et al. · Journal of Microbiological Methods
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12 Jul 2023 |
8 |
| 40 |
Directing HIV-1 for degradation by non-target cells, using bi-specific single-chain llama antibodies
Jord C. Stam, Steven de Maat, Dorien de Jong et al. · Scientific Reports
Open access |
4 Aug 2022 |
5 |
| 41 |
The development of single-domain VHH nanobodies that target the Candida albicans cell surface
Giuseppe Buda De Cesare, Frank M. Sauer, Anna Kolecka et al. · Microbiology Spectrum
Open access |
7 Oct 2024 |
4 |
| 42 |
Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies
Claudia V. Perez Almeria, Omolade Otun, Roman R. Schlimgen et al. · Nature Communications
Open access |
2 Dec 2025 |
3 |
| 43 |
Improvement of Proteolytic Stability Through In Silico Engineering
Lucy Rutten, Hans de Haard, Theo C. Verrips · Methods in molecular biology
Book chapter |
2012 |
3 |
| 44 |
Indium-111-Labeled Single-Domain Antibody for In Vivo CXCR4 Imaging Using Single-Photon Emission Computed Tomography
Muriel Aline Spahn, Stephanie Mareike Anbuhl, Kaat Luyten et al. · Bioconjugate Chemistry
Open access |
11 Mar 2025 |
2 |
| 45 |
Molecular Pharmacology of a Conformational‐Specific Extracellular Nanobody Against CXCR4
Mark Soave, Raimond Heukers, Martine J. Smit et al. · The FASEB Journal
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Apr 2019 |
2 |
| 46 |
Targeting the latent human cytomegalovirus reservoir with virus specific nanobodies
Timo W.M. De Groof, Elizabeth Elder, Raimond Heukers et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
13 May 2020 |
2 |
| 47 |
Monitoring ligand-induced changes in receptor conformation with NanoBiT conjugated nanobodies
Mark Soave, Raimond Heukers, Barrie Kellam et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
23 Apr 2020 |
2 |
| 48 |
Selection of VHHs Under Application Conditions
Edward Dolk, Theo C. Verrips, Hans de Haard · Methods in molecular biology
Book chapter |
2012 |
2 |
| 49 |
DKK1 AND FRZB are necessary for chondrocyte (RE)differentiation and prevention of cell hypertrophy in 3D cultures of human chondrocytes and human mesenchymal stem cells
Leilei Zhong, Xiaojian Huang, Elsa Rodrigues et al. · Osteoarthritis and Cartilage
Open access |
20 Mar 2016 |
2 |
| 50 |
Genetic Engineering of VHH Antibody Fragments for Efficient Site-Specific Conjugation to Polysaccharides
Lin Zhong, Lisanne Morshuis, Michelle Koerselman et al. · Bioconjugate Chemistry
Open access |
23 May 2025 |
1 |