| 1 |
Mutations of the BRAF gene in human cancer
Helen Ruth Davies et al. · Nature
|
Jun 2002 |
10,791 |
| 2 |
Chronic kidney disease: global dimension and perspectives
Vivekanand Jha, Guillermo García-García, Kunitoshi Iseki et al. · The Lancet
|
30 May 2013 |
4,435 |
| 3 |
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study
Kelvin Kai‐Wang To et al. · The Lancet Infectious Diseases
Open access |
23 Mar 2020 |
3,383 |
| 4 |
Patterns of somatic mutation in human cancer genomes
Christopher D. Greenman et al. · Nature
Open access |
Mar 2007 |
3,167 |
| 5 |
Coronavirus as a possible cause of severe acute respiratory syndrome
JSM Peiris, ST Lai, LLM Poon et al. · The Lancet
Open access |
Apr 2003 |
2,990 |
| 6 |
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Daniel J. Klionsky et al. · Autophagy
Open access2,930 authors |
2 Jan 2021 |
2,743 |
| 7 |
Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
Chung‐Mau Lo, Hys Ngan, Wai‐Kuen Tso et al. · Hepatology
Open access |
May 2002 |
2,641 |
| 8 |
Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China
Yi Guan, Bingxue Zheng, Yuxian He et al. · Science
Open access |
8 Sep 2003 |
2,492 |
| 9 |
Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study
JSM Peiris, Chung‐Ming Chu, VCC Cheng et al. · The Lancet
Open access |
May 2003 |
2,463 |
| 10 |
Respiratory virus shedding in exhaled breath and efficacy of face masks
Nancy Leung, Daniel K. W. Chu, Eunice Y. C. Shiu et al. · Nature Medicine
Open access |
3 Apr 2020 |
2,380 |
| 11 |
Posthepatectomy liver failure: A definition and grading by the International Study Group of Liver Surgery (ISGLS)
Nuh N. Rahbari et al. · Surgery
|
15 Jan 2011 |
2,325 |
| 12 |
A Consensus-Based Checklist for Reporting of Survey Studies (CROSS)
Akash Sharma et al. · Journal of General Internal Medicine
Open access |
22 Apr 2021 |
2,321 |
| 13 |
Subclinical Atrial Fibrillation and the Risk of Stroke
Jeff S. Healey, Stuart J. Connolly, Michael Robert Gold et al. · New England Journal of Medicine
Open access |
11 Jan 2012 |
2,112 |
| 14 |
Universal primer set for the full-length amplification of all influenza A viruses
E. Hoffmann, Jürgen Stech, Yi Guan et al. · Archives of Virology
Open access |
Dec 2001 |
2,086 |
| 15 |
Bile leakage after hepatobiliary and pancreatic surgery: A definition and grading of severity by the International Study Group of Liver Surgery
Moritz Koch et al. · Surgery
|
15 Feb 2011 |
2,011 |
| 16 |
Consistent Detection of 2019 Novel Coronavirus in Saliva
Kelvin Kai‐Wang To, Owen Tak-Yin Tsang, Cyril Chik‐Yan Yip et al. · Clinical Infectious Diseases
Open access |
10 Feb 2020 |
2,005 |
| 17 |
Coronaviruses — drug discovery and therapeutic options
Alimuddin I. Zumla, Jasper Fuk‐Woo Chan, Esam I. Azhar et al. · Nature Reviews Drug Discovery
ReviewOpen access |
12 Feb 2016 |
1,809 |
| 18 |
A One-Year Trial of Lamivudine for Chronic Hepatitis B
Ching‐Lung Lai, Rong‐Nan Chien, Nancy W.Y. Leung et al. · New England Journal of Medicine
Open access |
9 Jul 1998 |
1,763 |
| 19 |
Viral hepatitis B
Ching‐Lung Lai, Vlad Ratziu, Man‐Fung Yuen et al. · The Lancet
|
Dec 2003 |
1,735 |
| 20 |
Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings
Chung‐Ming Chu · Thorax
Open access |
25 Feb 2004 |
1,711 |
| 21 |
Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis
Ka Shing Cheung et al. · Gastroenterology
ReviewOpen access |
3 Apr 2020 |
1,708 |
| 22 |
Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003
NS Zhong, BJ Zheng, YM Li et al. · The Lancet
Open access |
Oct 2003 |
1,651 |
| 23 |
Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats
Susanna K. P. Lau, Patrick C. Y. Woo, Kenneth S. M. Li et al. · Proceedings of the National Academy of Sciences
Open access |
16 Sep 2005 |
1,595 |
| 24 |
Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
Ivan Fan-Ngai Hung et al. · The Lancet
Open access |
May 2020 |
1,573 |
| 25 |
Tremelimumab plus Durvalumab in Unresectable Hepatocellular Carcinoma
Ghassan K. Abou‐Alfa et al. · NEJM Evidence
Open access |
6 Jun 2022 |
1,534 |
| 26 |
The International Position on Laparoscopic Liver Surgery
Joseph F. Buell et al. · Annals of Surgery
|
29 Oct 2009 |
1,529 |
| 27 |
Frequency and Distribution of Chest Radiographic Findings in Patients Positive for COVID-19
Ho Yuen Frank Wong, Hiu Yin Sonia Lam, Ambrose Ho-Tung Fong et al. · Radiology
Open access |
27 Mar 2020 |
1,528 |
| 28 |
Peginterferon Alfa-2a, Lamivudine, and the Combination for HBeAg-Positive Chronic Hepatitis B
George K.K. Lau, Teerha Piratvisuth, Kang Luo et al. · New England Journal of Medicine
Open access |
29 Jun 2005 |
1,527 |
| 29 |
Antioxidant Capacity of 26 Spice Extracts and Characterization of Their Phenolic Constituents
Bin Shan, Yi‐Zhong Cai, Mei Sun et al. · Journal of Agricultural and Food Chemistry
|
9 Sep 2005 |
1,521 |
| 30 |
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
Eric C. J. Claas, Albert D. M. E. Osterhaus, Ruud van Beek et al. · The Lancet
|
Feb 1998 |
1,447 |
| 31 |
Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness
Kanta Subbarao, Alexander I Klimov, Jacqueline M. Katz et al. · Science
|
16 Jan 1998 |
1,366 |
| 32 |
Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study
Benjamin John Cowling, Sheikh Taslim Ali, Tiffany Ng et al. · The Lancet Public Health
Open access |
17 Apr 2020 |
1,357 |
| 33 |
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
Kangsheng Li et al. · Nature
|
Jul 2004 |
1,357 |
| 34 |
Obstructive Sleep Apnea Is Independently Associated with Insulin Resistance
Msm Ip, BING K. LAM, Matthew Ng et al. · American Journal of Respiratory and Critical Care Medicine
|
Mar 2002 |
1,314 |
| 35 |
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Marilda Mazzali, Jeremy Hughes, Yoon-Goo Kim et al. · Hypertension
|
Nov 2001 |
1,303 |
| 36 |
Stress and Psychological Distress among SARS Survivors 1 Year after the Outbreak
Antoinette M. Lee, Josephine GWS Wong, Grainne Mary McAlonan et al. · The Canadian Journal of Psychiatry
|
Apr 2007 |
1,248 |
| 37 |
Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage
Eric J. Snijder, Peter J. Bredenbeek, Jessika C. Dobbe et al. · Journal of Molecular Biology
Open access |
Aug 2003 |
1,239 |
| 38 |
Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells
Stephanie Ma, Kwok‐Wah Chan, Liang Hu et al. · Gastroenterology
Open access |
16 Apr 2007 |
1,211 |
| 39 |
Nasopharyngeal carcinoma
WI Wei, Jonathan S. T. Sham · The Lancet
|
Jun 2005 |
1,208 |
| 40 |
Entecavir versus Lamivudine for Patients with HBeAg-Negative Chronic Hepatitis B
Ching‐Lung Lai, Daniel Shouval, Anna S. Lok et al. · New England Journal of Medicine
Open access |
8 Mar 2006 |
1,196 |
| 41 |
Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility
Jasper Fuk‐Woo Chan et al. · Clinical Infectious Diseases
Open access |
26 Mar 2020 |
1,191 |
| 42 |
Imaging Profile of the COVID-19 Infection: Radiologic Findings and Literature Review
Ming‐Yen Ng, Elaine Yuen Phin Lee, Yang Jin et al. · Radiology Cardiothoracic Imaging
Open access |
Feb 2020 |
1,188 |
| 43 |
Severe acute respiratory syndrome
Malik J. S. Peiris, Yi Guan, Kwok‐Yung Yuen · Nature Medicine
Open access |
30 Nov 2004 |
1,181 |
| 44 |
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma
Anupama Reddy et al. · Cell
Open access |
Oct 2017 |
1,154 |
| 45 |
Peginterferon Alfa-2a Alone, Lamivudine Alone, and the Two in Combination in Patients with HBeAg-Negative Chronic Hepatitis B
Patrick Marcellin, George K.K. Lau, Ferruccio Bonino et al. · New England Journal of Medicine
Open access |
15 Sep 2004 |
1,149 |
| 46 |
Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial
Jordi Bruix, Tadatoshi Takayama, Vincenzo Mazzaferro et al. · The Lancet Oncology
|
8 Sep 2015 |
1,128 |
| 47 |
Tissue Doppler Echocardiographic Evidence of Reverse Remodeling and Improved Synchronicity by Simultaneously Delaying Regional Contraction After Biventricular Pacing Therapy in Heart Failure
Cheuk‐Man Yu, Elaine M. C. Chau, John Elsby Sanderson et al. · Circulation
Open access |
29 Jan 2002 |
1,115 |
| 48 |
Receptor and viral determinants of SARS‐coronavirus adaptation to human ACE2
Wenhui Li, Chengsheng Zhang, Jianhua Sui et al. · The EMBO Journal
Open access |
24 Mar 2005 |
1,082 |
| 49 |
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
Kai Wang et al. · Nature Genetics
|
11 May 2014 |
1,077 |
| 50 |
Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With COVID-19 (April 2020)
Adarsh Bhimraj, Rebecca L. Morgan, Amy Hirsch Shumaker et al. · Clinical Infectious Diseases
Open access |
22 Apr 2020 |
1,070 |