| 1 |
Nitazoxanide: A first-in-class broad-spectrum antiviral agent
Jean‐François Rossignol · Antiviral Research
Open access |
6 Aug 2014 |
578 |
| 2 |
Treatment of Diarrhea Caused by Cryptosporidium parvum: A Prospective Randomized, Double‐Blind, Placebo‐Controlled Study of Nitazoxanide
Jean-François Rossignol, Ayman Ayoub, Marc S. Ayers · The Journal of Infectious Diseases
|
Jul 2001 |
359 |
| 3 |
Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus
Jean‐François Rossignol · Journal of Infection and Public Health
Open access |
18 Apr 2016 |
301 |
| 4 |
Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial
Jason Haffizulla, Aaron L. Hartman, Melanie Hoppers et al. · The Lancet Infectious Diseases
Open access |
19 May 2014 |
264 |
| 5 |
Nitazoxanide for the Treatment of Clostridium difficile Colitis
Daniel M. Musher, Nancy D. Logan, Richard J. Hamill et al. · Clinical Infectious Diseases
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13 Jul 2006 |
250 |
| 6 |
Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
Brent E. Korba, Abigail Montero, Kristine Farrar et al. · Antiviral Research
|
5 Sep 2007 |
218 |
| 7 |
Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial
Jean‐François Rossignol, Mona Abu‐Zekry, Abeer Khalaf Hussein et al. · The Lancet
|
14 Jun 2006 |
202 |
| 8 |
Nitazoxanide in the treatment of viral gastroenteritis: a randomized double‐blind placebo‐controlled clinical trial
Jean François Rossignol, Y. El-Gohary · Alimentary Pharmacology & Therapeutics
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27 Oct 2006 |
186 |
| 9 |
Nitazoxanide versus Vancomycin inClostridium difficileInfection: A Randomized, Double‐Blind Study
Daniel M. Musher, Nancy D. Logan, Adam M. Bressler et al. · Clinical Infectious Diseases
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9 Jan 2009 |
186 |
| 10 |
Cryptosporidium and Giardia: Treatment options and prospects for new drugs
Jean‐François Rossignol · Experimental Parasitology
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25 Jul 2009 |
185 |
| 11 |
A double-‘blind’ placebo-controlled study of nitazoxanide in the treatment of cryptosporidial diarrhoea in aids patients in Mexico
Jean‐François Rossignol, Hilda Hidalgo, M. Feregrino et al. · Transactions of the Royal Society of Tropical Medicine and Hygiene
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Nov 1998 |
175 |
| 12 |
Treatment of Diarrhea Caused byGiardia intestinalisandEntamoeba histolyticaorE. dispar:A Randomized, Double‐Blind, Placebo‐Controlled Study of Nitazoxanide
Jean‐François Rossignol, Ayman Ayoub, Marc S. Ayers · The Journal of Infectious Diseases
Open access |
Aug 2001 |
158 |
| 13 |
Improved Virologic Response in Chronic Hepatitis C Genotype 4 Treated With Nitazoxanide, Peginterferon, and Ribavirin
Jean‐François Rossignol, Asem Ahmed Elfert, Yehia El–Gohary et al. · Gastroenterology
Open access |
20 Nov 2008 |
147 |
| 14 |
Effect of Nitazoxanide in Diarrhea and Enteritis Caused by Cryptosporidium Species
Jean‐François Rossignol, Samir M. Kabil, Yehia El–Gohary et al. · Clinical Gastroenterology and Hepatology
Open access |
Mar 2006 |
142 |
| 15 |
In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes
Mirjam Walker, Jean François Rossignol, Paul Robert Torgerson et al. · Journal of Antimicrobial Chemotherapy
Open access |
29 Jul 2004 |
118 |
| 16 |
Identification of Isoflavone Derivatives as Effective Anticryptosporidial Agents in Vitro and in Vivo
Andrew V. Stachulski, Neil G. Berry, Audrey Low et al. · Journal of Medicinal Chemistry
|
25 Jan 2006 |
114 |
| 17 |
In Vitro Parasiticidal Effect of Nitazoxanide against Echinococcus multilocularis Metacestodes
Marianne Stettler, Renate Fink, Mirjam Walker et al. · Antimicrobial Agents and Chemotherapy
Open access |
23 Jan 2003 |
109 |
| 18 |
Effect of Nitazoxanide in Persistent Diarrhea and Enteritis Associated With Blastocystis hominis
Jean‐François Rossignol, S KABIL, Mohamed Said et al. · Clinical Gastroenterology and Hepatology
Open access |
Oct 2005 |
108 |
| 19 |
Nitazoxanide in the treatment of amoebiasis
Jean‐François Rossignol, Samir M. Kabil, Yehia El–Gohary et al. · Transactions of the Royal Society of Tropical Medicine and Hygiene
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21 Jul 2007 |
104 |
| 20 |
The Anti-Hepatitis C Agent Nitazoxanide Induces Phosphorylation of Eukaryotic Initiation Factor 2α Via Protein Kinase Activated by Double-Stranded RNA Activation
Menashe Elazar, Michael Liu, Sean A. McKenna et al. · Gastroenterology
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5 Aug 2009 |
100 |
| 21 |
Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity
Marianne Stettler, Jean François Rossignol, Renate Fink et al. · International Journal for Parasitology
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27 Feb 2004 |
99 |
| 22 |
Synergistic Effect of Nitazoxanide with Neuraminidase Inhibitors against Influenza A Viruses In Vitro
Giuseppe Belardo, Orlando Cenciarelli, Simone La Frazia et al. · Antimicrobial Agents and Chemotherapy
Open access |
2 Dec 2014 |
93 |
| 23 |
Nitazoxanide, a Potential Drug for Eradication of Helicobacter pylori with No Cross-Resistance to Metronidazole
Françis Mégraud, Alessandra Occhialini, Jean François Rossignol · Antimicrobial Agents and Chemotherapy
Open access |
Nov 1998 |
92 |
| 24 |
Thiazolides, a New Class of Antiviral Agents Effective against Rotavirus Infection, Target Viral Morphogenesis, Inhibiting Viroplasm Formation
Simone La Frazia, Alessandra Ciucci, Francesca Arnoldi et al. · Journal of Virology
Open access |
8 Aug 2013 |
83 |
| 25 |
Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication
Andrew V. Stachulski, Chandrakala Pidathala, Eleanor C. Row et al. · Journal of Medicinal Chemistry
Open access |
9 May 2011 |
78 |
| 26 |
Nitazoxanide in the treatment of acquired immune deficiency syndrome‐related cryptosporidiosis: results of the United States compassionate use program in 365 patients
Jean‐François Rossignol · Alimentary Pharmacology & Therapeutics
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16 Aug 2006 |
78 |
| 27 |
In Vitro Effects of Thiazolides on Giardia lamblia WB Clone C6 Cultured Axenically and in Coculture with Caco2 Cells
Joachim Müller, Géraldine Rühle, Norbert Müller et al. · Antimicrobial Agents and Chemotherapy
Open access |
23 Dec 2005 |
73 |
| 28 |
The susceptibility of circulating human influenza viruses to tizoxanide, the active metabolite of nitazoxanide
Danielle Tilmanis, Carel van Baalen, Ding Yuan Oh et al. · Antiviral Research
Open access |
3 Oct 2017 |
65 |
| 29 |
Potential for Hepatitis C Virus Resistance to Nitazoxanide or Tizoxanide
Brent E. Korba, Menashe Elazar, Ping Lui et al. · Antimicrobial Agents and Chemotherapy
Open access |
18 Aug 2008 |
63 |
| 30 |
Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication
Daria Trabattoni, Federica Gnudi, Salomè V. Ibba et al. · Scientific Reports
Open access |
2 Jun 2016 |
59 |
| 31 |
In Vitro Efficacies of Nitazoxanide and Other Thiazolides against Neospora caninum Tachyzoites Reveal Antiparasitic Activity Independent of the Nitro Group
Marco Iván Esposito, Rebecca Stettler, Shelley L. Moores et al. · Antimicrobial Agents and Chemotherapy
Open access |
26 Aug 2005 |
55 |
| 32 |
Nitazoxanide for the empiric treatment of pediatric infectious diarrhea
Jean‐François Rossignol, Nicolás López-Chegne, Luis Martin Julcamoro et al. · Transactions of the Royal Society of Tropical Medicine and Hygiene
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Feb 2012 |
50 |
| 33 |
Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus Replication
Andrew V. Stachulski, Chandrakala Pidathala, Eleanor C. Row et al. · Journal of Medicinal Chemistry
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7 Nov 2011 |
47 |
| 34 |
A randomized double-blind placebo-controlled clinical trial of nitazoxanide for treatment of mild or moderate COVID-19
Jean‐François Rossignol, Matthew C. Bardin, Jessica Fulgencio et al. · EClinicalMedicine
Open access |
28 Feb 2022 |
46 |
| 35 |
Treatment of chronic viral hepatitis with nitazoxanide and second generation thiazolides
Emmet B. Keeffe, Jean‐François Rossignol · World Journal of Gastroenterology
Open access |
2009 |
46 |
| 36 |
Thiazolides: a new class of antiviral drugs
Jean‐François Rossignol · Expert Opinion on Drug Metabolism & Toxicology
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15 May 2009 |
45 |
| 37 |
A Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
Jean‐François Rossignol, Christian Bréchot · Hepatology Communications
Open access |
29 Mar 2019 |
42 |
| 38 |
Treatment of Chronic Hepatitis C Using a 4-week Lead-in With Nitazoxanide Before Peginterferon Plus Nitazoxanide
Jean‐François Rossignol, Asem Ahmed Elfert, Emmet B. Keeffe · Journal of Clinical Gastroenterology
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26 Mar 2010 |
40 |
| 39 |
Meeting the Challenge of Eliminating Chronic Hepatitis B Infection
Peter A. Revill, Capucine Pénicaud, Christian Bréchot et al. · Genes
Open access |
Apr 2019 |
33 |
| 40 |
Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
Frida Ek, Kristin Blom, Tove Selvin et al. · Scientific Reports
Open access |
27 May 2022 |
32 |
| 41 |
Inhibitory Activities of Epidermal Growth Factor Receptor Tyrosine Kinase-Targeted Dihydroxyisoflavone and Trihydroxydeoxybenzoin Derivatives on Sarcocystis neurona , Neospora caninum , and Cryptosporidium parvum Development
Gilles Gargala, Asiya Baishanbo, Loïc Favennec et al. · Antimicrobial Agents and Chemotherapy
Open access |
26 Oct 2005 |
32 |
| 42 |
Impairment of SARS-CoV-2 spike glycoprotein maturation and fusion activity by nitazoxanide: an effect independent of spike variants emergence
Anna Riccio, Silvia Santopolo, Antonio Rossi et al. · Cellular and Molecular Life Sciences
Open access |
7 Apr 2022 |
31 |
| 43 |
Second-Generation Nitazoxanide Derivatives: Thiazolides are Effective Inhibitors of the Influenza a Virus
Andrew V. Stachulski, M. Gabriella Santoro, Sara Piacentini et al. · Future Medicinal Chemistry
Open access |
Apr 2018 |
29 |
| 44 |
Synthesis and pre-clinical studies of new amino-acid ester thiazolide prodrugs
Andrew V. Stachulski, Karl A. D. Swift, Mark Cooper et al. · European Journal of Medicinal Chemistry
Open access |
29 Sep 2016 |
26 |
| 45 |
Syntheses and Antibacterial Activities of Tizoxanide, an N-(Nitrothiazolyl)salicylamide, and its O-Aryl Glucuronide
Jean‐François Rossignol, Andrew V. Stachulski · Journal of Chemical Research Synopses
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1999 |
25 |
| 46 |
Short Communication: Nitazoxanide Inhibits HIV Viral Replication in Monocyte-Derived Macrophages
Bethsebah Gekonge, Matthew C. Bardin, Luis J. Montaner · AIDS Research and Human Retroviruses
Open access |
10 Oct 2014 |
25 |
| 47 |
Prophylaxis of ferrets with nitazoxanide and oseltamivir combinations is more effective at reducing the impact of influenza a virus infection compared to oseltamivir monotherapy
Edin Jessica Mifsud, Danielle Tilmanis, Ding Yuan Oh et al. · Antiviral Research
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20 Feb 2020 |
23 |
| 48 |
68 RANDOMIZED CONTROLLED TRIAL OF NITAZOXANIDE-PEGINTERFERON-RIBAVIRIN, NITAZOXANIDE-PEGINTERFERON AND PEGINTERFERON-RIBAVIRIN IN THE TREATMENT OF PATIENTS WITH CHRONIC HEPATITIS C GENOTYPE 4
Jean‐François Rossignol, Asem Ahmed Elfert, Y. El-Gohary et al. · Journal of Hepatology
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2008 |
22 |
| 49 |
1190 SILEN-C2: EARLY ANTIVIRAL ACTIVITY AND SAFETY OF BI 201335 COMBINED WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN (PEGIFN/RBV) IN CHRONIC HCV GENOTYPE-1 PATIENTS WITH NON-RESPONSE TO PEGIFN/RBV
Mark Sulkowski, Marc Bourlière, J.‐P. Bronowicki et al. · Journal of Hepatology
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Apr 2010 |
22 |
| 50 |
Host-targeted nitazoxanide has a high barrier to resistance but does not reduce the emergence or proliferation of oseltamivir-resistant influenza viruses in vitro or in vivo when used in combination with oseltamivir
Danielle Tilmanis, Paulina Koszalka, Ian Barr et al. · Antiviral Research
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13 Jun 2020 |
19 |