| 1 |
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome
Siamak MahmoudianDehkordi et al. · Alzheimer s & Dementia
Open access |
15 Oct 2018 |
720 |
| 2 |
Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study
Vijay R. Varma, Anup Mammen Oommen, Sudhir Varma et al. · PLoS Medicine
Open access |
25 Jan 2018 |
508 |
| 3 |
Metabolic network failures in Alzheimer's disease: A biochemical road map
Jon B. Toledo et al. · Alzheimer s & Dementia
Open access |
21 Mar 2017 |
507 |
| 4 |
Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers
Kwangsik T. Nho et al. · Alzheimer s & Dementia
Open access |
15 Oct 2018 |
350 |
| 5 |
Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers
Kwangsik T. Nho, Alexandra Kueider‐Paisley, Shahzad Ahmad et al. · JAMA Network Open
Open access |
31 Jul 2019 |
244 |
| 6 |
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
Matthias Arnold et al. · Nature Communications
Open access |
2 Mar 2020 |
223 |
| 7 |
Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
Rima F Kaddurah-Daouk, Rebecca Baillie, Hongjie Zhu et al. · PLoS ONE
Open access |
13 Oct 2011 |
194 |
| 8 |
Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease
Emrin Horgusluoglu et al. · Alzheimer s & Dementia
Open access |
10 Nov 2021 |
184 |
| 9 |
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
Kevin Huynh et al. · Nature Communications
Open access |
10 Nov 2020 |
170 |
| 10 |
Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics
Joseph P. McEvoy, Rebecca Baillie, Hongjie Zhu et al. · PLoS ONE
Open access |
24 Jul 2013 |
131 |
| 11 |
Serum triglycerides in Alzheimer disease
Megan M. Bernath, Sudeepa Bhattacharyya, Kwangsik T. Nho et al. · Neurology
Open access |
2 May 2020 |
125 |
| 12 |
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
Priyanka Baloni et al. · Communications Biology
Open access |
8 Oct 2022 |
112 |
| 13 |
Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study
Rima F Kaddurah-Daouk, Rebecca Baillie, Hongjie Zhu et al. · Metabolomics
Open access |
31 Mar 2010 |
108 |
| 14 |
Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
Christopher R. Brydges et al. · Scientific Reports
Open access |
25 Oct 2021 |
102 |
| 15 |
Alterations in acylcarnitines, amines, and lipids inform about the mechanism of action of citalopram/escitalopram in major depression
Siamak MahmoudianDehkordi et al. · Translational Psychiatry
Open access |
2 Mar 2021 |
102 |
| 16 |
Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment
Miles Trupp, Hongjie Zhu, William R. Wikoff et al. · PLoS ONE
Open access |
9 Jul 2012 |
101 |
| 17 |
Impaired plasmalogens in patients with schizophrenia
Rima F Kaddurah-Daouk, Joseph P. McEvoy, Rebecca Baillie et al. · Psychiatry Research
|
16 Apr 2012 |
90 |
| 18 |
A model qualification method for mechanistic physiological QSP models to support model‐informed drug development
Christoph M. Friedrich · CPT Pharmacometrics & Systems Pharmacology
Open access |
26 Jan 2016 |
87 |
| 19 |
Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology
Dinesh Kumar Barupal, Rebecca Baillie, Sili Fan et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
Open access |
5 Sep 2019 |
76 |
| 20 |
Hereditary Pancreatitis
P.R. Davidson, DAVID COSTANZA, JOHN A. SWIECONEK et al. · Annals of Internal Medicine
|
1968 |
55 |
| 21 |
APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies
Tingting Wang et al. · Alzheimer s & Dementia
Open access |
25 Jan 2022 |
51 |
| 22 |
Higher naloxone dosing in a quantitative systems pharmacology model that predicts naloxone-fentanyl competition at the opioid mu receptor level
Ronald B. Moss, Meghan McCabe Pryor, Rebecca Baillie et al. · PLoS ONE
Open access |
16 Jun 2020 |
47 |
| 23 |
Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression
Kwangsik T. Nho, Alexandra Kueider‐Paisley, Matthias Arnold et al. · Brain Communications
Open access |
2021 |
46 |
| 24 |
Peripheral serum metabolomic profiles inform central cognitive impairment
Jingye Wang, Runmin Wei, Guoxiang Xie et al. · Scientific Reports
Open access |
20 Aug 2020 |
40 |
| 25 |
FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective
Jane P. F. Bai, Brian James Schmidt, Kapil G. Gadkar et al. · The AAPS Journal
|
30 Apr 2021 |
39 |
| 26 |
Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau
Mitchel Allan Kling, Dayan B. Goodenowe, Vijitha K. Senanayake et al. · Alzheimer s & Dementia
Open access |
27 Jul 2020 |
36 |
| 27 |
Plasma Omega-3 Polyunsaturated Fatty Acids and Survival in Patients with Chronic Heart Failure and Major Depressive Disorder
for the SADHART-CHF Investigators, Wei Jiang, Harry A. Oken et al. · Journal of Cardiovascular Translational Research
|
Nov 2011 |
34 |
| 28 |
Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease
Nuanyi Liang et al. · Scientific Reports
Open access |
29 Jul 2024 |
28 |
| 29 |
Human CD4+CD25+CD226- Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4+CD25+CD127lo/- Tregs for Adoptive Cell Therapy
Matthew E. Brown, Leeana D. Peters, Seif R. Hanbali et al. · Frontiers in Immunology
Open access |
26 May 2022 |
27 |
| 30 |
Is a Diabetes Mellitus–Linked Amino Acid Signature Associated With β-Blocker–Induced Impaired Fasting Glucose?
Rhonda M. Cooper‐DeHoff, Wei Hou, Liming Weng et al. · Circulation Cardiovascular Genetics
Open access |
13 Mar 2014 |
25 |
| 31 |
Systems Biology
Richard Ho, Christopher A. Lieu · Drugs in R&D
|
2008 |
25 |
| 32 |
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates
Vidya Ramakrishnan, Christina M. Friedrich, Colleen M. Witt et al. · CPT Pharmacometrics & Systems Pharmacology
Open access |
25 Oct 2022 |
22 |
| 33 |
Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics
Mohamed H. Shahin, Yan Gong, Reginald F. Frye et al. · Journal of the American Heart Association
Open access |
30 Dec 2017 |
22 |
| 34 |
Using machine learning surrogate modeling for faster QSP VP cohort generation
Renée C. Myers, Florian Augustin, Jérémy Huard et al. · CPT Pharmacometrics & Systems Pharmacology
Open access |
16 Jun 2023 |
21 |
| 35 |
From Cold to Hot: Changing Perceptions and Future Opportunities for Quantitative Systems Pharmacology Modeling in Cancer Immunotherapy
Vincent Lemaire, David M. Bassen, Mike Reed et al. · Clinical Pharmacology & Therapeutics
Open access |
25 Oct 2022 |
20 |
| 36 |
A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models
Saroja Ramanujan, Jason R. Chan, Christina M. Friedrich et al. · CPT Pharmacometrics & Systems Pharmacology
Open access |
15 Apr 2019 |
20 |
| 37 |
Pharmacometabolomic signature links simvastatin therapy and insulin resistance
Mona Elbadawi-Sidhu, Rebecca Baillie, Hongjie Zhu et al. · Metabolomics
Open access |
23 Dec 2016 |
19 |
| 38 |
Pharmacokinetic analysis of 14C‐ursodiol in newborn infants using accelerator mass spectrometry
Toufigh Gordi, Rebecca Baillie, Le Thuy Vuong et al. · The Journal of Clinical Pharmacology
|
8 May 2014 |
19 |
| 39 |
Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate
Rima F Kaddurah-Daouk, Thomas Hankemeier, Elizabeth H. Scholl et al. · CPT Pharmacometrics & Systems Pharmacology
Open access |
Aug 2018 |
17 |
| 40 |
A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics
Jeffrey E. Ming, Ruth E. Abrams, Derek W. Bartlett et al. · Gene Regulation and Systems Biology
Open access |
2017 |
17 |
| 41 |
Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models
Sergey Vasilyevich Ermakov, Peter Forster, Jyotsna Pagidala et al. · Frontiers in Pharmacology
Open access |
22 Oct 2014 |
17 |
| 42 |
A capacidade de leitos hospitalares no Brasil, as internações no SUS, a migração demográfica e os custos dos procedimentos
Beny José Finkelstein, LCDS Borges · Jornal Brasileiro de Economia da Saúde
Open access |
20 Dec 2020 |
15 |
| 43 |
Quantitative systems pharmacology model‐based investigation of adverse gastrointestinal events associated with prolonged treatment with PI3‐kinase inhibitors
Kapil G. Gadkar, Christina M. Friedrich, Vincent J. Hurez et al. · CPT Pharmacometrics & Systems Pharmacology
Open access |
Dec 2021 |
14 |
| 44 |
Alterations in Acylcarnitines, Amines, and Lipids Inform about Mechanism of Action of Citalopram/Escitalopram in Major Depression
Siamak MahmoudianDehkordi, Ahmed T. Ahmed, Sudeepa Bhattacharyya et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
10 Feb 2020 |
11 |
| 45 |
Quantitative Systems Pharmacology: Applications and Adoption in Drug Development
Saroja Ramanujan, Kapil G. Gadkar, Ananth Kadambi · AAPS advances in the pharmaceutical sciences series
Book chapter |
2016 |
11 |
| 46 |
La educación para la salud: una propuesta fundamentada desde el campo de la docencia
Valentín Gavidia Catalán, Ma J. Rodés Sala, A. Carratala Beguer · Enseñanza de las Ciencias Revista de investigación y experiencias didácticas
Open access |
15 Jan 1993 |
11 |
| 47 |
Steady-State Pharmacokinetics of Gabapentin after Administration of a Novel Gastroretentive Extended-Release Formulation in Postmenopausal Women with Vasomotor Symptoms
Verne E. Cowles, Toufigh Gordi, Sui Yuen Eddie Hou · Clinical Drug Investigation
|
Sep 2012 |
10 |
| 48 |
Synthesis of a novel cyclopropyl phosphonate nucleotide as a phosphate mimic
Erich Altenhofer, Michael J. Lawler, Pankaj Kumar et al. · Chemical Communications
|
2021 |
8 |
| 49 |
Serum triglycerides in Alzheimer’s disease: Relation to neuroimaging and CSF biomarkers
Megan M. Bernath, Sudeepa Bhattacharyya, Kwangsik T. Nho et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
13 Oct 2018 |
8 |
| 50 |
Virtual patients inspired by multiomics predict the efficacy of an anti-IFNα mAb in cutaneous lupus
Vincent J. Hurez, Glenn Gauderat, Perrine Soret et al. · iScience
Open access |
6 Jan 2025 |
5 |