| 1 |
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Roger C. Bone, ROBERT A. BALK, Frank B. Cerra et al. · CHEST Journal
Open access |
Jun 1992 |
13,306 |
| 2 |
NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Clifford R. Jack et al. · Alzheimer s & Dementia
Open access |
Apr 2018 |
10,885 |
| 3 |
Diagnosis and management of dementia with Lewy bodies
Ian Grant McKeith et al. · Neurology
|
27 Dec 2005 |
5,092 |
| 4 |
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Jason M. Brenchley, David Anthony Price, Timothy W. Schacker et al. · Nature Medicine
|
19 Nov 2006 |
3,596 |
| 5 |
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
Liesi E. Hebert, Jennifer Weuve, Paul A. Scherr et al. · Neurology
Open access |
7 Feb 2013 |
2,721 |
| 6 |
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
S Hong Lee et al. · Nature Genetics
Open access370 authors |
11 Aug 2013 |
2,374 |
| 7 |
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Peter T. Nelson et al. · Journal of Neuropathology & Experimental Neurology
Open access |
6 Apr 2012 |
2,144 |
| 8 |
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
Jonathan Kocarnik et al. · JAMA Oncology
Open access601 authors |
30 Dec 2021 |
2,100 |
| 9 |
Analysis of shared heritability in common disorders of the brain
Verneri Anttila et al. · Science
Open access577 authors |
21 Jun 2018 |
2,056 |
| 10 |
The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited
Jan J. Weening et al. · Journal of the American Society of Nephrology
Open access |
Feb 2004 |
2,021 |
| 11 |
Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Konrad Talbot, Hoau-Yan Wang, Hala Kazi et al. · Journal of Clinical Investigation
Open access |
27 Mar 2012 |
1,879 |
| 12 |
Effects of Treating Depression and Low Perceived Social Support on Clinical Events After Myocardial Infarction
Lisa F. Berkman, James A. Blumenthal, Matthew M. Burg et al. · JAMA
|
18 Jun 2003 |
1,875 |
| 13 |
Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument.
Marianne J. Brady, David F Cella, Fei Mo et al. · Journal of Clinical Oncology
|
Mar 1997 |
1,779 |
| 14 |
Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials
JoAnn E. Manson et al. · JAMA
Open access |
Oct 2013 |
1,645 |
| 15 |
Guidelines for the Evaluation and Management of Status Epilepticus
Gretchen M. Brophy, RODNEY D. BELL, Jan Claassen et al. · Neurocritical Care
|
23 Apr 2012 |
1,630 |
| 16 |
Fibromyalgia Criteria and Severity Scales for Clinical and Epidemiological Studies: A Modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia
Frederick Wolfe, Daniel Joseph Clauw, Mary‐Ann Fitzcharles et al. · The Journal of Rheumatology
Open access |
Feb 2011 |
1,516 |
| 17 |
Loneliness and Risk of Alzheimer Disease
Robert S. Wilson, Kristin R. Krueger, Steven Edward Arnold et al. · Archives of General Psychiatry
|
Feb 2007 |
1,380 |
| 18 |
A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction
Joshua M. Hare, Jay H. Traverse, Timothy D. Henry et al. · Journal of the American College of Cardiology
Open access |
Dec 2009 |
1,359 |
| 19 |
Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease
Robert S. Wilson · JAMA
|
13 Feb 2002 |
1,344 |
| 20 |
Scoliosis Research Society—Schwab Adult Spinal Deformity Classification
Frank Schwab, Benjamin Ungar, Benjamin Blondel et al. · Spine
|
Nov 2011 |
1,329 |
| 21 |
Validation of proposed diagnostic criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome
Norman R. Harden, Stephen P. Bruehl, Roberto S.G.M. Perez et al. · Pain
Open access |
21 May 2010 |
1,325 |
| 22 |
A Calcium Antagonist vs a Non–Calcium Antagonist Hypertension Treatment Strategy for Patients With Coronary Artery Disease
Carl J. Pepine, Eileen Handberg, Rhonda M. Cooper‐DeHoff et al. · JAMA
|
2 Dec 2003 |
1,293 |
| 23 |
Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function
Zoe Arvanitakis, R. J. Wilson, Julia L. Bienias et al. · Archives of Neurology
|
May 2004 |
1,273 |
| 24 |
Effect of Estrogen Plus Progestin on Stroke in Postmenopausal Women
Sylvia W Wassertheil-Smoller, Susan L. Hendrix, Marian C. Limacher et al. · JAMA
|
27 May 2003 |
1,162 |
| 25 |
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
Nigel J. Cairns et al. · Acta Neuropathologica
Open access |
19 Jun 2007 |
1,135 |
| 26 |
Critical Care Management of Patients Following Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference
Michael N. Diringer et al. · Neurocritical Care
|
19 Jul 2011 |
1,134 |
| 27 |
Pipeline for Uncoilable or Failed Aneurysms: Results from a Multicenter Clinical Trial
Tibor Becske, David F. Kallmes, Işıl Saatçi et al. · Radiology
Open access |
16 Feb 2013 |
1,107 |
| 28 |
Low-Fat Dietary Pattern and Risk of Cardiovascular Disease
Barbara V. Howard et al. · JAMA
|
7 Feb 2006 |
1,097 |
| 29 |
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
Zhenqiang Su et al. · Nature Biotechnology
Open access161 authors |
21 Aug 2014 |
1,092 |
| 30 |
Mood Disorders in the Medically Ill: Scientific Review and Recommendations
Dwight L. Evans et al. · Biological Psychiatry
|
Aug 2005 |
1,078 |
| 31 |
Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats
Yifeng Zhang et al. · Nature Medicine
Open access |
29 Aug 2016 |
1,054 |
| 32 |
Consensus Auditory-Perceptual Evaluation of Voice: Development of a Standardized Clinical Protocol
Gail B. Kempster, Bruce R. Gerratt, Katherine Verdolini Abbott et al. · American Journal of Speech-Language Pathology
|
May 2009 |
1,010 |
| 33 |
Deep Brain Stimulation for Parkinson Disease
Jeff M. Bronstein et al. · Archives of Neurology
Open access |
11 Oct 2010 |
981 |
| 34 |
Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline
Victor A. Ferraris, Suellen P. Ferraris, Sibu Pada Saha et al. · The Annals of Thoracic Surgery
|
25 Apr 2007 |
979 |
| 35 |
Corrosion of Metal Orthopaedic Implants*
Joshua James Jacobs, Jeremy L. Gilbert, Robert M. Urban · Journal of Bone and Joint Surgery
|
Feb 1998 |
963 |
| 36 |
The neuropathology of probable Alzheimer disease and mild cognitive impairment
Julie A. Schneider, Zoe Arvanitakis, Sue E. Leurgans et al. · Annals of Neurology
Open access |
23 Mar 2009 |
946 |
| 37 |
International Consensus Statement on Allergy and Rhinology: Rhinosinusitis
Richard R. Orlandi et al. · International Forum of Allergy & Rhinology
Open access |
Feb 2016 |
900 |
| 38 |
Involvement of dihydropyridine receptors in excitation–contraction coupling in skeletal muscle
Eduardo Rı́os, Gustavo Brum · Nature
|
Feb 1987 |
896 |
| 39 |
Developing and validating the Communication Function Classification System for individuals with cerebral palsy
Mary Jo Cooley Hidecker, Nigel Paneth, Peter Rosenbaum et al. · Developmental Medicine & Child Neurology
Open access |
27 Jun 2011 |
887 |
| 40 |
Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons
Andrew S. P. Lim, Matthew E. Kowgier, Lei Yu et al. · SLEEP
Open access |
28 Jun 2013 |
810 |
| 41 |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Philip L. De Jager et al. · Nature Genetics
ReviewOpen access |
14 Jun 2009 |
809 |
| 42 |
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Colm T. O'Dushlaine et al. · Nature Neuroscience
Open access375 authors |
19 Jan 2015 |
807 |
| 43 |
Metabolic Effects of Carvedilol vs Metoprolol in Patients With Type 2 Diabetes Mellitus and Hypertension
George L. Bakris, Vivian Andrew Fonseca, Richard E. Katholi et al. · JAMA
|
9 Nov 2004 |
800 |
| 44 |
National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2
Terry A. Jacobson et al. · Journal of clinical lipidology
Open access |
18 Sep 2015 |
792 |
| 45 |
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes: Executive Summary
Ezra A. Amsterdam, NANETTE KASS WENGER, Ralph G. Brindis et al. · Journal of the American College of Cardiology
Open access |
23 Sep 2014 |
782 |
| 46 |
Impact of multiple pathologies on the threshold for clinically overt dementia
Alifiya Kapasi, Charles S DeCarli, Julie A. Schneider · Acta Neuropathologica
Open access |
9 May 2017 |
763 |
| 47 |
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Simon I Hay et al. · The Lancet
Open access2,780 authors |
Oct 2025 |
762 |
| 48 |
Reliability and validity of the functional assessment of cancer therapy—lung (FACT-L) quality of life instrument
David F Cella, Amy E. Bonomi, Stephen R. Lloyd et al. · Lung Cancer
|
Jun 1995 |
756 |
| 49 |
Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-Based Chemoradiation Following Resection of Pancreatic Adenocarcinoma
William F. Regine, Kathryn A Winter, Ross Allen Abrams et al. · JAMA
|
4 Mar 2008 |
755 |
| 50 |
Clinical Correlates of Inpatient Suicide
Katie A. Busch, JAN A. FAWCETT, Douglas G. Jacobs · The Journal of Clinical Psychiatry
|
15 Jan 2003 |
752 |