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Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance
Roberto Maldonado, Robert A. LaMothe, Joseph D. Ferrari et al. · Proceedings of the National Academy of Sciences
Open access |
29 Dec 2014 |
441 |
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Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
Amine Meliani, Florence Boisgérault, Romain Hardet et al. · Nature Communications
Open access |
Oct 2018 |
266 |
| 3 |
Microfluidics-free single-cell genomics with templated emulsification
Iain C. Clark et al. · Nature Biotechnology
Open access |
6 Mar 2023 |
228 |
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Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles
Takashi Kishimoto, Joseph D. Ferrari, Robert A. LaMothe et al. · Nature Nanotechnology
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29 Jul 2016 |
200 |
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Nanoparticles for the Induction of Antigen-Specific Immunological Tolerance
Takashi Kishimoto, Roberto Maldonado · Frontiers in Immunology
Open access |
20 Feb 2018 |
171 |
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Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release
Petr O. Ilyinskii, Christopher J. Roy, Conlin P. O’Neil et al. · Vaccine
Open access |
Mar 2014 |
168 |
| 7 |
Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis
Robert A. LaMothe, Pallavi N. Kolte, Trinh Phuong Vo et al. · Frontiers in Immunology
Open access |
2 Mar 2018 |
112 |
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Generation of a universal CD4 memory T cell recall peptide effective in humans, mice and non-human primates
Christopher C. Fraser, David H. Altreuter, Petr O. Ilyinskii et al. · Vaccine
Open access |
26 Feb 2014 |
84 |
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TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25
Elizabeth A. Thompson, Sebastian Ols, Kazutoyo Miura et al. · JCI Insight
Open access |
16 May 2018 |
76 |
| 10 |
Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies
Takashi Kishimoto · Frontiers in Immunology
Open access |
20 May 2020 |
62 |
| 11 |
Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia
Earl Sands, Alan Kivitz, Wesley H. DeHaan et al. · Nature Communications
Open access |
12 Jan 2022 |
60 |
| 12 |
Enhancement of liver-directed transgene expression at initial and repeat doses of AAV vectors admixed with ImmTOR nanoparticles
Petr O. Ilyinskii, Alicia M. Michaud, Christopher J. Roy et al. · Science Advances
Open access |
24 Feb 2021 |
55 |
| 13 |
Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity
Ronit Mazor, Emily M. King, Masanori Onda et al. · Proceedings of the National Academy of Sciences
Open access |
8 Jan 2018 |
50 |
| 14 |
Detection of viral RNAs at ambient temperature via reporter proteins produced through the target-splinted ligation of DNA probes
Elizabeth A. Phillips, Adam D. Silverman, Aric Joneja et al. · Nature Biomedical Engineering
Open access |
4 May 2023 |
44 |
| 15 |
ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia
Petr O. Ilyinskii, Alicia M. Michaud, Gina L. Rizzo et al. · Molecular Therapy — Methods & Clinical Development
Open access |
16 Jul 2021 |
39 |
| 16 |
Tolerogenic Nanoparticles Impacting B and T Lymphocyte Responses Delay Autoimmune Arthritis in K/BxN Mice
Amrita Srivastava, Britni M. Arlian, Lijuan Pang et al. · ACS Chemical Biology
Open access |
26 May 2021 |
30 |
| 17 |
Query relaxation by structure and semantics for retrieval of logical Web documents
Wen-Syan Li, K. Selçuk Candan, Quoc Vu et al. · IEEE Transactions on Knowledge and Data Engineering
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Jul 2002 |
30 |
| 18 |
Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles
Petr O. Ilyinskii, Christopher J. Roy, Julie LePrevost et al. · Frontiers in Immunology
Open access |
25 May 2021 |
29 |
| 19 |
Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
Takashi Kishimoto, Max Fournier, Alicia M. Michaud et al. · Journal of Autoimmunity
Open access |
14 Oct 2023 |
28 |
| 20 |
The proteomics bottleneck: strategies for preliminary validation of potential biomarkers and drug targets
Steven Bodovitz · Trends in biotechnology
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24 Nov 2003 |
27 |
| 21 |
A pilot study on using rapamycin-carrying synthetic vaccine particles (SVP) in conjunction with enzyme replacement therapy to induce immune tolerance in Pompe disease
Han Hyuk Lim, Haiqing Yi, Takashi Kishimoto et al. · Molecular Genetics and Metabolism Reports
Open access |
23 Jul 2017 |
26 |
| 22 |
Phase 2 Dose-Finding Study in Patients with Gout Using SEL-212, a Novel PEGylated Uricase (SEL-037) Combined with Tolerogenic Nanoparticles (SEL-110)
Alan Kivitz, Wesley H. DeHaan, Rehan Azeem et al. · Rheumatology and Therapy
Open access |
17 Apr 2023 |
25 |
| 23 |
Long-term correction of ornithine transcarbamylase deficiency in Spf-Ash mice with a translationally optimized AAV vector
Giulia De Sabbata, Florence Boisgérault, Corrado Guarnaccia et al. · Molecular Therapy — Methods & Clinical Development
Open access |
16 Nov 2020 |
25 |
| 24 |
The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR™) versus pegloticase for refractory gout
Herbert S. B. Baraf, Puja P. Khanna, Alan Kivitz et al. · Lara D. Veeken
Open access |
13 Jul 2023 |
23 |
| 25 |
A New Natural Defense Against Airborne Pathogens
David Albert Edwards, Anthony James Hickey, Richard P. Batycky et al. · QRB Discovery
Open access |
2020 |
22 |
| 26 |
Unlocking the potential of iPSC-derived immune cells: engineering iNK and iT cells for cutting-edge immunotherapy
Minggang Fang, Alexander G. Allen, Chong Luo et al. · Frontiers in Immunology
Open access |
30 Aug 2024 |
21 |
| 27 |
Genome-wide identification of PTI1 family in Setaria italica and salinity-responsive functional analysis of SiPTI1–5
Yongguan Huangfu, Jiaowen Pan, Zhen Li et al. · BMC Plant Biology
Open access |
3 Jul 2021 |
21 |
| 28 |
Synthetic vaccine particles for durable cytolytic T lymphocyte responses and anti-tumor immunotherapy
Petr O. Ilyinskii, Grigoriy I. Kovalev, Conlin P. O’Neil et al. · PLoS ONE
Open access |
Jun 2018 |
20 |
| 29 |
Real-Time, Multiplexed SHERLOCK for in Vitro Diagnostics
Jennifer M Peña, Brendan J Manning, Xiang Li et al. · Journal of Molecular Diagnostics
Open access |
23 Apr 2023 |
19 |
| 30 |
Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity
Zeliang Zheng, Ryuhei Okada, Hisataka Kobayashi et al. · Molecular Cancer Therapeutics
Open access |
23 Dec 2019 |
19 |
| 31 |
Multiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia
Cheryl A.C. Peretz et al. · Nature Communications
Open access |
18 Sep 2024 |
17 |
| 32 |
Readministration of high-dose adeno-associated virus gene therapy vectors enabled by ImmTOR nanoparticles combined with B cell-targeted agents
Petr O. Ilyinskii, Christopher J. Roy, Alicia M. Michaud et al. · PNAS Nexus
Open access |
Nov 2023 |
16 |
| 33 |
Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays
Clifford G. Phaneuf, Konstantin Aizikov, Dmitry Grinfeld et al. · Communications Chemistry
Open access |
6 Apr 2023 |
14 |
| 34 |
Rescue of infant progressive familial intrahepatic cholestasis type 3 mice by repeated dosing of AAV gene therapy
Nicholas D. Weber, Leticia Odriozola, Irene Ros‐Gañán et al. · JHEP Reports
Open access |
24 Feb 2023 |
14 |
| 35 |
DFT Study on the His-Tag Binding Affinity of Metal Ions in Modeled Hexacationic Metal Complexes
Alparslan Numan Yildiz, Esra E. Kasapbasi, Zeynep Yurtsever et al. · ACS Omega
Open access |
8 Nov 2024 |
12 |
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A Platform for Controlled Template-Independent Enzymatic Synthesis of RNA Oligonucleotides and Therapeutics
Daniel J. Wiegand, Jonathan Rittichier, Ella Meyer et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
29 Jun 2023 |
12 |
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
Andreas Lundqvist et al. · Journal for ImmunoTherapy of Cancer
Open access1,762 authors |
Nov 2016 |
11 |
| 38 |
Eilat virus (EILV) causes superinfection exclusion against West Nile virus (WNV) in a strain-specific manner in Culex tarsalis mosquitoes
Renuka Elizabeth Joseph, Jovana Bozic, Kristine Werling et al. · Journal of General Virology
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27 Aug 2024 |
10 |
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Bioanalytical Challenges and Unique Considerations to Support Pharmacokinetic Characterization of Bispecific Biotherapeutics
Mark Ma, Kelly S. Colletti, Tong‐Yuan Yang et al. · Bioanalysis
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Mar 2019 |
10 |
| 40 |
Repeated dosing of AAV-mediated liver gene therapy in juvenile rat and mouse models of Crigler-Najjar syndrome type I
Xiaoxia Shi, Giulia Bortolussi, Fanny Collaud et al. · Molecular Therapy — Methods & Clinical Development
Open access |
30 Oct 2024 |
8 |
| 41 |
Use of a mutation-specific genotyping method to assess for HIV-1 drug resistance in antiretroviral-naïve HIV-1 Subtype C-infected patients in Botswana
Dorcas Maruapula, Iain J. MacLeod, Sikhulile M. Moyo et al. · AAS Open Research
Open access |
28 Sep 2020 |
7 |
| 42 |
Development of circular AAV cargos for targeted seamless insertion with large serine integrases
Brett Estes, Nisha Gandhi, Jessica R Von Stetina et al. · Molecular Therapy — Methods & Clinical Development
Open access |
14 May 2025 |
6 |
| 43 |
Single-cell analysis of the nervous system at small and large scales with instant partitions
Paul W. Frazel, K Fricano-Kugler, AA May-Zhang et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
15 Jul 2023 |
6 |
| 44 |
SAT0402 SEL-212 PHASE 2 CLINICAL STUDY IN SYMPTOMATIC GOUT PATIENTS: IMMTOR TOLEROGENIC NANOPARTICLES COMBINED WITH PEGADRICASE MITIGATES IMMUNOGENICITY AND ENABLES SUSTAINED REDUCTION OF SERUM URIC ACID LEVELS, LOW RATE OF GOUT FLARES AND MONTHLY DOSING
Stephen Smolinski, Alan Kivitz, Wesley H. DeHaan et al. · Annals of the Rheumatic Diseases
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Jun 2019 |
6 |
| 45 |
Meta-atlas of Juvenile and Adult Enteric Neuron scRNA-seq for Dataset Comparisons and Consensus on Transcriptomic Definitions of Enteric Neuron Subtypes
Joseph T. Benthal, Aaron A. May‐Zhang, E. Michelle Southard‐Smith · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
4 Nov 2024 |
5 |
| 46 |
P109 Clinical development of a novel strategy to mitigate biologic immunogenicity: monthly dosing of a pegylated uricase with SVP-R enables sustained reduction of serum uric acid (SUA) levels by mitigating formation of anti-drug antibodies (ADAS)
Emma M. Sands, Alan Kivitz, Wesley H. DeHaan et al. · Annals of the Rheumatic Diseases
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22 Feb 2018 |
5 |
| 47 |
Multiomic Single Cell Sequencing Identifies Stemlike Nature of Mixed Phenotype Acute Leukemia and Provides Novel Risk Stratification
Cheryl A.C. Peretz, Vanessa Elaine Kennedy, Anushka Walia et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
18 May 2023 |
4 |
| 48 |
Nanoparticle-Based Nicotine Vaccine
Petr O. Ilyinskii, Lloyd P. M. Johnston
Book chapter |
18 Dec 2015 |
4 |
| 49 |
Development and Clinical Translation Considerations for the Next Wave of Gene Modified Hematopoietic Stem and Progenitor Cells Therapies
Matthew Li, Brent A. Morse, Sadik H. Kassim · Expert Opinion on Biological Therapy
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14 Jul 2022 |
3 |
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ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics
Carsten Brunn, Takashi Kishimoto · Emerging Topics in Life Sciences
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13 Aug 2021 |
3 |