| 1 |
A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran
Viktoria Moschetti, Stephen H. Norris, Joachim Stangier et al. · Thrombosis and Haemostasis
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19 Mar 2015 |
245 |
| 2 |
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor
Douglas G. Johns et al. · Circulation
Open access |
May 2023 |
168 |
| 3 |
Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects
Steven Ramael, Florence De Smedt, Nathalie Toublanc et al. · Clinical Therapeutics
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May 2006 |
118 |
| 4 |
Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX‐02, a Potential Treatment for Genetic Disorders Caused by Nonsense Mutations, in Healthy Volunteers
Andi Leubitz, Anat Frydman‐Marom, Neal Sharpe et al. · Clinical Pharmacology in Drug Development
Open access |
16 Jan 2019 |
72 |
| 5 |
Bioequivalence, safety and immunogenicity of BI 695501, an adalimumab biosimilar candidate, compared with the reference biologic in a randomized, double-blind, active comparator phase I clinical study (VOLTAIRE®-PK) in healthy subjects
Christopher John Wynne, Mario Altendorfer, Ivo Sonderegger et al. · Expert Opinion on Investigational Drugs
Open access |
4 Nov 2016 |
59 |
| 6 |
Revamping corrosion damaged reinforced concrete balconies: Life cycle assessment and life cycle cost of life-extending repair methods
Lydia Wittocx, Matthias Buyle, Amaryllis Audenaert et al. · Journal of Building Engineering
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27 Mar 2022 |
58 |
| 7 |
Pharmacokinetics and Pharmacodynamics of Garetosmab (Anti‐Activin A): Results From a First‐in‐Human Phase 1 Study
Frédéric P. Vanhoutte, Liang Su, Marcella K. Ruddy et al. · The Journal of Clinical Pharmacology
Open access |
18 Jun 2020 |
55 |
| 8 |
Human challenge trials in vaccine development, Rockville, MD, USA, September 28–30, 2017
Marc F.D. Baay, Thomas L. Richie, Pieter Neels et al. · Biologicals
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21 Mar 2018 |
51 |
| 9 |
Transportation Risk ANalysis tool for hazardous Substances (TRANS) – A user-friendly, semi-quantitative multi-mode hazmat transport route safety risk estimation methodology for Flanders
Genserik Reniers, Katleen De Jongh, Bob Gorrens et al. · Transportation Research Part D Transport and Environment
Open access |
3 Aug 2010 |
46 |
| 10 |
Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies
Holger Rosenbrock, Michael P. Desch, Oliver Kleiner et al. · Clinical and Translational Science
Open access |
23 Aug 2018 |
45 |
| 11 |
Recommendations on The Interpretation of The New European Medicines Agency Guideline on Bioanalytical Method Validation By Global Cro Council For Bioanalysis (Gcc)
Mark Boterman et al. · Bioanalysis
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Mar 2012 |
45 |
| 12 |
Clinical pharmacology of exogenously administered alkaline phosphatase
Peter Pickkers, Ferdinand T. F. Snellen, Peter Rogiers et al. · European Journal of Clinical Pharmacology
Open access |
Dec 2008 |
41 |
| 13 |
A Randomized, Double‐Blind, Placebo‐Controlled, Multiple Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of ELX‐02 in Healthy Subjects
Andi Leubitz, Frédéric P. Vanhoutte, Ming‐yi Hu et al. · Clinical Pharmacology in Drug Development
Open access |
19 Jan 2021 |
36 |
| 14 |
Idarucizumab does not have procoagulant effects: Assessment of thrombosis biomarkers in healthy volunteers
Michael Schmohl, Stephan Glund, Akiko Harada et al. · Thrombosis and Haemostasis
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Dec 2016 |
36 |
| 15 |
Safety and immunogenicity of a measles-vectored SARS-CoV-2 vaccine candidate, V591 / TMV-083, in healthy adults: results of a randomized, placebo-controlled Phase I study
Odile Launay et al. · EBioMedicine
Open access |
2022 |
33 |
| 16 |
Characterisation of a wild-type influenza (A/H1N1) virus strain as an experimental challenge agent in humans
Jeannette M. Watson, James N. Francis, Sofie Mesens et al. · Virology Journal
Open access |
2 Feb 2015 |
33 |
| 17 |
Recommendations on Bioanalytical Method Stability Implications of Co-Administered And Co-Formulated Drugs By Global Cro Council For Bioanalysis (Gcc)
Steve Lowes et al. · Bioanalysis
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Sep 2012 |
33 |
| 18 |
Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study
Mohamed Farouk Chughlay, Myriam El Gaaloul, Cristina Donini et al. · American Journal of Tropical Medicine and Hygiene
Open access |
8 Feb 2021 |
32 |
| 19 |
Conference Report: The 3rd Global CRO Council for Bioanalysis at The International Reid Bioanalytical Forum
Massimo Breda et al. · Bioanalysis
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Dec 2011 |
32 |
| 20 |
First-in-Human Phase 1a Study of the Safety, Pharmacokinetics, and Pharmacodynamics of the Noncovalent Bruton Tyrosine Kinase (BTK) Inhibitor SNS-062 in Healthy Subjects
Linda L. Neuman, Renee Ward, David Arnold et al. · Blood
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2 Dec 2016 |
30 |
| 21 |
A phase I, randomized, proof‐of‐clinical‐mechanism study assessing the pharmacokinetics and pharmacodynamics of the oral PDE9A inhibitor BI 409306 in healthy male volunteers
Katja Boland, Viktoria Moschetti, Chantaratsamon Dansirikul et al. · Human Psychopharmacology Clinical and Experimental
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2017 |
29 |
| 22 |
Dialysability of Gadoteric Acid in Patients With End-Stage Renal Disease Undergoing Hemodialysis
Eric E. O. Gheuens, Ronald Daelemans, Sofie Mesens · Investigative Radiology
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11 Mar 2014 |
29 |
| 23 |
Systemic Exposure and Implications for Lung Deposition with an Extra-Fine Hydrofluoroalkane Beclometasone Dipropionate/Formoterol Fixed Combination
Jean Bousquet, Gianluigi Poli, Daniela Acerbi et al. · Clinical Pharmacokinetics
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Jun 2009 |
27 |
| 24 |
Mixed-Method Systematic Review and Meta-Analysis of Shared Decision-Making Tools for Cancer Screening
Deborah Jael Herrera, Wessel van de Veerdonk, Neamin M. Berhe et al. · Cancers
ReviewOpen access |
29 Jul 2023 |
25 |
| 25 |
Recommendations on Isr in Multi Analyte Assays, Qa/Bioanalytical Consultants And Gcp By Global Cro Council For Bioanalysis (Gcc)
Timothy Sangster et al. · Bioanalysis
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Jul 2012 |
25 |
| 26 |
Pharmacokinetics, Safety, and Tolerability of Fevipiprant (QAW039), a Novel CRTh2 Receptor Antagonist: Results From 2 Randomized, Phase 1, Placebo‐Controlled Studies in Healthy Volunteers
Veit J. Erpenbeck, Eva Vets, Lien Gheyle et al. · Clinical Pharmacology in Drug Development
Open access |
8 Dec 2015 |
24 |
| 27 |
Similar Pharmacokinetics of the Adalimumab (Humira®) Biosimilar BI 695501 Whether Administered via Subcutaneous Autoinjector or Prefilled Syringe (VOLTAIRE®-AI and VOLTAIRE®-TAI): Phase 1, Randomized, Open-Label, Parallel-Group Trials
Steven Ramael, Benjamin Van Hoorick, Renger G. Tiessen et al. · Rheumatology and Therapy
Open access |
29 Jun 2018 |
17 |
| 28 |
Assessment of CD8+ T-cell mediated immunity in an influenza A(H3N2) human challenge model in Belgium: a single centre, randomised, double-blind phase 2 study
Thomas G. Evans, Flora Castellino, Monika Kowalik Dobczyk et al. · The Lancet Microbe
Open access |
7 May 2024 |
14 |
| 29 |
2011 IL28B POLYMORPHISM IS SIGNIFICANTLY CORRELATED WITH IFN ANTI-VIRAL EFFECTIVENESS ALREADY ON FIRST DAY OF PEGYLATED INTERFERON-α AND RIBAVIRIN THERAPY OF CHRONIC HCV INFECTION
Avidan Uriel Neumann, Stéphanie Bibert, Bart L. Haagmans et al. · Journal of Hepatology
Open access |
Apr 2010 |
12 |
| 30 |
Evaluation of the immunogenicity of the dabigatran reversal agent idarucizumab during Phase I studies
Stephen H. Norris, Steven Ramael, Ippei Ikushima et al. · British Journal of Clinical Pharmacology
Open access |
23 Feb 2017 |
11 |
| 31 |
2012 VIROLOGICAL RESPONSE, SAFETY, AND PHARMACOKINETIC PROFILE FOLLOWING SINGLE- AND MULTIPLE-DOSE ADMINISTRATION OF ACH-0141625 PROTEASE INHIBITOR TO HEALTHY VOLUNTEERS AND HCV GENOTYPE-1 PATIENTS
V. Detishin, Wouter Haazen, Heather Robison et al. · Journal of Hepatology
Open access |
Apr 2010 |
10 |
| 32 |
Pharmacokinetics and pharmacodynamics of mibavademab (a leptin receptor agonist): Results from a first‐in‐human phase I study
Andrew D. Gewitz, Jeanne Mendell, Yuhuan Wang et al. · Clinical and Translational Science
Open access |
Apr 2024 |
8 |
| 33 |
LTA4H inhibitor LYS006: Clinical PK/PD and safety in a randomized phase I clinical trial
Christian Loesche, Damien Picard, Benjamin Van Hoorick et al. · Clinical and Translational Science
Open access |
Feb 2024 |
6 |
| 34 |
Time-to-Seizure Modeling of Lacosamide Used in Monotherapy in Patients with Newly Diagnosed Epilepsy
Andreas Lindauer, Christian Laveille, Armel Stockis · Clinical Pharmacokinetics
Open access |
13 Mar 2017 |
6 |
| 35 |
P1‐221: Safety and pharmacokinetics of the novel BACE inhibitor MK‐8931 in healthy subjects following single‐ and Multiple‐Dose administration
Jack Tseng, Marissa Fallon Dockendorf, Gopal Krishna et al. · Alzheimer s & Dementia
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Jul 2012 |
6 |
| 36 |
Polyfluoroalkyl substances in dedicated hazardous waste incinerators: Framework and industrial scale experimental estimation of destruction and removal efficiency
Jo Van Caneghem, Anneleen Verstegen, Geert Torremans et al. · Waste Management & Research The Journal for a Sustainable Circular Economy
Open access |
26 Jun 2025 |
5 |
| 37 |
Safety and Pharmacokinetics of MK ‐8527 in Adults Without HIV
Gillian Gillespie, Russ P. Carstens, Xiaowei Zang et al. · Clinical and Translational Science
Open access |
Sep 2025 |
4 |
| 38 |
Background morbidity in HIV vaccine trial participants from various geographic regions as assessed by unsolicited adverse events
Claudia S. Schmidt et al. · Human Vaccines & Immunotherapeutics
Open access |
May 2012 |
4 |
| 39 |
Systems Pharmacology: Enabling Multidimensional Therapeutics
Stuart R. Maudsley, Hanne Leysen, Jaana van Gastel et al. · Elsevier eBooks
Book chapter |
30 Jan 2021 |
3 |
| 40 |
Why do healthy volunteers participate in clinical trials?
Thijs van Iersel, Jelle Klein, Timothy Colin Hardman et al. · British Journal of Clinical Pharmacology
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7 Mar 2026 |
2 |
| 41 |
Mass balance, pharmacokinetics, metabolism, and excretion of radiolabeled acoziborole, a potential novel treatment for human African trypanosomiasis, following single microtracer oral dose to humans
Jean‐Yves Gillon, François Simon, Sharan Sidhu et al. · Antimicrobial Agents and Chemotherapy
Open access |
22 Sep 2025 |
2 |
| 42 |
Healthy participant engagement in early clinical trials: results from the European EUFEMED survey
Joshua P. Klein, Thijs van Iersel, Daniel H. de Vries et al. · Frontiers in Pharmacology
Open access |
Aug 2025 |
2 |
| 43 |
Anticoagulation with mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933A2) and cenvacibart (REGN7508Cat)
Dan Chalothorn et al. · Blood
Open access |
11 Jun 2026 |
1 |
| 44 |
Unexpected Clinical Drug-Drug Interaction of Fexinidazole on Midazolam Pharmacokinetics: Insights into Underlying Mechanisms from Clinical Phase I Study Results and Supporting In Vivo/Vitro Evidence
Matthieu Gassiot, Priscilla Brun, Valérie Wauthier et al. · Clinical Drug Investigation
Open access |
18 Dec 2025 |
1 |
| 45 |
Elevated arsenic in topsoils developed on an iron-rich sedimentary formation: From multi-scale spatial patterns to human bioaccessibility
Aubry Vandeuren, Benoît Pereira, Tanguy De Ryck et al. · Applied Geochemistry
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4 Jul 2026 |
0 |
| 46 |
Innate immune responsiveness predicts enhanced cellular immunity and symptomatic disease after controlled human influenza infection
Loukas Papargyris et al. · Nature Medicine
Open access |
Jul 2026 |
0 |
| 47 |
The possible institutionalisation of the carbon removal budget concept across the UNFCCC, UNCBD, and corporate net-zero strategies
Jacopo Bencini, Laura Iozzelli · Environmental Science & Policy
Open access |
30 Apr 2026 |
0 |
| 48 |
Ethylated Phosphorylcholine as a New Marker for Alcohol Consumption: A Proof of Concept
Catalina Dumitrascu, Elias Iturrospe, Els Scheir et al. · Drug Testing and Analysis
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4 Aug 2025 |
0 |
| 49 |
Mass Balance, Pharmacokinetics, Metabolism and Excretion of Radiolabelled Acoziborole, a Potential Novel Treatment for Human African Trypanosomiasis, following Single Microtracer Oral Dose to Humans
Jean‐Yves Gillon, François Simon, Sharan Sidhu et al.
Preprint |
16 Jun 2025 |
0 |
| 50 |
Ethylated phosphorylcholine – a new marker for ethanol consumption: A proof of concept
Catalina Dumitrascu, Elias Iturrospe, Celine Gys et al. · Annales de Toxicologie Analytique
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Mar 2025 |
0 |