| 1 |
A metagenome-wide association study of gut microbiota in type 2 diabetes
Junjie Qin et al. · Nature
Open access |
25 Sep 2012 |
7,088 |
| 2 |
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
Mingfeng Liao, Yang Liu, Jing Yuan et al. · Nature Medicine
Open access |
12 May 2020 |
2,780 |
| 3 |
Macrophages in immunoregulation and therapeutics
Shanze Chen, Abdullah F. U. H. Saeed, Quan Liu et al. · Signal Transduction and Targeted Therapy
Open access |
21 May 2023 |
2,233 |
| 4 |
Using Artificial Intelligence to Detect COVID-19 and Community-acquired Pneumonia Based on Pulmonary CT: Evaluation of the Diagnostic Accuracy
Lin Li, Lixin Qin, Zeguo Xu et al. · Radiology
Open access |
19 Mar 2020 |
2,032 |
| 5 |
Human neutralizing antibodies elicited by SARS-CoV-2 infection
Bin Ju et al. · Nature
Open access |
26 May 2020 |
1,835 |
| 6 |
The cytokine storm and COVID‐19
Biying Hu, Shaoying Huang, Lianghong Yin · Journal of Medical Virology
Open access |
27 Jun 2020 |
1,726 |
| 7 |
CRISPR-Cas12a-assisted nucleic acid detection
Shiyuan Li, Qiuxiang Cheng, Jing-Man Wang et al. · Cell Discovery
Open access |
18 Apr 2018 |
1,590 |
| 8 |
Engineering exosomes for targeted drug delivery
Yujie Liang, Li Duan, Jianping Lu et al. · Theranostics
Open access |
2021 |
1,547 |
| 9 |
Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes
Bing Jiang, Demin Duan, Lizeng Gao et al. · Nature Protocols
|
29 Jun 2018 |
1,304 |
| 10 |
COVID-19: Abnormal liver function tests
Qingxian Cai, Deliang Huang, Hong Yu et al. · Journal of Hepatology
Open access |
13 Apr 2020 |
1,086 |
| 11 |
miRTarBase update 2022: an informative resource for experimentally validated miRNA–target interactions
Hsi‐Yuan Huang et al. · Nucleic Acids Research
Open access |
25 Oct 2021 |
1,078 |
| 12 |
Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
Furong Qi, Qian Shen, Shuye Zhang et al. · Biochemical and Biophysical Research Communications
Open access |
18 Mar 2020 |
913 |
| 13 |
Nanomedicine in cancer therapy
Dahua Fan, Yongkai Cao, Meiqun Cao et al. · Signal Transduction and Targeted Therapy
Open access |
6 Aug 2023 |
857 |
| 14 |
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Yaoting Gui et al. · Nature Genetics
Open access |
7 Aug 2011 |
770 |
| 15 |
Advances in nanomaterials for photodynamic therapy applications: Status and challenges
Jianming Chen, Taojian Fan, Zhongjian Xie et al. · Biomaterials
|
27 Jan 2020 |
737 |
| 16 |
Unbox the black-box for the medical explainable AI via multi-modal and multi-centre data fusion: A mini-review, two showcases and beyond
Guang Zhong Yang, Qinghao Ye, Jun Xia · Information Fusion
ReviewOpen access |
31 Jul 2021 |
727 |
| 17 |
Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor
Xun Xu et al. · Cell
Open access |
Mar 2012 |
724 |
| 18 |
Emerging combination strategies with phototherapy in cancer nanomedicine
Zhongjian Xie, Taojian Fan, Jusung An et al. · Chemical Society Reviews
Review |
2020 |
720 |
| 19 |
Risk Factors of Fatal Outcome in Hospitalized Subjects With Coronavirus Disease 2019 From a Nationwide Analysis in China
Ruchong Chen et al. · CHEST Journal
Open access |
15 Apr 2020 |
694 |
| 20 |
Estimated Burden of Stroke in China in 2020
Wen‐Jun Tu et al. · JAMA Network Open
Open access |
2 Mar 2023 |
621 |
| 21 |
Kinetics of viral load and antibody response in relation to COVID-19 severity
Yanqun Wang et al. · Journal of Clinical Investigation
Open access |
7 Jul 2020 |
602 |
| 22 |
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Defang Li et al. · Nature Communications
Open access |
7 Mar 2016 |
600 |
| 23 |
A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2
Zhi Chen et al. · National Science Review
Open access |
3 Jun 2022 |
552 |
| 24 |
Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies
Jianlei Xie, Yingwei Wang, Wonseok Choi et al. · Chemical Society Reviews
Review |
2021 |
524 |
| 25 |
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Jimin Yuan, Xiaoduo Dong, Jiajun Yap et al. · Journal of Hematology & Oncology
Open access |
17 Aug 2020 |
521 |
| 26 |
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Guangwu Guo et al. · Nature Genetics
Open access |
13 Oct 2013 |
512 |
| 27 |
Segment anything model for medical images?
Yuhao Huang, Xin Yang, Lian Liu et al. · Medical Image Analysis
|
7 Dec 2023 |
503 |
| 28 |
High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy
Xiangqin Meng, Dandan Li, Lei Chen et al. · ACS Nano
|
11 Mar 2021 |
468 |
| 29 |
Novel biomaterial strategies for controlled growth factor delivery for biomedical applications
Zhenming Wang, Zhefeng Wang, William W. Lu et al. · NPG Asia Materials
Open access |
Oct 2017 |
447 |
| 30 |
Pericyte–fibroblast transition promotes tumor growth and metastasis
Kayoko Hosaka, Yunlong Yang, Takahiro Seki et al. · Proceedings of the National Academy of Sciences
Open access |
7 Sep 2016 |
442 |
| 31 |
Interleukin-6: an emerging regulator of pathological pain
Ya‐Qun Zhou, Zheng Liu, Zhiheng Liu et al. · Journal of Neuroinflammation
Open access |
7 Jun 2016 |
442 |
| 32 |
Weakly Supervised Deep Learning for COVID-19 Infection Detection and Classification From CT Images
Shaoping Hu, Yuan Gao, Zhangming Niu et al. · IEEE Access
Open access |
2020 |
405 |
| 33 |
Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury
Run Zhang, Yi Fan Liu, Ke Yan et al. · Journal of Neuroinflammation
Open access |
23 Aug 2013 |
397 |
| 34 |
Multitarget Therapy for Induction Treatment of Lupus Nephritis
Zhihong Liu et al. · Annals of Internal Medicine
|
10 Nov 2014 |
397 |
| 35 |
HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation
Qing Feng Li, Yong Ni, Liren Zhang et al. · Signal Transduction and Targeted Therapy
Open access |
22 Feb 2021 |
395 |
| 36 |
Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy
Yujie Liang, Xiao Gang Xu, Xingfu Li et al. · ACS Applied Materials & Interfaces
|
30 Jul 2020 |
393 |
| 37 |
Mobile Edge Computing Enabled 5G Health Monitoring for Internet of Medical Things: A Decentralized Game Theoretic Approach
Zhaolong Ning, Peiran Dong, Xiaojie Wang et al. · IEEE Journal on Selected Areas in Communications
|
25 Dec 2020 |
383 |
| 38 |
Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration
Xiao Gang Xu, Yujie Liang, Xingfu Li et al. · Biomaterials
|
18 Nov 2020 |
380 |
| 39 |
Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing
Li Duan, Kan Ouyang, Xiao Gang Xu et al. · Frontiers in Genetics
Open access |
12 May 2021 |
377 |
| 40 |
CT Imaging and Differential Diagnosis of COVID-19
Wei-cai Dai, Hanwen Zhang, Juan Yu et al. · Canadian Association of Radiologists Journal
Open access |
4 Mar 2020 |
377 |
| 41 |
Ultrafast Self‐Gelling and Wet Adhesive Powder for Acute Hemostasis and Wound Healing
Xin Peng, Xiao Gang Xu, Yingrui Deng et al. · Advanced Functional Materials
|
17 Jun 2021 |
366 |
| 42 |
pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing
Lingling Zhao, Lijing Niu, Hongze Liang et al. · ACS Applied Materials & Interfaces
Open access |
10 Oct 2017 |
365 |
| 43 |
Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study
Jin-Ping Zheng et al. · The Lancet
|
Jun 2008 |
359 |
| 44 |
Leukemia incidence trends at the global, regional, and national level between 1990 and 2017
Ying Dong, Oumin Shi, Quan-Xiang Zeng et al. · Experimental Hematology and Oncology
Open access |
19 Jun 2020 |
354 |
| 45 |
2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS
Jianqiao Zhou et al. · Endocrine
239 authors |
21 Aug 2020 |
348 |
| 46 |
tRF/miR-1280 Suppresses Stem Cell–like Cells and Metastasis in Colorectal Cancer
Bingqing Huang, Huipeng Yang, Xixi Cheng et al. · Cancer Research
|
26 Apr 2017 |
348 |
| 47 |
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
Guangwu Guo et al. · Nature Genetics
|
4 Dec 2011 |
332 |
| 48 |
Efficacy of Standard Trauma Craniectomy for Refractory Intracranial Hypertension with Severe Traumatic Brain Injury: A Multicenter, Prospective, Randomized Controlled Study
Jiyao Jiang, Wei Xu, Weiping Li et al. · Journal of Neurotrauma
|
Jun 2005 |
331 |
| 49 |
Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics
Xiaoyuan Ji, Lanlan Ge, Chuang LIU et al. · Nature Communications
Open access |
18 Feb 2021 |
328 |
| 50 |
Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History
SiYang Maggie Liu et al. · Cell
Open access |
Oct 2018 |
321 |