Most cited papers from Shionogi (Japan)

Shionogi (Japan)

What are the most cited papers from Shionogi (Japan)?

The most cited paper from Shionogi (Japan) is "Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion" (Toshio Imai, Kunio Hieshima, Christopher A. Haskell et al., 1997), with 1,492 citations. Next come "Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide." (1,363) and "Breeding of a Non-Obese, Diabetic Strain of Mice" (1,264).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 321 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion Toshio Imai, Kunio Hieshima, Christopher A. Haskell et al. · Cell Open access	Nov 1997	1,492
2	Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. Masashi Mukoyama, Kazuwa Nakao, Kiminori Hosoda et al. · Journal of Clinical Investigation Open access	Apr 1991	1,363
3	Breeding of a Non-Obese, Diabetic Strain of Mice Susumu Makino, Kikuko Kunimoto, Yoshihiro Muraoka et al. · EXPERIMENTAL ANIMALS Open access	1980	1,264
4	Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes Jean-Michel Escola, Monique J. Kleijmeer, Willem Stoorvogel et al. · Journal of Biological Chemistry Open access	Aug 1998	1,232
5	Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin Akihiro Asakawa, Akio Inui, Oshihiro Kaga et al. · Gastroenterology Open access	Feb 2001	1,186
6	Glutamate release in severe brain ischaemia is mainly by reversed uptake David J. Rossi, Takeo Oshima, David Attwell · Nature	2000	1,129
7	Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents Frederick G. Hayden, Norio Sugaya, Nobuo Hirotsu et al. · New England Journal of Medicine Open access	5 Sep 2018	952
8	Identification of methicillin-resistant strains of staphylococci by polymerase chain reaction Kazuhisa Murakami, W Minamide, Ken-ichiro Wada et al. · Journal of Clinical Microbiology Open access	Oct 1991	946
9	MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis Sachie Hiratsuka, Kazuhiro Nakamura, Shinobu Iwai et al. · Cancer Cell Open access	Oct 2002	913
10	Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice Noriko Sakaguchi, Takeshi Takahashi, Hiroshi Hata et al. · Nature	Nov 2003	894
11	Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Takeshi Itoh, Masatoshi Tanioka, Hiroki Yoshida et al. · PubMed	Mar 1998	878
12	Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial Matteo Bassetti, ROGER M. ECHOLS, Yuko Matsunaga et al. · The Lancet Infectious Diseases	12 Oct 2020	832
13	Circulating Exosomal microRNAs as Biomarkers of Colon Cancer Hiroko Ogata‐Kawata, Masashi Izumiya, Daisuke Kurioka et al. · PLoS ONE Open access	4 Apr 2014	816
14	Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine Toshio Imai, Morio Nagira, Shin Takagi et al. · International Immunology	1999	727
15	Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow Alan M. Fong, Lisa Annette Robinson, Douglas A. Steeber et al. · The Journal of Experimental Medicine Open access	19 Oct 1998	697
16	Cardiac fibrosis in mice lacking brain natriuretic peptide Naohisa Tamura, Yoshihiro Ogawa, Hideki Chusho et al. · Proceedings of the National Academy of Sciences Open access	28 Mar 2000	625
17	Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19 Yuto Unoh et al. · Journal of Medicinal Chemistry Open access	30 Mar 2022	613
18	Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties. Silvano Sozzani, Paola Allavena, Giovanna D’Amico et al. · PubMed	Aug 1998	608
19	Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen Yusuke Yoshioka, Nobuyoshi Kosaka, Yuki Konishi et al. · Nature Communications Open access	7 Apr 2014	607
20	The T Cell-directed CC Chemokine TARC Is a Highly Specific Biological Ligand for CC Chemokine Receptor 4 Toshio Imai, Masataka Baba, Miyuki Nishimura et al. · Journal of Biological Chemistry Open access	Jun 1997	566
21	Identification of the Product of Growth Arrest-specific Gene 6 as a Common Ligand for Axl, Sky, and Mer Receptor Tyrosine Kinases Kyoko Nagata, Kazumasa Ohashi, Toru Nakano et al. · Journal of Biological Chemistry Open access	Nov 1996	536
22	Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy Markus Meyer, Wolfgang Schillinger, Burkert Mathias Pieske et al. · Circulation	15 Aug 1995	536
23	Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension Yoshihiro Miyamoto et al. · Hypertension Open access	Jul 1998	525
24	Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. Masako Kijima, Minoru Yoshida, Kenji Sugita et al. · Journal of Biological Chemistry Open access	Oct 1993	516
25	Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties Silvano Sozzani, Paola Allavena, Giovanna D’Amico et al. · The Journal of Immunology Open access	Aug 1998	511
26	Once-daily dolutegravir versus darunavir plus ritonavir in antiretroviral-naive adults with HIV-1 infection (FLAMINGO): 48 week results from the randomised open-label phase 3b study Bonaventura Clotet, Judith Feinberg, Jan van Lunzen et al. · The Lancet	31 Mar 2014	509
27	The Murine Autoimmune Diabetes Model: NOD and Related Strains Hitoshi Kikutani, Susumu Makino · Advances in immunology Book chapter	1992	498
28	Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design Yehuda Goldgur, Robert Craigie, Gerson H. Cohen et al. · Proceedings of the National Academy of Sciences Open access	9 Nov 1999	496
29	Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion. Yoshiyuki Matsuo, Hiroshi Onodera, Yusei Shiga et al. · Stroke Open access	Jul 1994	488
30	Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial Richard G. Wunderink, Yuko Matsunaga, Mari Ariyasu et al. · The Lancet Infectious Diseases	12 Oct 2020	484
31	Vulvar and Vaginal Atrophy in Postmenopausal Women: Findings from the REVIVE (REal Women's VIews of Treatment Options for Menopausal Vaginal ChangEs) Survey Sheryl A. Kingsberg, Susan Wysocki, Leslie Magnus et al. · The Journal of Sexual Medicine	16 May 2013	480
32	A novel gene activated in regenerating islets. Kimio Terazono, Hiroshi Yamamoto, Shin Takasawa et al. · Journal of Biological Chemistry Open access	Feb 1988	477
33	Antagonism of ghrelin receptor reduces food intake and body weight gain in mice Akihiro Asakawa, A Inui, T Kaga et al. · Gut Open access	11 Jun 2003	474
34	Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil Shinya Omoto, Valentina Speranzini, Takashi Hashimoto et al. · Scientific Reports Open access	19 Jun 2018	460
35	Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis Hisashi Oku, Toshikatsu Shimizu, Tomoji Kawabata et al. · European Journal of Pharmacology	17 Jun 2008	444
36	Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC Masataka Baba, Toshio Imai, Miyuki Nishimura et al. · Journal of Biological Chemistry Open access	Jun 1997	422
37	The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex Masakazu Hattori, John B. Buse, R. A. JACKSON et al. · Science	14 Feb 1986	422
38	Molecular Cloning of Human Eotaxin, an Eosinophil-selective CC Chemokine, and Identification of a Specific Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3 Motoji Kitaura, Toshihiro Nakajima, Toshio Imai et al. · Journal of Biological Chemistry Open access	Mar 1996	418
39	Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial Simon Portsmouth, David van Veenhuyzen, ROGER M. ECHOLS et al. · The Lancet Infectious Diseases	25 Oct 2018	417
40	Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. Karin Bornfeldt, Elaine W. Raines, Tohru Nakano et al. · Journal of Clinical Investigation Open access	Mar 1994	412
41	Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7 Ryu Yoshida, Toshio Imai, Kunio Hieshima et al. · Journal of Biological Chemistry Open access	May 1997	404
42	A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection Tsutomu Murakami, Toshihiro Nakajima, Yoshio Koyanagi et al. · The Journal of Experimental Medicine Open access	20 Oct 1997	402
43	In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria Akinobu Ito, Takafumi Sato, Merime Ota et al. · Antimicrobial Agents and Chemotherapy Open access	24 Oct 2017	399
44	In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit Takeshi Noshi, Mitsutaka Kitano, K. Taniguchi et al. · Antiviral Research Open access	11 Oct 2018	391
45	Macrophage-derived Chemokine Is a Functional Ligand for the CC Chemokine Receptor 4 Toshio Imai, David Chantry, Carol J. Raport et al. · Journal of Biological Chemistry Open access	1998	387
46	Selective Expression of a Novel Surface Molecule by Human Th2 Cells In Vivo Kinya Nagata, Kazuya Tanaka, Kazuyuki Ogawa et al. · The Journal of Immunology	Feb 1999	380
47	In VitroAntiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor Masanori Kobayashi, Tomokazu Yoshinaga, Takahiro Seki et al. · Antimicrobial Agents and Chemotherapy Open access	30 Nov 2010	379
48	Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin Takafumi Sato, Kenji Yamawaki · Clinical Infectious Diseases Open access	28 Sep 2019	378
49	Molecular Cloning of a Novel Human CC Chemokine Liver and Activation-regulated Chemokine (LARC) Expressed in Liver Kunio Hieshima, Toshio Imai, Ghislain Opdenakker et al. · Journal of Biological Chemistry Open access	Feb 1997	364
50	Adrenomedullin Stimulates Two Signal Transduction Pathways, cAMP Accumulation and Ca2+ Mobilization, in Bovine Aortic Endothelial Cells Yoshiyuki Shimekake, Kiyoshi Nagata, Shigeki Ohta et al. · Journal of Biological Chemistry Open access	Mar 1995	363

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.