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Institution · Siena Biotech (Italy)

Most cited papers from Siena Biotech (Italy)

What are the most cited papers from Siena Biotech (Italy)?

The most cited paper from Siena Biotech (Italy) is "Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58" (Hervé Tettelin et al., 2000), with 1,105 citations. Next come "Target deconvolution strategies in drug discovery" (438) and "Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain" (401).

Showing 50 of 61 papers. Every paper with more than 44 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Complete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58 Hervé Tettelin et al. · Science 10 Mar 2000 1,105
2 Target deconvolution strategies in drug discovery Georg C. Terstappen, Christina Schlüpen, Roberto Raggiaschi et al. · Nature Reviews Drug Discovery Review 5 Oct 2007 438
3 Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain Andrea Caricasole, Agata Copani, Filippo Caraci et al. · Journal of Neuroscience Open access 30 Jun 2004 401
4 BLUEPRINT to decode the epigenetic signature written in blood David J. Adams et al. · Nature Biotechnology Open access Mar 2012 384
5 ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia Alessia Melani, D. Turchi, Maria Giuliana Vannucchi et al. · Neurochemistry International 19 Jul 2005 257
6 Increased Dickkopf‐1 expression in transgenic mouse models of neurodegenerative disease Maria Cristina Rosi, Ilaria Luccarini, Cristina Grossi et al. · Journal of Neurochemistry 29 Dec 2009 173
7 An exploratory double‐blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with H untington's disease Sigurd D. Süßmuth et al. · British Journal of Clinical Pharmacology Open access 16 Sep 2014 170
8 Dietary fatty acids influence the growth and fatty acid composition of the yellow mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) Elena Dreassi, Annarita Cito, Assunta Zanfini et al. · Lipids 12 Jan 2017 153
9 A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease Marianne R. Smith et al. · Human Molecular Genetics Open access 16 Jan 2014 149
10 Signals from the IL-1 Receptor Homolog, Toll, Can Activate an Immune Response in a Drosophila Hemocyte Cell Line Marco Rosetto, Ylva Engström, C. T. Baldari et al. · Biochemical and Biophysical Research Communications Apr 1995 145
11 Functional Characterization of WNT7A Signaling in PC12 Cells Andrea Caricasole, Teresa Ferraro, Luisa Iacovelli et al. · Journal of Biological Chemistry Open access Sep 2003 144
12 Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death Irene Cappuccio, Agata Calderone, Carla Letizia Busceti et al. · Journal of Neuroscience Open access 9 Mar 2005 138
13 Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1 Carla Scali, Filippo Caraci, Marco Gianfriddo et al. · Neurobiology of Disease Open access 18 Aug 2006 128
14 The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease? Andrea Caricasole, Agata Copani, Alessandra J. Caruso et al. · Trends in Pharmacological Sciences Review May 2003 126
15 A Radial Glia Gene Marker, Fatty Acid Binding Protein 7 (FABP7), Is Involved in Proliferation and Invasion of Glioblastoma Cells Antonella De Rosa, Serena Pellegatta, Marco Rossi et al. · PLoS ONE Open access 21 Dec 2012 124
16 Induction of the Wnt Antagonist, Dickkopf-1, Contributes to the Development of Neuronal Death in Models of Brain Focal Ischemia Federica Mastroiacovo, Carla Letizia Busceti, Francesca Biagioni et al. · Journal of Cerebral Blood Flow & Metabolism Oct 2008 119
17 Digital Dermoscopy Analysis and Artificial Neural Network for the Differentiation of Clinically Atypical Pigmented Skin Lesions: A Retrospective Study Pietro Rubegni, Marco Burroni, Roberto Perotti et al. · Journal of Investigative Dermatology Open access Aug 2002 118
18 Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents Annalaura Brai, Roberta Fazi, Cristina Tintori et al. · Proceedings of the National Academy of Sciences Open access 26 Apr 2016 113
19 β-catenin and Gli1 are prognostic markers in glioblastoma Marco Rossi, Letizia Magnoni, Clelia Miracco et al. · Cancer Biology & Therapy Open access 15 Apr 2011 107
20 Induction of the Wnt Inhibitor, Dickkopf‐1, Is Associated with Neurodegeneration Related to Temporal Lobe Epilepsy Carla Letizia Busceti, Francesca Biagioni, Eleonora Aronica et al. · Epilepsia 13 Mar 2007 103
21 Extracellular Vesicles as Shuttles of Tumor Biomarkers and Anti-Tumor Drugs Davide Zocco, Pietro Ferruzzi, Francesco Cappello et al. · Frontiers in Oncology Open access 8 Oct 2014 103
22 Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis Massimiliano Calabrese et al. · Annals of Neurology Open access 3 Apr 2024 101
23 MF59 Adjuvant Enhances the Antibody Response to Recombinant Hepatitis B Surface Antigen Vaccine in Primates Paula Traquina, Maurizio Morandi, Mario Contorni et al. · The Journal of Infectious Diseases Dec 1996 100
24 siRNA screen identifies QPCT as a druggable target for Huntington's disease María Jiménez-Sánchez et al. · Nature Chemical Biology Open access 6 Apr 2015 100
25 Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders Renza Roncarati, Carla Scali, Thomas A. Comery et al. · Journal of Pharmacology and Experimental Therapeutics 18 Feb 2009 99
26 Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells Alessandra J. Caruso, Marta Motolese, Luisa Iacovelli et al. · Journal of Neurochemistry 30 May 2006 99
27 Searching for the Perfect Wave: The Effect of Radiofrequency Electromagnetic Fields on Cells Lisa M. Gherardini, Gastone Ciuti, Selene Tognarelli et al. · International Journal of Molecular Sciences Open access 27 Mar 2014 93
28 Straightforward Recursive Partitioning Model for Discarding Insoluble Compounds in the Drug Discovery Process Claudia Lamanna, Marta Bellini, Alessandro Padova et al. · Journal of Medicinal Chemistry 18 Apr 2008 84
29 Rapid aggregation and assembly in aqueous solution of Aβ (25–35) peptide Lia Millucci, Roberto Raggiaschi, Davide Franceschini et al. · Journal of Biosciences Jun 2009 80
30 Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients Stefania Mantovani et al. · Genes and Immunity Open access193 authors 24 Dec 2021 79
31 Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs Ugo Zanelli, Nicola Pasquale Caradonna, David Hallifax et al. · Drug Metabolism and Disposition 14 Oct 2011 76
32 Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells Margherita Gaviraghi, Patrizia Tunici, Silvia Valensin et al. · Bioscience Reports Open access 29 Apr 2010 76
33 Two Sides of the Same Coin: Wnt Signaling in Neurodegeneration and Neuro-Oncology Andrea Caricasole, Annette C. Bakker, Agata Copani et al. · Bioscience Reports 12 Oct 2005 76
34 Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex Luigi Messori, Michela Camarri, Teresa Ferraro et al. · ACS Medicinal Chemistry Letters Open access 13 Feb 2013 75
35 Pharmacological inactivation of the prion protein by targeting a folding intermediate Giovanni Spagnolli et al. · Communications Biology Open access 12 Jan 2021 72
36 Novel genes and sex differences in COVID-19 severity Raquel Cruz et al. · Human Molecular Genetics Open access168 authors 16 Jun 2022 67
37 Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition Arnulf Dorn, Francis Hermann, Andreas Ebneth et al. · SLAS DISCOVERY Open access Jun 2005 67
38 Phosphoproteome Analysis Roberto Raggiaschi, Stefano Gotta, Georg C. Terstappen · Bioscience Reports 4 Feb 2005 66
39 Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males Margherita Baldassarri et al. · EBioMedicine Open access149 authors 26 Feb 2021 66
40 The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen‐glucose deprivation in rat CA1 hippocampal slices Anna Maria Pugliese, Chiara Traini, Sara Cipriani et al. · British Journal of Pharmacology Open access 5 May 2009 63
41 Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats Vanessa Pitozzi, Michela Jacomelli, Mohamed M. Zaid et al. · British Journal Of Nutrition Open access 14 Jan 2010 63
42 A Practical Synthesis of 2,4(5)-Diarylimidazoles from Simple Building Blocks Valentina Zuliani, Giuseppe Cocconcelli, Marco Fantini et al. · The Journal of Organic Chemistry 9 May 2007 62
43 The murine interleukin 1β gene: structure and evolution John L. Telford, G Macchia, Annalisa Massone et al. · Nucleic Acids Research Open access 1986 62
44 The Wnt Antagonist, Dickkopf-1, as a Target for the Treatment of Neurodegenerative Disorders Filippo Caraci, Carla Letizia Busceti, Francesca Biagioni et al. · Neurochemical Research 21 Apr 2008 61
45 Safety, pharmacokinetics, pharmacogenomics and QT concentration−effect modelling of the SirT1 inhibitor selisistat in healthy volunteers Göran Westerberg, Joseph Chiesa, Claus A. F. Andersen et al. · British Journal of Clinical Pharmacology Open access 16 Sep 2014 61
46 EV Separation: Release of Intact Extracellular Vesicles Immunocaptured on Magnetic Particles Dario Brambilla, Laura Solá, Anna Maria Ferretti et al. · Analytical Chemistry 26 Mar 2021 59
47 DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection Annalaura Brai, Francesco Martelli, Valentina Riva et al. · Journal of Medicinal Chemistry Open access 5 Feb 2019 58
48 Three-dimensional computation of atom depth in complex molecular structures D. Varrazzo, Andrea Bernini, Ottavia Spiga et al. · Computer applications in the biosciences Open access 12 Apr 2005 56
49 Screening Technologies for Ion Channel Drug Discovery Georg C. Terstappen, Renza Roncarati, John Dunlop et al. · Future Medicinal Chemistry May 2010 55
50 Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic–pituitary–adrenocortical axis Sergio Scaccianoce, Francesco Matrisciano, Paolo Bianco et al. · Neuropharmacology Apr 2003 55

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.