Science Explorer Back to mapMap
Institution · SingHealth

Most cited papers from SingHealth

What are the most cited papers from SingHealth?

The most cited paper from SingHealth is "The repertoire of mutational signatures in human cancer" (Ludmil B. Alexandrov et al., 2020), with 3,854 citations. Next come "Pan-cancer analysis of whole genomes" (3,360) and "Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes" (2,445).

Showing 50 of 60 papers. Every paper with more than 264 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The repertoire of mutational signatures in human cancer Ludmil B. Alexandrov et al. · Nature Open access1,384 authors 5 Feb 2020 3,854
2 Pan-cancer analysis of whole genomes Lauri A. Aaltonen et al. · Nature Open access1,324 authors 5 Feb 2020 3,360
3 Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes Daniel Shu Wei Ting et al. · JAMA Open access 12 Dec 2017 2,445
4 Digital technology and COVID-19 Daniel Shu Wei Ting, Lawrence Carin, Victor J. Dzau et al. · Nature Medicine Open access 27 Mar 2020 1,487
5 A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction Chee Wah Tan, Wan Ni Chia, Xijian Qin et al. · Nature Biotechnology Open access 23 Jul 2020 1,377
6 The evolutionary history of 2,658 cancers Moritz Gerstung et al. · Nature Open access1,441 authors 5 Feb 2020 1,149
7 Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review Daniel Shu Wei Ting, Chui Ming Gemmy Cheung, Tien Yin Wong · Clinical and Experimental Ophthalmology Open access 30 Dec 2015 1,088
8 Patterns of somatic structural variation in human cancer genomes Yilong Li et al. · Nature Open access1,411 authors 5 Feb 2020 1,005
9 Revisiting the role of CD4+ T cells in cancer immunotherapy—new insights into old paradigms Rong En Tay, Emma K. Richardson, Han Chong Toh · Cancer Gene Therapy Open access 26 May 2020 862
10 Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing Isidro Cortés-Ciriano et al. · Nature Genetics Open access1,407 authors 5 Feb 2020 793
11 Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore Jolin Wong, Qing Yuan Goh, Zihui Tan et al. · Canadian Journal of Anesthesia/Journal canadien d anesthésie Open access 11 Mar 2020 712
12 Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma Ankur Sharma et al. · Cell Open access 24 Sep 2020 704
13 SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma Pierce K. H. Chow et al. · Journal of Clinical Oncology 2 Mar 2018 660
14 Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective Ji-Peng Olivia Li, Hanruo Liu, Darren Shu Jeng Ting et al. · Progress in Retinal and Eye Research Open access 6 Sep 2020 632
15 Immunogenicity of engineered antibodies William Ying Khee Hwang, Jefferson Foote · Methods 13 Apr 2005 632
16 Mapping the human DC lineage through the integration of high-dimensional techniques Peter See et al. · Science Open access 4 May 2017 591
17 Association Between Malnutrition and Clinical Outcomes in the Intensive Care Unit: A Systematic Review Charles Chin Han Lew, Rosalie Yandell, Robert J. Fraser et al. · Journal of Parenteral and Enteral Nutrition Review 2 Feb 2016 556
18 Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells Charles‐Antoine Dutertre et al. · Immunity Open access 29 Aug 2019 537
19 Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation Michael W.L. Chee, Wei Chieh Choo · Journal of Neuroscience Open access 12 May 2004 518
20 Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma Jo L. Eyles, Anne‐Laure Puaux, Xiaojie Wang et al. · Journal of Clinical Investigation Open access 24 May 2010 506
21 Association of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants Nicholas L Syn, David E Cummings, Louis Z Wang et al. · The Lancet Review May 2021 501
22 Online eLearning for undergraduates in health professions: A systematic review of the impact on knowledge, skills, attitudes and satisfaction Pradeep Paul George, Nikos Papachristou, José S Marcano Belisario et al. · Journal of Global Health ReviewOpen access Jun 2014 492
23 Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men E Shyong Tai, M. L. Tan, Robert Stevens et al. · Diabetologia Open access 14 Jan 2010 482
24 Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma Marta Garnelo, Alex Y. Tan, Zhisheng Her et al. · Gut Open access 15 Dec 2015 474
25 Cardiovascular Events Associated With SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs Mikhail Kosiborod et al. · Journal of the American College of Cardiology Open access 14 Mar 2018 472
26 Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer Ignasius Joanito et al. · Nature Genetics Open access 30 Jun 2022 471
27 Social isolation, loneliness and their relationships with depressive symptoms: A population-based study Lixia Ge, Chun Wei Yap, Reuben Ong et al. · PLoS ONE Open access 23 Aug 2017 443
28 COVID-19 Vaccine Hesitancy—A Scoping Review of Literature in High-Income Countries Junjie Aw, Jun Jie Benjamin Seng, Sharna Si Ying Seah et al. · Vaccines Open access 13 Aug 2021 442
29 Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia Supaporn Wacharapluesadee et al. · Nature Communications Open access 9 Feb 2021 440
30 Lessons from the host defences of bats, a unique viral reservoir Aaron Trent Irving, Matae Ahn, Geraldine Goh et al. · Nature Open access 20 Jan 2021 440
31 Cancer Risks Associated With GermlinePALB2Pathogenic Variants: An International Study of 524 Families Xin Yang et al. · Journal of Clinical Oncology Open access119 authors 16 Dec 2019 440
32 Genomic basis for RNA alterations in cancer PCAWG Transcriptome Core Group et al. · Nature Open access1,461 authors 5 Feb 2020 425
33 The landscape of viral associations in human cancers Marc Zapatka et al. · Nature Genetics Open access1,355 authors 5 Feb 2020 412
34 European S2k Guideline on Chronic Pruritus Elke Weißhaar, Jacek Cezary Szepietowski, Florence Dalgard et al. · Acta Dermato Venereologica Open access 2019 406
35 Global developments in social prescribing Daniel F Morse et al. · BMJ Global Health Open access May 2022 390
36 International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma Anne W.M. Lee et al. · Radiotherapy and Oncology Open access 16 Nov 2017 390
37 Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia Alvin Wei Tian Ng, Song Ling Poon, Mi Ni Huang et al. · Science Translational Medicine 18 Oct 2017 389
38 Digital Screen Time During the COVID-19 Pandemic: Risk for a Further Myopia Boom? Chee Wai Wong, Andrew S. H. Tsai, Jost Bruno Jonas et al. · American Journal of Ophthalmology Open access 29 Jul 2020 385
39 Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen Michael P. Menden et al. · Nature Communications Open access354 authors 17 Jun 2019 378
40 Large language models in health care: Development, applications, and challenges Rui Yang, Ting Fang Tan, Wei Lu et al. · Health care science Open access 24 Jul 2023 372
41 Roles of macrophages in tumor development: a spatiotemporal perspective Mathilde Bied, William W. Ho, Florent Ginhoux et al. · Cellular and Molecular Immunology Open access 10 Jul 2023 348
42 Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer Kie Kyon Huang et al. · Cancer Cell Open access 28 Dec 2017 336
43 A Dynamic Immune Response Shapes COVID-19 Progression Eugenia Ziying Ong, Yvonne Fu Zi Chan, Wan Ying Leong et al. · Cell Host & Microbe Open access 30 Apr 2020 332
44 Ethical and regulatory challenges of large language models in medicine Jasmine Chiat Ling Ong, Yin‐Hsi Chang, William Wasswa et al. · The Lancet Digital Health Open access 23 Apr 2024 328
45 GA4GH: International policies and standards for data sharing across genomic research and healthcare Heidi L. Rehm et al. · Cell Genomics Open access202 authors Nov 2021 325
46 Microbial exposure during early human development primes fetal immune cells Archita Mishra et al. · Cell Open access Jun 2021 321
47 Somatic mutations reveal asymmetric cellular dynamics in the early human embryo Young Seok Ju et al. · Nature Open access Mar 2017 318
48 Predictors of poor functional outcomes and mortality in patients with hip fracture: a systematic review Bang Yu Xu, Shi Yan, Lian Leng Low et al. · BMC Musculoskeletal Disorders ReviewOpen access 27 Nov 2019 317
49 Atropine for the Treatment of Childhood Myopia: Effect on Myopia Progression after Cessation of Atropine Louis Hak Tien Tong, Xiao Ling Huang, Angeline L.T. Koh et al. · Ophthalmology 23 Jan 2009 317
50 The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation Y. M. Lisa Chuah, Vinod Venkatraman, David F. Dinges et al. · Journal of Neuroscience Open access 5 Jul 2006 304

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.