| 1 |
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell
|
May 1994 |
2,298 |
| 2 |
Disseminated Intravascular Coagulation
Marcel M Levi, Hugo Ten Cate · New England Journal of Medicine
|
19 Aug 1999 |
2,005 |
| 3 |
Identification of a new human coronavirus
Lia van der Hoek, Krzysztof Pyrć, Maarten F. Jebbink et al. · Nature Medicine
Open access |
21 Mar 2004 |
1,938 |
| 4 |
Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
Yvonne P M Goekoop-Ruiterman, Jeska K de Vries‐Bouwstra, Cornelia F Allaart et al. · Arthritis & Rheumatism
Open access |
28 Oct 2005 |
1,466 |
| 5 |
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids
Krijn K. Dijkstra et al. · Cell
Open access |
9 Aug 2018 |
1,129 |
| 6 |
Treatment of Venous Thrombosis with Intravenous Unfractionated Heparin Administered in the Hospital as Compared with Subcutaneous Low-Molecular-Weight Heparin Administered at Home
Maria M.W. Koopman, Paolo Prandoni, Franco Piovella et al. · New England Journal of Medicine
Open access |
14 Mar 1996 |
1,118 |
| 7 |
Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis
Dees PM Brandjes, Harry Roger Buller, Harriët Heijboer et al. · The Lancet
Open access |
Mar 1997 |
875 |
| 8 |
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Ara Koh, Antonio Molinaro, Marcus Ståhlman et al. · Cell
Open access |
25 Oct 2018 |
847 |
| 9 |
Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial
Evelien de Jong et al. · The Lancet Infectious Diseases
Open access |
2 Mar 2016 |
847 |
| 10 |
A Phase I and Pharmacological Study with Imidazolium- trans- DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
Jeany M. Rademaker-Lakhai, H.J.G.D. van den Bongard, Dick Pluim et al. · Clinical Cancer Research
Open access |
Jun 2004 |
831 |
| 11 |
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria
Johan W. Jonker, Marije Buitelaar, Els Wagenaar et al. · Proceedings of the National Academy of Sciences
Open access |
12 Nov 2002 |
824 |
| 12 |
Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis
Thomas P. C. Dorlo, Manica Balasegaram, Jos H. Beijnen et al. · Journal of Antimicrobial Chemotherapy
|
24 Jul 2012 |
784 |
| 13 |
Atrophic Gastritis andHelicobacter pyloriInfection in Patients with Reflux Esophagitis Treated with Omeprazole or Fundoplication
Ernst Johan Kuipers, Lars R. Lundell, Elly C. Klinkenberg–Knol et al. · New England Journal of Medicine
Open access |
18 Apr 1996 |
778 |
| 14 |
Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies
Ron J. Keizer, Alwin D. R. Huitema, Jan H.M. Schellens et al. · Clinical Pharmacokinetics
|
8 Jul 2010 |
728 |
| 15 |
Development and Clinical Evaluation of a Highly Sensitive PCR-Reverse Hybridization Line Probe Assay for Detection and Identification of Anogenital Human Papillomavirus
Bernhard Kleter, Leen‐Jan van Doorn, Lianne Schrauwen et al. · Journal of Clinical Microbiology
Open access |
Aug 1999 |
665 |
| 16 |
Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review
Marije Emilie Hamaker, J.M. Jonker, Sophia E de Rooij et al. · The Lancet Oncology
Review |
28 Sep 2012 |
647 |
| 17 |
Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan
Johan W. Jonker · JNCI Journal of the National Cancer Institute
|
18 Oct 2000 |
640 |
| 18 |
Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma
Sanne B. Schagen, Frits S.A.M. van Dam, Martin J. Muller et al. · Cancer
Open access |
Feb 1999 |
630 |
| 19 |
Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?
Ellen Stokvis, Hilde Rosing, Jos H. Beijnen · Rapid Communications in Mass Spectrometry
|
12 Jan 2005 |
589 |
| 20 |
Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors
Kimberley M. Heinhuis, Willeke Ros, Marleen Kok et al. · Annals of Oncology
Open access |
3 Jan 2019 |
575 |
| 21 |
Safety of Low-Molecular-Weight Heparin in Pregnancy: A Systematic Review
Bernd‐Jan Sanson, Anthonie W.A. Lensing, Martin M.H. Prins et al. · Thrombosis and Haemostasis
|
1999 |
555 |
| 22 |
Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer
Ramón Salazar, Paul Roepman, Gabriel Capellá et al. · Journal of Clinical Oncology
|
23 Nov 2010 |
545 |
| 23 |
Long-term omeprazole treatment in resistant gastroesophageal reflux disease: Efficacy, safety, and influence on gastric mucosa
Elly C. Klinkenberg–Knol, Frits G. Nelis, John Dent et al. · Gastroenterology
Open access |
Apr 2000 |
545 |
| 24 |
Effect of Periodontal Treatment on Glycemic Control of Diabetic Patients
Wijnand J. Teeuw, Victor E. A. Gerdes, Bruno G. Loos · Diabetes Care
Open access |
26 Jan 2010 |
526 |
| 25 |
A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.
Giuseppe Giaccone, Cornelis J. A. Punt, Yoshitaka Ando et al. · PubMed
|
Dec 2002 |
507 |
| 26 |
Converting a breast cancer microarray signature into a high-throughput diagnostic test
Annuska M. Glas, Arno N. Floore, Leonie J. M. J. Delahaye et al. · BMC Genomics
Open access |
30 Oct 2006 |
497 |
| 27 |
Acenocoumarol and Heparin Compared with Acenocoumarol Alone in the Initial Treatment of Proximal-Vein Thrombosis
Dees P. M. Brandjes, Harriët Heijboer, Harry Roger Buller et al. · New England Journal of Medicine
Open access |
19 Nov 1992 |
485 |
| 28 |
Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis
Gertjan Wolbink, Marijn Vis, Willem F. Lems et al. · Arthritis & Rheumatism
|
28 Feb 2006 |
472 |
| 29 |
Clinical Pharmacokinetics of Cyclophosphamide
Milly E. de Jonge, Alwin D. R. Huitema, Sjoerd Rodenhuis et al. · Clinical Pharmacokinetics
|
2005 |
453 |
| 30 |
Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
Jan Wijnholds, Raymond Evers, Manuel R. van Leusden et al. · Nature Medicine
|
Nov 1997 |
440 |
| 31 |
Long-Term Treatment with Omeprazole for Refractory Reflux Esophagitis: Efficacy and Safety
Elly C. Klinkenberg–Knol, Henk P. M. Festen, Jan B. M. J. Jansen et al. · Annals of Internal Medicine
|
Aug 1994 |
430 |
| 32 |
The influence of prehospital time on trauma patients outcome: A systematic review
Annelieke M. K. Harmsen, Georgios Fredericus Giannakopoulos, Patrick R. Moerbeek et al. · Injury
Review |
16 Jan 2015 |
429 |
| 33 |
Cardiovascular risk profile of patients with spondylarthropathies, particularly ankylosing spondylitis and psoriatic arthritis
Mike J. L. Peters, Irene Eva van der Horst-Bruinsma, Ben A. C. Dijkmans et al. · Seminars in Arthritis and Rheumatism
Open access |
Dec 2004 |
383 |
| 34 |
Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy
Suzanne Leijen, Sjaak A. Burgers, Paul Baas et al. · Investigational New Drugs
Open access |
24 Oct 2014 |
371 |
| 35 |
Operative Treatment of Spontaneous Spinal Epidural Hematomas: A Study of the Factors Determining Postoperative Outcome
Rob J. M. Groen, H. August M. van Alphen · Neurosurgery
|
Sep 1996 |
359 |
| 36 |
Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta‐analysis
Wijnand J. Teeuw, Dagmar Else Slot, Hendri Murti Susanto et al. · Journal Of Clinical Periodontology
Review |
12 Oct 2013 |
354 |
| 37 |
Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis
Maarten J. Deenen, Didier Meulendijks, Annemieke Cats et al. · Journal of Clinical Oncology
Open access |
17 Nov 2015 |
352 |
| 38 |
Prevalence of Human Papillomavirus DNA in Different Histological Subtypes of Cervical Adenocarcinoma
Edyta Catalina Pirog, Bernhard Kleter, Semra Olgac et al. · American Journal Of Pathology
Open access |
Oct 2000 |
345 |
| 39 |
The Preventive Antibiotics in Stroke Study (PASS): a pragmatic randomised open-label masked endpoint clinical trial
Willeke F. Westendorp et al. · The Lancet
Open access |
19 Jan 2015 |
339 |
| 40 |
Piraña and PCluster: A modeling environment and cluster infrastructure for NONMEM
Ron J. Keizer, Michel van Benten, Jos H. Beijnen et al. · Computer Methods and Programs in Biomedicine
|
3 Jun 2010 |
334 |
| 41 |
Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis
Lidewine Daniels et al. · British journal of surgery
Open access |
30 Sep 2016 |
329 |
| 42 |
Total Ankle Arthroplasty in Inflammatory Joint Disease with Use of Two Mobile-Bearing Designs
H. Cornelis Doets, Ronald Brand, Rob G. H. H. Nelissen · Journal of Bone and Joint Surgery
|
Jun 2006 |
326 |
| 43 |
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
Pauline Breedveld, Jos H. Beijnen, Jan H.M. Schellens · Trends in Pharmacological Sciences
Review |
6 Dec 2005 |
325 |
| 44 |
Increasing Failure of Miltefosine in the Treatment of Kala-azar in Nepal and the Potential Role of Parasite Drug Resistance, Reinfection, or Noncompliance
Suman Rijal, Bart Ostyn, Surendra Kumar Uranw et al. · Clinical Infectious Diseases
|
20 Feb 2013 |
323 |
| 45 |
ENDOTOXAEMIA: AN EARLY PREDICTOR OF SEPTICAEMIA IN FEBRILE PATIENTS
SanderJ.H. Van Deventer, JanW. Ten Gate, HarryR. Buller et al. · The Lancet
|
Mar 1988 |
319 |
| 46 |
Review: Viral infections and mechanisms of thrombosis and bleeding
Marco Goeijenbier, Matthijs Van Wissen, C. van de Weg et al. · Journal of Medical Virology
Open access |
15 Aug 2012 |
314 |
| 47 |
Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids
Jeanine M.L. Roodhart, Laura G.M. Daenen, Edwin C.A. Stigter et al. · Cancer Cell
Open access |
Sep 2011 |
309 |
| 48 |
Breast cancer in pregnancy: Recommendations of an international consensus meeting
Frédéric Amant et al. · European Journal of Cancer
|
7 Oct 2010 |
308 |
| 49 |
The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients
Angelique C.M. Jansen, E. S. van Aalst‐Cohen, Michael W.T. Tanck et al. · Journal of Internal Medicine
Open access |
19 Nov 2004 |
303 |
| 50 |
Concise Drug Review: Azacitidine and Decitabine
Ellen J. B. Derissen, Jos H. Beijnen, Jan H.M. Schellens · The Oncologist
Open access |
May 2013 |
302 |