| 1 |
A greener path for the EU Common Agricultural Policy
Guy Pe’er, Yves M. Zinngrebe, FRANCISCO EDVANDO DE AQUINO MOREIRA et al. · Science
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Aug 2019 |
508 |
| 2 |
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors: An Update
Ralph‐Steven Wedemeyer, Henning H. Blume · Drug Safety
Open access |
18 Feb 2014 |
312 |
| 3 |
Pharmacokinetic Drug Interaction Profiles of Proton Pump Inhibitors
Henning H. Blume, Frank Donath, A Warnke et al. · Drug Safety
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2006 |
217 |
| 4 |
Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype
Nienwen Chow, Robert D. Bell, Rashid Deane et al. · Proceedings of the National Academy of Sciences
Open access |
10 Jan 2007 |
211 |
| 5 |
Exomics and immunogenics
Stéphane Champiat, Charles Ferté, Sophie Lebel‐Binay et al. · OncoImmunology
Open access |
2014 |
193 |
| 6 |
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
Zhihui Zhong, Hristelina S. Ilieva, Lee D. Hallagan et al. · Journal of Clinical Investigation
Open access |
16 Oct 2009 |
177 |
| 7 |
Pharmaceutical quality of different Ginkgo biloba brands
S. Kressmann, Wernér E.G. Müller, Henning H. Blume · Journal of Pharmacy and Pharmacology
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May 2002 |
150 |
| 8 |
The biopharmaceutics classification system (BCS): Class III drugs — better candidates for BA/BE waiver?
Henning H. Blume, Barbara S. Schug · European Journal of Pharmaceutical Sciences
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Dec 1999 |
148 |
| 9 |
Magnetic Marker Monitoring: High resolution real-time tracking of oral solid dosage forms in the gastrointestinal tract
Werner Weitschies, Henning H. Blume, Hubert Mönnikes · European Journal of Pharmaceutics and Biopharmaceutics
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19 Jul 2009 |
133 |
| 10 |
Formulations of Fentanyl for the Management of Pain
Sina Grape, Stephan Alexander Schug, Stefan Lauer et al. · Drugs
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28 Dec 2009 |
109 |
| 11 |
Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers
Audrey Gilson, Mathias Dreger, Jill P. G. Urban · Arthritis Research & Therapy
Open access |
12 Feb 2010 |
100 |
| 12 |
Dose-proportionality of oral thioctic acid — coincidence of assessments via pooled plasma and individual data
Kerstin Breithaupt‐Grögler, Georg Niebch, Edith M. Schneider et al. · European Journal of Pharmaceutical Sciences
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Apr 1999 |
96 |
| 13 |
The influence of hydroxypropyl methylcellulose (HPMC) molecular weight, concentration and effect of food on in vivo erosion behavior of HPMC matrix tablets
Arun Kumar Jain, Erik Söderlind, Anna Viridén et al. · Journal of Controlled Release
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10 May 2014 |
86 |
| 14 |
Formulation-dependent food effects demonstrated for nifedipine modified-release preparations marketed in the European Union
Barbara S. Schug, Erich Brendel, Dörte Wolf et al. · European Journal of Pharmaceutical Sciences
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Apr 2002 |
68 |
| 15 |
The effect of food on the pharmacokinetics of nifedipine in two slow release formulations: pronounced lag‐time after a high fat breakfast
Barbara S. Schug, Erich Brendel, E. Chantraine et al. · British Journal of Clinical Pharmacology
Open access |
Jun 2002 |
66 |
| 16 |
Analysis of Three-Carrier Ambiguity Resolution Technique for Precise Relative Positioning in GNSS-2
Ulrich Vollath, S. Birnbach, Lukas T. N. Landau et al. · NAVIGATION Journal of the Institute of Navigation
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Mar 1999 |
64 |
| 17 |
Influence of pharmaceutical quality on the bioavailability of active components from Ginkgo biloba preparations
S. Kressmann, A. Biber, Meinolf Wonnemann et al. · Journal of Pharmacy and Pharmacology
Open access |
Nov 2002 |
62 |
| 18 |
Understanding the in vivo performance of enteric coated tablets using an in vitro-in silico-in vivo approach: Case example diclofenac
Atsushi Kambayashi, Henning H. Blume, Jennifer Dressman · European Journal of Pharmaceutics and Biopharmaceutics
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18 Sep 2013 |
56 |
| 19 |
Who is a ‘healthy subject’?—consensus results on pivotal eligibility criteria for clinical trials
Kerstin Breithaupt-Groegler, Christoph Coch, Martin Coenen et al. · European Journal of Clinical Pharmacology
Open access |
7 Jan 2017 |
54 |
| 20 |
Dosage form-related food interaction observed in a marketed once-daily nifedipine formulation after a high-fat American breakfast
Barbara S. Schug, Erich Brendel, Meinolf Wonnemann et al. · European Journal of Clinical Pharmacology
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17 Apr 2002 |
51 |
| 21 |
Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospan® Cough Tablets) in the treatment of colds accompanied by coughing
Manuela Stauss‐Grabo, Saynab Atiye, A Warnke et al. · Phytomedicine
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6 Jan 2011 |
49 |
| 22 |
Determination of Hyperforin in Mouse Brain by High-Performance Liquid Chromatography/Tandem Mass Spectrometry
Jan-Henning Keller, Michael Karas, Walter E. Müller et al. · Analytical Chemistry
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9 Oct 2003 |
48 |
| 23 |
Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability
Marco Bartoloni, Xian Jin, María J. Marcaida et al. · Chemical Science
Open access |
2015 |
47 |
| 24 |
Felodipine quantification in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry
L MIGLIORANCA, Rafael Eliseo Barrientos-Astigarraga, Barbara S. Schug et al. · Journal of Chromatography B
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15 Dec 2004 |
40 |
| 25 |
Stereoselective pharmacokinetics of propafenone and its major metabolites in healthy Chinese volunteers
Xiaoyan Chen, Dafang Zhong, Henning H. Blume · European Journal of Pharmaceutical Sciences
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Mar 2000 |
31 |
| 26 |
Significant food interactions observed with a nifedipine modified-release formulation marketed in the European Union
Meinolf Wonnemann, Barbara S. Schug, K. Schmücker et al. · International Journal of Clinical Pharmacology and Therapeutics
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2006 |
30 |
| 27 |
Predicting the oral pharmacokinetic profiles of multiple-unit (pellet) dosage forms using a modeling and simulation approach coupled with biorelevant dissolution testing: Case example diclofenac sodium
Atsushi Kambayashi, Henning H. Blume, Jennifer Dressman · European Journal of Pharmaceutics and Biopharmaceutics
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23 Jan 2014 |
30 |
| 28 |
Lack of a pharmacokinetic interaction between steady‐state roflumilast and single‐dose midazolam in healthy subjects
Nassr Nassr, Gëzim Lahu, Oliver von Richter et al. · British Journal of Clinical Pharmacology
Open access |
29 Sep 2006 |
28 |
| 29 |
How to Interpret an Investigator’s Brochure for Meaningful Risk Assessment: Results of an AGAH Discussion Forum
Jens Rengelshausen, Kerstin Breithaupt-Groegler, Frank Donath et al. · Therapeutic Innovation & Regulatory Science
Open access |
3 Feb 2021 |
27 |
| 30 |
Workshop/Conference Report on EMA Draft Guideline on Validation of Bioanalytical Methods
Henning H. Blume, Erich Brendel, Margarete Brudny‐Klöppel et al. · European Journal of Pharmaceutical Sciences
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25 Dec 2010 |
27 |
| 31 |
Comparison of two marketed nifedipine modified-release formulations: An exploratory clinical food interaction study
Meinolf Wonnemann, Barbara S. Schug, Maria Anschütz et al. · Clinical Therapeutics
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2008 |
26 |
| 32 |
Harmonization of Regulatory Approaches for Evaluating Therapeutic Equivalence and Interchangeability of Multisource Drug Products: Workshop summary report
Mei‐Ling Chen, Vinod P. Shah, Daan J.A. Crommelin et al. · European Journal of Pharmaceutical Sciences
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17 Sep 2011 |
26 |
| 33 |
Determination of 11-keto-boswellic acid in human plasma
Astrid Kaunzinger, Alwin Baumeister, Klaus Cuda et al. · Journal of Pharmaceutical and Biomedical Analysis
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May 2002 |
26 |
| 34 |
The Global Bioequivalence Harmonization Initiative: Summary report for EUFEPS international conference
Mei‐Ling Chen, Henning H. Blume, Gerald Beuerle et al. · European Journal of Pharmaceutical Sciences
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29 Sep 2017 |
25 |
| 35 |
Past, Present, and Future of Bioequivalence: Improving Assessment and Extrapolation of Therapeutic Equivalence for Oral Drug Products
Rodrigo Cristofoletti, Malcolm Rowland, Lawrence J. Lesko et al. · Journal of Pharmaceutical Sciences
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20 Jun 2018 |
24 |
| 36 |
SAHA Capture Compound – A novel tool for the profiling of histone deacetylases and the identification of additional vorinostat binders
Jenny J. Fischer, Simon Michaelis, Anna K. Schrey et al. · PROTEOMICS
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7 Sep 2011 |
21 |
| 37 |
Biomarkers and Coagulation Tests for Assessing the Biosimilarity of a Generic Low‐Molecular‐Weight Heparin: Results of a Study in Healthy Subjects With Enoxaparin
Karina Kuczka, Sebastian Harder, Bettina Picard‐Willems et al. · The Journal of Clinical Pharmacology
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21 Aug 2008 |
21 |
| 38 |
Differences in bioavailability between 60 mg of nifedipine osmotic push-pull systems after fasted and fed administration
Maria Anschütz, Meinolf Wonnemann, Barbara S. Schug et al. · International Journal of Clinical Pharmacology and Therapeutics
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Feb 2010 |
20 |
| 39 |
Improved therapeutic entities derived from known generics as an unexplored source of innovative drug products
Sven Stegemann, Imre Klebovich, István Antal et al. · European Journal of Pharmaceutical Sciences
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25 Sep 2011 |
20 |
| 40 |
Lidocaine 8 mg Sore Throat Lozenges in the Treatment of Acute Pharyngitis
Meinolf Wonnemann, I van der Helm, Manuela Stauss‐Grabo et al. · Arzneimittelforschung
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21 Dec 2011 |
20 |
| 41 |
Vericiguat in combination with isosorbide mononitrate in patients with chronic coronary syndromes: The randomized, phase Ib, VISOR study
Michael Böettcher, Gerd Mikus, Dietmar Trenk et al. · Clinical and Translational Science
Open access |
17 Mar 2022 |
19 |
| 42 |
Pain relief of sore throat with a new anti-inflammatory throat lozenge, ibuprofen 25 mg: A randomised, double-blind, placebo-controlled, international phase III study
Athmane Bouroubi, Yves Donazzolo, Franck Donath et al. · International Journal of Clinical Practice
Open access |
Sep 2017 |
18 |
| 43 |
Vericiguat in Combination with Short‐Acting Nitroglycerin in Patients With Chronic Coronary Syndromes: The Randomized, Phase Ib, VENICE Study
Michael Böettcher, Hans‐Dirk Düngen, Frank Donath et al. · Clinical Pharmacology & Therapeutics
Open access |
8 Mar 2022 |
17 |
| 44 |
Development of a furosemide-containing expandable system for gastric retention
Marco Neumann, Claudia Heimhardt, Knut Seidlitz et al. · Journal of Controlled Release
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18 Aug 2021 |
16 |
| 45 |
Investigation of the Dissolution Characteristics of Nifedipine Extended-Release Formulations Using USP Apparatus 2 and a Novel Dissolution Apparatus
Grzegorz Garbacz, Henning H. Blume, Werner Weitschies · Dissolution Technologies
Open access |
2009 |
16 |
| 46 |
Simultaneous determination of flupirtine and its major active metabolite in human plasma by liquid chromatography–tandem mass spectrometry
Xiaoyan Chen, Dafang Zhong, Haiyan Xu et al. · Journal of Chromatography B Biomedical Sciences and Applications
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May 2001 |
16 |
| 47 |
Sensitive and specific liquid chromatographic–tandem mass spectrometric assay for dihydroergotamine and its major metabolite in human plasma
Xiaoyan Chen, Dafang Zhong, Haiyan Xu et al. · Journal of Chromatography B
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Mar 2002 |
15 |
| 48 |
Vericiguat: A Randomized, Phase Ib, Placebo-Controlled, Double-Blind, QTc Interval Study in Patients with Chronic Coronary Syndromes
M. Böttcher, Hans‐Dirk Düngen, Vasile Corcea et al. · American Journal of Cardiovascular Drugs
Open access |
12 Jan 2023 |
14 |
| 49 |
Topical administration of regorafenib eye drops: phase I dose‐escalation study in healthy volunteers
Torsten Zimmermann, Joachim Höchel, Michael Becka et al. · British Journal of Clinical Pharmacology
Open access |
10 Jan 2018 |
14 |
| 50 |
Comparative Bioavailability Study of a Novel Multi-Day Patch Formulation of Rivastigmine (Twice Weekly) with Exelon® Transdermal Patch (Daily)- A Randomized Clinical Trial
Björn Schurad, Cornelius Koch, Barbara S. Schug et al. · Current Alzheimer Research
Open access |
Jun 2022 |
13 |