Most cited papers from Sojo University

Sojo University

What are the most cited papers from Sojo University?

The most cited paper from Sojo University is "The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect" (Jun Qun Fang, Hideaki Nakamura, Hiroshi Maeda, 2010), with 3,563 citations. Next come "The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo" (2,378) and "Exploiting the enhanced permeability and retention effect for tumor targeting" (1,845).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 119 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Jun Qun Fang, Hideaki Nakamura, Hiroshi Maeda · Advanced Drug Delivery Reviews Review	3 May 2010	3,563
2	The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo Hiroshi Maeda, Hideaki Nakamura, Jun Qun Fang · Advanced Drug Delivery Reviews Review	23 Oct 2012	2,378
3	Exploiting the enhanced permeability and retention effect for tumor targeting Arun K. Iyer, Khaled F. Greish, Jun Qun Fang et al. · Drug Discovery Today	26 Aug 2006	1,845
4	Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology Uma Prabhakar, Hiroshi Maeda, Rakesh K. Jain et al. · Cancer Research Open access	19 Feb 2013	1,488
5	Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity Hiroshi Maeda · Advanced Drug Delivery Reviews Review	9 Jan 2015	1,179
6	Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect Hiroshi Maeda, Gahininath Y. Bharate, Jurstine Daruwalla · European Journal of Pharmaceutics and Biopharmaceutics	5 Dec 2008	1,164
7	Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects Hiroshi Maeda · Bioconjugate Chemistry	16 Apr 2010	990
8	Macromolecular therapeutics in cancer treatment: The EPR effect and beyond Hiroshi Maeda · Journal of Controlled Release	May 2012	809
9	Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers Jun Qun Fang, Waliul Islam, Hiroshi Maeda · Advanced Drug Delivery Reviews Review	2020	750
10	Critical review on the cooling effect of urban blue-green space: A threshold-size perspective Zhaowu Yu, Gaoyuan Yang, Shudi Zuo et al. · Urban forestry & urban greening Open access	8 Feb 2020	695
11	Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines Khaled F. Greish · Journal of drug targeting	2007	597
12	Therapeutic strategies by modulating oxygen stress in cancer and inflammation Jun Qun Fang, Takahiro Seki, Hiroshi Maeda · Advanced Drug Delivery Reviews Review	27 Feb 2009	542
13	Albumin–drug interaction and its clinical implication Keishi Yamasaki, Victor Tuan Giam Chuang, Toru Maruyama et al. · Biochimica et Biophysica Acta (BBA) - General Subjects	9 May 2013	467
14	p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase Hiroshi Watanabe, Yohei Miyamoto, Daisuke Honda et al. · Kidney International Open access	16 Jan 2013	386
15	A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next‐Generation Chemotherapeutics and Photodynamic Therapy—Problems, Solutions, and Prospects Hiroshi Maeda, Kenji Tsukigawa, Jun Qun Fang · Microcirculation	3 Aug 2015	334
16	What Kind of “Soft Materials” Can We Design from Molecular Gels? Arnab Dawn, Tomohiro Shiraki, Shuichi Haraguchi et al. · Chemistry - An Asian Journal	16 Aug 2010	308
17	Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting Hiroshi Maeda · Proceedings of the Japan Academy Series B Open access	2012	288
18	Functionalized magnetic nanoparticles as chemosensors and adsorbents for toxic metal ions in environmental and biological fields Jong Hwa Jung, Ji Ha Lee, Seiji Shinkai · Chemical Society Reviews Review	2011	274
19	Redox properties of serum albumin Makoto Anraku, Victor Tuan Giam Chuang, Toru Maruyama et al. · Biochimica et Biophysica Acta (BBA) - General Subjects	3 May 2013	265
20	Physiological characterization of anaerobic ammonium oxidizing bacterium ‘ C andidatus J ettenia caeni’ Muhammad Ali, Mamoru Oshiki, Takanori Awata et al. · Environmental Microbiology	3 Nov 2014	252
21	Tumor-targeted induction of oxystress for cancer therapy Jun Qun Fang, Hideaki Nakamura, Arun K. Iyer · Journal of drug targeting	2007	238
22	Variations in land surface temperature and cooling efficiency of green space in rapid urbanization: The case of Fuzhou city, China Zhaowu Yu, Xieying Guo, Yuxi Zeng et al. · Urban forestry & urban greening	16 Nov 2017	228
23	Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls Hideaki Nakamura, Fang Jun, Hiroshi Maeda · Expert Opinion on Drug Delivery	26 Nov 2014	228
24	Biodiesel production from waste cooking oil using calcined scallop shell as catalyst Suchada Sirisomboonchai, Maidinamu Abuduwayiti, Guoqing Guan et al. · Energy Conversion and Management	27 Feb 2015	226
25	Effect of deformation temperature on Hall–Petch relationship registered for polycrystalline magnesium N. Ono, Roman Nowak, Seiji Miura · Materials Letters	30 Jun 2003	225
26	Regulation of Nitric Oxide Synthesis and Apoptosis by Arginase and Arginine Recycling Masataka Mori · Journal of Nutrition Open access	Jun 2007	222
27	Experimental and numerical investigations of flow fields behind a small wind turbine with a flanged diffuser Kenichi Abe, Minoru Nishida, Atsushi Sakurai et al. · Journal of Wind Engineering and Industrial Aerodynamics	28 Oct 2005	217
28	EPR effect based drug design and clinical outlook for enhanced cancer chemotherapy Hiroshi Maeda, Yasuhiro Matsumura · Advanced Drug Delivery Reviews	11 May 2010	204
29	Cys34-Cysteinylated Human Serum Albumin Is a Sensitive Plasma Marker in Oxidative Stress-Related Chronic Diseases Kohei Nagumo, Motohiko Tanaka, Victor Tuan Giam Chuang et al. · PLoS ONE Open access	8 Jan 2014	202
30	Towards better understanding of explosive welding by combination of numerical simulation and experimental study Ivan A. Bataev, Shigeru Tanaka, Qiang Zhou et al. · Materials & Design Open access	5 Mar 2019	192
31	Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1 Yuki Enoki, Hiroshi Watanabe, Riho Arake et al. · Scientific Reports Open access	23 Aug 2016	188
32	Clinical significance of MCP‐1 levels in BALF and serum in patients with interstitial lung diseases Motomu Suga, Kazuhiro Iyonaga, Hidenori Ichiyasu et al. · European Respiratory Journal	Aug 1999	188
33	Elevating Blood Pressure as a Strategy to Increase Tumor-targeted Delivery of Macromolecular Drug SMANCS: Cases of Advanced Solid Tumors Akinori Nagamitsu, Khaled F. Greish, Hiroshi Maeda · Japanese Journal of Clinical Oncology Open access	11 Jul 2009	180
34	Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom Tomohisa Ogawa, Takahito Chijiwa, Naoko Oda‐Ueda et al. · Toxicon	18 Nov 2004	180
35	Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies Makoto Anraku, Janusz M. Gebicki, Daisuke Iohara et al. · Carbohydrate Polymers	7 Jul 2018	179
36	Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application Takahiro Seki, Jun Qun Fang, Hiroshi Maeda · Cancer Science Open access	26 Aug 2009	179
37	Isolation of a Multiheme Protein with Features of a Hydrazine-Oxidizing Enzyme from an Anaerobic Ammonium-Oxidizing Enrichment Culture Munetaka Shimamura, Takashi Nishiyama, Hiroyuki Shigetomo et al. · Applied and Environmental Microbiology Open access	16 Dec 2006	175
38	The EPR Effect and Polymeric Drugs: A Paradigm Shift for Cancer Chemotherapy in the 21st Century Hiroshi Maeda, Khaled F. Greish, Jun Qun Fang · Advances in polymer science Book chapter	30 Nov 2005	173
39	Influence of Fluid Viscosity on the Hydraulic Fracturing Mechanism Tsuyoshi Ishida, Qu Chen, Yoshiaki MIZUTA et al. · Journal of Energy Resources Technology	Sep 2004	173
40	Analysis of Double Step-Down Two-Phase Buck Converter for VRM Kazutoshi Nishijima, K. Harada, Tomoyuki Nakano et al. Conference paper	Sep 2005	170
41	Myoblasts Derived From Normal hESCs and Dystrophic hiPSCs Efficiently Fuse With Existing Muscle Fibers Following Transplantation Sébastien Goudenege, Carl P. LeBel, Nicolas B Huot et al. · Molecular Therapy Open access	18 Sep 2012	170
42	Fabrication of silica nanotubes by using self-assembled gels and their applications in environmental and biological fields Jong Hwa Jung, Minsung Park, Seiji Shinkai · Chemical Society Reviews Review	2010	169
43	Rho-associated kinase inhibitors: A novel glaucoma therapy Toshihiro Inoue, Hidenobu Tanihara · Progress in Retinal and Eye Research	12 Jun 2013	165
44	The link between infection and cancer: Tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect Hiroshi Maeda · Cancer Science Open access	17 Mar 2013	162
45	Potential therapeutic interventions for chronic kidney disease‐associated sarcopenia via indoxyl sulfate‐induced mitochondrial dysfunction Yuki Enoki, Hiroshi Watanabe, Riho Arake et al. · Journal of Cachexia Sarcopenia and Muscle Open access	12 Jun 2017	157
46	Comparison of the WST-8 colorimetric method and the CLSI broth microdilution method for susceptibility testing against drug-resistant bacteria Tadayuki Tsukatani, Hikaru Suenaga, Masanobu Shiga et al. · Journal of Microbiological Methods	27 May 2012	157
47	Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice Kazuo Umezawa, Takaaki Akaike, Shin‐ichiro Fujii et al. · Infection and Immunity Open access	Jul 1997	156
48	Low-temperature steam reforming of methanol to produce hydrogen over various metal-doped molybdenum carbide catalysts Yufei Ma, Guoqing Guan, Chuan Shi et al. · International Journal of Hydrogen Energy Open access	6 Nov 2013	152
49	Control of energetic conditions by employing interlayer of different thickness for explosive welding of titanium/304 stainless steel P. Manikandan, Kazuyuki Hokamoto, Masahiro Fujita et al. · Journal of Materials Processing Technology	17 May 2007	149
50	Anammox organism KSU‐1 expresses a NirK‐type copper‐containing nitrite reductase instead of a NirS‐type with cytochrome cd1 Daisuke Hira, Hidehiro Toh, Catharina Taiko Migita et al. · FEBS Letters	2 May 2012	148

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.