Most cited papers from Springhouse

Springhouse

What are the most cited papers from Springhouse?

The most cited paper from Springhouse is "The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus" (Dafna D. Gladman et al., 1996), with 2,609 citations. Next come "Glucagon-like peptide 1 (GLP-1)" (1,836) and "Possible Emergence of New Geminiviruses by Frequent Recombination" (1,621).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 226 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus Dafna D. Gladman et al. · Arthritis & Rheumatism Open access	Mar 1996	2,609
2	Glucagon-like peptide 1 (GLP-1) Timo D. Müller et al. · Molecular Metabolism Open access	30 Sep 2019	1,836
3	Possible Emergence of New Geminiviruses by Frequent Recombination Malla Padidam, Stanley A. Sawyer, Claude Fauquet · Virology Open access	Dec 1999	1,621
4	Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures 1 Ahmed F. Abdel‐Magid, Kenneth G. Carson, Bruce D. Harris et al. · The Journal of Organic Chemistry	1996	1,504
5	Adeno-Associated Virus (AAV) as a Vector for Gene Therapy Michael F. Naso, Brian E. Tomkowicz, William L. Perry et al. · BioDrugs Open access	Jul 2017	1,399
6	Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. Robert B. Raffa, Elmar Friderichs, Wolfgang Reimann et al. · Journal of Pharmacology and Experimental Therapeutics	1992	1,174
7	Michael addition reactions in macromolecular design for emerging technologies Brian D. Mather, K. V. Viswanathan, Kevin M. Miller et al. · Progress in Polymer Science	May 2006	1,122
8	NEW INSECTICIDES WITH ECDYSTEROIDAL AND JUVENILE HORMONE ACTIVITY Tarlochan Singh Dhadialla, Glenn R. Carlson, Dat P. Le · Annual Review of Entomology Review	1998	920
9	Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator–controlled VOYAGE 1 trial Andrew Blauvelt, Kim Alexander Papp, Christopher E.M. Griffiths et al. · Journal of the American Academy of Dermatology Open access	4 Jan 2017	898
10	β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity Hoau-Yan Wang, Daniel H. S. Lee, Michael R. D’Andrea et al. · Journal of Biological Chemistry Open access	Feb 2000	816
11	An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action Richard P. Shank, Joseph F. Gardocki, Anthony J. Streeter et al. · Epilepsia	2000	815
12	Gene expression profiles of laser-captured adjacent neuronal subtypes Lin Luo, Ranelle C. Salunga, Hongqing Guo et al. · Nature Medicine	1999	698
13	The importance of synthetic chemistry in the pharmaceutical industry Kevin R. Campos, Paul J. Coleman, Juan C. Alvarez et al. · Science	17 Jan 2019	692
14	Evaluation of Docking Performance: Comparative Data on Docking Algorithms Maria Kontoyianni, Laura M. McClellan, Glenn S. Sokol · Journal of Medicinal Chemistry	31 Dec 2003	603
15	Role for protease activity in visceral pain in irritable bowel syndrome Nicolas Cénac, Christopher N. Andrews, Marinella Holzhausen et al. · Journal of Clinical Investigation Open access	15 Feb 2007	591
16	A Software-Defined GPS and Galileo Receiver A Single-Frequency Approach Kai Borre, DENNIS M. AKOS, Nicolaj Bertelsen et al. · CU Scholar (University of Colorado Boulder)	2007	569
17	Reproducing human and cross-species drug toxicities using a Liver-Chip Kyung‐Jin Jang et al. · Science Translational Medicine	6 Nov 2019	506
18	Gaussian docking functions Mark R. McGann, Harold R. Almond, Anthony O. Nicholls et al. · Biopolymers	2 Dec 2002	496
19	Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study Mario Castro, Sally E. Wenzel, Eugene R. Bleecker et al. · The Lancet Respiratory Medicine	9 Oct 2014	490
20	Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway Nathalie Vergnolle, Nigel W. Bunnett, Keith A. Sharkey et al. · Nature Medicine	Jul 2001	474
21	Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling Autumn Gabrielle York et al. · Cell Open access	Dec 2015	462
22	Intracellular accumulation of β-amyloid1–42 in neurons is facilitated by the α7 nicotinic acetylcholine receptor in Alzheimer’s disease Robert G. Nagele, M. R. D’Andrea, W. J. Anderson et al. · Neuroscience	Mar 2002	456
23	Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity Dylan Richards, Yang Li, Charles M. Kerr et al. · Nature Biomedical Engineering Open access	13 Apr 2020	449
24	Amyloid Peptide Aβ1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors Hoau‐Yan Wang, Daniel H. S. Lee, Coralie B. Davis et al. · Journal of Neurochemistry	Sep 2000	436
25	Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains Robert G. Nagele, Michael R. D’Andrea, H. Lee et al. · Brain Research	23 Apr 2003	426
26	Enhanced Avoidance Habits in Obsessive-Compulsive Disorder Claire M. Gillan, Sharon Morein‐Zamir, Gonzalo Pablo Urcelay et al. · Biological Psychiatry Open access	16 Mar 2013	413
27	Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease M. R. D’Andrea, Robert G. Nagele, H‐Y Wang et al. · Histopathology	Feb 2001	398
28	RH 5849, a Nonsteroidal Ecdysone Agonist: Effects on Larval Lepidoptera Keith D. Wing, Richard A. Slawecki, Glenn R. Carlson · Science	22 Jul 1988	398
29	Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. E E Codd, Richard P. Shank, James J. Schupsky et al. · Journal of Pharmacology and Experimental Therapeutics Open access	Sep 1995	387
30	The pharmacology and therapeutic applications of monoclonal antibodies Sofia Castelli, Paul McGonigle, Pamela J. Hornby · Pharmacology Research & Perspectives Open access	Dec 2019	371
31	Mortality in a Cohort of Homeless Adults in Philadelphia Jonathan R. Hibbs, Lawrence Benner, Lawrence Klugman et al. · New England Journal of Medicine Open access	4 Aug 1994	369
32	RH 5849, a Nonsteroidal Ecdysone Agonist: Effects on a Drosophila Cell Line Keith D. Wing · Science	22 Jul 1988	359
33	Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor Timothy Pietro Suren Perera et al. · Molecular Cancer Therapeutics Open access	24 Mar 2017	349
34	Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant Richard P. Shank, Joseph F. Gardocki, Jeffry L. Vaught et al. · Epilepsia	Mar 1994	346
35	Efficacy and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: results of the randomized, double‐blind, phase III NAVIGATE trial Richard G B Langley, Tsen‐Fang Tsai, Susan K. Flavin et al. · British Journal of Dermatology	21 Jun 2017	343
36	Bicyclobutanes: from curiosities to versatile reagents and covalent warheads Christopher B. Kelly, John A. Milligan, Leon J. Tilley et al. · Chemical Science Open access	2022	333
37	Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial Atul A. Deodhar, Philip Helliwell, Wolf‐Henning Boehncke et al. · The Lancet Open access	13 Mar 2020	331
38	Primary Human Lung Alveolus‐on‐a‐chip Model of Intravascular Thrombosis for Assessment of Therapeutics Abhishek Ramesh Jain, Riccardo Barrile, Andries D. van der Meer et al. · Clinical Pharmacology & Therapeutics Open access	18 May 2017	329
39	Topiramate as an Inhibitor of Carbonic Anhydrase Isoenzymes Susanna J. Dodgson, Richard P. Shank, Bruce E. Maryanoff · Epilepsia	May 2000	318
40	Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia Rafał Pawliński, Brian Pedersen, Gernot Schabbauer et al. · Blood Open access	28 Oct 2003	313
41	Selecting the right compounds for screening: does Lipinski's Rule of 5 for pharmaceuticals apply to agrochemicals? Colin M. Tice · Pest Management Science	2001	305
42	Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR–MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion–Driven NSCLC Jiyeon Yun, Soo‐Hwan Lee, Seok-Young Kim et al. · Cancer Discovery Open access	15 May 2020	300
43	VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance Mohamed A. ElTanbouly et al. · Science Open access	16 Jan 2020	299
44	A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor–Resistant Lung Tumors Sheri L. Moores, Mark L. Chiu, Barbara S. Bushey et al. · Cancer Research	24 May 2016	289
45	The Pharmacological and Functional Characteristics of the Serotonin 5-HT3A Receptor Are Specifically Modified by a 5-HT3B Receptor Subunit Adrienne E. Dubin, Rene Huvar, Michael R. D’Andrea et al. · Journal of Biological Chemistry Open access	Oct 1999	281
46	Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity Mathieu Uzzan et al. · Nature Medicine Open access	21 Feb 2022	265
47	Revealing the Hidden Language of Complex Networks Ömer Nebil Yaveroğlu, Noël Malod‐Dognin, D. Davis et al. · Scientific Reports Open access	Apr 2014	257
48	Pharmacokinetics and Exposure Response Relationships of Ustekinumab in Patients With Crohn's Disease Omoniyi J. Adedokun, Zhenhua Xu, Christopher Gasink et al. · Gastroenterology Open access	Feb 2018	256
49	Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study Anas Younes, Catherine Thiéblemont, Franck Morschhauser et al. · The Lancet Oncology	17 Jul 2014	255
50	Subcutaneous versus intravenous daratumumab in patients with relapsed or refractory multiple myeloma (COLUMBA): a multicentre, open-label, non-inferiority, randomised, phase 3 trial María‐Victoria Mateos et al. · The Lancet Haematology Open access	23 Mar 2020	251

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.