| 1 |
Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial
Salah‐Eddin Al‐Batran et al. · The Lancet
|
11 Apr 2019 |
2,700 |
| 2 |
Management Strategies and Determinants of Outcome in Acute Major Pulmonary Embolism: Results of a Multicenter Registry
Wolfgang E. Kasper, Stavros Konstantinides, Annette Geibel et al. · Journal of the American College of Cardiology
Open access |
Nov 1997 |
1,044 |
| 3 |
Heparin plus Alteplase Compared with Heparin Alone in Patients with Submassive Pulmonary Embolism
Stavros Konstantinides, Annette Geibel, Gerhard Heusel et al. · New England Journal of Medicine
Open access |
9 Oct 2002 |
1,000 |
| 4 |
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
John Burn et al. · The Lancet
Open access |
28 Oct 2011 |
959 |
| 5 |
Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome
Nicholas Hearle et al. · Clinical Cancer Research
|
15 May 2006 |
861 |
| 6 |
Peutz–Jeghers syndrome: a systematic review and recommendations for management
Andrew David Beggs et al. · Gut
ReviewOpen access |
25 Jun 2010 |
832 |
| 7 |
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
Hans F. A. Vasen et al. · Gut
Open access |
13 Feb 2013 |
758 |
| 8 |
Guidelines for the clinical management of familial adenomatous polyposis (FAP)
Hans F. A. Vasen et al. · Gut
Open access |
14 Jan 2008 |
707 |
| 9 |
Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database
Pål Møller et al. · Gut
Open access |
9 Dec 2015 |
560 |
| 10 |
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)
Hans F. A. Vasen et al. · Journal of Medical Genetics
Open access |
27 Feb 2007 |
556 |
| 11 |
Extended Treatment Duration for Hepatitis C Virus Type 1: Comparing 48 Versus 72 Weeks of Peginterferon-Alfa-2a Plus Ribavirin
Thomas Berg, Michael Wagner, Samer Nasser et al. · Gastroenterology
Open access |
Apr 2006 |
518 |
| 12 |
Curative endoscopic resection of early esophageal adenocarcinomas (Barrett's cancer)
Christian Ell, Andrea May, Oliver Pech et al. · Gastrointestinal Endoscopy
|
20 Dec 2006 |
517 |
| 13 |
Association Between Thrombolytic Treatment and the Prognosis of Hemodynamically Stable Patients With Major Pulmonary Embolism
Stavros Konstantinides, Annette Geibel, Manfred Olschewski et al. · Circulation
|
5 Aug 1997 |
464 |
| 14 |
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial
John Burn et al. · The Lancet
Open access |
Jun 2020 |
431 |
| 15 |
A Comparison of Surgical and Medical Therapy for Atrial Septal Defect in Adults
Stavros Konstantinides, Annette Geibel, Manfred Olschewski et al. · New England Journal of Medicine
Open access |
24 Aug 1995 |
414 |
| 16 |
Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism.
Wolfgang E. Kasper, Stavros Konstantinides, Annette Geibel et al. · Heart
Open access |
Apr 1997 |
409 |
| 17 |
Double-balloon enteroscopy (push-and-pull enteroscopy) of the small bowel: feasibility and diagnostic and therapeutic yield in patients with suspected small bowel disease
Andrea D. May, Lars Nachbar, Christian Ell · Gastrointestinal Endoscopy
|
30 Jun 2005 |
378 |
| 18 |
Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process
Cathy Bennett et al. · Gastroenterology
Open access |
24 Apr 2012 |
378 |
| 19 |
Whipple's disease: new aspects of pathogenesis and treatment
Thomas Schneider, Verena Moos, Christoph Loddenkemper et al. · The Lancet Infectious Diseases
|
20 Feb 2008 |
372 |
| 20 |
The projected volume of primary and revision total knee arthroplasty will place an immense burden on future health care systems over the next 30 years
Alexander Klug, Yves Gramlich, Maximilian Rudert et al. · Knee Surgery Sports Traumatology Arthroscopy
Open access |
15 Jul 2020 |
333 |
| 21 |
Croup Is Associated with the Novel Coronavirus NL63
Lia van der Hoek, Klaus Sure, Gabriele Ihorst et al. · PLoS Medicine
Open access |
16 Aug 2005 |
317 |
| 22 |
Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life
Daniela Posa et al. · Journal of Allergy and Clinical Immunology
|
25 Oct 2016 |
282 |
| 23 |
Ewing Sarcoma—Diagnosis, Treatment, Clinical Challenges and Future Perspectives
Stefan K. Zöllner, James F. Amatruda, Sebastian Bauer et al. · Journal of Clinical Medicine
Open access |
14 Apr 2021 |
277 |
| 24 |
Accuracy of staging in early oesophageal cancer using high resolution endoscopy and high resolution endosonography: a comparative, prospective, and blinded trial
Andrea D. May, E Günter, F Roth et al. · Gut
Open access |
13 Apr 2004 |
270 |
| 25 |
Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever
Laura Hatzler, Valentina Panetta, Susanne Lau et al. · Journal of Allergy and Clinical Immunology
Open access |
25 Jul 2012 |
269 |
| 26 |
PIK3CA Mutations Are Associated With Lower Rates of Pathologic Complete Response to Anti–Human Epidermal Growth Factor Receptor 2 (HER2) Therapy in Primary HER2-Overexpressing Breast Cancer
Sibylle Loibl et al. · Journal of Clinical Oncology
Open access |
9 Sep 2014 |
261 |
| 27 |
Acute intussusception in infants and children as an adverse event following immunization: case definition and guidelines of data collection, analysis, and presentation
Julie E. Bines, Katrin S. Kohl, Johannes Förster et al. · Vaccine
|
16 Oct 2003 |
243 |
| 28 |
The Severe Respiratory Insufficiency (SRI) Questionnaire A specific measure of health-related quality of life in patients receiving home mechanical ventilation
Wolfram Windisch, Klaus Freidel, Bernd Schucher et al. · Journal of Clinical Epidemiology
|
Aug 2003 |
232 |
| 29 |
Prognostic value of the ECG on admission in patients with acute major pulmonary embolism
Annette Geibel, Manfred Zehender, Wolfgang E. Kasper et al. · European Respiratory Journal
Open access |
29 Apr 2005 |
227 |
| 30 |
Cervical Pedicle Screws: Conventional Versus Computer-Assisted Placement of Cannulated Screws
Marcus Richter, Balkan Cakir, R. Schmidt · Spine
|
Oct 2005 |
226 |
| 31 |
Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis
Udo A. Heuschen, Ulf Hinz, E. H. Allemeyer et al. · Gastroenterology
Open access |
Mar 2001 |
224 |
| 32 |
Cytokine Gene Transcription By NF‐κB Family Members in Patients with Inflammatory Bowel Disease
Markus Friedrich Neurath, Ivan J. Fuss, Guido Schürmann et al. · Annals of the New York Academy of Sciences
|
Nov 1998 |
221 |
| 33 |
Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016
Andrew J. Ullmann, Martin Schmidt‐Hieber, Hartmut Bertz et al. · Annals of Hematology
Open access |
24 Jun 2016 |
215 |
| 34 |
Long-term results of photodynamic therapy with 5-aminolevulinic acid for superficial Barrett's cancer and high-grade intraepithelial neoplasia
Oliver Pech, Liebwin Goßner, Andrea May et al. · Gastrointestinal Endoscopy
|
30 Jun 2005 |
198 |
| 35 |
Transfusion‐related acute lung injury due to HLA‐A2‐specific antibodies in recipient and NB1‐specific antibodies in donor blood
Jürgen Bux, Frank Becker, Werner Seeger et al. · British Journal of Haematology
|
Jun 1996 |
196 |
| 36 |
Effectiveness of triclosan-coated PDS Plus versus uncoated PDS II sutures for prevention of surgical site infection after abdominal wall closure: the randomised controlled PROUD trial
Markus K. Diener et al. · The Lancet
Open access |
7 Apr 2014 |
191 |
| 37 |
Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: Experimental psychosis as a tool for psychiatric research
Leo Hermle, Matthias Fünfgeld, Godehard Oepen et al. · Biological Psychiatry
|
Dec 1992 |
185 |
| 38 |
Quality of Life in Women With Idiopathic Scoliosis
Klaus Freidel, Franz Petermann, Dagmar Reichel et al. · Spine
|
Feb 2002 |
182 |
| 39 |
German Association of Endocrine Surgeons practice guidelines for the surgical treatment of benign thyroid disease
Thomas J. Musholt et al. · Langenbeck s Archives of Surgery
|
21 Mar 2011 |
178 |
| 40 |
Efficacy of Annual Colonoscopic Surveillance in Individuals With Hereditary Nonpolyposis Colorectal Cancer
Christoph Engel, Nils Rahner, Karsten Schulmann et al. · Clinical Gastroenterology and Hepatology
|
15 Oct 2009 |
177 |
| 41 |
Comparison of alteplase versus heparin for resolution of major pulmonary embolism
Stavros Konstantinides, N. Tiede, Annette Geibel et al. · The American Journal of Cardiology
|
Oct 1998 |
173 |
| 42 |
Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS
Hannah Gough, Linus Grabenhenrich, Andreas Reich et al. · Pediatric Allergy and Immunology
Open access |
22 May 2015 |
172 |
| 43 |
KNOWLEDGE AND ATTITUDE REGARDING ORGAN DONATION AMONG MEDICAL STUDENTS AND PHYSICIANS
Elke Schäeffner, Wolfram Windisch, Klaus Freidel et al. · Transplantation
|
Jun 2004 |
169 |
| 44 |
Blood‐based detection of RAS mutations to guide anti‐ EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue‐based RAS testing
Wolff Schmiegel et al. · Molecular Oncology
Open access |
20 Jan 2017 |
162 |
| 45 |
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene
Þórunn Rafnar et al. · Human Molecular Genetics
Open access |
12 Jul 2011 |
158 |
| 46 |
Brain stem catecholamine mechanisms in tonic and reflex control of blood pressure.
DONALD J. REIS, Antonio Raffaele Michele Granata, Tong H. Joh et al. · Hypertension
Open access |
Sep 1984 |
157 |
| 47 |
Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
John Cummings Mathers et al. · The Lancet Oncology
Open access |
6 Nov 2012 |
152 |
| 48 |
Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals
Julia Dietz et al. · Gastroenterology
225 authors |
13 Nov 2017 |
151 |
| 49 |
Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)
Cornelius Engelmann et al. · Journal of Hepatology
Open access |
5 Aug 2021 |
145 |
| 50 |
Anterior Cruciate Ligament Reconstruction Using Patellar Tendon Versus Hamstring Tendon: A Prospective Comparative Study With 9‐Year Follow‐Up
Benjamin Wipfler, Stefanie Donner, Christian M. Zechmann et al. · Arthroscopy The Journal of Arthroscopic and Related Surgery
Open access |
19 Apr 2011 |
139 |