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The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction
Philipp Schwabl, Eva Hambruch, Berit Seeland et al. · Journal of Hepatology
Open access |
18 Dec 2016 |
176 |
| 2 |
Quorum-Quenching and Matrix-Degrading Enzymes in Multilayer Coatings Synergistically Prevent Bacterial Biofilm Formation on Urinary Catheters
Kristina Ivanova, Margarida M. Fernandes, António Francesko et al. · ACS Applied Materials & Interfaces
Open access |
23 Nov 2015 |
159 |
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Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion
Florian C. Maier, Hans F. Wehrl, Andreas M. Schmid et al. · Nature Medicine
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10 Nov 2014 |
128 |
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Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice
Eva Hambruch, Shinobu Miyazaki‐Anzai, Ulrike K. Hahn et al. · Journal of Pharmacology and Experimental Therapeutics
Open access |
24 Aug 2012 |
99 |
| 5 |
Elevated wound fluid pH correlates with increased risk of wound infection
Daniel Gary Metcalf, Marieke Haalboom, Philip G. Bowler et al. · Wound Medicine
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24 Jul 2019 |
82 |
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Dexamethasone attenuates early expression of three molecules associated with microglia/macrophages activation following rat traumatic brain injury
Zhiyuan Zhang, Zhiren Zhang, Zhiren Zhang et al. · Acta Neuropathologica
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31 Jan 2007 |
76 |
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The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model
Philipp Schwabl, Eva Hambruch, Grant R. Budas et al. · Biomedicines
Open access |
9 Jan 2021 |
69 |
| 8 |
Early infiltration of CD8+ macrophages/microglia to lesions of rat traumatic brain injury
Zhiren Zhang, Matthias Artelt, Michael W. M. Burnet et al. · Neuroscience
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2006 |
61 |
| 9 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists
Ulrich R. Abel, Thomas Schlüter, Andreas Schulz et al. · Bioorganic & Medicinal Chemistry Letters
Open access |
20 Jun 2010 |
60 |
| 10 |
Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis
Andrea Mencarelli, Eleonora Distrutti, Barbara Renga et al. · European Journal of Pharmacology
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30 Apr 2011 |
59 |
| 11 |
Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice
Eugénia Nogueira, Franck Lager, Delphine Le Roux et al. · Journal of Biomedical Nanotechnology
Open access |
30 Jul 2015 |
58 |
| 12 |
Lesional accumulation of P2X4 receptor+ monocytes following experimental traumatic brain injury
Zhiren Zhang, Matthias Artelt, Michael W. M. Burnet et al. · Experimental Neurology
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3 Nov 2005 |
57 |
| 13 |
pH-responsive materials for optical monitoring of wound status
Clemens Gamerith, Daniel Luschnig, Andreas Ortner et al. · Sensors and Actuators B Chemical
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9 Aug 2019 |
55 |
| 14 |
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa
Thomas E. Blank, Tobias Goldmann, Mirja Koch et al. · Frontiers in Immunology
Open access |
4 Jan 2018 |
55 |
| 15 |
Cellobiose dehydrogenase functionalized urinary catheter as novel antibiofilm system
Barbara Thallinger, Martin Brandauer, Peter Burger et al. · Journal of Biomedical Materials Research Part B Applied Biomaterials
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6 Aug 2015 |
44 |
| 16 |
Azithromycin analogue CSY 0073 attenuates lung inflammation induced by LPS challenge
Viviane Balloy, April E. Deveaux, David Lebeaux et al. · British Journal of Pharmacology
Open access |
13 Jan 2014 |
43 |
| 17 |
Culture results from wound biopsy versus wound swab: does it matter for the assessment of wound infection?
Marieke Haalboom, Miriam H.E. Blokhuis‐Arkes, Roland J. Beuk et al. · Clinical Microbiology and Infection
Open access |
23 Aug 2018 |
40 |
| 18 |
FTY720 attenuates accumulation of EMAP‐II+ and MHC‐II+ monocytes in early lesions of rat traumatic brain injury
Zhiyuan Zhang, Zhiyuan Zhang, Zhiren Zhang et al. · Journal of Cellular and Molecular Medicine
Open access |
Mar 2007 |
40 |
| 19 |
Structural changes within the bifunctional cryptochrome/photolyase CraCRY upon blue light excitation
Sophie Franz-Badur, Alexander Penner, Simon Straß et al. · Scientific Reports
Open access |
9 Jul 2019 |
33 |
| 20 |
Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties
Olaf D. Kinzel, Christoph Steeneck, Thomas Schlüter et al. · Bioorganic & Medicinal Chemistry Letters
Open access |
24 May 2016 |
32 |
| 21 |
Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt’s disease and dry age‐related macular degeneration
Sylvie Julien, Barbara Illing, Alexander Tschulakow et al. · Pharmacology Research & Perspectives
Open access |
8 Nov 2020 |
26 |
| 22 |
AWD-12-281 (inhaled) (elbion/GlaxoSmithKline).
Hans-Jürgen Gutke, Jan‐Hinrich Guse, Moussa Khobzaoui et al. · PubMed
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Nov 2005 |
23 |
| 23 |
Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis
Luigina Graziosi, Andrea Mencarelli, Chiara Santorelli et al. · European Journal of Pharmacology
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20 Nov 2011 |
23 |
| 24 |
A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss
Barbara Peixoto Pinheiro, Marcus Müller, Michael Bös et al. · Cell Death and Disease
Open access |
11 Jul 2022 |
21 |
| 25 |
Removal of RPE lipofuscin results in rescue from retinal degeneration in a mouse model of advanced Stargardt disease: Role of reactive oxygen species
Yuan Fang, Tatjana Taubitz, Alexander Tschulakow et al. · Free Radical Biology and Medicine
Open access |
24 Feb 2022 |
21 |
| 26 |
The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine‐rich glycoprotein
Ulrich Deuschle, Manfred Birkel, Eva Hambruch et al. · International Journal of Cancer
Open access |
Nov 2014 |
19 |
| 27 |
Low Prevalence of Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions—A Multiregional Study in Central and West Africa
Tina Krueger, Moses Ikegbunam, Abel Lissom et al. · Pathogens
Open access |
14 Mar 2023 |
18 |
| 28 |
Bone morphogenetic protein-6 is expressed early by activated astrocytes in lesions of rat traumatic brain injury
Zhiren Zhang, Katrin Trautmann, Matthias Artelt et al. · Neuroscience
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2006 |
17 |
| 29 |
A Connection between the Mitochondrial Permeability Transition Pore, Autophagy, and Cerebral Amyloidogenesis
Vukić Šoškić, Martina Klemm, Tassula Proikas‐Cezanne et al. · Journal of Proteome Research
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9 May 2008 |
16 |
| 30 |
Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors
Niklas M. Tormählen, Mariella Martorelli, Annette Kühn et al. · Journal of Medicinal Chemistry
Open access |
11 May 2021 |
15 |
| 31 |
Lysozyme‐responsive polymer systems for detection of infection
Doris Schiffer, Vanessa Verient, Daniel Luschnig et al. · Engineering in Life Sciences
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12 Jan 2015 |
15 |
| 32 |
Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo
Manuel Keppler, Simon Straß, Sophia Geiger et al. · Frontiers in Immunology
Open access |
20 Jun 2023 |
14 |
| 33 |
Pharmacokinetics, Pharmacodynamics and Antiviral Efficacy of the MEK Inhibitor Zapnometinib in Animal Models and in Humans
Julia Koch-Heier, Annika Schönsiegel, Lara Maria Waidele et al. · Frontiers in Pharmacology
Open access |
15 Jun 2022 |
14 |
| 34 |
Folate-Targeted Liposomal Formulations Improve Effects of Methotrexate in Murine Collagen-Induced Arthritis
Diana Guimarães, Franck Lager, Gilles Renault et al. · Biomedicines
Open access |
21 Jan 2022 |
14 |
| 35 |
Intramolecular sulfoxide electrophilic sulfenylation in 2- and 3-indoleanilides
Mary E. Eggers, Parag V. Jog, Dallas K. Bates · Tetrahedron
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24 Oct 2007 |
13 |
| 36 |
Dexamethasone transiently attenuates up-regulation of endostatin/collagen XVIII following traumatic brain injury
Zhiyuan Zhang, Zhiyuan Zhang, Zhiren Zhang et al. · Neuroscience
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8 Jun 2007 |
13 |
| 37 |
Complementary methods for SARS-CoV-2 diagnosis in times of material shortage
Thaisa Lucas Sandri, Juliana Inoue, Johanna Geiger et al. · Scientific Reports
Open access |
7 Jun 2021 |
11 |
| 38 |
A Host-Directed Approach to the Detection of Infection in Hard-to-Heal Wounds
Michael W. M. Burnet, Daniel Gary Metcalf, Scarlet Milo et al. · Diagnostics
Open access |
4 Oct 2022 |
8 |
| 39 |
Inhibition of Sema-3A Promotes Cell Migration, Axonal Growth, and Retinal Ganglion Cell Survival
Anat Nitzan, Miriam Corredor-Sanchez, Ronit Galron et al. · Translational Vision Science & Technology
Open access |
24 Nov 2021 |
8 |
| 40 |
Efficacy of Bioactive Cyclic Peptides in Rheumatoid Arthritis: Translation from In Vitro to In Vivo Models
Roger R. C. New, Michal Bogus, Gurpal S. Bansal et al. · Molecules
Open access |
25 Sep 2017 |
8 |
| 41 |
Isostearic acid is an active component of imiquimod formulations used to induce psoriaform disease models
Simon Straß, Johanna Geiger, Mariella Martorelli et al. · Inflammopharmacology
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21 Mar 2023 |
7 |
| 42 |
Synthesis, Characterization, and in vivo Distribution of Intracellular Delivered Macrolide Short‐Chain Fatty Acid Derivatives
Simon Straß, Anna Schwamborn, Manuel Keppler et al. · ChemMedChem
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31 Mar 2021 |
7 |
| 43 |
The Azithromycin Pro-Drug CSY5669 Boosts Bacterial Killing While Attenuating Lung Inflammation Associated with Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus
Anno Saris, Wanhai Qin, Christine C. A. van Linge et al. · Antimicrobial Agents and Chemotherapy
Open access |
16 Aug 2022 |
6 |
| 44 |
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells
Julian Laux, Michael Förster, Laura Riexinger et al. · ACS Pharmacology & Translational Science
Open access |
14 Jul 2022 |
6 |
| 45 |
Evaluating Malaria Rapid Diagnostic Tests and Microscopy for Detecting Plasmodium Infection and Status of Plasmodium falciparum Histidine-Rich Protein 2/3 Gene Deletions in Southeastern Nigeria
Moses Ikegbunam, Maike Maurer, Harrison Odera Abone et al. · American Journal of Tropical Medicine and Hygiene
Open access |
26 Mar 2024 |
5 |
| 46 |
Immune cell targeted fumaric esters support a role of GPR109A as a primary target of monomethyl fumarate in vivo
Simon Straß, Johanna Geiger, Natascha Cloos et al. · Inflammopharmacology
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Apr 2023 |
5 |
| 47 |
Anti-Inflammatory Macrolides to Manage Chronic Neutrophilic Inflammation
Michael W. M. Burnet, Jan‐Hinrich Guse, Hans-Jürgen Gutke et al. · Royal Society of Chemistry eBooks
Book chapter |
3 Oct 2014 |
5 |
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Glucagon-like peptide-1 receptor agonists for treatment of diabetes and obesity: advantage of oral delivery
Roger R. C. New, M. Bogus, G. N. Travers et al. · Frontiers in Drug Delivery
Open access |
6 Nov 2024 |
3 |
| 49 |
Selective Inhibitors of Janus Kinase 3 Modify Responses to Lipopolysaccharides by Increasing the Interleukin-10-to-Tumor Necrosis Factor α Ratio
Julian Laux, Mariella Martorelli, Nadja Späth et al. · ACS Pharmacology & Translational Science
Open access |
18 May 2023 |
3 |
| 50 |
99 NOVEL FXR AGONISTS WITH POTENT LIPID LOWERING, INSULIN SENSITISING, ANTI-INFLAMMATORY AND ANTI-FIBROTISATION EFFECTS IN MOUSE MODELS OF METABOLIC SYNDROME AND NASH
Claus Kremoser, Eva Hambruch, Ulrich Deuschle et al. · Journal of Hepatology
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Mar 2011 |
3 |