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Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases
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24 Nov 2022 |
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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
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Tim Hsiau, David S. Conant, Nicholas A. A. Rossi et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer
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6 Apr 2023 |
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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors
Ferdinandos Skoulidis et al. · Nature
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9 Oct 2024 |
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Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication
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120 |
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SARS-CoV-2 variants evolve convergent strategies to remodel the host response
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21 Sep 2023 |
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Combination of biochar and immobilized bacteria accelerates polyacrylamide biodegradation in soil by both bio-augmentation and bio-stimulation strategies
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Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression
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An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma
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IL-2 based cancer immunotherapies: an evolving paradigm
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24 Jul 2024 |
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CRISPRoff enables spatio-temporal control of CRISPR editing
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7 Oct 2020 |
73 |
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BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2
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71 |
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Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
Kelsey M. Haas et al. · Nature Communications
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27 Sep 2023 |
68 |
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Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells
Alejandro Méndez‐Mancilla, Hans‐Hermann Wessels, Mateusz Legut et al. · Cell chemical biology
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2 Aug 2021 |
68 |
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Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases
Somnath Tagore et al. · Nature Medicine
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27 Feb 2025 |
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NLRP3 licenses NLRP11 for inflammasome activation in human macrophages
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27 May 2022 |
63 |
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Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro
Leiping Zeng et al. · Nature Communications
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19 May 2022 |
55 |
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Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression
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2 Nov 2021 |
52 |
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Graphene Oxide Nanoparticles Induce Apoptosis in wild-type and CRISPR/Cas9-IGF/IGFBP3 knocked-out Osteosarcoma Cells
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52 |
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Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen
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4 May 2022 |
51 |
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Lung cancer research and treatment: global perspectives and strategic calls to action
May‐Lucie Meyer et al. · Annals of Oncology
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Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors with chemotherapy
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30 Sep 2024 |
42 |
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Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases
Eleonora I. Ioannidi, Matthew T. N. Yarnall, Cian Schmitt-Ulms et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses
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24 Sep 2020 |
33 |
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Generation of precision preclinical cancer models using regulated in vivo base editing
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10 Aug 2023 |
32 |
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MAT2A as Key Regulator and Therapeutic Target in MLLr Leukemogenesis
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24 May 2020 |
32 |
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Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations
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Lexical and sublexical cortical tuning for print revealed by Steady‐State Visual Evoked Potentials (SSVEPs) in early readers
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Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2
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27 Jun 2022 |
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Enhanced RNA-targeting CRISPR-Cas technology in zebrafish
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Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes
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The Evolution of Single-Cell Analysis and Utility in Drug Development
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13 Aug 2021 |
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Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications
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Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
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21 Oct 2022 |
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Controlling homology-directed repair outcomes in human stem cells with dCas9
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16 Dec 2021 |
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19 Jul 2023 |
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Society for Immunotherapy of Cancer (SITC) checkpoint inhibitor resistance definitions: efforts to harmonize terminology and accelerate immuno-oncology drug development
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Jul 2023 |
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Analyzing CRISPR Editing Results
Jessica Roginsky · Genetic Engineering & Biotechnology News
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31 May 2024 |
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11 Nov 2021 |
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Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action
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29 Jul 2021 |
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Rb-E2F-HDAC Repressor Complexes Control Interferon-Induced Repression of Adenovirus To Promote Persistent Infection
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12 May 2022 |
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Ammonium Nitrogen Streamflow Transport Modelling and Spatial Analysis in Two Chinese Basins
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11 Jan 2022 |
6 |