Institution · Taiho Pharmaceutical (Japan)

Most cited papers from Taiho Pharmaceutical (Japan)

Taiho Pharmaceutical (Japan)

What are the most cited papers from Taiho Pharmaceutical (Japan)?

The most cited paper from Taiho Pharmaceutical (Japan) is "Five-Year Outcomes of a Randomized Phase III Trial Comparing Adjuvant Chemotherapy With S-1 Versus Surgery Alone in Stage II or III Gastric Cancer" (Mitsuru Sasako, Shinichi Sakuramoto, Hitoshi Katai et al., 2011), with 1,495 citations. Next come "Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer" (1,457) and "NCCN Guidelines Insights: Colon Cancer, Version 2.2018" (1,045).

Published TypeFieldAccessCitations

Showing 50 of 59 papers. Every paper with more than 124 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Five-Year Outcomes of a Randomized Phase III Trial Comparing Adjuvant Chemotherapy With S-1 Versus Surgery Alone in Stage II or III Gastric Cancer Mitsuru Sasako, Shinichi Sakuramoto, Hitoshi Katai et al. · Journal of Clinical Oncology Open access	18 Oct 2011	1,495
2	Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer Robert J. Mayer et al. · New England Journal of Medicine Open access	13 May 2015	1,457
3	NCCN Guidelines Insights: Colon Cancer, Version 2.2018 Al B. Benson et al. · Journal of the National Comprehensive Cancer Network Open access	Apr 2018	1,045
4	Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators Tetsuhiko Shirasaka, Yuji Shimamato, Hideyuki Ohshimo et al. · Anti-Cancer Drugs	Jul 1996	825
5	Modulation of oestrogen receptor signalling by association with the activated dioxin receptor Fumiaki Ohtake, Ken‐ichi Takeyama, Takahiro Μatsumoto et al. · Nature	May 2003	797
6	Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species Sawako Suzuki, Tomoaki Tanaka, Masha V. Poyurovsky et al. · Proceedings of the National Academy of Sciences Open access	29 Mar 2010	703
7	Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors Jason J. Luke, Jeffrey M. Lemons, Theodore G Karrison et al. · Journal of Clinical Oncology Open access	13 Feb 2018	597
8	Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats Yasundo Yamasaki, Naosuke Matsuura, Hidetaka Shozuhara et al. · Stroke	Apr 1995	580
9	Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells Shinji Yamashita, Tomoyuki Furubayashi, Makoto Kataoka et al. · European Journal of Pharmaceutical Sciences	May 2000	571
10	Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation Yoshiaki Tsutsumi, Hiroaki Matsubara, Hiroya Masaki et al. · Journal of Clinical Investigation Open access	Oct 1999	566
11	The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs Atsushi Nagayasu, Kazuko Uchiyama, Hiroshi Kiwada · Advanced Drug Delivery Reviews Review	Nov 1999	440
12	TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma Lipika Goyal et al. · Cancer Discovery Open access	20 May 2019	379
13	Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats. Tetsuhiko Shirasaka, K Nakano, T Takechi et al. · PubMed	Jun 1996	370
14	Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma Y. Takebayashi, Shin‐ichi Akiyama, Suminori Akiba et al. · JNCI Journal of the National Cancer Institute	21 Aug 1996	368
15	Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: Effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes Tatsuhiro Ishida, Masae Harada, Xinyu Wang et al. · Journal of Controlled Release	24 May 2005	363
16	Bone Marrow Monocyte Lineage Cells Adhere on Injured Endothelium in a Monocyte Chemoattractant Protein-1–Dependent Manner and Accelerate Reendothelialization as Endothelial Progenitor Cells Soichiro Fujiyama, Katsuya Amano, Kazutaka Uehira et al. · Circulation Research Open access	7 Oct 2003	360
17	Angiogenic activity of enzymes Misako Haraguchi, Kazutaka Miyadera, Katsuo Uemura et al. · Nature	17 Mar 1994	352
18	Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Tetsuhiko Shirasaka, Yuji Shimamoto, Masakazu Fukushima · PubMed	Sep 1993	350
19	Risk Assessment in Immunotoxicology II. Relationships between Immune and Host Resistance Tests M I Luster · Fundamental and Applied Toxicology	Jul 1993	329
20	Accelerated clearance of PEGylated liposomes in rats after repeated injections Tatsuhiro Ishida, Ryuhei Maeda, Masako Ichihara et al. · Journal of Controlled Release	Feb 2003	328
21	TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial Takayuki Yoshino, Nobuyuki Mizunuma, Kentaro Yamazaki et al. · The Lancet Oncology	27 Aug 2012	326
22	Angiogenic factor Tatsuhiko Furukawa, Akihiko Yoshimura, Tomoyuki Sumizawa et al. · Nature	23 Apr 1992	310
23	Deubiquitylation of histone H2A activates transcriptional initiation via trans -histone cross-talk with H3K4 di- and trimethylation Takeya Nakagawa, Takuya Kajitani, Shinji Togo et al. · Genes & Development Open access	2008	268
24	Antibacterial and Antioxidant Activities of Quercetin Oxidation Products from Yellow Onion (Allium cepa) Skin Freddy Alejandro Ramos, Yoshihisa Takaishi, Miki Shirotori et al. · Journal of Agricultural and Food Chemistry	21 Apr 2006	254
25	Angiotensin Type 2 Receptors Are Reexpressed by Cardiac Fibroblasts From Failing Myopathic Hamster Hearts and Inhibit Cell Growth and Fibrillar Collagen Metabolism Naohiko Ohkubo, Hiroaki Matsubara, Yoshihisa Nozawa et al. · Circulation	2 Dec 1997	247
26	Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition Atsushi Hamabe, Masamitsu Konno, Nobuhiro Tanuma et al. · Proceedings of the National Academy of Sciences Open access	13 Oct 2014	243
27	Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2′-deoxyribonucleosides Masakazu Fukushima, Norihiko Suzuki, Tomohiro Emura et al. · Biochemical Pharmacology	May 2000	239
28	Safety, Pharmacokinetics, and Effects on Cognitive Function of Multiple Doses of GTS-21 in Healthy, Male Volunteers Harumi KITAGAWA, Toshiharu TAKENOUCHI, Ryotaro Azuma et al. · Neuropsychopharmacology	11 Jul 2002	238
29	MK-1775, a Novel Wee1 Kinase Inhibitor, Radiosensitizes p53-Defective Human Tumor Cells Kathleen A. Bridges, Hiroshi Hirai, Carolyn A. Buser et al. · Clinical Cancer Research Open access	28 Jul 2011	238
30	Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocation-related sarcoma: a randomised, open-label, phase 2 study Akira Kawai, Nobuhito Araki, Hideshi Sugiura et al. · The Lancet Oncology	23 Mar 2015	218
31	NCCN Guidelines® Insights: Biliary Tract Cancers, Version 2.2023 Al B. Benson et al. · Journal of the National Comprehensive Cancer Network Open access	Jul 2023	213
32	Futibatinib Is a Novel Irreversible FGFR 1–4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors Hiroshi Sootome, Hidenori Fujita, Kenjiro Ito et al. · Cancer Research Open access	24 Sep 2020	205
33	Angiotensin II Type 1 Receptor–Induced Extracellular Signal–Regulated Protein Kinase Activation Is Mediated by Ca 2+ /Calmodulin-Dependent Transactivation of Epidermal Growth Factor Receptor Satoshi Murasawa, Yasukiyo Mori, Yoshihisa Nozawa et al. · Circulation Research Open access	29 Jun 1998	195
34	Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide Yasuo Oyama, Lumi Chikahisa, Toshiko Ueha et al. · Brain Research	Mar 1996	190
35	Reduction of delayed neuronal death by inhibition of protein synthesis Taku Shigeno, Yasundo Yamasaki, Gunshiro Kato et al. · Neuroscience Letters	Nov 1990	188
36	Accelerated clearance of a second injection of PEGylated liposomes in mice Tatsuhiro Ishida, Kaori Masuda, Takako Ichikawa et al. · International Journal of Pharmaceutics	Apr 2003	184
37	The activity and expression of thymidine phosphorylase in human solid tumours Yuji Takebayashi, Kazutaka Yamada, Kazutaka Miyadera et al. · European Journal of Cancer	Jun 1996	183
38	hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes Tomoaki Tanaka, Shuichi Ohkubo, Ichiro Tatsuno et al. · Cell Open access	Aug 2007	176
39	Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer Ken Takezawa, Isamu Okamoto, Wataru Okamoto et al. · British Journal of Cancer Open access	12 Apr 2011	171
40	Impact of Diabetes, Insulin, and Metformin Use on the Outcome of Patients With Human Epidermal Growth Factor Receptor 2–Positive Primary Breast Cancer: Analysis From the ALTTO Phase III Randomized Trial Amir Sonnenblick, Dominique Agbor‐Tarh, Ian Bradbury et al. · Journal of Clinical Oncology Open access	5 Apr 2017	169
41	Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro. Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima et al. · PubMed	Nov 2000	167
42	Antitumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats Teiji Takechi, Koushi Nakano, Junji Uchida et al. · Cancer Chemotherapy and Pharmacology	2 Dec 1996	162
43	Steady particulate flows in a horizontal rotating cylinder Kenji Yamane, Masami Nakagawa, S. A. Altobelli et al. · Physics of Fluids	Jun 1998	160
44	In vitro and in vivo nasal mucoadhesion of some water-soluble polymers Fumihiko Nakamura · International Journal of Pharmaceutics	28 May 1996	159
45	Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo Tetsuhiko Shirasaka, Yuji Shimamoto, Hideyuki Ohshimo et al. · Cancer Chemotherapy and Pharmacology	1993	152
46	Fluorescent Estimation of H2O2-Induced Changes in Cell Viability and Cellular Nonprotein Thiol Level of Dissociated Rat Thymocytes Lumi Chikahisa, Yasuo Oyama, Eisuke Okazaki et al. · The Japanese Journal of Pharmacology Open access	1996	150
47	Denaturation of Protein by Chlorine Dioxide: Oxidative Modification of Tryptophan and Tyrosine Residues Norio Ogata · Biochemistry	31 Mar 2007	147
48	A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity. Ji-lan Hu, Yu-chuan Xue, MEI-YU XIE et al. · The Journal of Antibiotics Open access	1988	146
49	TAS-116, a Highly Selective Inhibitor of Heat Shock Protein 90α and β, Demonstrates Potent Antitumor Activity and Minimal Ocular Toxicity in Preclinical Models Shuichi Ohkubo, Yasuo Kodama, Hiromi Muraoka et al. · Molecular Cancer Therapeutics	22 Nov 2014	145
50	Elevated expression of vacuolar proton pump genes and cellular ph in cisplatin resistance Tadashi Murakami, Izumi Shibuya, Tomoko Ise et al. · International Journal of Cancer	2001	145

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.