| 1 |
Type 2 diabetes mellitus
Ralph Anthony DeFronzo, Ele Ferrannini, Leif Groop et al. · Nature Reviews Disease Primers
Review |
22 Jul 2015 |
2,651 |
| 2 |
Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus
Ralph Anthony DeFronzo, A. Goodman · New England Journal of Medicine
|
31 Aug 1995 |
1,378 |
| 3 |
Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes
Melanie J. Davies, Richard M. Bergenstal, Bruce W. Bode et al. · JAMA
Open access |
18 Aug 2015 |
1,172 |
| 4 |
Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle
Kenneth J. Cusi, Katsumi Maezono, Abdullah A. Osman et al. · Journal of Clinical Investigation
Open access |
Feb 2000 |
1,143 |
| 5 |
Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
Aurora Merovci, Carolina Solis‐Herrera, Giuseppe Daniele et al. · Journal of Clinical Investigation
Open access |
26 Jan 2014 |
793 |
| 6 |
Pioglitazone for Diabetes Prevention in Impaired Glucose Tolerance
Ralph A. DeFronzo, Devjit Tripathy, Dawn C. Schwenke et al. · New England Journal of Medicine
Open access |
23 Mar 2011 |
752 |
| 7 |
Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity in Type 2 Diabetic Patients
Yoshinori Miyazaki, Archana Mahankali, Masafumi Matsuda et al. · The Journal of Clinical Endocrinology & Metabolism
|
Jun 2002 |
707 |
| 8 |
Continuous Glucose Monitoring Versus Usual Care in Patients With Type 2 Diabetes Receiving Multiple Daily Insulin Injections
Roy W. Beck, Tonya D. Riddlesworth, Katrina J. Ruedy et al. · Annals of Internal Medicine
|
19 Sep 2017 |
629 |
| 9 |
Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents
Antonino Di Pino, Ralph A. DeFronzo · Endocrine Reviews
Open access |
3 May 2019 |
565 |
| 10 |
Renal, metabolic and cardiovascular considerations of SGLT2 inhibition
Ralph Anthony DeFronzo, Luke Norton, Muhammad A Abdul‐Ghani · Nature Reviews Nephrology
Review |
12 Dec 2016 |
560 |
| 11 |
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
Amy L. Williams et al. · Nature
Open access109 authors |
24 Dec 2013 |
529 |
| 12 |
Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases
Eugênio Cersósimo, Ralph Anthony DeFronzo · Diabetes/Metabolism Research and Reviews
|
28 Feb 2006 |
528 |
| 13 |
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia
Ralph Anthony DeFronzo, Jaime A. Davidson, Stefano Del Prato · Diabetes Obesity and Metabolism
|
28 Sep 2011 |
495 |
| 14 |
Metabolic syndrome: Definition, pathophysiology, and mechanisms
Phillippa J. Miranda, Ralph Anthony DeFronzo, Robert M. Califf et al. · American Heart Journal
|
2005 |
483 |
| 15 |
Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
Romina Lomonaco, Carolina Ortiz‐Lopez, Beverly Orsak et al. · Hepatology
Open access |
20 Dec 2011 |
468 |
| 16 |
Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus: a balanced overview
R. A. DeFronzo · Diabetologia
Open access |
Apr 1992 |
435 |
| 17 |
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
Kenneth J. Cusi, Agostino Consoli, Ralph Anthony DeFronzo · The Journal of Clinical Endocrinology & Metabolism
Open access |
Nov 1996 |
425 |
| 18 |
Improved Glycemic Control and Enhanced Insulin Sensitivity in Type 2 Diabetic Subjects Treated With Pioglitazone
Yoshinori Miyazaki, Archana Mahankali, Masafumi Matsuda et al. · Diabetes Care
|
Apr 2001 |
407 |
| 19 |
Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
Alberto O. Chávez, Marjorie Molina‐Carrión, Muhammad A. Abdul-Ghani et al. · Diabetes Care
Open access |
Jun 2009 |
393 |
| 20 |
Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects
Sara M. Reyna, Sangeeta Ghosh, Puntip Tantiwong et al. · Diabetes
Open access |
16 Jul 2008 |
387 |
| 21 |
The Role of Oxidative Stress in the Pathogenesis of Type 2 Diabetes Mellitus Micro- and Macrovascular Complications: Avenues for a Mechanistic-Based Therapeutic Approach
Franco B. Folli, Domenico Corradi, Paolo Fanti et al. · Current Diabetes Reviews
|
Sep 2011 |
379 |
| 22 |
Obesity and insulin resistance in humans: A dose-response study
Riccardo C. Bonadonna, Groop Leif, Nancy Kraemer et al. · Metabolism
|
May 1990 |
361 |
| 23 |
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Broad Genomics Platform et al. · Nature
Open access173 authors |
22 May 2019 |
343 |
| 24 |
Insulin: The master regulator of glucose metabolism
Luke Norton, Chris E. Shannon, Amalia Gastaldelli et al. · Metabolism
|
20 Jan 2022 |
332 |
| 25 |
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations
Madeline H. Kowalski et al. · PLoS Genetics
Open access |
23 Dec 2019 |
328 |
| 26 |
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man
Stefano Del Prato, Frida Leonetti, Donald C. Simonson et al. · Diabetologia
Open access |
Oct 1994 |
326 |
| 27 |
Assessment and Treatment of Cardiovascular Risk in Prediabetes: Impaired Glucose Tolerance and Impaired Fasting Glucose
Ralph A. DeFronzo, Muhammad A Abdul‐Ghani · The American Journal of Cardiology
|
29 Jul 2011 |
321 |
| 28 |
Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects With Type 2 Diabetes
Apiradee Sriwijitkamol, Dawn K. Coletta, Estela Wajcberg et al. · Diabetes
Open access |
27 Feb 2007 |
306 |
| 29 |
Assessment of Pancreatic β-Cell Function: Review of Methods and Clinical Applications
Eugênio Cersósimo, Carolina Solis‐Herrera, MICHAEL E. TRAUTMANN et al. · Current Diabetes Reviews
Open access |
20 Mar 2014 |
296 |
| 30 |
Chronic Hyperglycemia Impairs Endothelial Function and Insulin Sensitivity Via Different Mechanisms in Insulin-Dependent Diabetes Mellitus
Sari Ma ̈kimattila, Antti Virkama ̈ki, Per‐Henrik Groop et al. · Circulation
|
15 Sep 1996 |
288 |
| 31 |
Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis
R. A. DeFronzo · The Netherlands Journal of Medicine
|
May 1997 |
280 |
| 32 |
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients
Y. Miyazaki, Leonard C. Glass, Curtis L. Triplitt et al. · Diabetologia
Open access |
Dec 2001 |
276 |
| 33 |
Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle
Dawn K. Richardson, Sangeeta Kashyap, Mandeep Bajaj et al. · Journal of Biological Chemistry
Open access |
14 Dec 2004 |
259 |
| 34 |
Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake. A dose-response euglycemic clamp study in normal and diabetic rats.
Luciano Rossetti, Andrea Giaccari · Journal of Clinical Investigation
Open access |
Jun 1990 |
257 |
| 35 |
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus
Yoshinori Miyazaki, Leonard C. Glass, Curtis L. Triplitt et al. · American Journal of Physiology-Endocrinology and Metabolism
|
Dec 2002 |
256 |
| 36 |
Bromocriptine: a novel approach to the treatment of type 2 diabetes.
Hanno Pijl, Satoru Ohashi, Masafumi Matsuda et al. · Diabetes Care
Open access |
Aug 2000 |
241 |
| 37 |
Dose-Response Effect of Pioglitazone on Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes
Yoshinori Miyazaki, Masafumi Matsuda, Ralph Anthony DeFronzo · Diabetes Care
Open access |
Mar 2002 |
236 |
| 38 |
Insulin resistance and coronary artery disease
Peter B. Bressler, Steven R. Bailey, Masafumi Matsuda et al. · Diabetologia
Open access |
23 Oct 1996 |
235 |
| 39 |
AMP‐activated protein kinase: role in metabolism and therapeutic implications
Greg Schimmack, Ralph Anthony DeFronzo, Nicolas Musi · Diabetes Obesity and Metabolism
|
27 Feb 2006 |
229 |
| 40 |
Effect of Pioglitazone on Circulating Adipocytokine Levels and Insulin Sensitivity in Type 2 Diabetic Patients
Yoshinori Miyazaki, Archana Mahankali, Estela Wajcberg et al. · The Journal of Clinical Endocrinology & Metabolism
|
Sep 2004 |
228 |
| 41 |
Autophagy inhibition enhances vorinostat‐induced apoptosis via ubiquitinated protein accumulation
Jennifer S. Carew, Ernest C. Medina, Juan Esquivel et al. · Journal of Cellular and Molecular Medicine
Open access |
6 Jul 2009 |
223 |
| 42 |
Relationship of baseline HbA1c and efficacy of current glucose‐lowering therapies: a meta‐analysis of randomized clinical trials
R. A. DeFronzo, Anthony H. Stonehouse, Jennifer Han et al. · Diabetic Medicine
|
Mar 2010 |
215 |
| 43 |
Effect of Lipopolysaccharide on Inflammation and Insulin Action in Human Muscle
Hanyu Liang, Sophie E. Hussey, Alicia Sanchez-Avila et al. · PLoS ONE
Open access |
21 May 2013 |
215 |
| 44 |
Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add‐on therapy in subjects with new‐onset diabetes. Results from the E fficacy and D urability of I nitial C ombination T herapy for T ype 2 D iabetes ( EDICT ): a randomized trial
M. A. Abdul‐Ghani, CURTISS L. PUCKETT, Curtis L. Triplitt et al. · Diabetes Obesity and Metabolism
Open access |
26 Nov 2014 |
205 |
| 45 |
Review of methods for detecting glycemic disorders
Michael Bergman et al. · Diabetes Research and Clinical Practice
Open access |
Jun 2020 |
202 |
| 46 |
Thiazolidinediones improve β-cell function in type 2 diabetic patients
Amalia Gastaldelli, Ele Ferrannini, Yoshinori Miyazaki et al. · American Journal of Physiology-Endocrinology and Metabolism
|
15 Nov 2006 |
201 |
| 47 |
Combination therapy with GLP ‐1 receptor agonist and SGLT2 inhibitor
Ralph A. DeFronzo · Diabetes Obesity and Metabolism
Open access |
22 Apr 2017 |
193 |
| 48 |
Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes.
Luciano Rossetti, Andrea Giaccari, Nir Barzilai et al. · Journal of Clinical Investigation
Open access |
Sep 1993 |
190 |
| 49 |
Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans
Livio Luzi, Ralph Anthony DeFronzo · American Journal of Physiology-Endocrinology and Metabolism
|
Aug 1989 |
190 |
| 50 |
Insulin Resistance, Hyperinsulinemia, and Coronary Artery Disease: A Complex Metabolic Web
Ralph Anthony DeFronzo · Journal of Cardiovascular Pharmacology
|
1992 |
186 |