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Institution · Therapeutics Clinical Research

Most cited papers from Therapeutics Clinical Research

Therapeutics Clinical Research

What are the most cited papers from Therapeutics Clinical Research?

The most cited paper from Therapeutics Clinical Research is "Association of reactive oxygen species levels and radioresistance in cancer stem cells" (Maximilian Diehn et al., 2009), with 2,565 citations. Next come "Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations" (1,330) and "Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome" (1,326).

Showing 50 of 61 papers. Every paper with more than 156 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Association of reactive oxygen species levels and radioresistance in cancer stem cells Maximilian Diehn et al. · Nature Open access 5 Feb 2009 2,565
2 Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations Jun Gong, Alex Chehrazi‐Raffle, Srikanth Reddi et al. · Journal for ImmunoTherapy of Cancer Open access 22 Jan 2018 1,330
3 Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Chun Kwok Wong, Charles Lam, Alan K. L. Wu et al. · Clinical & Experimental Immunology Open access 5 Mar 2004 1,326
4 Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease Rebecca C. Sims et al. · Nature Genetics Open access450 authors 17 Jul 2017 1,122
5 Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure Takayoshi Ohkubo, Atsushi Hozawa, Junko Yamaguchi et al. · Journal of Hypertension Nov 2002 1,061
6 Incidence and Outcomes in Acute Kidney Injury Tariq Ali, Izhar H. Khan, William G. Simpson et al. · Journal of the American Society of Nephrology 21 Feb 2007 834
7 Stomach NO synthesis Nigel Benjamin, Fionnuala O'Driscoll, Hamish Dougall et al. · Nature 7 Apr 1994 660
8 Cytoplasmic pH Measurement and Homeostasis in Bacteria and Archaea Joan L. Slonczewski, Makoto Fujisawa, Mark Dopson et al. · Advances in microbial physiology/Advances in Microbial Physiology Book chapter 2009 567
9 Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza Nelson L.S. Lee, Paul K.S. Chan, David S.C. Hui et al. · The Journal of Infectious Diseases Open access 10 Jul 2009 535
10 Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study Eric M. Reiman et al. · Nature Communications Open access192 authors 3 Feb 2020 513
11 A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality Val Mann, Emma E. Hobson, Baohua Li et al. · Journal of Clinical Investigation Open access Apr 2001 471
12 Efficacy of Human Papillomavirus-16 Vaccine to Prevent Cervical Intraepithelial Neoplasia Constance Mao, Laura A. Koutsky, Kevin A. Ault et al. · Obstetrics and Gynecology 2006 452
13 Long-Term Outcomes in IgA Nephropathy David Pitcher, Fiona Braddon, Bruce M. Hendry et al. · Clinical Journal of the American Society of Nephrology Open access 13 Apr 2023 446
14 Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. Brian K. Reuter, Samuel Asfaha, André G. Buret et al. · Journal of Clinical Investigation Open access Nov 1996 425
15 The Association of Aminoglycoside Plasma Levels with Mortality in Patients with Gram-Negative Bacteremia Richard D. Moore, Craig R. Smith, P. S. Lietman · The Journal of Infectious Diseases Mar 1984 392
16 To tell or not to tell: barriers and facilitators in family communication about genetic risk Karen M. Forrest, SA Simpson, Wilson Bj et al. · Clinical Genetics 15 Sep 2003 375
17 Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity John Lawrence Wallace, Adrian William Bak, Webb McKnight et al. · Gastroenterology Open access Jul 1998 348
18 Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade Martin Alejandro Bruno, A. Claudio Cuello · Proceedings of the National Academy of Sciences 17 Apr 2006 348
19 Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP Jonas Byström, Ian M. Evans, Justine Newson et al. · Blood Open access 8 Sep 2008 342
20 Increased prevalence of precancerous changes in relatives of gastric cancer patients: Critical role of H. pylori Emad M. El-Omar, Karin A. Oien, Lilian S. Murray et al. · Gastroenterology Open access 2000 336
21 Aerobic and resistance exercise improves physical fitness, bone health, and quality of life in overweight and obese breast cancer survivors: a randomized controlled trial Christina Marie Dieli-Conwright, Kerry S. Courneya, Wendy Demark‐Wahnefried et al. · Breast Cancer Research Open access 19 Oct 2018 326
22 Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans Thea Morris, Melanie J. Stables, Adrian J. Hobbs et al. · The Journal of Immunology Open access 14 Jul 2009 324
23 The Validity, Reliability and Clinical Utility of the Hong Kong Montreal Cognitive Assessment (HK-MoCA) in Patients with Cerebral Small Vessel Disease Adrian Wong, Yunyun Xiong, Pauline Wing-Lam Kwan et al. · Dementia and Geriatric Cognitive Disorders 2009 324
24 Amyloid β Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization Igor V. Klyubin, Vicki Betts, Alfred T. Welzel et al. · Journal of Neuroscience Open access 16 Apr 2008 320
25 A novel Alzheimer disease locus located near the gene encoding tau protein Gyungah Jun et al. · Molecular Psychiatry Open access429 authors 17 Mar 2015 315
26 The Signature of Maternal Rearing in the Methylome in Rhesus Macaque Prefrontal Cortex and T Cells Nadine Provençal, Matthew J Suderman, Claire Guillemin et al. · Journal of Neuroscience Open access 31 Oct 2012 314
27 Bacteria-Induced Intestinal Cancer in Mice with DisruptedGpx1andGpx2Genes Fong‐Fong Chu, Robert Steven Esworthy, Peiguo G. Chu et al. · Cancer Research Feb 2004 310
28 Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial Brad H. Rovin et al. · The Lancet Open access734 authors 3 Nov 2023 300
29 Prognostic Use of Circulating Plasma Nucleic Acid Concentrations in Patients with Acute Stroke Timothy Hudson Rainer, Ka Sing Wong, Wynnie W.M. Lam et al. · Clinical Chemistry Apr 2003 288
30 How many times should blood pressure be measured at home for better prediction of stroke risk? Ten-year follow-up results from the Ohasama study Takayoshi Ohkubo, Kei Asayama, Masahiro Kikuya et al. · Journal of Hypertension Open access 12 May 2004 286
31 Alzheimer's Disease Brain-Derived Amyloid-β-Mediated Inhibition of LTPIn VivoIs Prevented by Immunotargeting Cellular Prion Protein Andrew E. Barry, Igor V. Klyubin, Jessica M. Mc Donald et al. · Journal of Neuroscience Open access 18 May 2011 237
32 A Phase II Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) in Metastatic Breast Cancer: A California Cancer Consortium Study Thehang H. Luu, Robert J. Morgan, Lucille Leong et al. · Clinical Cancer Research Open access Nov 2008 237
33 Early Enhanced Expression of Interferon-Inducible Protein-10 (CXCL-10) and Other Chemokines Predicts Adverse Outcome in Severe Acute Respiratory Syndrome Nelson L.S. Tang, Paul K.S. Chan, Chun-Kwok Wong et al. · Clinical Chemistry Open access 30 Sep 2005 236
34 Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial Hiddo J.L. Heerspink et al. · The Lancet Open access731 authors Apr 2023 225
35 Prevalence of metabolic syndrome in the United States National Health and Nutrition Examination Survey 2011–18 Xiaopeng Liang, Benjamin Or, Man Fung Tsoi et al. · Postgraduate Medical Journal Open access 11 Mar 2023 224
36 Clinical Pharmacology and Toxicology of Cocaine Neal L. Benowitz · Pharmacology & Toxicology 1993 221
37 SOLITARY PLASMACYTOMA OF BONE AND EXTRAMEDULLARY PLASMACYTOMA Meletios Athanasios Dimopoulos, Christos Kiamouris, Lia Angela Moulopoulos · Hematology/Oncology Clinics of North America Dec 1999 219
38 Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells Lanxi Song, Domenico Coppola, Sandy Livingston et al. · Cancer Biology & Therapy Open access Mar 2005 216
39 Transethnic genome‐wide scan identifies novel Alzheimer's disease loci Gyungah Jun et al. · Alzheimer s & Dementia Open access206 authors 6 Feb 2017 215
40 Intrinsic Phenotypic Differences of Asthmatic Epithelium and Its Inflammatory Responses to Respiratory Syncytial Virus and Air Pollution Tillie‐Louise Hackett, Gurpreet Kaur Singhera, Furquan Shaheen et al. · American Journal of Respiratory Cell and Molecular Biology 4 Jun 2011 215
41 Ecstasy and the dance of death. John Aaron Henry · BMJ Open access 4 Jul 1992 212
42 Hemofiltration Reverses Left Ventricular Dysfunction during Sepsis in Dogs Arturo Gómez, R. Wang, Helmut W. Unruh et al. · Anesthesiology Oct 1990 197
43 Excitotoxic Death of Retinal NeuronsIn VivoOccurs via a Non-Cell-Autonomous Mechanism Frédéric Lebrun-Julien, Laure Duplan, Vincent Pernet et al. · Journal of Neuroscience Open access 29 Apr 2009 186
44 The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans Junko Imanaga, Tsutomu Kotegawa, Hiromitsu Imai et al. · Pharmacogenetics and Genomics 28 Dec 2010 182
45 Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery Jeannie L. Callum et al. · JAMA Open access 21 Oct 2019 180
46 Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction Iain B Squire, Jon Evans, Leong L. Ng et al. · Journal of Cardiac Failure Aug 2004 174
47 Modulation of the Purinergic P2X7Receptor Attenuates Lipopolysaccharide-Mediated Microglial Activation and Neuronal Damage in Inflamed Brain Hyun B. Choi, Jae Kyu Ryu, Seung Up Kim et al. · Journal of Neuroscience Open access 2 May 2007 173
48 Quantitative Analysis of Circulating Methylated DNA as a Biomarker for Hepatocellular Carcinoma K.C. Allen Chan, Paul B.S. Lai, Tony S.K. Mok et al. · Clinical Chemistry Open access 25 Jul 2008 172
49 Family Communication about Genetic Risk: The Little That Is Known Brenda J. Wilson, Karen M. Forrest, Edwin van Teijlingen et al. · Public Health Genomics 2004 172
50 Diagnostic imaging and therapeutic application of nanoparticles targeting the liver Haolu Wang, Camilla A. Thorling, Xiaowen Liang et al. · Journal of Materials Chemistry B 10 Dec 2014 172

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.