| 1 |
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
Thierry Conroy, Françoise Desseigne, Marc Ychou et al. · New England Journal of Medicine
Open access |
11 May 2011 |
7,927 |
| 2 |
Monte Carlo Statistical Methods
Hoon Kim, Christian P. Robert, George Casella · Technometrics
Open access |
Nov 2000 |
5,603 |
| 3 |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
European Alzheimer's Disease Initiative (EADI) et al. · Nature Genetics
ReviewOpen access184 authors |
27 Oct 2013 |
4,711 |
| 4 |
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle et al. · Nature Genetics
ReviewOpen access469 authors |
28 Feb 2019 |
3,277 |
| 5 |
FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer
Thierry Conroy et al. · New England Journal of Medicine
Open access |
19 Dec 2018 |
2,918 |
| 6 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Vassily Vladimirovich Trubetskoy et al. · Nature
Open access613 authors |
8 Apr 2022 |
2,894 |
| 7 |
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Daniel J. Klionsky et al. · Autophagy
Open access2,930 authors |
2 Jan 2021 |
2,743 |
| 8 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez et al. · Nature Genetics
Open access1,266 authors |
Apr 2022 |
2,608 |
| 9 |
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome
Alain Combes et al. · New England Journal of Medicine
Open access |
23 May 2018 |
2,451 |
| 10 |
High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure
J. P. Frat et al. · New England Journal of Medicine
Open access |
17 May 2015 |
2,419 |
| 11 |
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators et al. · Nature Genetics
Open access |
6 Sep 2009 |
2,292 |
| 12 |
TRY plant trait database – enhanced coverage and open access
Jens Kattge et al. · Global Change Biology
Open access729 authors |
31 Dec 2019 |
2,168 |
| 13 |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
the Alzheimer's Disease Neuroimaging Initiative et al. · Nature Genetics
Open access173 authors |
3 Apr 2011 |
2,100 |
| 14 |
Analysis of shared heritability in common disorders of the brain
Verneri Anttila et al. · Science
Open access577 authors |
21 Jun 2018 |
2,056 |
| 15 |
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Jaimie D Steinmetz et al. · The Lancet Neurology
Open access1,264 authors |
14 Mar 2024 |
1,978 |
| 16 |
A Dataset for Breast Cancer Histopathological Image Classification
Fábio Alexandre Spanhol, Luiz S. Oliveira, Caroline Petitjean et al. · IEEE Transactions on Biomedical Engineering
|
30 Oct 2015 |
1,840 |
| 17 |
Prevalence of eating disorders over the 2000–2018 period: a systematic literature review
Marie C. Galmiche, Pierre Déchelotte, Grégory Lambert et al. · American Journal of Clinical Nutrition
ReviewOpen access |
Nov 2018 |
1,746 |
| 18 |
A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry
Carlo Sambiagio, David Schönbauer, Rémi Blieck et al. · Chemical Society Reviews
ReviewOpen access |
2018 |
1,686 |
| 19 |
Soil invertebrates and ecosystem services
P. Lavelle, Thibaud Decaëns, Michaël Aubert et al. · European Journal of Soil Biology
|
18 Oct 2006 |
1,597 |
| 20 |
Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis
Jean‐Louis Mas et al. · New England Journal of Medicine
Open access |
18 Oct 2006 |
1,586 |
| 21 |
Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Valentina Escott‐Price et al. · PLoS ONE
Open access188 authors |
12 Jun 2014 |
1,408 |
| 22 |
Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome
Alain Mercat, Jean-Christophe M. Richard, Bruno Vielle et al. · JAMA
|
12 Feb 2008 |
1,383 |
| 23 |
Recurrent Cerebrovascular Events Associated with Patent Foramen Ovale, Atrial Septal Aneurysm, or Both
Jean‐Louis Mas, Caroline Arquizan, Catherine Lamy et al. · New England Journal of Medicine
Open access |
13 Dec 2001 |
1,368 |
| 24 |
A Communication Strategy and Brochure for Relatives of Patients Dying in the ICU
Alexandre Lautrette et al. · New England Journal of Medicine
Open access |
Feb 2007 |
1,278 |
| 25 |
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
Anne Rovelet‐Lecrux, Didier Hannequin, Grégory Raux et al. · Nature Genetics
|
20 Dec 2005 |
1,276 |
| 26 |
Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit
Stèphane Gaudry et al. · New England Journal of Medicine
Open access |
15 May 2016 |
1,269 |
| 27 |
Large-scale 3D random polycrystals for the finite element method: Generation, meshing and remeshing
Romain Quey, Paul R. Dawson, Fabrice Barbe · Computer Methods in Applied Mechanics and Engineering
Open access |
24 Jan 2011 |
1,265 |
| 28 |
High versus Low Blood-Pressure Target in Patients with Septic Shock
Pierre Asfar et al. · New England Journal of Medicine
Open access |
18 Mar 2014 |
1,248 |
| 29 |
Registry of Transcatheter Aortic-Valve Implantation in High-Risk Patients
Martine Gilard et al. · New England Journal of Medicine
Open access |
2 May 2012 |
1,237 |
| 30 |
Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial
Lila Bouadma, Charles‐Édouard Luyt, Florence Tubach et al. · The Lancet
|
26 Jan 2010 |
1,195 |
| 31 |
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
David Vaudry, Bruno José Gonzalez, Magali Basille et al. · Pharmacological Reviews
Open access |
Jun 2000 |
1,133 |
| 32 |
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca C. Sims et al. · Nature Genetics
Open access450 authors |
17 Jul 2017 |
1,122 |
| 33 |
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
Bernhard Mlecnik et al. · Immunity
Open access |
Mar 2016 |
1,098 |
| 34 |
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
David Vaudry, Anthony Falluel‐Morel, Steve Bourgault et al. · Pharmacological Reviews
|
Sep 2009 |
1,069 |
| 35 |
Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆
Alessandro Gronchi et al. · Annals of Oncology
Open access |
22 Jul 2021 |
1,057 |
| 36 |
The DRESS Syndrome: A Literature Review
P. Cacoub, Philippe Musette, Vincent Descamps et al. · The American Journal of Medicine
|
22 May 2011 |
1,017 |
| 37 |
Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)
Fabrice Barlési et al. · The Lancet
Open access |
15 Jan 2016 |
1,011 |
| 38 |
The Ectocarpus genome and the independent evolution of multicellularity in brown algae
Jeremy Mark Cock et al. · Nature
Open access |
Jun 2010 |
974 |
| 39 |
Breast cancer histopathological image classification using Convolutional Neural Networks
Fábio Alexandre Spanhol, Luiz S. Oliveira, Caroline Petitjean et al.
Conference paper |
Jul 2016 |
957 |
| 40 |
Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Hervé Tilly, María Gomes da Silva, Umberto Vitolo et al. · Annals of Oncology
Open access |
27 Aug 2015 |
937 |
| 41 |
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Catherine A. Ledent, Jean‐Marie Vaugeois, Serge N. Schiffmann et al. · Nature
|
14 Aug 1997 |
918 |
| 42 |
TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis
Cyril Quivoron et al. · Cancer Cell
Open access |
Jul 2011 |
915 |
| 43 |
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Isabelle Janoueix‐Lerosey, Delphine Lequin, Laurence Brugières et al. · Nature
|
Oct 2008 |
908 |
| 44 |
Grain boundary stability governs hardening and softening in extremely fine nanograined metals
Jian Cheng Hu, Yinong Shi, Xavier Sauvage et al. · Science
|
23 Mar 2017 |
907 |
| 45 |
Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study
Béatrice Larroque, Pierre‐Yves Ancel, Stéphane Marret et al. · The Lancet
|
Mar 2008 |
898 |
| 46 |
The neurobiological basis of spontaneous alternation
Robert Lalonde · Neuroscience & Biobehavioral Reviews
|
2002 |
885 |
| 47 |
Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions
Jun‐An Ma, Dominique Cahard · Chemical Reviews
Review |
12 Oct 2004 |
882 |
| 48 |
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii , a commensal bacterium deficient in Crohn’s disease
Elodie Quévrain et al. · Gut
Open access |
4 Jun 2015 |
863 |
| 49 |
Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study
Bertrand Cariou et al. · Diabetologia
Open access |
29 May 2020 |
845 |
| 50 |
Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation
Eric Legius et al. · Genetics in Medicine
Open access |
4 Jun 2021 |
832 |