Most cited papers from Xention (United Kingdom)

Xention (United Kingdom)

What are the most cited papers from Xention (United Kingdom)?

The most cited paper from Xention (United Kingdom) is "Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology" (Harsha D. Devalla, Verena Schwach, John W. Ford et al., 2015), with 378 citations. Next come "Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial" (243) and "VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation" (207).

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Showing 46 of 46 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology Harsha D. Devalla, Verena Schwach, John W. Ford et al. · EMBO Molecular Medicine Open access	19 Feb 2015	378
2	Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial G. Kees Hovingh, John J.P. Kastelein, Sander J. H. van Deventer et al. · The Lancet Open access	5 Jun 2015	243
3	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation Birger Herzog, Caroline Pellet‐Many, Gary I. Britton et al. · Molecular Biology of the Cell Open access	8 Jun 2011	207
4	The role of sodium channels in neuropathic pain Marc Rogers, Lam Tang, David J. Madge et al. · Seminars in Cell and Developmental Biology	Oct 2006	146
5	New Drugs Targeting the Cardiac Ultra-Rapid Delayed-Rectifier Current (IKur): Rationale, Pharmacology and Evidence for Potential Therapeutic Value John W. Ford, James T. Milnes · Journal of Cardiovascular Pharmacology	Aug 2008	95
6	The positive frequency-dependent electrophysiological effects of the IKur inhibitor XEN-D0103 are desirable for the treatment of atrial fibrillation John W. Ford, James S. Milnes, Saïd El Haou et al. · Heart Rhythm Open access	21 Oct 2015	73
7	An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN‐D0501 in healthy subjects Patrick Round, Anthony Priestley, Jan Robinson · British Journal of Clinical Pharmacology Open access	16 Jun 2011	67
8	Human Electrophysiological and Pharmacological Properties of XEN-D0101 John W. Ford, James S. Milnes, Erich Wettwer et al. · Journal of Cardiovascular Pharmacology Open access	30 Jan 2013	63
9	Tolerability, pharmacokinetics and pharmacodynamics of TA ‐8995, a selective cholesteryl ester transfer protein ( CETP ) inhibitor, in healthy subjects J. Ford, Matt Lawson, David E. Fowler et al. · British Journal of Clinical Pharmacology Open access	17 Mar 2014	59
10	Effects of IKur blocker MK-0448 on human right atrial action potentials from patients in sinus rhythm and in permanent atrial fibrillation Simone Mueller Loose, Judith E. Mueller, Erich Wettwer et al. · Frontiers in Pharmacology Open access	4 Mar 2014	49
11	Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses Julian C. van Capelleveen, John J.P. Kastelein, Aeilko Having Zwinderman et al. · Journal of clinical lipidology Open access	25 Jun 2016	38
12	Effect of selective IK,ACh inhibition by XAF‐1407 in an equine model of tachypacing‐induced persistent atrial fibrillation Merle Friederike Fenner, Helena Carstensen, Sarah Dalgas Nissen et al. · British Journal of Pharmacology Open access	21 May 2020	32
13	Near‐Thorough QT Study as Part of a First‐In‐Man Study Marek Malík, Katerina Hnatkova, John W. Ford et al. · The Journal of Clinical Pharmacology	30 Aug 2008	30
14	Prediction of Ion Channel Activity Using Binary Kernel Discrimination Peter Willett, David J. Wilton, Basil Hartzoulakis et al. · Journal of Chemical Information and Modeling	10 Jul 2007	29
15	Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh) Christiaan C. Veerman, Isabella Mengarelli, Charlotte D. Koopman et al. · Disease Models & Mechanisms Open access	17 Jun 2019	26
16	A double-blind, randomised, placebo-controlled, cross-over study assessing the use of XEN-D0103 in patients with paroxysmal atrial fibrillation and implanted pacemakers allowing continuous beat-to-beat monitoring of drug efficacy S. R. Shunmugam, Conn Sugihara, Nick Freemantle et al. · Journal of Interventional Cardiac Electrophysiology	19 Feb 2018	26
17	Novel K+ Channel Targets in Atrial Fibrillation Drug Development—Where Are We? Saïd El-Haou, John W. Ford, James T. Milnes · Journal of Cardiovascular Pharmacology	15 May 2015	26
18	New pharmacological approaches to atrial fibrillation James T. Milnes, David J. Madge, John W. Ford · Drug Discovery Today	20 Feb 2012	26
19	Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening Marc Rogers, Nace Zidar, D. Kikelj et al. · Assay and Drug Development Technologies Open access	Mar 2016	25
20	Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High‐Throughput Virtual Screening and Automated Patch Clamp Sören Wacker, Wiktor Jurkowski, Katie J. Simmons et al. · ChemMedChem Open access	30 Mar 2012	22
21	Activation of Glibenclamide-Sensitive ATP-Sensitive K + Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia Shang‐Jin Kim, Haifei Zhang, Игорь Германович Халиулин et al. · Circulation Arrhythmia and Electrophysiology Open access	17 Nov 2012	20
22	The Acetylcholine-Activated Potassium Current Inhibitor XAF-1407 Terminates Persistent Atrial Fibrillation in Goats Vladimír Sobota, Giulia Gatta, Arne van Hunnik et al. · Frontiers in Pharmacology Open access	27 Jan 2021	18
23	Exploiting High-Throughput Ion Channel Screening Technologies in Integrated Drug Discovery J. Mark Treherne · Current Pharmaceutical Design	30 Jan 2006	18
24	Ligand- and Structure-Based Virtual Screening for Clathrodin-Derived Human Voltage-Gated Sodium Channel Modulators Tihomir Tomašič, Basil Hartzoulakis, Nace Zidar et al. · Journal of Chemical Information and Modeling	11 Nov 2013	17
25	P3-17 Akiko Shiroshita-Takeshita, Chantal Maltais, John W. Ford et al. · Heart Rhythm	May 2006	16
26	Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators Nace Zidar, Žiga Jakopin, David J. Madge et al. · European Journal of Medicinal Chemistry Open access	4 Jan 2014	15
27	Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels Nace Zidar, Aleš Žula, Tihomir Tomašič et al. · European Journal of Medicinal Chemistry Open access	7 Aug 2017	14
28	Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges Žiga Hodnik, Tihomir Tomašič, Lucíja Peterlin Mašič et al. · European Journal of Medicinal Chemistry Open access	10 Aug 2013	12
29	Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence Klaus Urbahns, Takeshi Yura, Muneto Mogi et al. · Bioorganic & Medicinal Chemistry Letters Open access	15 Apr 2011	11
30	Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels Steve Peigneur, Aleš Žula, Nace Zidar et al. · Marine Drugs Open access	4 Apr 2014	11
31	A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels Meng Qi Cui, Yaser Alhamshari, Lucas Cantwell et al. · Journal of Biological Chemistry Open access	2021	8
32	Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes Rachel E. Caves, Alexander Carpenter, Stéphanie C.M. Choisy et al. · Heart Rhythm O2 Open access	25 May 2020	8
33	Generation of Antibodies That Are Externally Acting Isoform-Specific Inhibitors of Ion Channels Jacqueline Naylor, David J. Beech · Methods in molecular biology Book chapter	2013	6
34	Carbon‐14 radiosynthesis of 4‐(5‐chloro‐2‐hydroxyphenyl)‐3‐(2‐hydroxyethyl)‐6‐(trifluoromethyl)‐[4‐14C]quinolin‐2(1H)‐one (XEN‐D0401), A novel BK channel activator Sean L. Kitson, Stuart D Jones, William H. Watters et al. · Journal of Labelled Compounds and Radiopharmaceuticals	25 Jan 2010	6
35	Use of Continuous ECG for Improvements in Assessing the Standing Response as a Positive Control for QT Prolongation Anthony A. Fossa, Meijian Zhou, Nuala Brennan et al. · Annals of Noninvasive Electrocardiology Open access	9 Sep 2013	6
36	Tetrahydro-naphthols as orally available TRPV1 inhibitors Klaus Urbahns, Takeshi Yura, Jang Bahadur Gupta et al. · Bioorganic & Medicinal Chemistry Letters Open access	6 Apr 2012	5
37	Analysis of drug-induced and spontaneous cardioversions reveals similar patterns leading to termination of atrial fibrillation Arne van Hunnik, Vladimír Sobota, Stef Zeemering et al. · Frontiers in Physiology Open access	18 Jul 2024	4
38	Pharmacological inhibition of acetylcholine-regulated potassium current (IK,ACh) prevents atrial arrhythmogenic changes in a rat model of repetitive obstructive respiratory events Benedikt Linz, Anne Hauge Thostrup, Arnela Saljic et al. · Heart Rhythm O2 Open access	19 Nov 2021	2
39	Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators Marko Jukič, Rok Frlan, Fiona Chan et al. · Medicinal Chemistry Research	25 Nov 2014	2
40	Biophysical Characterization Of Duloxetine Activity On Voltage-gated Sodium Channels Involved In Pain Transmission Jean‐François Rolland, David J. Madge, John W. Ford et al. · Biophysical Journal Open access	Feb 2009	1
41	Time is a critical factor in evaluating indirect hERG inhibition by Oligonucleotide Therapeutics Yusheng Qu, Robert W. Kirby, BaoXi Gao et al. PreprintOpen access	2 Jun 2022	0
42	Molecular Mechanism of the Potent Benzopyran-G1 Blocker of Heteromeric G-Protein Gated Potassium Channels Meng Qi Cui, Yaser Alhamshari, Lucas Cantwell et al. · Biophysical Journal Open access	Feb 2021	0
43	Eleclazine Inhibition of Voltage-gated Sodium Currents in Rat Atrial and Ventricular Myocytes Rachel E. Caves, Ben Clennell, Alexander Carpenter et al. · Biophysical Journal Open access	Feb 2020	0
44	362 STATE‐DEPENDENT INHIBITORS OF THE NAV1.3 SODIUM CHANNEL FOR TREATING NEUROPATHIC PAIN Marc Rogers, Lam Tang, Roy Davies et al. · European Journal of Pain	10 May 2007	0
45	Cover Picture: Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High‐Throughput Virtual Screening and Automated Patch Clamp (ChemMedChem 10/2012) Sören Wacker, Wiktor Jurkowski, Katie J. Simmons et al. · ChemMedChem	24 Sep 2012	0
46	10 Voltage-dependent affinity of some compounds that inhibit hERG: rapid dissociation and reassociation? James T. Milnes, Mark J. McPate, Christopher E. Dempsey et al. · Heart	10 Dec 2010	0

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.