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Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial
Lieven G. Lagae, Joseph E. Sullivan, Kelly G. Knupp et al. · The Lancet
Open access |
Dec 2019 |
381 |
| 2 |
Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens
Rima Nabbout, Arun Mistry, Sameer M. Zuberi et al. · JAMA Neurology
Open access |
2 Dec 2019 |
251 |
| 3 |
Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome
Kelly G. Knupp, Ingrid Eileen Scheffer, Berten Ceulemans et al. · JAMA Neurology
Open access |
2 May 2022 |
136 |
| 4 |
Bioinspired Design Provides High‐Strength Benzoxazine Structural Adhesives
Cody James Higginson, Katerina G. Malollari, Yunqi Xu et al. · Angewandte Chemie International Edition
Open access |
5 Jul 2019 |
134 |
| 5 |
Low‐dose fenfluramine significantly reduces seizure frequency in Dravet syndrome: a prospective study of a new cohort of patients
An‐Sofie Schoonjans, Bernard P. Paelinck, Fabienne Marchau et al. · European Journal of Neurology
Open access |
28 Oct 2016 |
107 |
| 6 |
Fenfluramine acts as a positive modulator of sigma-1 receptors
Parthena Martin, Peter A.M. de Witte, Tangui Maurice et al. · Epilepsy & Behavior
Open access |
10 Mar 2020 |
99 |
| 7 |
Impact of fenfluramine on the expected SUDEP mortality rates in patients with Dravet syndrome
Judith Helen Cross, Bradley S. Galer, António Gil‐Nagel et al. · Seizure
Open access |
2 Nov 2021 |
85 |
| 8 |
A pilot, open‐label study of the effectiveness and tolerability of low‐dose ZX 008 (fenfluramine HC l) in Lennox‐Gastaut syndrome
Lieven G. Lagae, An‐Sofie Schoonjans, Arnold R. Gammaitoni et al. · Epilepsia
Open access |
26 Aug 2018 |
71 |
| 9 |
Life impact of caregiving for severe childhood epilepsy: Results of expert panels and caregiver focus groups
Mark P. Jensen, Kendra S. Liljenquist, Fraser D. Bocell et al. · Epilepsy & Behavior
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20 Jul 2017 |
71 |
| 10 |
Fenfluramine HCl (Fintepla®) provides long‐term clinically meaningful reduction in seizure frequency: Analysis of an ongoing open‐label extension study
Joseph E. Sullivan, Ingrid Eileen Scheffer, Lieven G. Lagae et al. · Epilepsia
Open access |
19 Oct 2020 |
69 |
| 11 |
Assessing the impact of caring for a child with Dravet syndrome: Results of a caregiver survey
Jonathan D. Campbell, Melanie D. Whittington, Chong Kim et al. · Epilepsy & Behavior
Open access |
2 Feb 2018 |
68 |
| 12 |
Porting the synthetic D‐glucaric acid pathway from Escherichia coli to Saccharomyces cerevisiae
Amita Gupta, Michael A. Hicks, Shawn P. Manchester et al. · Biotechnology Journal
Open access |
17 Jun 2016 |
68 |
| 13 |
A randomized controlled trial of ganaxolone in posttraumatic stress disorder
Ann M. Rasmusson, Christine E. Marx, Sonia Jain et al. · Psychopharmacology
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30 Jun 2017 |
67 |
| 14 |
A phase I, randomized, open-label, single-dose, 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol, clobazam, and valproate in healthy subjects
Brooks Boyd, Steven M. Smith, Arnold R. Gammaitoni et al. · International Journal of Clinical Pharmacology and Therapeutics
Open access |
19 Oct 2018 |
64 |
| 15 |
Improved everyday executive functioning following profound reduction in seizure frequency with fenfluramine: Analysis from a phase 3 long-term extension study in children/young adults with Dravet syndrome
Kim I. Bishop, Peter K. Isquith, Gérard A. Gioia et al. · Epilepsy & Behavior
Open access |
20 May 2021 |
61 |
| 16 |
The humanistic and economic burden of Dravet syndrome on caregivers and families: Implications for future research
Mark P. Jensen, Andreas Brunklaus, Liam Dorris et al. · Epilepsy & Behavior
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18 Apr 2017 |
60 |
| 17 |
An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies
Parthena Martin, Thadd Reeder, Jo Sourbron et al. · International Journal of Molecular Sciences
Open access |
5 Aug 2021 |
55 |
| 18 |
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting
Kyle E. Landgraf, Steven R. Williams, Daniel Steiger et al. · Communications Biology
Open access |
9 Jun 2020 |
54 |
| 19 |
Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox–Gastaut syndrome: Interim analysis of an open‐label extension study
Kelly G. Knupp, Ingrid Eileen Scheffer, Berten Ceulemans et al. · Epilepsia
Open access |
5 Oct 2022 |
53 |
| 20 |
Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo‐controlled clinical trial
Joseph E. Sullivan, Lieven G. Lagae, Judith Helen Cross et al. · Epilepsia
Open access |
6 Aug 2023 |
52 |
| 21 |
Single-Entity Hydrocodone Extended-Release Capsules in Opioid-Tolerant Subjects with Moderate-to-Severe Chronic Low Back Pain: A Randomized Double-Blind, Placebo-Controlled Study
Richard L Rauck, Srinivas R. Nalamachu, James E. Wild et al. · Pain Medicine
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12 Feb 2014 |
52 |
| 22 |
Bidirectional C and N transfer and a potential role for sulfur in an epiphytic diazotrophic mutualism
Rhona K. Stuart, Eric R. A. Pederson, Philip D. Weyman et al. · The ISME Journal
Open access |
19 Aug 2020 |
48 |
| 23 |
Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long‐term open‐label safety extension study
Wyman W. Lai, Bradley S. Galer, Pierre C. Wong et al. · Epilepsia
Open access |
18 Aug 2020 |
48 |
| 24 |
Needle‐Free Subcutaneous Sumatriptan (Sumavel™ DosePro™): Bioequivalence and Ease of Use
Jan Lewis Brandes, Roger K. Cady, Fred G. Freitag et al. · Headache The Journal of Head and Face Pain
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22 Oct 2009 |
47 |
| 25 |
An examination of the efficacy and safety of fenfluramine in adults, children, and adolescents with Dravet syndrome in a real‐world practice setting: A report from the Fenfluramine European Early Access Program
Renzo Guerrini, Nicola Specchio, Ángel Aledo‐Serrano et al. · Epilepsia Open
Open access |
8 Jul 2022 |
45 |
| 26 |
Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment
Kim I. Bishop, Peter K. Isquith, Gérard A. Gioia et al. · Epilepsy & Behavior
Open access |
Dec 2022 |
44 |
| 27 |
The direct and indirect costs of Dravet Syndrome
Melanie D. Whittington, Kelly G. Knupp, Gina R. VanderVeen et al. · Epilepsy & Behavior
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2 Feb 2018 |
44 |
| 28 |
Cardiovascular safety of low-dose fenfluramine in Dravet syndrome: a review of its benefit-risk profile in a new patient population
An‐Sofie Schoonjans, Fabienne Marchau, Bernard P. Paelinck et al. · Current Medical Research and Opinion
Open access |
13 Jul 2017 |
44 |
| 29 |
Communicating Structure and Function in Synthetic Biology Diagrams
Jacob Beal et al. · ACS Synthetic Biology
Open access |
26 Jul 2019 |
43 |
| 30 |
A Mechanistic Study of Polyol Hydrodeoxygenation over a Bifunctional Pt-WOx/TiO2 Catalyst
Kyle J. Stephens, Alan M. Allgeier, Alysha L. Bell et al. · ACS Catalysis
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23 Oct 2020 |
42 |
| 31 |
Synthetic Biology Open Language (SBOL) Version 2.3
Curtis Madsen et al. · Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics
Open access |
13 Jun 2019 |
39 |
| 32 |
Fenfluramine significantly reduces day‐to‐day seizure burden by increasing number of seizure‐free days and time between seizures in patients with Dravet syndrome: A time‐to‐event analysis
Joseph E. Sullivan, Nicola Specchio, Orrin Devinsky et al. · Epilepsia
Open access |
22 Oct 2021 |
38 |
| 33 |
Collaborating constructively for sustainable biotechnology
Nicholas E. Matthews, Carrie A. Cizauskas, Donovan S. Layton et al. · Scientific Reports
Open access |
13 Dec 2019 |
38 |
| 34 |
Long-term cardiovascular safety of fenfluramine in patients with Dravet syndrome treated for up to 3 years: Findings from serial echocardiographic assessments
Anupam Agarwal, Gail M. Farfel, Arnold R. Gammaitoni et al. · European Journal of Paediatric Neurology
Open access |
24 May 2022 |
30 |
| 35 |
Catalyzed reaction of isocyanates (RNCO) with water
Mark E. Wolf, Jonathon E. Vandezande, Henry F. Schaefer · Physical Chemistry Chemical Physics
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2021 |
30 |
| 36 |
Fenfluramine treatment for dravet syndrome: Real-world benefits on quality of life from the caregiver perspective
Mark P. Jensen, Arnold R. Gammaitoni, Bradley S. Galer et al. · Epilepsy Research
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7 Jul 2022 |
29 |
| 37 |
In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions
Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye et al. · Pharmacology Research & Perspectives
Open access |
22 May 2022 |
23 |
| 38 |
In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions
Parthena Martin, Maciej Czerwiński, Pallavi B. Limaye et al. · Pharmacology Research & Perspectives
Open access |
22 May 2022 |
22 |
| 39 |
Psychosocial impact on siblings of patients with developmental and epileptic encephalopathies
Laurie Bailey, Lauren Schwartz, Tracy Dixon‐Salazar et al. · Epilepsy & Behavior
Open access |
22 Aug 2020 |
22 |
| 40 |
Fenfluramine treatment for Dravet syndrome: Caregiver- and clinician-reported benefits on the quality of life of patients, caregivers, and families living in Germany, Spain, Italy, and the United Kingdom
Mark P. Jensen, Arnold R. Gammaitoni, Rana Salem et al. · Epilepsy Research
Open access |
15 Jan 2023 |
21 |
| 41 |
Synthetic Biology Open Language Visual (SBOL Visual) Version 2.1
Curtis Madsen et al. · Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics
Open access |
13 Jun 2019 |
21 |
| 42 |
Satisfaction With and Confidence in Needle‐Free Subcutaneous Sumatriptan in Patients Currently Treated with Triptans
Roger K. Cady, Sheena K. Aurora, Jan Lewis Brandes et al. · Headache The Journal of Head and Face Pain
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3 Aug 2011 |
21 |
| 43 |
Treatment with fenfluramine in patients with Dravet syndrome has no long-term effects on weight and growth
António Gil‐Nagel, Joseph E. Sullivan, Berten Ceulemans et al. · Epilepsy & Behavior
Open access |
2 Aug 2021 |
19 |
| 44 |
The Lack of Effect of Food on the Pharmacokinetics of ZX008 (Fenfluramine Oral Solution): Results of a Single-dose, Two-period Crossover Study
Arnold R. Gammaitoni, Steven M. Smith, Brooks Boyd · Clinical Therapeutics
Open access |
22 Jun 2018 |
18 |
| 45 |
A real‐world study to assess the association of cardiovascular adverse events (CVAEs) with ibrutinib as first‐line (1L) treatment for patients with chronic lymphocytic leukaemia (CLL) in the United States
Anthony R. Mato, Boxiong Tang, Soraya Azmi et al. · eJHaem
Open access |
23 Jan 2023 |
16 |
| 46 |
Fenfluramine modulates the anti-amnesic effects induced by sigma-1 receptor agonists and neuro(active)steroids in vivo
Parthena Martin, Tangui Maurice, Arnold R. Gammaitoni et al. · Epilepsy & Behavior
Open access |
7 Jan 2022 |
16 |
| 47 |
A long-term, open-label safety study of single-entity hydrocodone bitartrate extended release for the treatment of moderate to severe chronic pain
Srinivas R. Nalamachu, Richard L Rauck, Martin E Hale et al. · Journal of Pain Research
Open access |
Nov 2014 |
16 |
| 48 |
The impact of TK2 deficiency syndrome and its treatment by nucleoside therapy on quality of life
Dagmar Amtmann, Arnold R. Gammaitoni, Bradley S. Galer et al. · Mitochondrion
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29 Oct 2022 |
15 |
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Development and validation of the University of Washington caregiver stress and benefit scales for caregivers of children with or without serious health conditions
Dagmar Amtmann, Kendra S. Liljenquist, Alyssa M. Bamer et al. · Quality of Life Research
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4 Jan 2020 |
15 |
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Influence of Sulfur‐Containing Diamino Acid Structure on Covalently Crosslinked Copolypeptide Hydrogels
Eric D. Raftery, Eric G. Gharkhanian, Nicole G. Ricapito et al. · Chemistry - An Asian Journal
Open access |
17 Sep 2018 |
14 |