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Most cited papers in Analytical Chemistry

What are the most cited papers in Analytical Chemistry?

The most cited paper in Analytical Chemistry is "The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis" (Norden Eh Huang, Zhengwei Shen, Steven Long et al., 1998), with 23,779 citations. Next come "An Analysis of Transformations" (15,274) and "Antioxidant Determinations by the Use of a Stable Free Radical" (13,038).

Showing 50 of 100 papers. Every paper with more than 2,357 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis Norden Eh Huang, Zhengwei Shen, Steven Long et al. · Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences Open access 8 Mar 1998 23,779
2 An Analysis of Transformations George E. P. Box, David Roxbee Cox · Journal of the Royal Statistical Society Series B (Statistical Methodology) Jul 1964 15,274
3 Antioxidant Determinations by the Use of a Stable Free Radical Marsden S. Blois · Nature Apr 1958 13,038
4 Principal component analysis Svante Wold, Kim H. Esbensen, Paul L. M. Geladi · Chemometrics and Intelligent Laboratory Systems Aug 1987 11,762
5 Principal component analysis Hervé Abdi, Lynne J. Williams · Wiley Interdisciplinary Reviews Computational Statistics Jul 2010 10,890
6 Principal component analysis: a review and recent developments Ian T. Jolliffe, Jorge F. C. L. Cadima · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences Open access 7 Mar 2016 10,078
7 PLS-regression: a basic tool of chemometrics Svante Wold, Michael Sjöstróm, Lennart Eriksson · Chemometrics and Intelligent Laboratory Systems Oct 2001 10,019
8 Arzneimittelforschung Barbara Miletzki, C. H. Gleiter · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Apr 2005 9,404
9 An Information-Maximization Approach to Blind Separation and Blind Deconvolution Anthony J. Bell, Terrence J. Sejnowski · Neural Computation Nov 1995 9,265
10 Independent component analysis: algorithms and applications Aapo Hyvärinen, Erkki Oja · Neural Networks Jun 2000 8,914
11 Principal Component Analysis Colin R. Goodall, Ian T. Jolliffe · Technometrics Aug 1988 8,697
12 Removal of heavy metal ions from wastewaters: A review Fenglian Fu, Qi Wang · Journal of Environmental Management 8 Dec 2010 8,678
13 Independent component analysis, A new concept? Pierre Comon · Signal Processing Open access Apr 1994 8,300
14 Random forest in remote sensing: A review of applications and future directions Mariana Belgiu, Lucian Drăguţ · ISPRS Journal of Photogrammetry and Remote Sensing 14 Feb 2016 7,201
15 Partial least-squares regression: a tutorial Paul L. M. Geladi, Bruce R. Kowalski · Analytica Chimica Acta 1986 7,034
16 A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY Open access Apr 1999 7,022
17 Fast and robust fixed-point algorithms for independent component analysis Aapo Hyvärinen · IEEE Transactions on Neural Networks May 1999 6,400
18 Response surface methodology (RSM) as a tool for optimization in analytical chemistry Marcos Almeida Bezerra, Ricardo Erthal Santelli, Eliane Pádua Oliveira et al. · Talanta 22 May 2008 6,059
19 PLS path modeling Michel Tenenhaus, Vincenzo Esposito Vinzi, Yves-Marie Chatelin et al. · Computational Statistics & Data Analysis 22 Apr 2004 6,047
20 A note on a general definition of the coefficient of determination N. J. D. Nagelkerke · Biometrika 1991 5,805
21 Applications of ionic liquids in the chemical industry Natalia V. Plechkova, Kenneth Richard Seddon · Chemical Society Reviews Review 30 Nov 2007 5,674
22 Fast and Easy Multiresidue Method Employing Acetonitrile Extraction/Partitioning and “Dispersive Solid-Phase Extraction” for the Determination of Pesticide Residues in Produce Michelangelo Anastassiades, Steven J. Lehotay, Darinka Štajnbaher et al. · Journal of AOAC International Mar 2003 5,638
23 A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research Mar 1995 5,389
24 Remediation of dyes in textile effluent: a critical review on current treatment technologies with a proposed alternative Tim Robinson, Geoff McMullan, Roger Marchant et al. · Bioresource Technology May 2001 5,357
25 Impulse response analysis in nonlinear multivariate models Gary M. Koop, M. Hashem Pesaran, Simon Potter · Journal of Econometrics Sep 1996 5,158
26 Deep learning in agriculture: A survey Andreas Kamilaris, Francesc Xavier Prenafeta-Boldú · Computers and Electronics in Agriculture Open access 22 Feb 2018 5,070
27 On Methods in the Analysis of Profile Data Samuel W. Greenhouse, Seymour Geisser · Psychometrika Jun 1959 5,032
28 Chemistry and Biological Activities of Flavonoids: An Overview Shashank Kumar, Abhay Kumar Pandey · The Scientific World JOURNAL Open access 2013 4,993
29 In situ analysis of major and trace elements of anhydrous minerals by LA-ICP-MS without applying an internal standard Yongsheng Liu, Zhaochu Hu, Shan Gao et al. · Chemical Geology 7 Sep 2008 4,861
30 Non-conventional low-cost adsorbents for dye removal: A review Grégorio Crini · Bioresource Technology 30 Jun 2005 4,508
31 Quantitative assessment of worldwide contamination of air, water and soils by trace metals Jerome O. Nriagu, Józef M. Pacyna · Nature May 1988 4,396
32 Dye and its removal from aqueous solution by adsorption: A review Mustafa T. Yagub, Tushar Kanti Sen, Sharmeen Afroze et al. · Advances in Colloid and Interface Science 13 Apr 2014 4,362
33 Some distance properties of latent root and vector methods used in multivariate analysis J. C. Gower · Biometrika 1966 4,152
34 ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap Tauno Metsalu, Jaak Vilo · Nucleic Acids Research Open access 12 May 2015 4,030
35 AGREE─Analytical GREEnness Metric Approach and Software Francisco Pena‐Pereira, W. Wojnowski, Marek Tobiszewski · Analytical Chemistry Open access 15 Jun 2020 3,989
36 Heavy metals, occurrence and toxicity for plants: a review P. C. Nagajyoti, K. D. Lee, T.V.M. Sreekanth · Environmental Chemistry Letters 27 Jul 2010 3,978
37 Phytoremediation of heavy metals—Concepts and applications Hazrat Ali, Ezzat Khan, Muhammad Anwar Sajad · Chemosphere 7 Mar 2013 3,938
38 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Jeremy Kirk Nicholson, John C. Lindon, Elaine C. Holmes · Xenobiotica 1999 3,918
39 Application of low-cost adsorbents for dye removal – A review Vinod Kumar Gupta, S Suhas · Journal of Environmental Management 5 Mar 2009 3,873
40 Standard Normal Variate Transformation and De-Trending of Near-Infrared Diffuse Reflectance Spectra Richard J. Barnes, M.S. Dhanoa, S.J. Lister · Applied Spectroscopy Jul 1989 3,851
41 Heavy Metals in Contaminated Soils: A Review of Sources, Chemistry, Risks and Best Available Strategies for Remediation Raymond Ahulle Wuana, Felix Ebhodaghe Okieimen · ISRN Ecology Open access 24 Oct 2011 3,844
42 Generalized Cross-Validation as a Method for Choosing a Good Ridge Parameter Gene Howard Golub, Michael T. Heath, Grace Wahba · Technometrics May 1979 3,822
43 Probabilistic Principal Component Analysis Michael E. Tipping, Chris Bishop · Journal of the Royal Statistical Society Series B (Statistical Methodology) Open access Sep 1999 3,779
44 Time-frequency distributions-a review Leon W. Cohen · Proceedings of the IEEE Jul 1989 3,593
45 Least Median of Squares Regression Peter J. Rousseeuw · Journal of the American Statistical Association Dec 1984 3,592
46 Removal of synthetic dyes from wastewaters: a review Esther Forgács, Tibor Cserháti, Gyula Oros · Environment International 8 May 2004 3,423
47 Determination of organic compounds in water using dispersive liquid–liquid microextraction Mohammad Bagher Rezaee, Yaghoub Assadi, Mohammad Reza Milani Hosseini et al. · Journal of Chromatography A 31 Mar 2006 3,396
48 Tests for Specification Errors in Classical Linear Least-Squares Regression Analysis James B. Ramsey · Journal of the Royal Statistical Society Series B (Statistical Methodology) Jul 1969 3,375
49 Handbook of Pharmaceutical Excipients Flynn W. Warren · American Journal of Health-System Pharmacy Aug 1987 3,343
50 Machine Learning in Agriculture: A Review Konstantinos G. Liakos, Patrizia Busato, Dimitrios Moshou et al. · Sensors Open access 14 Aug 2018 3,332

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.