Subfield · Biotechnology
Most cited papers in Biotechnology
What are the most cited papers in Biotechnology?
The most cited paper in Biotechnology is "Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma" (Roger Stupp, Warren P. Mason, Martin J. van den Bent et al., 2005), with 22,109 citations. Next come "Hallmarks of Cancer: New Dimensions" (9,794) and "Microenvironmental regulation of tumor progression and metastasis" (8,290).
Showing 50 of 100 papers. Every paper with more than 2,234 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma Roger Stupp, Warren P. Mason, Martin J. van den Bent et al. · New England Journal of Medicine | 9 Mar 2005 | 22,109 |
| 2 | Hallmarks of Cancer: New Dimensions Douglas Hanahan · Cancer Discovery | 2022 | 9,794 |
| 3 | Microenvironmental regulation of tumor progression and metastasis Daniela F. Quail, Johanna A. Joyce · Nature Medicine | Nov 2013 | 8,290 |
| 4 | Solvent content of protein crystals Brian W. Matthews · Journal of Molecular Biology | Apr 1968 | 7,987 |
| 5 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial Roger Stupp et al. · The Lancet Oncology | 10 Mar 2009 | 7,889 |
| 6 | Specific Association of Human Telomerase Activity with Immortal Cells and Cancer Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse et al. · Science | 23 Dec 1994 | 7,190 |
| 7 | The carbohydrate-active enzymes database (CAZy) in 2013 Vincent Lombard, Hemalatha Golaconda Ramulu, Élodie Drula et al. · Nucleic Acids Research | 21 Nov 2013 | 6,637 |
| 8 | Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer Edward B. Garon et al. · New England Journal of Medicine | 19 Apr 2015 | 6,312 |
| 9 | Protein production by auto-induction in high-density shaking cultures F. William Studier · Protein Expression and Purification | 8 Feb 2005 | 6,238 |
| 10 | The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation Peter Walter, David Ron · Science | 24 Nov 2011 | 6,131 |
| 11 | The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics Brandi L. Cantarel, P. M. Coutinho, Corinne Rancurel et al. · Nucleic Acids Research | 6 Oct 2008 | 6,110 |
| 12 | Natural Products as Sources of New Drugs from 1981 to 2014 David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 7 Feb 2016 | 5,967 |
| 13 | Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy Rakesh K. Jain · Science | 6 Jan 2005 | 5,534 |
| 14 | Natural Products as Sources of New Drugs over the Last 25 Years David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 20 Feb 2007 | 5,531 |
| 15 | The Ecological Role of Water-Column Microbes in the Sea F Azam, Tom Fenchel, JG Field et al. · Marine Ecology Progress Series | 1983 | 5,476 |
| 16 | Cancer Cell Cycles Charles J. Sherr · Science | 6 Dec 1996 | 5,411 |
| 17 | A MEDIUM FOR THE CULTIVATION OF LACTOBACILLI J. C. de Man, Morrison Rogosa, M. Elisabeth Sharpe · Journal of Applied Bacteriology | Apr 1960 | 5,358 |
| 18 | Fingerprinting genomes using PCR with arbitrary primers John B. Welsh, Michael McClelland · Nucleic Acids Research | 1990 | 5,224 |
| 19 | Diarrheagenic Escherichia coli James P. Nataro, James B. Kaper · Clinical Microbiology Reviews | 1998 | 5,032 |
| 20 | A Perspective on Cancer Cell Metastasis Christine Louise Chaffer, Robert A. Weinberg · Science | 24 Mar 2011 | 4,934 |
| 21 | Marine natural products D. J. Faulkner · Natural Product Reports | 1990 | 4,883 |
| 22 | Characteristics of the Microplate Method of Enzyme-Linked Immunosorbent Assay for the Detection of Plant Viruses M. F. Clark, A.N. Adams · Journal of General Virology | Mar 1977 | 4,838 |
| 23 | KEGG: integrating viruses and cellular organisms Minoru I. Kanehisa, Miho Furumichi, Yoko Sato et al. · Nucleic Acids Research | 9 Oct 2020 | 4,784 |
| 24 | A Simple and General Method for Transferring Genes into Plants R. Horsch, Joyce E. Fry, Nancy L. Hoffmann et al. · Science | 8 Mar 1985 | 4,784 |
| 25 | The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited Isaiah J. Fidler · Nature reviews. Cancer | 30 May 2003 | 4,744 |
| 26 | Microbial Cellulose Utilization: Fundamentals and Biotechnology Lee Rybeck Lynd, Paul J. Weimer, Willem Heber van Zyl et al. · Microbiology and Molecular Biology Reviews | Sep 2002 | 4,736 |
| 27 | Dissolution of Cellose with Ionic Liquids Richard P. Swatloski, Scott K. Spear, John D. Holbrey et al. · Journal of the American Chemical Society | 17 Apr 2002 | 4,729 |
| 28 | Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature | Mar 1992 | 4,702 |
| 29 | Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 8 Feb 2012 | 4,699 |
| 30 | Biomass Recalcitrance: Engineering Plants and Enzymes for Biofuels Production Michael E. Himmel, Shi-You Ding, David K. Johnson et al. · Science | 8 Feb 2007 | 4,628 |
| 31 | Mdm2 promotes the rapid degradation of p53 Ygal Haupt, Ruth Ben-Yakar Maya, Anat Kazaz et al. · Nature | May 1997 | 4,575 |
| 32 | The biology and function of fibroblasts in cancer Raghu K. Kalluri · Nature reviews. Cancer | 23 Aug 2016 | 4,462 |
| 33 | Lignin Biosynthesis Wout Boerjan, John Ralph, Marie Baucher · Annual Review of Plant Biology | 12 May 2003 | 4,458 |
| 34 | Modeling of the Bacterial Growth Curve Marcel H. Zwietering, Ida Jongenburger, FRANK M. ROMBOUTS et al. · Applied and Environmental Microbiology | Jun 1990 | 4,275 |
| 35 | Tumor Metastasis: Molecular Insights and Evolving Paradigms Scott Valastyan, Robert A. Weinberg · Cell | Oct 2011 | 4,179 |
| 36 | Phylogenetic structure of the prokaryotic domain: The primary kingdoms Carl R. Woese, George E. Fox · Proceedings of the National Academy of Sciences | Nov 1977 | 4,135 |
| 37 | A human colon cancer cell capable of initiating tumour growth in immunodeficient mice Catherine Adell O'Brien, Aaron F. Pollett, Steven Gallinger et al. · Nature | 19 Nov 2006 | 4,107 |
| 38 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Toshiyuki Miyashita, John C. Reed · Cell | 1995 | 4,079 |
| 39 | Amino Acid Metabolism in Mammalian Cell Cultures Harry Eagle · Science | 21 Aug 1959 | 4,032 |
| 40 | Somatic generation of antibody diversity Susumu Tonegawa · Nature | Apr 1983 | 4,012 |
| 41 | Identification and expansion of human colon-cancer-initiating cells Lucia Ricci‐Vitiani, Dario Giuseppe Lombardi, Emanuela Pilozzi et al. · Nature | 19 Nov 2006 | 4,008 |
| 42 | Collagen Structure and Stability Matthew D. Shoulders, Ronald T. Raines · Annual Review of Biochemistry | 3 Apr 2009 | 3,926 |
| 43 | Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium Toshiro Sato, Daniel E. Stange, Marc Ferrante et al. · Gastroenterology | 3 Sep 2011 | 3,882 |
| 44 | Microenvironmental regulation of metastasis Johanna A. Joyce, Jeffrey W. Pollard · Nature reviews. Cancer | 12 Mar 2008 | 3,730 |
| 45 | Efficient transformation of rice ( Oryza sativa L.) mediated by Agrobacterium and sequence analysis of the boundaries of the T‐DNA Yukoh Hiei, Shozo Ohta, Toshihiko Komari et al. · The Plant Journal | Aug 1994 | 3,595 |
| 46 | Inositol trisphosphate and diacylglycerol as second messengers Michael John Berridge · Biochemical Journal | Jun 1984 | 3,535 |
| 47 | Clinical development and potential of photothermal and photodynamic therapies for cancer Xingshu Li, Jonathan F. Lovell, Juyoung Yoon et al. · Nature Reviews Clinical Oncology | 22 Jul 2020 | 3,467 |
| 48 | Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial Walter Stummer, Uwe Pichlmeier, Thomas R. Meinel et al. · The Lancet Oncology | 13 Apr 2006 | 3,416 |
| 49 | p21 is a universal inhibitor of cyclin kinases Yue Xiong, Gregory James Hannon, Hui Zhang et al. · Nature | Dec 1993 | 3,400 |
| 50 | Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma M. OʼReilly · Cell | 21 Oct 1994 | 3,369 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.