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Subfield · Epidemiology

Most cited papers in Epidemiology

What are the most cited papers in Epidemiology?

The most cited paper in Epidemiology is "Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries" (Hyuna Sung, Adalberto M. Filho, Mathieu Laversanne et al., 2021), with 114,522 citations. Next come "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews" (105,915) and "Global cancer statistics" (55,108).

Showing 50 of 97 papers. Every paper with more than 7,214 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries Hyuna Sung, Adalberto M. Filho, Mathieu Laversanne et al. · CA A Cancer Journal for Clinicians Open access 4 Feb 2021 114,522
2 The PRISMA 2020 statement: an updated guideline for reporting systematic reviews Matthew James Page et al. · BMJ ReviewOpen access 29 Mar 2021 105,915
3 Global cancer statistics Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians Open access 4 Feb 2011 55,108
4 A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation Mary E. Charlson, Peter Pompei, Kathy L. Aleš et al. · Journal of Chronic Diseases 1987 50,676
5 A new mathematical model for relative quantification in real-time RT-PCR Michael Walter Pfaffl · Nucleic Acids Research Open access May 2001 35,329
6 Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 Jacques Ferlay, Isabelle Soerjomataram, Rajesh Prabhakar Dikshit et al. · International Journal of Cancer Open access 13 Sep 2014 29,250
7 The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al. · JAMA Open access 22 Feb 2016 29,012
8 Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement PRISMA-P Group, David Moher, Larissa Shamseer et al. · Systematic Reviews ReviewOpen access 2015 27,092
9 Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Freddie Bray, Mathieu Laversanne, Hyuna Sung et al. · CA A Cancer Journal for Clinicians Open access 4 Apr 2024 25,936
10 Frailty in Older Adults: Evidence for a Phenotype Linda P. Fried, Catherine M. Tangen, Jeremy D Walston et al. · The Journals of Gerontology Series A Mar 2001 25,162
11 The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants Elda Dermyshi, Yizhong Wang, Chongbing Yan et al. · Neonatology Review 2017 24,491
12 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Nanshan Chen, Min Zhou, Xuan Dong et al. · The Lancet Open access 30 Jan 2020 22,766
13 Atherosclerosis — An Inflammatory Disease Russell Ross · New England Journal of Medicine 14 Jan 1999 21,815
14 Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Jacques Ferlay, Hai‐Rim Shin, Freddie Bray et al. · International Journal of Cancer 17 Jun 2010 21,446
15 Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell Open access May 2012 19,018
16 Antibiotic Susceptibility Testing by a Standardized Single Disk Method Alfred W. Bauer, William M. M. Kirby, J. C. Sherris et al. · American Journal of Clinical Pathology Apr 1966 18,626
17 Global Cancer Statistics, 2002 Donald Maxwell Parkin, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians Open access Mar 2005 18,430
18 Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses Andreas Stang · European Journal of Epidemiology 21 Jul 2010 18,104
19 Cancer statistics, 2023 Rebecca L. Siegel, Kimberly D. Miller, Nikita Sandeep Wagle et al. · CA A Cancer Journal for Clinicians Open access 2023 17,031
20 Repertoires of Autophagy in the Pathogenesis of Ocular Diseases Yujie Li, Qin Li Jiang, Guo-Fan Cao et al. · Cellular Physiology and Biochemistry Open access 2015 16,339
21 The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary David N. Louis, Arie Perry, Guido Reifenberger et al. · Acta Neuropathologica Open access 7 May 2016 16,152
22 Multiplex Genome Engineering Using CRISPR/Cas Systems Le Dinh Công, F. Ann Ran, David B. T. Cox et al. · Science Open access 4 Jan 2013 16,026
23 pROC: an open-source package for R and S+ to analyze and compare ROC curves Xavier Robin, Natacha Turck, Alexandre Hainard et al. · BMC Bioinformatics Open access 17 Mar 2011 14,550
24 Dermatologist-level classification of skin cancer with deep neural networks Andre Esteva, Brett Kuprel, Roberto A. Novoa et al. · Nature Open access 25 Jan 2017 14,423
25 Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 Spencer Lewis James et al. · The Lancet Open access990 authors Nov 2018 14,263
26 Apoptosis: A Review of Programmed Cell Death Susan A. Elmore · Toxicologic Pathology Open access Jun 2007 13,911
27 APACHE II William A. Knaus, Elizabeth A. Draper, Douglas P. Wagner et al. · Critical Care Medicine Oct 1985 13,863
28 Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption‐II JOHN B. DEC. M. SAUNDERS, Olaf Gjerløw Aasland, Thomas F. Babor et al. · Addiction Jun 1993 13,467
29 Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis Roger C. Bone, ROBERT A. BALK, Frank B. Cerra et al. · CHEST Journal Open access Jun 1992 13,306
30 ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS Graham M. Teasdale, Bryan Jennett · The Lancet Jul 1974 13,268
31 Phosphorus Assay in Column Chromatography Grant R. Bartlett · Journal of Biological Chemistry Open access Mar 1959 12,866
32 Cancer Statistics, 2010 Ahmedin Jemal, Rebecca L. Siegel, Jiaquan Xu et al. · CA A Cancer Journal for Clinicians Open access 7 Jul 2010 12,627
33 Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Harold P. Adams, Birgitte H. Bendixen, L. Jaap Kappelle et al. · Stroke Open access 1993 12,468
34 Structure, function and diversity of the healthy human microbiome Curtis Huttenhower et al. · Nature Open access248 authors Jun 2012 12,195
35 The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure Jean‐Louis Vincent, Rui Paulo Moreno, Jukka A. Takala et al. · Intensive Care Medicine Jul 1996 11,938
36 Correspondence - Tranexamic acid for traumatic brain injury Marina Romanello et al. · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) Open access 2005 11,912
37 Development of a new resilience scale: The Connor-Davidson Resilience Scale (CD-RISC) Kathryn M. Connor, Jonathan R. T. Davidson · Depression and Anxiety Sep 2003 11,835
38 PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews Matthew James Page et al. · BMJ ReviewOpen access 29 Mar 2021 11,781
39 Tissue Plasminogen Activator for Acute Ischemic Stroke The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study G · New England Journal of Medicine 14 Dec 1995 11,752
40 Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis Qinghua Zhang, Chao Wang, Maoyong Zheng et al. · Cerebrovascular Diseases ReviewOpen access 24 Dec 2014 11,556
41 Pharmacological interventions for somatoform disorders in adults Maria Kleinstäuber, Michael Witthöft, Andrés Steffanowski et al. · Cochrane Database of Systematic Reviews Open access 7 Nov 2014 11,357
42 An interactive web-based dashboard to track COVID-19 in real time Ensheng Dong, Hongru Du, Lauren M. Gardner · The Lancet Infectious Diseases Open access 19 Feb 2020 11,219
43 Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes Zobair M. Younossi, Aaron B. Koenig, Dinan Abdelatif et al. · Hepatology 28 Dec 2015 11,032
44 Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance Jaakko O. Tuomilehto, Jaana Lindström, Johan Gunnar Eriksson et al. · New England Journal of Medicine Open access 3 May 2001 10,985
45 Design and validation of a histological scoring system for nonalcoholic fatty liver disease† David Erwin Kleiner, Elizabeth M. Brunt, Mark L. Van Natta et al. · Hepatology 24 May 2005 10,904
46 Coding Algorithms for Defining Comorbidities in ICD-9-CM and ICD-10 Administrative Data Hude Quan, Vijaya Sundararajan, Patricia Halfon et al. · Medical Care 13 Oct 2005 10,878
47 Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock Emanuel P. Rivers, Bryant Nguyen, Suzanne L Havstad et al. · New England Journal of Medicine Open access 8 Nov 2001 10,842
48 Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases Richard A. Deyo · Journal of Clinical Epidemiology Jun 1992 10,573
49 Cancer Statistics, 2008 Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians Open access 28 Jan 2008 10,219
50 Intensive Insulin Therapy in Critically Ill Patients Greet Van den Berghe, Pieter Jozef Wouters, Frank Weekers et al. · New England Journal of Medicine Open access 8 Nov 2001 10,071

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.