Subfield · Microbiology
Most cited papers in Microbiology (Immunology and Microbiology)
What are the most cited papers in Microbiology?
The most cited paper in Microbiology is "DADA2: High-resolution sample inference from Illumina amplicon data" (Benjamin J. Callahan, Paul J. McMurdie, Michael Rosen et al., 2016), with 37,958 citations. Next come "Neutrophil Extracellular Traps Kill Bacteria" (10,383) and "Antimicrobial peptides of multicellular organisms" (8,479).
Showing 50 of 99 papers. Every paper with more than 1,663 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | DADA2: High-resolution sample inference from Illumina amplicon data Benjamin J. Callahan, Paul J. McMurdie, Michael Rosen et al. · Nature Methods | 23 May 2016 | 37,958 |
| 2 | Neutrophil Extracellular Traps Kill Bacteria Volker Brinkmann, Ulrike Reichard, Christian Goosmann et al. · Science | 4 Mar 2004 | 10,383 |
| 3 | Antimicrobial peptides of multicellular organisms MICHAEL A. ZASLOFF · Nature | 2002 | 8,479 |
| 4 | Genome sequencing in microfabricated high-density picolitre reactors Marcel Margulies et al. · Nature | 31 Jul 2005 | 7,761 |
| 5 | Methods for in vitro evaluating antimicrobial activity: A review Mounyr Balouiri, Moulay Sadiki, Saâd Ibnsouda Koraichi · Journal of Pharmaceutical Analysis | 2 Dec 2015 | 7,292 |
| 6 | Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances Irith Wiegand, Kai Hilpert, Robert E. W. Hancock · Nature Protocols | 17 Jan 2008 | 6,274 |
| 7 | Toll-Like Receptors Kiyoshi Takeda, Tsuneyasu Kaisho, Shizuo Akira · Annual Review of Immunology | 3 Mar 2003 | 6,179 |
| 8 | Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Kim A. Brogden · Nature Reviews Microbiology | 10 Feb 2005 | 5,842 |
| 9 | Exosomes: composition, biogenesis and function Clotilde Théry, Laurence Zitvogel, Sebastián Amigorena · Nature reviews. Immunology | Aug 2002 | 5,446 |
| 10 | Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns Maria Gloria Domínguez-Bello, Elizabeth K. Costello, Mónica Contreras et al. · Proceedings of the National Academy of Sciences | 21 Jun 2010 | 4,819 |
| 11 | Toll-like receptors: critical proteins linking innate and acquired immunity Shizuo Akira, Kiyoshi Takeda, Tsuneyasu Kaisho · Nature Immunology | Aug 2001 | 4,814 |
| 12 | Antiseptics and Disinfectants: Activity, Action, and Resistance Gerald E. McDonnell, A.D. Russell · Clinical Microbiology Reviews | 1999 | 4,811 |
| 13 | SignalP 5.0 improves signal peptide predictions using deep neural networks José Juan Almagro Armenteros, Konstantinos D. Tsirigos, Casper Kaae Sønderby et al. · Nature Biotechnology | 18 Feb 2019 | 4,807 |
| 14 | Guideline for Prevention of Surgical Site Infection, 1999 Alicia J. Mangram, Teresa C Horan, Michele L. Pearson et al. · Infection Control and Hospital Epidemiology | Apr 1999 | 4,641 |
| 15 | Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance Ian Chopra, Marilyn C. Roberts · Microbiology and Molecular Biology Reviews | Jun 2001 | 4,554 |
| 16 | Vaginal microbiome of reproductive-age women Jacques Ravel, Pawel Gajer, Zaid Abdo et al. · Proceedings of the National Academy of Sciences | 3 Jun 2010 | 4,394 |
| 17 | 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults Kenneth G. Castro, Jill Ward, Laurence Slutsker et al. · Clinical Infectious Diseases | Oct 1993 | 4,364 |
| 18 | Toll-like receptors and innate immunity Ruslan M. Medzhitov · Nature reviews. Immunology | Nov 2001 | 4,298 |
| 19 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Robert E. W. Hancock, Hans‐Georg Sahl · Nature Biotechnology | Dec 2006 | 4,225 |
| 20 | Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 Florian Heil, Hiroaki Hemmi, Hubertus Hochrein et al. · Science | 23 Feb 2004 | 3,973 |
| 21 | Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response Philip T. Liu et al. · Science | 23 Feb 2006 | 3,966 |
| 22 | Mechanisms of biofilm resistance to antimicrobial agents Thien-Fah C Mah, George A. O’Toole · Trends in Microbiology | 2001 | 3,934 |
| 23 | Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms Martin C. J. Maiden, Jane A. Bygraves, Edward J. Feil et al. · Proceedings of the National Academy of Sciences | 17 Mar 1998 | 3,872 |
| 24 | Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications Keith A. Jolley, James E. Bray, Martin C. J. Maiden · Wellcome Open Research | 24 Sep 2018 | 3,700 |
| 25 | 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings Jane D. Siegel, Emily Rhinehart, Marguerite McMillan Jackson et al. · American Journal of Infection Control | Dec 2007 | 3,489 |
| 26 | Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation Rachel Nugent, Marijane A. Krohn, Sharon L. Hillier · Journal of Clinical Microbiology | Feb 1991 | 3,402 |
| 27 | Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity | Oct 1999 | 3,391 |
| 28 | Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology | Apr 1999 | 3,391 |
| 29 | LPS/TLR4 signal transduction pathway Yong‐Chen Lu, Wen‐Chen Yeh, Pamela S. Ohashi · Cytokine | 7 Mar 2008 | 3,314 |
| 30 | Sexually Transmitted Diseases Treatment Guidelines, 2006 NEIL SKOLNIK · Humana Press eBooks | 19 Nov 2007 | 3,131 |
| 31 | Materials fabrication from Bombyx mori silk fibroin Danielle N. Rockwood, Rucsanda C. Preda, Tuna Yücel et al. · Nature Protocols | 22 Sep 2011 | 3,106 |
| 32 | Defensins: antimicrobial peptides of innate immunity Tomas Ganz · Nature reviews. Immunology | Sep 2003 | 3,100 |
| 33 | A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels Chao-Ming Tsai, Carl E. Frasch · Analytical Biochemistry | 1982 | 3,100 |
| 34 | Mechanisms of Antimicrobial Peptide Action and Resistance Michael R. Yeaman, Nannette Y. Yount · Pharmacological Reviews | Mar 2003 | 3,007 |
| 35 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study Silvia de Sanjosé et al. · The Lancet Oncology | 18 Oct 2010 | 2,774 |
| 36 | Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae : Implications for the microbial “pan-genome” Hervé Tettelin et al. · Proceedings of the National Academy of Sciences | 19 Sep 2005 | 2,773 |
| 37 | CpG Motifs in Bacterial DNA and Their Immune Effects Arthur M. Krieg · Annual Review of Immunology | Apr 2002 | 2,585 |
| 38 | Intrauterine Infection and Preterm Delivery Robert L. Goldenberg, John C. Hauth, William W. Andrews · New England Journal of Medicine | 18 May 2000 | 2,580 |
| 39 | A modified microtiter-plate test for quantification of staphylococcal biofilm formation Srdjan Stepanović, Dragana Vuković, Ivana Dakić et al. · Journal of Microbiological Methods | Apr 2000 | 2,576 |
| 40 | The Minimal Gene Complement of Mycoplasma genitalium Claire M. Fraser et al. · Science | 20 Oct 1995 | 2,551 |
| 41 | Peptide Antimicrobial Agents Håvard Jenssen, Pamela Hamill, Robert E. W. Hancock · Clinical Microbiology Reviews | Jul 2006 | 2,519 |
| 42 | The Placenta Harbors a Unique Microbiome Kjersti Marie Aagaard, Jun Ma, Kathleen M. Antony et al. · Science Translational Medicine | 21 May 2014 | 2,501 |
| 43 | BIGSdb: Scalable analysis of bacterial genome variation at the population level Keith A. Jolley, Martin C. J. Maiden · BMC Bioinformatics | Dec 2010 | 2,494 |
| 44 | The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex Beom Seok Park, Dong Hyun Song, Ho Min Kim et al. · Nature | Mar 2009 | 2,458 |
| 45 | Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates Katherine L. O'Flynn O'Brien, Lara J. Wolfson, James Watt et al. · The Lancet | Sep 2009 | 2,455 |
| 46 | Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women Quarraisha Abdool Karim, Salim S. Abdool Karim, Janet Frohlich et al. · Science | 20 Jul 2010 | 2,450 |
| 47 | APD3: the antimicrobial peptide database as a tool for research and education Guangshun Wang, Xia Li, Zhe Wang · Nucleic Acids Research | 23 Nov 2015 | 2,445 |
| 48 | Multilocus Sequence Typing of Total-Genome-Sequenced Bacteria Mette Voldby Larsen, Salvatore Cosentino, Simon Rasmussen et al. · Journal of Clinical Microbiology | 12 Jan 2012 | 2,424 |
| 49 | Nonspecific vaginitis R Amsel, Patricia A. Totten, Carol A. Spiegel et al. · The American Journal of Medicine | 1983 | 2,397 |
| 50 | Practice Guidelines for the Management of Bacterial Meningitis Allan R. Tunkel, Barry J. Hartman, Sheldon L. Kaplan et al. · Clinical Infectious Diseases | 15 Oct 2004 | 2,341 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.