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Most cited papers in Neurology (Neuroscience)

What are the most cited papers in Neurology?

The most cited paper in Neurology is "[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients]." (Nobutsugu Hirono, Etsuro Mori, Yoshitaka Ikejiri et al., 1997), with 20,864 citations. Next come "Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment." (12,468) and "A synaptic model of memory: long-term potentiation in the hippocampus" (11,655).

Showing 50 of 100 papers. Every paper with more than 3,081 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 [Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients]. Nobutsugu Hirono, Etsuro Mori, Yoshitaka Ikejiri et al. · PubMed Mar 1997 20,864
2 Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Harold P. Adams, Birgitte H. Bendixen, L. Jaap Kappelle et al. · Stroke Open access 1993 12,468
3 A synaptic model of memory: long-term potentiation in the hippocampus T.V.P. Bliss, Graham L. Collingridge · Nature 1993 11,655
4 Staging of brain pathology related to sporadic Parkinson’s disease Heiko Braak, Kelly Del Tredici, Udo Rüb et al. · Neurobiology of Aging 28 Dec 2002 10,980
5 The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Marilyn S. Albert, Steven T. DeKosky, Dennis W. Dickson et al. · Alzheimer s & Dementia Open access 22 Apr 2011 10,419
6 Exploring the full spectrum of macrophage activation David M. Mosser, Justin P. Edwards · Nature reviews. Immunology ReviewOpen access 25 Nov 2008 9,246
7 Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity Elisabetta Polazzi, Ilaria Mengoni, Marco Caprini et al. · Neurosignals Open access 9 May 2012 9,018
8 α-Synuclein in Lewy bodies Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.‐Y. Lee et al. · Nature 28 Aug 1997 8,529
9 Neurotoxic reactive astrocytes are induced by activated microglia Shane A. Liddelow et al. · Nature Open access 2017 8,364
10 Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease Mihael H. Polymeropoulos, Christian N. Lavedan, Elisabeth Leroy et al. · Science 27 Jun 1997 8,336
11 Glutamate neurotoxicity and diseases of the nervous system Dennis W. Choi · Neuron Oct 1988 8,019
12 MDS clinical diagnostic criteria for Parkinson's disease Ronald B. Postuma, Daniela Berg, Matthew Stern et al. · Movement Disorders Oct 2015 7,758
13 Reversible middle cerebral artery occlusion without craniectomy in rats. Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke Open access 1989 7,562
14 From inflammation to sickness and depression: when the immune system subjugates the brain Robert Dantzer, Jason C. O’Connor, Gregory G. Freund et al. · Nature reviews. Neuroscience ReviewOpen access 12 Dec 2007 7,434
15 The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology Karen Bedard, Karl‐Heinz Krause · Physiological Reviews ReviewOpen access 2007 7,002
16 ShuffleNet V2: Practical Guidelines for Efficient CNN Architecture Design Ningning Ma, Xiangyu Zhang, Hai-Tao Zheng et al. · Lecture notes in computer science Conference paper 2018 6,903
17 The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) Bjoern H. Menze et al. · IEEE Transactions on Medical Imaging Open access 4 Dec 2014 6,843
18 Changes of Intestinal Functions in Liver Cirrhosis Hiroshi Fukui, Reiner Wiest · Inflammatory Intestinal Diseases Open access 2016 6,814
19 Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong et al. · Science 5 Oct 2006 6,756
20 THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE Richard C. Graham, Morris J. Karnovsky · Journal of Histochemistry & Cytochemistry Open access Apr 1966 6,512
21 Place navigation impaired in rats with hippocampal lesions Richard Morris, Paul Garrud, J. N. P. Rawlins et al. · Nature Jun 1982 6,447
22 Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines Peter J. Murray et al. · Immunity Open access Jul 2014 6,444
23 Neuroinflammation in Alzheimer's disease Michael Thomas Heneka et al. · The Lancet Neurology Open access 16 Mar 2015 6,318
24 Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo Axel Nimmerjahn, Frank Kirchhoff, Fritjof Helmchen · Science 14 Apr 2005 5,970
25 A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease Hadas Keren‐Shaul, Amit Spinrad, Assaf Weiner et al. · Cell Open access Jun 2017 5,874
26 Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation Michael Andreas Nitsche, Walter Paulus · The Journal of Physiology Open access Sep 2000 5,776
27 Astrocyte–endothelial interactions at the blood–brain barrier N. Joan Abbott, Lars Rönnbäck, Elisabeth Hansson · Nature reviews. Neuroscience Review 21 Dec 2005 5,649
28 Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research Símone Rossi, Mark Hallett, Paolo Maria Rossini et al. · Clinical Neurophysiology Open access 15 Oct 2009 5,541
29 El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis Benjamin Rix Brooks, Robert G. Miller, Michael Swash et al. · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2000 5,487
30 Prions Stanley Ben Prusiner · Proceedings of the National Academy of Sciences Open access 10 Nov 1998 5,428
31 Astrocytes: biology and pathology Michael V. Sofroniew, Harry V. Vinters · Acta Neuropathologica Open access 9 Dec 2009 5,277
32 Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages Florent Ginhoux, Melanie Greter, Marylène Leboeuf et al. · Science Open access 21 Oct 2010 5,266
33 Alzheimer's disease Philip Scheltens, Bart De Strooper, Miia Kivipelto et al. · The Lancet Open access 2 Mar 2021 5,240
34 Monocyte and macrophage heterogeneity Siamon Gordon, Philip R. Taylor · Nature reviews. Immunology Review Dec 2005 5,210
35 Structure and function of the blood–brain barrier N. Joan Abbott, Adjanie Patabendige, Diana E. M. Dolman et al. · Neurobiology of Disease Open access 6 Aug 2009 5,185
36 Vascular dementia Gustavo C. Román et al. · Neurology Feb 1993 4,937
37 Exercise training increases size of hippocampus and improves memory Kirk I. Erickson, Michelle W. Voss, Ruchika Shaurya Prakash et al. · Proceedings of the National Academy of Sciences Open access 31 Jan 2011 4,886
38 Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice Patrice D. Cani, Rodrigo Bibiloni, Claude Knauf et al. · Diabetes Open access 27 Feb 2008 4,821
39 Current Concepts in Mild Cognitive Impairment Ronald C. Petersen, Rachelle Smith Doody, Alexander Kurz et al. · Archives of Neurology Dec 2001 4,821
40 Inflammation and Alzheimer's disease Haruhiko Akiyama · Neurobiology of Aging Open access Jun 2000 4,553
41 A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD Alan Edward Renton et al. · Neuron Open access 22 Sep 2011 4,545
42 Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B William E. Klunk et al. · Annals of Neurology 21 Jan 2004 4,528
43 Microglia: a sensor for pathological events in the CNS Georg W. Kreutzberg · Trends in Neurosciences Review Aug 1996 4,410
44 Multiple sclerosis Alastair Compston, Alasdair J. Coles · The Lancet Oct 2008 4,397
45 Synaptic Pruning by Microglia Is Necessary for Normal Brain Development Rosa Chiara Paolicelli, Giulia Bolasco, Francesca Pagani et al. · Science 21 Jul 2011 4,383
46 Theta Burst Stimulation of the Human Motor Cortex Ying‐Zu Huang, Mark John Edwards, Elisabeth Rounis et al. · Neuron Open access 2005 4,260
47 Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin Lyudmila V. Borovikova, Svetlana Ivanova, Minghuang Zhang et al. · Nature May 2000 4,235
48 Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman et al. · Neuron Open access May 2012 4,228
49 Succinate is an inflammatory signal that induces IL-1β through HIF-1α Gillian M. Tannahill et al. · Nature Open access 22 Mar 2013 4,197
50 Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation Mark E. Gurney, Haifeng Pu, Arlene Y. Chiu et al. · Science 17 Jun 1994 4,179

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.