Subfield · Pharmaceutical Science
Most cited papers in Pharmaceutical Science
What are the most cited papers in Pharmaceutical Science?
The most cited paper in Pharmaceutical Science is "Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1" (Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al., 2001), with 18,154 citations. Next come "Molecular Properties That Influence the Oral Bioavailability of Drug Candidates" (8,390) and "Engineering precision nanoparticles for drug delivery" (7,854).
Showing 50 of 100 papers. Every paper with more than 1,734 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1 Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews | Mar 2001 | 18,154 |
| 2 | Molecular Properties That Influence the Oral Bioavailability of Drug Candidates Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry | 11 May 2002 | 8,390 |
| 3 | Engineering precision nanoparticles for drug delivery Michael J. Mitchell, Margaret M. Billingsley, Rebecca M. Haley et al. · Nature Reviews Drug Discovery | 4 Dec 2020 | 7,854 |
| 4 | Fluorine in medicinal chemistry Sophie Purser, Peter R. Moore, Steve Swallow et al. · Chemical Society Reviews | 13 Dec 2007 | 7,580 |
| 5 | A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter George A. Bray · Analytical Biochemistry | Dec 1960 | 7,511 |
| 6 | Nano based drug delivery systems: recent developments and future prospects Jayanta Kumar Patra, Gitishree Das, Leonardo Fernandes Fraceto et al. · Journal of Nanobiotechnology | 19 Sep 2018 | 6,726 |
| 7 | Fluorine in Pharmaceuticals: Looking Beyond Intuition Klaus Müller, Christoph Faeh, François Diederich · Science | 27 Sep 2007 | 6,622 |
| 8 | THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE Richard C. Graham, Morris J. Karnovsky · Journal of Histochemistry & Cytochemistry | Apr 1966 | 6,512 |
| 9 | Capillary flow as the cause of ring stains from dried liquid drops Robert D. Deegan, Olgica Bakajin, Todd F. Dupont et al. · Nature | 23 Oct 1997 | 6,437 |
| 10 | Stimuli-responsive nanocarriers for drug delivery Simona Mura, Julien Nicolas, Patrick Couvreur · Nature Materials | 23 Oct 2013 | 6,259 |
| 11 | Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues Frank Tietze · Analytical Biochemistry | Mar 1969 | 6,083 |
| 12 | A review of chitin and chitosan applications Majeti N. V. Ravi Kumar · Reactive and Functional Polymers | Nov 2000 | 6,029 |
| 13 | Modeling and comparison of dissolution profiles Paulo C. Costa, José Manuel Sousa Lobo · European Journal of Pharmaceutical Sciences | May 2001 | 5,484 |
| 14 | A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research | Mar 1995 | 5,389 |
| 15 | Mechanisms of solute release from porous hydrophilic polymers Richard W. Korsmeyer, Robert Gurny, Éric Doelker et al. · International Journal of Pharmaceutics | May 1983 | 5,233 |
| 16 | Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices Tsunehiko Higuchi · Journal of Pharmaceutical Sciences | Dec 1963 | 4,890 |
| 17 | Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems M. Danaei, M. Dehghankhold, Shahla Ataei et al. · Pharmaceutics | 18 May 2018 | 4,847 |
| 18 | Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011) Jiang Wang, María Sánchez‐Roselló, José Luis Aceña et al. · Chemical Reviews | 3 Dec 2013 | 4,838 |
| 19 | Designing hydrogels for controlled drug delivery Jianyu Li, David J. Mooney · Nature Reviews Materials | 18 Oct 2016 | 4,836 |
| 20 | Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier Hirenkumar K. Makadia, Steven J. Siegel · Polymers | 26 Aug 2011 | 4,766 |
| 21 | How a century of ammonia synthesis changed the world Jan Willem Erisman, Mark A. Sutton, James N. Galloway et al. · Nature Geoscience | 28 Sep 2008 | 4,691 |
| 22 | Drug Delivery Systems: Entering the Mainstream Theresa M. Allen, Pieter R. Cullis · Science | 19 Mar 2004 | 4,545 |
| 23 | PEGylation as a strategy for improving nanoparticle-based drug and gene delivery Jung Soo Suk, Qingguo Xu, Nam‐Ho Kim et al. · Advanced Drug Delivery Reviews | 19 Oct 2015 | 4,511 |
| 24 | Understanding organofluorine chemistry. An introduction to the C–F bond David O’Hagan · Chemical Society Reviews | 17 Oct 2007 | 4,043 |
| 25 | Environment-sensitive hydrogels for drug delivery Yong Qiu, Kinam Park · Advanced Drug Delivery Reviews | Dec 2001 | 3,907 |
| 26 | A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs Philip L. Ritger, Nikolaos A. Peppas · Journal of Controlled Release | Jun 1987 | 3,824 |
| 27 | PLGA-based nanoparticles: An overview of biomedical applications Fabienne Danhier, Eduardo Ansorena, Joana M. Silva et al. · Journal of Controlled Release | 4 Feb 2012 | 3,807 |
| 28 | Hydrogels in drug delivery: Progress and challenges Todd R. Hoare, Daniel S. Kohane · Polymer | 21 Jan 2008 | 3,776 |
| 29 | Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art R Müller · European Journal of Pharmaceutics and Biopharmaceutics | 3 Jul 2000 | 3,758 |
| 30 | Biodegradable polymeric nanoparticles based drug delivery systems Avnesh Kumari, Sudesh Kumar Yadav, Subhash Chandra Yadav · Colloids and Surfaces B Biointerfaces | 9 Sep 2009 | 3,716 |
| 31 | Applications of Fluorine in Medicinal Chemistry Eric P. Gillis, Kyle J. Eastman, Matthew Davenport Hill et al. · Journal of Medicinal Chemistry | 22 Jul 2015 | 3,653 |
| 32 | Liposome: classification, preparation, and applications Abolfazl Akbarzadeh, Rogaie Rezaei-Sadabady, Soodabeh Davaran et al. · Nanoscale Research Letters | 22 Feb 2013 | 3,634 |
| 33 | The Many Roles for Fluorine in Medicinal Chemistry William K. Hagmann · Journal of Medicinal Chemistry | 21 Jun 2008 | 3,617 |
| 34 | Biodegradable polymeric nanoparticles as drug delivery devices Kumaresh S. Soppimath, Tejraj Malleshappa Aminabhavi, Anandrao R. Kulkarni et al. · Journal of Controlled Release | 2001 | 3,537 |
| 35 | Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives Katrin Knop, Richard Hoogenboom, Dagmar Fischer et al. · Angewandte Chemie International Edition | 20 Jul 2010 | 3,525 |
| 36 | Transdermal drug delivery Mark R. Prausnitz, Róbert Langer · Nature Biotechnology | Nov 2008 | 3,525 |
| 37 | Biodegradable nanoparticles for drug and gene delivery to cells and tissue Jayanth Panyam, Vinod D. Labhasetwar · Advanced Drug Delivery Reviews | Feb 2003 | 3,364 |
| 38 | Cyclodextrins and their uses: a review Eva M. Martín del Valle · Process Biochemistry | 11 Oct 2003 | 3,359 |
| 39 | Handbook of Pharmaceutical Excipients Flynn W. Warren · American Journal of Health-System Pharmacy | Aug 1987 | 3,343 |
| 40 | Solid lipid nanoparticles Production, characterization and applications W. Mehnert · Advanced Drug Delivery Reviews | 25 Apr 2001 | 3,147 |
| 41 | Culture Medium for Enterobacteria Frederick C. Neidhardt, Philip L. Bloch, David F. Smith · Journal of Bacteriology | Sep 1974 | 3,062 |
| 42 | Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode Barnett Rosenberg, Loretta Van Camp, Thomas Krigas · Nature | Feb 1965 | 3,054 |
| 43 | Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release Nazila Kamaly, Basit Yameen, Jun Hua Wu et al. · Chemical Reviews | 8 Feb 2016 | 3,033 |
| 44 | Chitosan Chemistry and Pharmaceutical Perspectives M. N. V. Ravi Kumar, Riccardo A.A. Müzzarelli, Corrado Muzzarelli et al. · Chemical Reviews | Dec 2004 | 2,949 |
| 45 | Biodegradable Long-Circulating Polymeric Nanospheres Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia et al. · Science | 18 Mar 1994 | 2,919 |
| 46 | Chitosan—A versatile semi-synthetic polymer in biomedical applications Mamoni Dash, Emo Chiellini, Raphael M. Ottenbrite et al. · Progress in Polymer Science | 23 Feb 2011 | 2,889 |
| 47 | Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas Yu Chang Zhou, Jiang Wang, Zhanni Gu et al. · Chemical Reviews | 12 Jan 2016 | 2,807 |
| 48 | Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics | Jul 1994 | 2,793 |
| 49 | Nanoparticle-based targeted drug delivery Rajesh Singh, James W. Lillard · Experimental and Molecular Pathology | 8 Jan 2009 | 2,747 |
| 50 | Dual Catalysis Strategies in Photochemical Synthesis Kazimer L. Skubi, Travis R. Blum, Tehshik P. Yoon · Chemical Reviews | 25 Apr 2016 | 2,724 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.