Subfield · Physiology
Most cited papers in Physiology (Medicine)
What are the most cited papers in Physiology?
The most cited paper in Physiology is "Mutation of the mouse klotho gene leads to a syndrome resembling ageing." (M Kuro-o, Y Matsumura, H Aizawa et al., 1997), with 66,570 citations. Next come "STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT" (48,188) and "Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues" (47,289).
Showing 50 of 99 papers. Every paper with more than 6,285 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Mutation of the mouse klotho gene leads to a syndrome resembling ageing. M Kuro-o, Y Matsumura, H Aizawa et al. · PubMed | 6 Nov 1997 | 66,570 |
| 2 | STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT J Martin Bland, DouglasG. Altman · The Lancet | Feb 1986 | 48,188 |
| 3 | Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues Haider Raza, Annie John, Abderrahim Nemmar · Cellular Physiology and Biochemistry | 2013 | 47,289 |
| 4 | Frailty in Older Adults: Evidence for a Phenotype Linda P. Fried, Catherine M. Tangen, Jeremy D Walston et al. · The Journals of Gerontology Series A | Mar 2001 | 25,162 |
| 5 | Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal Ndiaye, Matar, Lespez, Laurent, Tribolo, Chantal et al. · Monash University Research Portal (Monash University) | 28 Mar 2024 | 24,104 |
| 6 | International Physical Activity Questionnaire: 12-Country Reliability and Validity Cora L. Craig, Alison L. Marshall, MICHAEL SJ??STR??M et al. · Medicine & Science in Sports & Exercise | Aug 2003 | 22,204 |
| 7 | Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin Diabetes Prevention Program Research Group · New England Journal of Medicine | 7 Feb 2002 | 19,192 |
| 8 | The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Guy M. McKhann, David S. Knopman, Howard Mark Chertkow et al. · Alzheimer s & Dementia | 22 Apr 2011 | 19,132 |
| 9 | A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale Murray W. Johns · SLEEP | Nov 1991 | 17,509 |
| 10 | Establishing a standard definition for child overweight and obesity worldwide: international survey Tim James Cole · BMJ | 6 May 2000 | 16,616 |
| 11 | Neuropathological stageing of Alzheimer-related changes Heiko Braak, Eva Braak · Acta Neuropathologica | Sep 1991 | 16,612 |
| 12 | Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease Jørgen Vestbo, Suzanne S. Hurd, Alvar G.N. Agustí et al. · American Journal of Respiratory and Critical Care Medicine | 9 Aug 2012 | 16,116 |
| 13 | Standardisation of spirometry Martin R. Miller, J. Hankinson, Vito Brusasco et al. · European Respiratory Journal | 29 Jul 2005 | 15,846 |
| 14 | Nitric oxide: physiology, pathophysiology, and pharmacology. Salvador Moncada, Richard M. J. Palmer, E.A. Higgs · Pharmacological Reviews | Jun 1991 | 15,612 |
| 15 | The Hallmarks of Aging Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell | Jun 2013 | 15,388 |
| 16 | Sarcopenia: revised European consensus on definition and diagnosis Alfonso José Cruz-Jentoft et al. · Age and Ageing | 24 Sep 2018 | 14,151 |
| 17 | The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics John Hardy, Dennis J. Selkoe · Science | 19 Jul 2002 | 14,017 |
| 18 | Positional cloning of the mouse obese gene and its human homologue Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature | Dec 1994 | 13,483 |
| 19 | Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease Valentina Cappello, Laura Marchetti, Paola Parlanti et al. · Scientific Reports | 11 Nov 2016 | 13,289 |
| 20 | Superoxide Dismutase Joe M. McCord, Irwin Fridovich · Journal of Biological Chemistry | Nov 1969 | 12,906 |
| 21 | An obesity-associated gut microbiome with increased capacity for energy harvest Peter James Turnbaugh, Ruth E. Ley, Michael A. Mahowald et al. · Nature | Dec 2006 | 12,679 |
| 22 | Role of Insulin Resistance in Human Disease Gerald M. Reaven · Diabetes | Dec 1988 | 12,183 |
| 23 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Robert F. Furchgott, John V. Zawadzki · Nature | Nov 1980 | 12,123 |
| 24 | World Health Organization 2020 guidelines on physical activity and sedentary behaviour Fiona Bull et al. · British Journal of Sports Medicine | 25 Nov 2020 | 11,799 |
| 25 | Sarcopenia: European consensus on definition and diagnosis Alfonso José Cruz-Jentoft, Jean‐Pierre Baeyens, Jürgen Martin Bauer et al. · Age and Ageing | 13 Apr 2010 | 11,720 |
| 26 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease Clifford R. Jack et al. · Alzheimer s & Dementia | Apr 2018 | 10,885 |
| 27 | The Fagerström Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire Todd F. Heatherton, Lynn T. Kozlowski, Richard C. Frecker et al. · British Journal of Addiction | Sep 1991 | 10,879 |
| 28 | A simple technique for quantitation of low levels of DNA damage in individual cells Narendra Prasad Singh, Michael T. McCoy, Raymond R. Tice et al. · Experimental Cell Research | Mar 1988 | 10,851 |
| 29 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature | Mar 1988 | 10,827 |
| 30 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Richard M. J. Palmer, Anthony G. Ferrige, Salvador Moncada · Nature | Jun 1987 | 10,799 |
| 31 | Diet rapidly and reproducibly alters the human gut microbiome Lawrence A. David, Corinne F. Maurice, Rachel N. Carmody et al. · Nature | 11 Dec 2013 | 10,461 |
| 32 | The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Marilyn S. Albert, Steven T. DeKosky, Dennis W. Dickson et al. · Alzheimer s & Dementia | 22 Apr 2011 | 10,419 |
| 33 | Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy Maj-Linda B. Selenica, Milene Lara Brownlow, Jeffy P. Jimenez et al. · Neurodegenerative Diseases | 10 Jul 2012 | 10,400 |
| 34 | The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults Terry B Young, Mari Palta, Jerome A. Dempsey et al. · New England Journal of Medicine | 29 Apr 1993 | 10,268 |
| 35 | A Short Physical Performance Battery Assessing Lower Extremity Function: Association With Self-Reported Disability and Prediction of Mortality and Nursing Home Admission Jack M. Guralnik, E. M. Simonsick, Luigi Ferrucci et al. · Journal of Gerontology | Mar 1994 | 9,940 |
| 36 | The Physical Activity Guidelines for Americans Katrina L. Piercy, Richard P. Troiano, Rachel Ballard et al. · JAMA | 12 Nov 2018 | 9,860 |
| 37 | Hallmarks of Cancer: New Dimensions Douglas Hanahan · Cancer Discovery | 2022 | 9,794 |
| 38 | Functional rafts in cell membranes Kai Simons, Elina Ikonen · Nature | Jun 1997 | 9,793 |
| 39 | Frailty in elderly people Andrew Paul Clegg, John B. Young, Steve Iliffe et al. · The Lancet | 7 Feb 2013 | 9,683 |
| 40 | Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science | 13 Aug 1993 | 9,582 |
| 41 | ‘Small Changes' to Diet and Physical Activity Behaviors for Weight Management Andrew Peter Hills, Nuala Mary Byrne, Rachel C. Lindstrom et al. · Obesity Facts | 2013 | 9,508 |
| 42 | Oxidants, oxidative stress and the biology of ageing Toren Finkel, Nikki J. Holbrook · Nature | Nov 2000 | 9,446 |
| 43 | The capsaicin receptor: a heat-activated ion channel in the pain pathway Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga et al. · Nature | Oct 1997 | 9,220 |
| 44 | A global clinical measure of fitness and frailty in elderly people Kenneth J. Rockwood · Canadian Medical Association Journal | 29 Aug 2005 | 9,214 |
| 45 | Inflammation and metabolic disorders Gökhan S. Hotamışlıgil · Nature | 13 Dec 2006 | 9,214 |
| 46 | Whole Brain Segmentation Bruce R. Fischl, David H. Salat, Evelina Busa et al. · Neuron | 2002 | 9,165 |
| 47 | Biochemistry and molecular cell biology of diabetic complications Michael Brownlee · Nature | 13 Dec 2001 | 9,153 |
| 48 | Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity Elisabetta Polazzi, Ilaria Mengoni, Marco Caprini et al. · Neurosignals | 9 May 2012 | 9,018 |
| 49 | Development of a WHO growth reference for school-aged children and adolescents Mercedes de Onís · Bulletin of the World Health Organization | Sep 2007 | 8,902 |
| 50 | Human gut microbes associated with obesity Ruth E. Ley, Peter James Turnbaugh, Samuel Klein et al. · Nature | 20 Dec 2006 | 8,887 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.