Subfield · Toxicology
Most cited papers in Toxicology
What are the most cited papers in Toxicology?
The most cited paper in Toxicology is "A method for estimating the probability of adverse drug reactions" (C. A. Naranjo, U. Busto, Edward M. Sellers et al., 1981), with 11,879 citations. Next come "Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes" (6,700) and "Incidence of Adverse Drug Reactions in Hospitalized Patients" (4,842).
Showing 50 of 99 papers. Every paper with more than 1,037 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | A method for estimating the probability of adverse drug reactions C. A. Naranjo, U. Busto, Edward M. Sellers et al. · Clinical Pharmacology & Therapeutics | Aug 1981 | 11,879 |
| 2 | Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Hermann Esterbauer, Rudolf Jörg Schaur, Helmward Zöllner · Free Radical Biology and Medicine | 1991 | 6,700 |
| 3 | Incidence of Adverse Drug Reactions in Hospitalized Patients Jason Lazarou, Bruce H. Pomeranz, Paul Corey · JAMA | 15 Apr 1998 | 4,842 |
| 4 | NITRIC OXIDE AND MACROPHAGE FUNCTION John D. MacMicking, Q W Xie, Carl Nathan · Annual Review of Immunology | Apr 1997 | 4,227 |
| 5 | Crosstalk of reactive oxygen species and NF-κB signaling Michael J Morgan, Zheng-gang Liu · Cell Research | 28 Dec 2010 | 3,489 |
| 6 | Molecular basis of agonism and antagonism in the oestrogen receptor Andrzej Marek Brzozowski, Ashley C. W. Pike, Zbigniew Dauter et al. · Nature | Oct 1997 | 3,370 |
| 7 | Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients Munir Pirmohamed, Sally James, Shaun Meakin et al. · BMJ | Jul 2004 | 3,262 |
| 8 | Adverse drug reactions: definitions, diagnosis, and management Ivor Ralph Edwards, Jeffrey K Aronson · The Lancet | Oct 2000 | 3,019 |
| 9 | Recent advances in the phencyclidine model of schizophrenia Daniel C. Javitt, Stephen R. Zukin · American Journal of Psychiatry | Oct 1991 | 2,933 |
| 10 | 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis Jasvinder A. Singh et al. · Arthritis & Rheumatology | 6 Nov 2015 | 2,810 |
| 11 | DNA Topoisomerases: Structure, Function, and Mechanism James J. Champoux · Annual Review of Biochemistry | Jun 2001 | 2,754 |
| 12 | Anticancer potential of curcumin: preclinical and clinical studies. Bharat Bhushan Aggarwal, Anushree Jai Kumar, Alok Chandra Bharti · PubMed | May 2003 | 2,576 |
| 13 | The Danish National Prescription Registry Helle Wallach‐Kildemoes, Henrik Toft Sørensen, Jesper Hallas · Scandinavian Journal of Public Health | Jul 2011 | 2,502 |
| 14 | The beliefs about medicines questionnaire: The development and evaluation of a new method for assessing the cognitive representation of medication Robert Horne, John A Weinman, Matthew C. Hankins · Psychology and Health | 1999 | 2,444 |
| 15 | Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry | Nov 1985 | 2,367 |
| 16 | The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada G. Ross Baker · Canadian Medical Association Journal | 25 May 2004 | 2,366 |
| 17 | Extraction, Purification and Properties of Aequorin, a Bioluminescent Protein from the Luminous Hydromedusan, Aequorea Osamu Shimomura, Frank H. Johnson, Yo Saiga · Journal of Cellular and Comparative Physiology | Jun 1962 | 2,360 |
| 18 | Establishment of Diagnostic Validity in Psychiatric Illness: Its Application to Schizophrenia Eli Robins, Samuel B. Guzé · American Journal of Psychiatry | 1970 | 2,253 |
| 19 | T Cell Activation Jennifer E. Smith‐Garvin, Gary A. Koretzky, Martha S. Jordan · Annual Review of Immunology | 8 Jan 2009 | 2,151 |
| 20 | Pharmacology and Management of the Vitamin K Antagonists Jack Ansell, Jack Hirsh, Elaine M. Hylek et al. · CHEST Journal | Jun 2008 | 2,121 |
| 21 | Drugs of abuse: anatomy, pharmacology and function of reward pathways George F. Koob · Trends in Pharmacological Sciences | 1992 | 2,095 |
| 22 | Adverse events in British hospitals: preliminary retrospective record review Charles A. Vincent, Graham Neale, Maria Woloshynowych · BMJ | 3 Mar 2001 | 2,082 |
| 23 | The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): development, reliability and feasibility WHO ASSIST Working Group · Addiction | 30 Aug 2002 | 2,027 |
| 24 | Under-Reporting of Adverse Drug Reactions Lorna Hazell, Saad Shakir · Drug Safety | 2006 | 1,950 |
| 25 | Glutathione peroxidases Regina Brigelius‐Flohé, Matilde Maiorino · Biochimica et Biophysica Acta (BBA) - General Subjects | 29 Nov 2012 | 1,909 |
| 26 | Estrogen Receptors: How Do They Signal and What Are Their Targets Nina Heldring, Ashley C. W. Pike, Sandra Andersson et al. · Physiological Reviews | Jul 2007 | 1,887 |
| 27 | Van der Waals Radii of Elements S. S. Bat︠s︡anov · Inorganic Materials | Sep 2001 | 1,860 |
| 28 | Emergency Hospitalizations for Adverse Drug Events in Older Americans Daniel S. Budnitz, Maribeth C. Lovegrove, Nadine Shehab et al. · New England Journal of Medicine | 23 Nov 2011 | 1,845 |
| 29 | Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports Stephen Evans, PATRICK C. WALLER, Sarah J. Davis · Pharmacoepidemiology and Drug Safety | Oct 2001 | 1,823 |
| 30 | The incidence and nature of in-hospital adverse events: a systematic review Eefje N. de Vries, Maya A. Ramrattan, Susanne M. Smorenburg et al. · BMJ Quality & Safety | Jun 2008 | 1,814 |
| 31 | Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action Kenta Hara, Yoshiko Maruki, Samuel Long et al. · Cell | Jul 2002 | 1,814 |
| 32 | Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Roland R. Griffiths, William A. Richards, U. McCann et al. · Psychopharmacology | 7 Jul 2006 | 1,716 |
| 33 | Role of Quinones in Toxicology Judy L. Bolton, Michael A. Trush, T.M. Penning et al. · Chemical Research in Toxicology | 23 Feb 2000 | 1,707 |
| 34 | Incidence and Preventability of Adverse Drug Events Among Older Persons in the Ambulatory Setting Jerry H. Gurwitz, Terry S. Field, Leslie R. Harrold et al. · JAMA | 5 Mar 2003 | 1,693 |
| 35 | Chemistry of Biologically Important Synthetic Organoselenium Compounds Govindasamy Mugesh, Wolf-Walther Du Μοnt, Helmut Sies · Chemical Reviews | 13 Jun 2001 | 1,690 |
| 36 | The reinstatement model of drug relapse: history, methodology and major findings Yavin Shaham, Uri Shalev, Lin Lü et al. · Psychopharmacology | 26 Oct 2002 | 1,644 |
| 37 | Self-Consistent Orbitals for Radicals John Anthony Pople, R. K. Nesbet · The Journal of Chemical Physics | Mar 1954 | 1,601 |
| 38 | Natural Products in Drug Discovery and Development Gordon M. L. Cragg, David J. Newman, Kenneth M. Snader · Journal of Natural Products | 1997 | 1,592 |
| 39 | Formation and inactivation of endogenous cannabinoid anandamide in central neurons Vincenzo Di Marzo, Angelo Fontana, Hugues Cadas et al. · Nature | Dec 1994 | 1,589 |
| 40 | Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study Robin Lester Carhart-Harris, Mark Bolstridge, James Rucker et al. · The Lancet Psychiatry | 17 May 2016 | 1,581 |
| 41 | Severe Adverse Cutaneous Reactions to Drugs Jean Claude Roujeau, Robert S. Stern · New England Journal of Medicine | 10 Nov 1994 | 1,578 |
| 42 | Apoptosis: A Target for Anticancer Therapy Claire M. Pfeffer, Amareshwar T.K. Singh · International Journal of Molecular Sciences | 2 Feb 2018 | 1,570 |
| 43 | Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science | 26 Oct 1984 | 1,551 |
| 44 | Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA Ben F. Luisi, Wei Xu, Zbyszek Otwinowski et al. · Nature | Aug 1991 | 1,519 |
| 45 | Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study Luc F. Van Gaal, Aila Rissanen, André Jacques Scheen et al. · The Lancet | Apr 2005 | 1,504 |
| 46 | STOPP (Screening Tool of Older Persons Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation Paul G. Gallagher, Cristín A. Ryan, Shauna E. Byrne et al. · International Journal of Clinical Pharmacology and Therapeutics | Feb 2008 | 1,503 |
| 47 | Causality assessment of adverse reactions to drugs—I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries Gaby Danan, Christian Benichou · Journal of Clinical Epidemiology | Nov 1993 | 1,494 |
| 48 | Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Hitoshi Katayama, Koichi Yamaguchi, Takenori Kozuka et al. · Radiology | Jun 1990 | 1,481 |
| 49 | A Bayesian neural network method for adverse drug reaction signal generation Andrew M. Bate, Marie Lindquist, Ivor Ralph Edwards et al. · European Journal of Clinical Pharmacology | 6 Jul 1998 | 1,476 |
| 50 | Medication Use and the Risk of Stevens–Johnson Syndrome or Toxic Epidermal Necrolysis Jean‐Claude Roujeau, Judith Parsells Kelly, Luigi Naldi et al. · New England Journal of Medicine | 14 Dec 1995 | 1,473 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.