Topic · Animal Genetics and Reproduction
Most cited papers in Animal Genetics and Reproduction
What are the most cited papers in Animal Genetics and Reproduction?
The most cited paper in Animal Genetics and Reproduction is "A series of normal stages in the development of the chick embryo" (Viktor Hamburger, Howard L. Hamilton, 1951), with 12,399 citations. Next come "Establishment in culture of pluripotential cells from mouse embryos" (8,657) and "Site-directed mutagenesis by overlap extension using the polymerase chain reaction" (7,540).
Showing 50 of 99 papers. Every paper with more than 1,344 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | A series of normal stages in the development of the chick embryo Viktor Hamburger, Howard L. Hamilton · Journal of Morphology | 1951 | 12,399 |
| 2 | Establishment in culture of pluripotential cells from mouse embryos Martin John Evans, M. H. Kaufman · Nature | Jul 1981 | 8,657 |
| 3 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene | Apr 1989 | 7,540 |
| 4 | The new frontier of genome engineering with CRISPR-Cas9 Jennifer A. Doudna, Emmanuelle Charpentier · Science | 28 Nov 2014 | 7,176 |
| 5 | Global quantification of mammalian gene expression control Björn Schwanhäußer, Dorothea Busse, Na Li et al. · Nature | 17 May 2011 | 7,057 |
| 6 | Green Fluorescent Protein as a Marker for Gene Expression Martin Chalfie, Yuan Tu, Ghia M. Euskirchen et al. · Science | 11 Feb 1994 | 6,824 |
| 7 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density W. Scott Simonet et al. · Cell | Apr 1997 | 5,161 |
| 8 | Generalized lacZ expression with the ROSA26 Cre reporter strain Philippe M. Soriano · Nature Genetics | 1999 | 4,935 |
| 9 | Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5 Frank L. Graham, W. C. Russell, James R. Smiley et al. · Journal of General Virology | Jul 1977 | 4,887 |
| 10 | Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Michael A. Frohman, Michael K. Dush, Gail R. Martin · Proceedings of the National Academy of Sciences | Dec 1988 | 4,638 |
| 11 | Direct Gene Transfer into Mouse Muscle in Vivo Jon A. Wolff, Robert W. Malone, Phillip A. Williams et al. · Science | 23 Mar 1990 | 4,189 |
| 12 | A gene complex controlling segmentation in Drosophila E. B. Lewis · Nature | Dec 1978 | 3,889 |
| 13 | ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering Thomas Gaj, Charles A. Gersbach, Carlos F. Barbas · Trends in biotechnology | 8 May 2013 | 3,844 |
| 14 | Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences | Apr 1989 | 3,646 |
| 15 | One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering Haoyi Wang, Hui Xiang Yang, Chikdu Shivalila et al. · Cell | May 2013 | 3,600 |
| 16 | Defining ‘Evolutionarily Significant Units’ for conservation Craig C. Moritz · Trends in Ecology & Evolution | Oct 1994 | 3,395 |
| 17 | Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus Shankar Srinivas, Tomoko Watanabe, Chyuan‐Sheng Lin et al. · BMC Developmental Biology | 27 Mar 2001 | 3,258 |
| 18 | Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Daniel Pinkel, T. Straume, Joe W. Gray · Proceedings of the National Academy of Sciences | May 1986 | 3,242 |
| 19 | Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Luda B. Diatchenko, Yun‐Fai Chris Lau, A. Patricia Campbell et al. · Proceedings of the National Academy of Sciences | 11 Jun 1996 | 3,037 |
| 20 | Genetic Transformation of Drosophila with Transposable Element Vectors Gerald M. Rubin, Allan C. Spradling · Science | 22 Oct 1982 | 3,023 |
| 21 | The hitch-hiking effect of a favourable gene JOHN MAYNARD, John Haigh · Genetics Research | Dec 2007 | 2,822 |
| 22 | A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila Georg Dietzl, Doris Chen, Frank Schnorrer et al. · Nature | Jul 2007 | 2,785 |
| 23 | High-resolution in situ hybridization to whole-mount zebrafish embryos Christine Thisse, Bernard Thisse · Nature Protocols | 20 Dec 2007 | 2,768 |
| 24 | Genome sequence, comparative analysis and haplotype structure of the domestic dog Broad Sequencing Platform members et al. · Nature | Dec 2005 | 2,660 |
| 25 | ‘Touchdown’ PCR to circumvent spurious priming during gene amplification R.H. Don, Peter T Cox, Brandon J. Wainwright et al. · Nucleic Acids Research | 1991 | 2,620 |
| 26 | Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences Robert H. Devlin, Yoshitaka Nagahama · Aquaculture | Jun 2002 | 2,614 |
| 27 | A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback Diethard Tautz, Christine Pfeifle · Chromosoma | Aug 1989 | 2,562 |
| 28 | In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells Gabriela Dontu, Wissam M. Abdallah, Jessica M. Foley et al. · Genes & Development | 15 May 2003 | 2,426 |
| 29 | Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Junying Yu, Kejin Hu, Kim Smuga-Otto et al. · Science | 26 Mar 2009 | 2,403 |
| 30 | Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors Andrew V. Anzalone, Luke W. Koblan, David R. Liu · Nature Biotechnology | 22 Jun 2020 | 2,384 |
| 31 | Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. András Nagy, Janet Rossant, Roland Nagy et al. · Proceedings of the National Academy of Sciences | 15 Sep 1993 | 2,368 |
| 32 | In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2 Donald J. Giard, Stuart A. Aaronson, George J. Todaro et al. · JNCI Journal of the National Cancer Institute | Nov 1973 | 2,340 |
| 33 | Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A Stephen Green, Philippe L. Walter, Vijay Kumar et al. · Nature | Mar 1986 | 2,332 |
| 34 | Engineering the Provitamin A (β-Carotene) Biosynthetic Pathway into (Carotenoid-Free) Rice Endosperm Xudong Ye, Salim Al‐Babili, Andreas Klöti et al. · Science | 14 Jan 2000 | 2,289 |
| 35 | Male development of chromosomally female mice transgenic for Sry Peter A. Koopman, John Gubbay, Nigel Vivian et al. · Nature | May 1991 | 2,242 |
| 36 | Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. Christopher M. Counter, Ariel A. Avilion, Catherine LeFeuvre et al. · The EMBO Journal | May 1992 | 2,119 |
| 37 | Hox genes in vertebrate development Robb K. Krumlauf · Cell | Jul 1994 | 2,100 |
| 38 | Manipulating the Mouse Embryo: A Laboratory Manual Richard R. Behringer, Marina Gertsenstein, Kristina Vintersten Nagy et al. | 15 Dec 2002 | 2,094 |
| 39 | Preparation of Genomic DNA from Bacteria Kate J. Wilson · Current Protocols in Molecular Biology | Oct 2001 | 2,091 |
| 40 | Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors Carlos Lois, Elizabeth J. Hong, Shirley Pease et al. · Science | Feb 2002 | 2,047 |
| 41 | An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases Johannes Bischof, Robert K. Maeda, Monika Hediger et al. · Proceedings of the National Academy of Sciences | 22 Feb 2007 | 2,041 |
| 42 | Altering the Genome by Homologous Recombination Mario R. Capecchi · Science | 16 Jun 1989 | 2,036 |
| 43 | Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype Olivier Jaillon et al. · Nature | Oct 2004 | 2,036 |
| 44 | Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors Keisuke Okita, Masato Nakagawa, Hyenjong Hong et al. · Science | 9 Oct 2008 | 2,010 |
| 45 | DNA Modification Mechanisms and Gene Activity During Development R. Holliday, J. E. Pugh · Science | 24 Jan 1975 | 1,986 |
| 46 | Position-independent, high-level expression of the human β-globin gene in transgenic mice Frank G. Grosveld, Greet Blom van Assendelft, David R. Greaves et al. · Cell | Dec 1987 | 1,958 |
| 47 | Inducible Gene Targeting in Mice Ralf Kühn, Frieder Schwenk, Michel Aguet et al. · Science | 8 Sep 1995 | 1,950 |
| 48 | A chemical method for fast and sensitive detection of DNA synthesis in vivo Adrian N. Salic, Timothy John Mitchison · Proceedings of the National Academy of Sciences | 12 Feb 2008 | 1,914 |
| 49 | Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides Austin G Smith, John K. Heath, Deborah D. Donaldson et al. · Nature | Dec 1988 | 1,869 |
| 50 | Sheep cloned by nuclear transfer from a cultured cell line Keith Campbell, J. McWhir, William A. Ritchie et al. · Nature | Mar 1996 | 1,856 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.