Topic · Animal testing and alternatives
Most cited papers in Animal testing and alternatives
What are the most cited papers in Animal testing and alternatives?
The most cited paper in Animal testing and alternatives is "Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels" (Charles Beauchamp, Irwin Fridovich, 1971), with 12,959 citations. Next come "Ethical guidelines for investigations of experimental pain in conscious animals" (7,814) and "Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research" (7,456).
Showing 50 of 95 papers. Every paper with more than 696 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels Charles Beauchamp, Irwin Fridovich · Analytical Biochemistry | Nov 1971 | 12,959 |
| 2 | Ethical guidelines for investigations of experimental pain in conscious animals Manfred Zimmermann · Pain | Jun 1983 | 7,814 |
| 3 | Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · PLoS Biology | 29 Jun 2010 | 7,456 |
| 4 | A simple practice guide for dose conversion between animals and human Anroop Balachandran Nair, Shery Jacob · Journal of Basic and Clinical Pharmacy | 2016 | 6,160 |
| 5 | The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research Nathalie Percie du Sert et al. · PLoS Biology | 14 Jul 2020 | 6,005 |
| 6 | The 1996 Guide for the Care and Use of Laboratory Animals J. Derrell Clark, Gerald F. Gebhart, Janet C. Gonder et al. · ILAR Journal | 1997 | 4,448 |
| 7 | STAMP: statistical analysis of taxonomic and functional profiles Donovan H. Parks, Gene W. Tyson, Philip Hugenholtz et al. · Bioinformatics | 23 Jul 2014 | 4,381 |
| 8 | SYRCLE’s risk of bias tool for animal studies Carlijn R. Hooijmans, Maroeska Mariet Rovers, Rob BM de Vries et al. · BMC Medical Research Methodology | 25 Mar 2014 | 4,374 |
| 9 | Animal research: Reporting in vivo experiments: The ARRIVE guidelines Carol Kilkenny, William J. Browne, Innes C. Cuthill et al. · British Journal of Pharmacology | 6 Jul 2010 | 3,667 |
| 10 | Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill Morten Hansen, Svend Erik Nielsen, Kurt Berg · Journal of Immunological Methods | May 1989 | 3,534 |
| 11 | ProTox-II: a webserver for the prediction of toxicity of chemicals Priyanka Banerjee, Andreas Philipp Eckert, Anna K. Schrey et al. · Nucleic Acids Research | 26 Apr 2018 | 3,237 |
| 12 | Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses Laura N. Vandenberg, Theo L. Colborn, Tyrone B. Hayes et al. · Endocrine Reviews | 14 Mar 2012 | 3,182 |
| 13 | A new approach to practical acute toxicity testing Dietrich Ernst Lorke · Archives of Toxicology | Dec 1983 | 3,052 |
| 14 | Physiological Parameters in Laboratory Animals and Humans Brian E. Davies, Tim Morris · Pharmaceutical Research | Jul 1993 | 2,937 |
| 15 | Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 Nathalie Percie du Sert et al. · PLoS Biology | 14 Jul 2020 | 2,875 |
| 16 | Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS) Martin Downes, Marnie Louise Brennan, Hywel C Williams et al. · BMJ Open | Dec 2016 | 2,432 |
| 17 | Comparison of Two Methods to Detect Publication Bias in Meta-analysis Jaime Peters · JAMA | 7 Feb 2006 | 2,341 |
| 18 | Growing points in ethology Stephen J. Hutt · Animal Behaviour | Aug 1977 | 2,327 |
| 19 | Neutral red uptake assay for the estimation of cell viability/cytotoxicity Guillermo Repetto, Ana del Peso, Jorge L. Zurita · Nature Protocols | 12 Jun 2008 | 2,226 |
| 20 | The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta‐analysis, and clinical practice guideline: a systematic review Xian‐Tao Zeng, Yonggang Zhang, Joey S.W. Kwong et al. · Journal of Evidence-Based Medicine | 16 Jan 2015 | 2,137 |
| 21 | Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals Harry M. Olson, Graham R. Betton, Denise E. Robinson et al. · Regulatory Toxicology and Pharmacology | Aug 2000 | 2,056 |
| 22 | Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients A.M. Api et al. · Food and Chemical Toxicology | 12 Dec 2014 | 1,965 |
| 23 | Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products Bob J. Safford, A.M. Api, Christopher L. R. Barratt et al. · Regulatory Toxicology and Pharmacology | 13 Jun 2015 | 1,925 |
| 24 | How to calculate sample size in animal studies? Jaykaran Charan, N. D. Kantharia · Journal of Pharmacology and Pharmacotherapeutics | 10 Oct 2013 | 1,915 |
| 25 | Toxicity determined in vitro by morphological alterations and neutral red absorption Ellen Borenfreund, James A. Puerner · Toxicology Letters | Feb 1985 | 1,902 |
| 26 | Novel database for exposure to fragrance ingredients in cosmetics and personal care products Damien Comiskey, A.M. Api, Christopher L. R. Barratt et al. · Regulatory Toxicology and Pharmacology | 19 May 2015 | 1,867 |
| 27 | Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products Bob J. Safford, A.M. Api, Christopher L. R. Barratt et al. · Regulatory Toxicology and Pharmacology | 28 Feb 2017 | 1,848 |
| 28 | Sex bias in neuroscience and biomedical research Annaliese K. Beery, Irving Zucker · Neuroscience & Biobehavioral Reviews | 9 Jul 2010 | 1,817 |
| 29 | CAESAR models for developmental toxicity Antonio Cassano, Alberto Manganaro, Todd M. Martin et al. · Chemistry Central Journal | Jul 2010 | 1,583 |
| 30 | In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride George Fotakis, John A. Timbrell · Toxicology Letters | 19 Aug 2005 | 1,572 |
| 31 | A good practice guide to the administration of substances and removal of blood, including routes and volumes Karl‐Heinz Diehl, Robin Hull, David B. Morton et al. · Journal of Applied Toxicology | 2001 | 1,569 |
| 32 | 1,026 Experimental treatments in acute stroke Victoria E. O’Collins, Malcolm Robert Macleod, Geoffrey Alan Donnan et al. · Annals of Neurology | Feb 2006 | 1,484 |
| 33 | Guidelines for the welfare and use of animals in cancer research Paul Workman, Eric Ofori Aboagye, Frances R. Balkwill et al. · British Journal of Cancer | May 2010 | 1,468 |
| 34 | The Laboratory Rat: Relating Its Age With Human's. Pallav Sengupta · PubMed | Jun 2013 | 1,428 |
| 35 | Swine as Models in Biomedical Research and Toxicology Testing M. Michael Swindle, Andy Makin, A. J. Herron et al. · Veterinary Pathology | 25 Mar 2011 | 1,387 |
| 36 | Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity Adrian J. Hill, Hiroki Teraoka, Warren Heideman et al. · Toxicological Sciences | 9 Feb 2005 | 1,375 |
| 37 | Can Animal Models of Disease Reliably Inform Human Studies? H. Bart van der Worp, David William Howells, Emily S. Sena et al. · PLoS Medicine | 29 Mar 2010 | 1,372 |
| 38 | Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers Michael J. Curtis, Steve Alexander, Giuseppe Cirino et al. · British Journal of Pharmacology | 9 Mar 2018 | 1,369 |
| 39 | Validation of new methods Frank T. Peters, Olaf H. Drummer, Frank Mußhoff · Forensic Science International | 19 Jun 2006 | 1,346 |
| 40 | Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations Marc Fisher, Giora Feuerstein, David William Howells et al. · Stroke | 26 Feb 2009 | 1,344 |
| 41 | Histopathology in fish: proposal for a protocol to assess aquatic pollution Daniel Benjamin Bernet, H. Schmidt, Willy E. Meier et al. · Journal of Fish Diseases | 1999 | 1,339 |
| 42 | Design and analysis of ecological experiments Stuart H. Hurlbert · Trends in Ecology & Evolution | Dec 1994 | 1,323 |
| 43 | Policy: NIH plans to enhance reproducibility Francis S. Collins, Lawrence A. Tabak · Nature | 24 Jan 2014 | 1,289 |
| 44 | Toxicity testing in the 21st century: A vision and a strategy Steven Gibb · Reproductive Toxicology | 14 Nov 2007 | 1,266 |
| 45 | A call for transparent reporting to optimize the predictive value of preclinical research Story C. Landis et al. · Nature | Oct 2012 | 1,229 |
| 46 | ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020 Elliot J. Lilley, S. Clare Stanford, David Kendall et al. · British Journal of Pharmacology | 14 Jul 2020 | 1,201 |
| 47 | Clarifying Tissue Clearing Douglas S. Richardson, Jeff William Lichtman · Cell | Jul 2015 | 1,183 |
| 48 | An Extensive New Literature Concerning Low-Dose Effects of Bisphenol A Shows the Need for a New Risk Assessment Frederick S. vom Saal, Claude L. Hughes · Environmental Health Perspectives | 12 Apr 2005 | 1,175 |
| 49 | Assessing nest building in mice Robert M. J. Deacon · Nature Protocols | Aug 2006 | 1,158 |
| 50 | SEROTYPING FOR HOMOTRANSPLANTATION XVIII. REFINEMENT OF MICRODROPLET LYMPHOCYTE CYTOTOXICITY TEST Ketan Mittal, M. R. Mickey, Dharam P. Singal et al. · Transplantation | Nov 1968 | 1,145 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.