Topic · Biomarkers in Disease Mechanisms
Most cited papers in Biomarkers in Disease Mechanisms
What are the most cited papers in Biomarkers in Disease Mechanisms?
The most cited paper in Biomarkers in Disease Mechanisms is "Origin and physiological roles of inflammation" (Ruslan M. Medzhitov, 2008), with 6,592 citations. Next come "Inflammatory responses and inflammation-associated diseases in organs" (5,185) and "Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis" (3,528).
Showing 50 of 100 papers. Every paper with more than 506 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Origin and physiological roles of inflammation Ruslan M. Medzhitov · Nature | Jul 2008 | 6,592 |
| 2 | Inflammatory responses and inflammation-associated diseases in organs Linlin Chen, Huidan Deng, Hengmin Cui et al. · Oncotarget | 14 Dec 2017 | 5,185 |
| 3 | Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis Michael A. Gimbrone, Guillermo García‐Cardeña · Circulation Research | 18 Feb 2016 | 3,528 |
| 4 | A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases Rebecca C. Coll et al. · Nature Medicine | 16 Feb 2015 | 2,894 |
| 5 | Colchicine in Patients with Chronic Coronary Disease Stefan Mark Nidorf et al. · New England Journal of Medicine | 31 Aug 2020 | 2,252 |
| 6 | IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin Elizabeta Nemeth, Seth Rivera, Victoria R. Gabayan et al. · Journal of Clinical Investigation | May 2004 | 2,174 |
| 7 | Obesity and inflammation: the linking mechanism and the complications Mohammed S. Ellulu, Ismail Patimah, Huzwah Khaza’ai et al. · Archives of Medical Science | 20 May 2016 | 1,999 |
| 8 | Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women Paul M. Ridker, Julie E. Buring, Nader Rifai et al. · JAMA | 13 Feb 2007 | 1,815 |
| 9 | Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway Noriyuki Bob Ouchi, Shinji Kihara, Yukio Arita et al. · Circulation | 12 Sep 2000 | 1,743 |
| 10 | Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China. Qiao-Wei Jia, Zhao-Hong Chen, Xiao-Qing Ding et al. · PubMed | 2017 | 1,682 |
| 11 | The Vascular Endothelium and Human Diseases Peramaiyan Rajendran, Thamaraiselvan Rengarajan, Jayakumar Thangavel et al. · International Journal of Biological Sciences | 2013 | 1,486 |
| 12 | Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes Anna Zampetaki, Stefan Julia Kiechl, Ignat A. Drozdov et al. · Circulation Research | 23 Jul 2010 | 1,474 |
| 13 | Cellular and molecular mechanisms of renal fibrosis Youhua Liu · Nature Reviews Nephrology | 18 Oct 2011 | 1,464 |
| 14 | Atherosclerosis is an inflammatory disease Russell Ross · American Heart Journal | Nov 1999 | 1,455 |
| 15 | Worldwide Increasing Incidence of Thyroid Cancer: Update on Epidemiology and Risk Factors Gabriella Pellegriti, Francesco Frasca, Concetto Regalbuto et al. · Journal of Cancer Epidemiology | 2013 | 1,307 |
| 16 | Circulating MicroRNAs in Patients With Coronary Artery Disease Stephan Fichtlscherer, Salvatore De Rosa, Henrik Fox et al. · Circulation Research | Jul 2010 | 1,250 |
| 17 | From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis Stavros C. Manolagas · Endocrine Reviews | Jun 2010 | 1,212 |
| 18 | Endothelial Dysfunction Dierk Endemann, Ernesto L. Schiffrin · Journal of the American Society of Nephrology | Aug 2004 | 1,195 |
| 19 | Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans Guokun Wang, Jiaqi Zhu, Juntao Zhang et al. · European Heart Journal | 16 Feb 2010 | 1,192 |
| 20 | Inflammation and atherosclerosis: signaling pathways and therapeutic intervention Peng Kong, Ziyang Cui, Xiao-Fu Huang et al. · Signal Transduction and Targeted Therapy | 22 Apr 2022 | 1,168 |
| 21 | Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin Wei‐Shiung Yang, Wei-Jei Lee, Tohru Funahashi et al. · The Journal of Clinical Endocrinology & Metabolism | Aug 2001 | 1,154 |
| 22 | Pyroptosis: A new frontier in cancer Yuan Fang, Shengwang Tian, Yutian Pan et al. · Biomedicine & Pharmacotherapy | 8 Nov 2019 | 1,140 |
| 23 | Adiponectin and protection against type 2 diabetes mellitus Joachim Spranger, Anja Kroke, Matthias Möhlig et al. · The Lancet | 2003 | 1,130 |
| 24 | Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness Andrew L. Durham, Mei Y. Speer, Marta Scatena et al. · Cardiovascular Research | 15 Feb 2018 | 1,110 |
| 25 | Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis Masabumi Shibuya, Lena Claesson‐Welsh · Experimental Cell Research | 6 Dec 2005 | 1,063 |
| 26 | Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease Stefan Mark Nidorf, John W. Eikelboom, Charley Ann Budgeon et al. · Journal of the American College of Cardiology | 19 Dec 2012 | 1,059 |
| 27 | Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism Paul B. Yu, Charles C. Hong, Chetana Sachidanandan et al. · Nature Chemical Biology | 18 Nov 2007 | 1,056 |
| 28 | Multipotent mesenchymal stromal cells and the innate immune system Katarina Le Blanc, Dimitrios Mougiakakos · Nature reviews. Immunology | 25 Apr 2012 | 1,039 |
| 29 | The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein Diana M. Steel, Alexander S. Whitehead · Immunology Today | Feb 1994 | 1,036 |
| 30 | Pathophysiology of Atherosclerosis Shifa Jebari‐Benslaiman, Unai Galicia-García, Asier Larrea Sebal et al. · International Journal of Molecular Sciences | 20 Mar 2022 | 1,000 |
| 31 | Interleukin-6 induces hepcidin expression through STAT3 Diedra M. Wrighting, Nancy C. Andrews · Blood | 12 Jul 2006 | 985 |
| 32 | Which White Blood Cell Subtypes Predict Increased Cardiovascular Risk? Benjamin Davies Horne, Jeffrey L. Anderson, Jerry M. John et al. · Journal of the American College of Cardiology | 26 Apr 2005 | 980 |
| 33 | The role of IL-6 and STAT3 in inflammation and cancer David R. Hodge, Elaine M. Hurt, William L. Farrar · European Journal of Cancer | 3 Oct 2005 | 974 |
| 34 | Biomarkers associated with COVID-19 disease progression Giovanni Ponti, Monia Maccaferri, Cristel Ruini et al. · Critical Reviews in Clinical Laboratory Sciences | 5 Jun 2020 | 940 |
| 35 | Inflammatory mediators in the elderly Karen S. Krabbe, Maria Pedersen, Helle Brüünsgaard · Experimental Gerontology | 21 Feb 2004 | 938 |
| 36 | Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures Pratyaksha Wirapati, Christos P. Sotiriou, Susanne Kunkel et al. · Breast Cancer Research | 28 Jul 2008 | 899 |
| 37 | Adiponectin as an anti-inflammatory factor Noriyuki Bob Ouchi, Kenneth Walsh · Clinica Chimica Acta | 5 Feb 2007 | 878 |
| 38 | Osteoblast–osteoclast interactions Xiao Chen, Zhongqiu Wang, Na Duan et al. · Connective Tissue Research | 8 Feb 2017 | 876 |
| 39 | The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells Yi-Hong Hsin, Chunfeng Chen, Shing Huang et al. · Toxicology Letters | 5 May 2008 | 874 |
| 40 | Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue Noriyuki Bob Ouchi, Shinji Kihara, Tohru Funahashi et al. · Circulation | 11 Feb 2003 | 854 |
| 41 | Inflammatory Markers and Risk of Type 2 Diabetes Xia Wang, Wei Bao, Jun Liu et al. · Diabetes Care | 11 Dec 2012 | 842 |
| 42 | Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube Atsuya Takagi, Akihiko Hirose, Tetsuji Nishimura et al. · The Journal of Toxicological Sciences | 2008 | 837 |
| 43 | PENTRAXINS AT THE CROSSROADS BETWEEN INNATE IMMUNITY, INFLAMMATION, MATRIX DEPOSITION, AND FEMALE FERTILITY Cecília Garlanda, Barbara Bottazzi, Antonio Bastone et al. · Annual Review of Immunology | 12 Nov 2004 | 835 |
| 44 | Circulating microRNAs are new and sensitive biomarkers of myocardial infarction Yuri D’Alessandra, Paolo Devanna, Federica Limana et al. · European Heart Journal | 9 Jun 2010 | 818 |
| 45 | Role of Adiponectin in Preventing Vascular Stenosis Morihiro Matsuda, Iichiro Shimomura, Masataka Sata et al. · Journal of Biological Chemistry | 27 Sep 2002 | 817 |
| 46 | Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis Amanda C. Doran, Nahum Meller, Coleen A. McNamara · Arteriosclerosis Thrombosis and Vascular Biology | 14 Feb 2008 | 813 |
| 47 | Lung adenocarcinoma promotion by air pollutants William D. Hill et al. · Nature | 5 Apr 2023 | 809 |
| 48 | Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Guijuan Cheng, Howard M. Loree, Roger Dale Kamm et al. · Circulation | Apr 1993 | 796 |
| 49 | Osteoclast–osteoblast communication Koichi Matsuo, Naoko Irie · Archives of Biochemistry and Biophysics | 31 Mar 2008 | 790 |
| 50 | Coronary Risk Stratification, Discrimination, and Reclassification Improvement Based on Quantification of Subclinical Coronary Atherosclerosis Raimund Erbel, Stefan Möhlenkamp, Susanne Moebus et al. · Journal of the American College of Cardiology | Oct 2010 | 772 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.