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Most cited papers in Biomedical and Chemical Research

What are the most cited papers in Biomedical and Chemical Research?

The most cited paper in Biomedical and Chemical Research is "The cytoarchitectonic organization of the spinal cord in the cat" (Bror Rexed, 1952), with 1,630 citations. Next come "‘Zur Lehre von der Wirkung der Salze’ (about the science of the effect of salts): Franz Hofmeister's historical papers" (1,125) and "Clinical practice guideline on diagnosis and treatment of hyponatraemia" (1,025).

Showing 50 of 99 papers. Every paper with more than 166 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The cytoarchitectonic organization of the spinal cord in the cat Bror Rexed · The Journal of Comparative Neurology Jun 1952 1,630
2 ‘Zur Lehre von der Wirkung der Salze’ (about the science of the effect of salts): Franz Hofmeister's historical papers Werner Kunz, Jane Henle, Barry William Ninham · Current Opinion in Colloid & Interface Science 22 Jun 2004 1,125
3 Clinical practice guideline on diagnosis and treatment of hyponatraemia Goce B. Spasovski, Raymond Camille Vanholder, Bruno Allolio et al. · Intensive Care Medicine 21 Feb 2014 1,025
4 Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications Stephen M. Stahl Mar 2008 894
5 Hypernatremia Horacio J. Adrogué, Nicolaos E. Madias · New England Journal of Medicine 18 May 2000 891
6 Proposed supplements and amendments to ‘A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects’, the Rechtschaffen & Kales (1968) standard Tadao Hori, Yoshio Sugita, Einosuke Koga et al. · Psychiatry and Clinical Neurosciences Jun 2001 807
7 Abdominal field block: a new approach via the lumbar triangle Aisha Rafi · Anaesthesia Oct 2001 693
8 An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle Jay P. Shah, Terry M. Phillips, JEROME V. DANOFF et al. · Journal of Applied Physiology 21 Jul 2005 671
9 Hyponatremia: A Prospective Analysis of Its Epidemiology and the Pathogenetic Role of Vasopressin Robert J. Anderson, HSIAO-MIN CHUNG, RUDIGER KLUGE et al. · Annals of Internal Medicine Feb 1985 668
10 Assessment of cardiac output from systemic arterial pressure in humans Salvatore Mario Romano, Massimo Pistolesi · Critical Care Medicine Aug 2002 617
11 Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations Joseph George Verbalis, Stephen R. Goldsmith, Arthur Greenberg et al. · The American Journal of Medicine Nov 2007 614
12 Incidence of immediate allergy to latex gloves in hospital personnel Kristiina Turjanmaa · Contact Dermatitis Nov 1987 562
13 A Remark on Stirling’s Formula Herbert E. Robbins Book chapter 1985 543
14 Central pontine and extrapontine myelinolysis: the osmotic demyelination syndromes Ruvie Martin · Journal of Neurology Neurosurgery & Psychiatry Open access 16 Aug 2004 516
15 Severe Symptomatic Hyponatremia: Treatment and Outcome Richard H. Sterns · Annals of Internal Medicine Nov 1987 499
16 The Thermal Grill Illusion: Unmasking the Burn of Cold Pain A. D. Craig, M. Catherine Bushnell · Science 8 Jul 1994 498
17 Über quantentheoretische Umdeutung kinematischer und mechanischer Beziehungen W. Heisenberg Book chapter 1985 484
18 Trigger points: diagnosis and management. David J. Alvarez, Pamela G Rockwell · PubMed 15 Feb 2002 475
19 Acute compartment syndromes: diagnosis and treatment with the aid of the wick catheter. Scott J. Mubarak, C.A. Owen, Alan R. Hargens et al. · PubMed Dec 1978 464
20 Über die Sauerstoffversorgung des Gehirns und den Mechanismus von Mangelwirkungen Erich Opitz, Max Schneider · Reviews of physiology, biochemistry and pharmacology Dec 1950 463
21 A theory of drug action based on the rate of drug-receptor combination William Drummond Macdonald Paton · Proceedings of the Royal Society B Biological Sciences 18 Apr 1961 437
22 Hyponatremia-induced osteoporosis Joseph George Verbalis, Joseph George Verbalis, Julianna Barsony et al. · Journal of Bone and Mineral Research Open access 14 Sep 2009 426
23 Neurologic sequelae after treatment of severe hyponatremia Richard H. Sterns, Joseph D. Cappuccio, Stephen M. Silver et al. · Journal of the American Society of Nephrology Feb 1994 402
24 Somatotroph Hyperplasia Michael O. Thorner, RICHARD L. PERRYMAN, M. J. Cronin et al. · Journal of Clinical Investigation Open access Nov 1982 394
25 J.B. Wolffe memorial lecture. Neural control of the circulation during exercise. Jere H. Mitchell · PubMed Apr 1990 382
26 Local Anaesthesia—Early Spinal Anaesthesia Christine M Ball, Rod N. Westhorpe · Anaesthesia and Intensive Care Open access Oct 2003 378
27 Nause and vomiting in pregnancy Denys V. I. Fairweather · American Journal of Obstetrics and Gynecology Sep 1968 370
28 Zur Darstellungstheorie der inhomogenen Lorentzgruppe als Grundlage quantenmechanischer Kinematik Hans Ludwig Joos · Fortschritte der Physik 1962 368
29 Oral Tolvaptan Is Safe and Effective in Chronic Hyponatremia Tomás Berl, Friederike Quittnat-Pelletier, Joseph George Verbalis et al. · Journal of the American Society of Nephrology Open access 25 Feb 2010 352
30 Clinical Pharmacokinetics of H1-Receptor Antagonists (The Antihistamines) David M. Paton, DIANNE R. WEBSTER · Clinical Pharmacokinetics 1985 337
31 Rapid Correction of Hyponatremia Causes Demyelination: Relation to Central Pontine Myelinolysis Bette Kay Kleinschmidt-DeMasters, Michael D. Norenberg · Science 6 Mar 1981 331
32 Experimental Hypertension Produced by a Plastic Capsule Applied to the Kidney G. Carl Rau · Science 3 Mar 1950 326
33 Intra-abdominal pressure mechanism for stabilizing the lumbar spine Jacek Cholewicki, Krishna Juluru, Stuart M. McGill · Journal of Biomechanics Open access 1999 318
34 Double-Incision Fasciotomy of the Leg for Decompression in Compartment Syndromes Scott J. Mubarak, Charles A. Owen · Journal of Bone and Joint Surgery Mar 1977 315
35 Association between rise in serum sodium and central pontine myelinolysis Michael D. Norenberg, Kevin Orr Leslie, Andrew S Robertson · Annals of Neurology Feb 1982 313
36 Central Pontine Myelinolysis Christian Lampl, Kambiz Yazdi · European Neurology 2002 309
37 The Treatment of Hyponatremia Richard H. Sterns, Sagar U. Nigwekar, John Kevin Hix · Seminars in Nephrology May 2009 306
38 Restraint stress in biomedical research: An update Gary B. Glavin, William P. Paré, Tone Sandbak et al. · Neuroscience & Biobehavioral Reviews Jun 1994 304
39 An experimental study of some pressure effects on tissues, with reference to the bed‐sore problem Tafazzul Husain · The Journal of Pathology and Bacteriology Oct 1953 299
40 Abdominal and thoracic pressures at different lung volumes Emilio Agostoni, Hermann Rahn · Journal of Applied Physiology Nov 1960 298
41 Prevalence of latex allergy in operating room nurses Françoise Lagier, DANIEL VERVLOET, Ide Lhermet et al. · Journal of Allergy and Clinical Immunology Sep 1992 296
42 Polydipsia and hyponatremia in psychiatric patients B P Illowsky, Darrell G. Kirch · American Journal of Psychiatry Jun 1988 291
43 Study of brain electrolytes and organic osmolytes during correction of chronic hyponatremia. Implications for the pathogenesis of central pontine myelinolysis. Yeong-Hau Howard Lien, J I Shapiro, Laurence K. Chan · Journal of Clinical Investigation Open access Jul 1991 278
44 Silicone Wristbands as Personal Passive Samplers Steven G. O’Connell, Laurel D. Kincl, Kim A. Anderson · Environmental Science & Technology Open access 18 Feb 2014 276
45 Diaphragm Strength in Chronic Obstructive Pulmonary Disease Michael Iain Polkey, D Kyroussis, C H Hamnegärd et al. · American Journal of Respiratory and Critical Care Medicine Nov 1996 265
46 Clinical Practice Guideline: Maintenance Intravenous Fluids in Children Leonard G. Feld, Daniel Robert Neuspiel, Byron Alexander Foster et al. · PEDIATRICS 26 Nov 2018 259
47 Central pontine myelinolysis following rapid correction of hyponatremia Robert Laureno · Annals of Neurology Mar 1983 252
48 Osmotic demyelination disorders: central pontine and extrapontine myelinolysis William D. Brown · Current Opinion in Neurology Dec 2000 249
49 Inorganic Phosphate Treatment of Hypercalcemia of Diverse Etiologies Ralph S. Goldsmith, Sidney H. Ingbar · New England Journal of Medicine 6 Jan 1966 246
50 A role for amines in the antidepressant effect of exercise Charles Ransford · Medicine & Science in Sports & Exercise 1982 242

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.