Topic · Biotechnology and Related Fields
Most cited papers in Biotechnology and Related Fields
What are the most cited papers in Biotechnology and Related Fields?
The most cited paper in Biotechnology and Related Fields is "Transportation Research Record" (Anne Vingaard Olesen, Erik Kjems, Kristian Hegner Reinau et al., 2016), with 11,437 citations. Next come "Magnitude and complex based diffusion signal reconstruction" (6,753) and "Can the pharmaceutical industry reduce attrition rates?" (4,181).
Showing 50 of 100 papers. Every paper with more than 330 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Transportation Research Record Anne Vingaard Olesen, Erik Kjems, Kristian Hegner Reinau et al. | 23 Jul 2016 | 11,437 |
| 2 | Magnitude and complex based diffusion signal reconstruction Marco Pizzolato, Ashis Ghosh, Timothé Boutelier et al. · HAL (Le Centre pour la Communication Scientifique Directe) | 18 Sep 2014 | 6,753 |
| 3 | Can the pharmaceutical industry reduce attrition rates? Ismail Kola, John Richard Landis · Nature Reviews Drug Discovery | 30 Jul 2004 | 4,181 |
| 4 | How to improve R&D productivity: the pharmaceutical industry's grand challenge Steven M. Paul, Daniel S. Mytelka, Christopher T. Dunwiddie et al. · Nature Reviews Drug Discovery | 19 Feb 2010 | 3,579 |
| 5 | Clinical development success rates for investigational drugs Michael Hay, David Wayne Thomas, John L. Craighead et al. · Nature Biotechnology | 2014 | 2,577 |
| 6 | Growing points in ethology Stephen J. Hutt · Animal Behaviour | Aug 1977 | 2,327 |
| 7 | NITRIC OXIDE: A Physiologic Messenger Molecule David S. Bredt, S. H. Snyder · Annual Review of Biochemistry | Jun 1994 | 2,314 |
| 8 | How were new medicines discovered? David C. Swinney, Jason Anthony · Nature Reviews Drug Discovery | 24 Jun 2011 | 1,840 |
| 9 | DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS Leroy F. Liu · Annual Review of Biochemistry | Jun 1989 | 1,804 |
| 10 | hnRNP PROTEINS AND THE BIOGENESIS OF mRNA Gideon Dreyfuss, Michael J. Matunis, Serafı́n Piñol-Roma et al. · Annual Review of Biochemistry | Jun 1993 | 1,539 |
| 11 | Paul Ehrlich's magic bullet concept: 100 years of progress Klaus Strebhardt, Axel Ullrich · Nature reviews. Cancer | 12 May 2008 | 1,443 |
| 12 | National Center for Biotechnology Information Axel M. Gressner, Torsten Arndt · Springer Reference Medizin | 2019 | 1,414 |
| 13 | American Society of Agricultural Engineers Status changed from an Associated to an Affiliated Society, AAAS Ralph A. Palmer · Science | 4 Dec 1953 | 1,354 |
| 14 | Lessons from 60 years of pharmaceutical innovation Bernard H. Munos · Nature Reviews Drug Discovery | Dec 2009 | 1,225 |
| 15 | BIOCHEMISTRY OF ENDOTOXINS Christian R.H. Raetz · Annual Review of Biochemistry | Jun 1990 | 1,210 |
| 16 | World Journal of Microbiology and Biotechnology 2008 Lynn G. Dover, Peter J. Large, Nasib Qureshi et al. · World Journal of Microbiology and Biotechnology | 14 Jul 2008 | 1,132 |
| 17 | TRANSLATIONAL CONTROL IN MAMMALIAN CELLS John W.B. Hershey · Annual Review of Biochemistry | Jun 1991 | 1,037 |
| 18 | Biochemical Properties of Hormone-Sensitive Adenylate Cyclase Elliott M. Ross, Alfred G. Gilman · Annual Review of Biochemistry | Jun 1980 | 1,016 |
| 19 | Complementarity and external linkages: the strategies of large firms in biotechnology Alfonso Gambardella · Science and Innovation | 9 Mar 1995 | 991 |
| 20 | The Natural History of Lone Atrial Fibrillation Stephen Louis Kopecky, Bernard John Gersh, Michael D. McGoon et al. · New England Journal of Medicine | 10 Sep 1987 | 938 |
| 21 | Tuberculosis control and elimination 2010–50: cure, care, and social development Knut Lönnroth, Kenneth G. Castro, Jeremiah Muhwa Chakaya et al. · The Lancet | May 2010 | 926 |
| 22 | The productivity crisis in pharmaceutical R&D Fabio Pammolli, Laura Magazzini, Massimo Riccaboni · Nature Reviews Drug Discovery | Jun 2011 | 921 |
| 23 | Drug development for neglected diseases: a deficient market and a public-health policy failure Patrice Trouiller, Piero Olliaro, Els Torreele et al. · The Lancet | Jun 2002 | 903 |
| 24 | DNA Repair Enzymes Tomas L. Lindahl · Annual Review of Biochemistry | Jun 1982 | 903 |
| 25 | Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Stanley J. Korsmeyer, John R. Shutter, Deborah J. Veis et al. · PubMed | Dec 1993 | 874 |
| 26 | Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs Joseph A. DiMasi, Laurent J. Feldman, A Seckler et al. · Clinical Pharmacology & Therapeutics | 3 Feb 2010 | 856 |
| 27 | BIOCHEMISTRY OF PEROXISOMES Henk van den Bosch, Ruud B. H. Schutgens, Ronald J. A. Wanders et al. · Annual Review of Biochemistry | Jun 1992 | 837 |
| 28 | Cancer--A Biological Approach: I. The Processes Of Control. II. The Significance of Somatic Mutation Michael W. M. Burnet · BMJ | 6 Apr 1957 | 809 |
| 29 | What Is the Bioeconomy? A Review of the Literature Markus M. Bugge, Teis Hansen, Antje Klitkou · Sustainability | 19 Jul 2016 | 761 |
| 30 | The market economy, and the scientific commons Richard R. Nelson · Research Policy | 5 Dec 2003 | 753 |
| 31 | RNA POLYMERASE II Richard A. Young · Annual Review of Biochemistry | Jun 1991 | 731 |
| 32 | TRANSCRIPTION BY RNA POLYMERASE III E. Peter Geiduschek, Glauco P. Tocchini‐Valentini · Annual Review of Biochemistry | Jun 1988 | 709 |
| 33 | Science and technology roadmaps Ronald Neil Kostoff, Ross Schaller · IEEE Transactions on Engineering Management | May 2001 | 693 |
| 34 | Developments in Biological Standardization Elizabeth Miller · Journal of Epidemiology & Community Health | Feb 1993 | 684 |
| 35 | The odyssey of marine pharmaceuticals: a current pipeline perspective Alejandro M. S. Mayer, Keith B. Glaser, Carmen Cuevas et al. · Trends in Pharmacological Sciences | 6 Apr 2010 | 669 |
| 36 | Genomic and personalized medicine: foundations and applications Geoffrey S. Ginsburg, Huntington F. Willard · Translational research | 2 Oct 2009 | 641 |
| 37 | Challenge of portable power Bruno Scrosati · Nature | Feb 1995 | 618 |
| 38 | The JAM test A simple assay for DNA fragmentation and cell death Polly Matzinger · Journal of Immunological Methods | Dec 1991 | 613 |
| 39 | Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective Surovi Saikia, Manobjyoti Bordoloi · Current Drug Targets | 25 Oct 2018 | 583 |
| 40 | CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY Kenneth Allen Johnson · Annual Review of Biochemistry | Jun 1993 | 567 |
| 41 | Human gene therapy W. French Anderson · Science | 8 May 1992 | 562 |
| 42 | TELOMERASES Elizabeth Helen Blackburn · Annual Review of Biochemistry | Jun 1992 | 542 |
| 43 | The governance of innovation: Vertical integration and collaborative arrangements in the biotechnology industry Gary Paul Pisano · Research Policy | Jun 1991 | 542 |
| 44 | EUKARYOTIC PROTEIN SYNTHESIS Kivie Moldave · Annual Review of Biochemistry | Jun 1985 | 541 |
| 45 | ENERGY TRANSDUCTION BY CYTOCHROME COMPLEXES IN MITOCHONDRIAL AND BACTERIAL RESPIRATION: The Enzymology of Coupling Electron Transfer Reactions to Transmembrane Proton Translocation Bernard L. Trumpower, Robert B. Gennis · Annual Review of Biochemistry | Jun 1994 | 537 |
| 46 | ICOSAHEDRAL RNA VIRUS STRUCTURE Michael George Rossmann, John Emil Johnson · Annual Review of Biochemistry | Jun 1989 | 537 |
| 47 | The discovery of first-in-class drugs: origins and evolution Jörg Eder, Richard C. Sedrani, Christian Wiesmann · Nature Reviews Drug Discovery | 18 Jul 2014 | 516 |
| 48 | Weapons of math destruction Thomas S. Woodson · Journal of Responsible Innovation | Aug 2018 | 514 |
| 49 | Adopt a moratorium on heritable genome editing Eric S. Lander, Françoise Βaylis, Feng Zhang et al. · Nature | 13 Mar 2019 | 511 |
| 50 | CHEMICAL SYNTHESIS OF PEPTIDES AND PROTEINS Stephen B. H. Kent · Annual Review of Biochemistry | Jun 1988 | 508 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.