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Most cited papers in Cancer and biochemical research

What are the most cited papers in Cancer and biochemical research?

The most cited paper in Cancer and biochemical research is "PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT" (OliverH. Lowry, NiraJ. Rosebrough, A. Lewis Farr et al., 1951), with 319,095 citations. Next come "CYTOCHEMISTRY AND ELECTRON MICROSCOPY" (4,109) and "The 2001 Bethesda System Terminology for Reporting Results of Cervical Cytology" (3,150).

Showing 50 of 100 papers. Every paper with more than 317 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT OliverH. Lowry, NiraJ. Rosebrough, A. Lewis Farr et al. · Journal of Biological Chemistry Open access Nov 1951 319,095
2 CYTOCHEMISTRY AND ELECTRON MICROSCOPY David D. Sabatini, Klaus G. Bensch, Russell J. Barrnett · The Journal of Cell Biology Open access Apr 1963 4,109
3 The 2001 Bethesda System Terminology for Reporting Results of Cervical Cytology Diane Solomon · JAMA 24 Apr 2002 3,150
4 A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress Daniele Del Rio, Amanda Janis Stewart, Nicoletta Pellegrini · Nutrition Metabolism and Cardiovascular Diseases 29 Jul 2005 2,741
5 Diamagnetic Corrections and Pascal's Constants Gordon A. Bain, John F. Berry · Journal of Chemical Education Apr 2008 2,739
6 Archives of Biochemistry and Biophysics Herbert E. Carter, Pushpak Bhattacharyya, Katharine R. Weidman et al. · Nutrition Reviews 27 Apr 2009 1,907
7 ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS Judah Folkman, Ezio Merler, Charles M. Abernathy et al. · The Journal of Experimental Medicine Open access Feb 1971 1,672
8 MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS Joseph P. Hendrick, F. Ulrich Hartl · Annual Review of Biochemistry Jun 1993 1,604
9 Prevalence of Monoclonal Gammopathy of Undetermined Significance Robert A. Kyle, Terry M. Therneau, S. Vincent Rajkumar et al. · New England Journal of Medicine Open access 29 Mar 2006 1,434
10 Molecular systematics Svante Pääbo · Trends in Genetics Aug 1991 1,387
11 OPM: Orientations of Proteins in Membranes database Mikhail A. Lomize, Andrei L. Lomize, Irina D. Pogozheva et al. · Bioinformatics Open access 5 Jan 2006 1,214
12 Comprehensive medicinal chemistry Hendrik Timmerman, Aalt Bast, Henk Van der Goot et al. · Trends in Pharmacological Sciences 1991 1,168
13 Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2012 Kyu‐Won Jung, Young‐Joo Won, Hyun-Joo Kong et al. · Cancer Research and Treatment Open access 3 Mar 2015 1,167
14 Accuracy of the Papanicolaou Test in Screening for and Follow-up of Cervical Cytologic Abnormalities Kavita Nanda, Douglas C McCrory, Evan R. Myers et al. · Annals of Internal Medicine 16 May 2000 1,107
15 The International Neuroblastoma Pathology Classification (the Shimada system) Hiroyuki Shimada, Inge M. Ambros, Louis P. Dehner et al. · Cancer 15 Jul 1999 1,042
16 THE CYTOCHEMICAL STAINING AND MEASUREMENT OF PROTEIN WITH MERCURIC BROMPHENOL BLUE Daniel Mazia, PHILIP A. BREWER, Max Alfert · Biological Bulletin Open access Feb 1953 1,038
17 Diagnosis and Management of Multiple Myeloma Andrew J. Cowan, Damian J. Green, Mary Kwok et al. · JAMA Feb 2022 1,033
18 Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma Sagar Lonial, Susanna Joan Jacobus, RAFAEL RICARDO AURELIANO DA FONSECA et al. · Journal of Clinical Oncology Open access 25 Oct 2019 909
19 Radical Lymph Node Dissection for Cancer of the Thoracic Esophagus Hiroshi Akiyama, Masahiko Tsurumaru, Harushi Udagawa et al. · Annals of Surgery Open access Sep 1994 907
20 SELF-SPLICING OF GROUP I INTRONS Thomas R. Cech · Annual Review of Biochemistry Jun 1990 878
21 Plantas medicinais: a necessidade de estudos multidisciplinares Maria Aparecida Medeiros Maciel, Angelo Cunha Pinto, Valdir Florêncio da Veiga et al. · Química Nova Open access May 2002 868
22 Annual Review of Cell and Developmental Biology 2001 Alvin G. Telser · Shock Sep 2002 853
23 Curative resection is the single most important factor determining outcome in patients with pancreatic adenocarcinoma Markus Wagner, C. Redaelli, Michael Lietz et al. · British journal of surgery Open access 22 Mar 2004 852
24 Chance and Necessity Jacques Monod, Alfred A. Knopf, A. S. Iberall et al. · Journal of Dynamic Systems Measurement and Control Mar 1973 835
25 Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study Michèle Cavo et al. · The Lancet Dec 2010 825
26 A Modified Staining Technique for Carbonates in Thin Section J. A. D. Dickson · Nature 6 Feb 1965 807
27 Impact of Mutational Testing on the Diagnosis and Management of Patients with Cytologically Indeterminate Thyroid Nodules: A Prospective Analysis of 1056 FNA Samples Yuri E. Nikiforov, N. Paul Ohori, Steven P. Hodak et al. · The Journal of Clinical Endocrinology & Metabolism Open access Sep 2011 792
28 Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin Mary Ann Jordan · Anti-Cancer Agents in Medicinal Chemistry 25 Mar 2005 781
29 Dual AO/EB Staining to Detect Apoptosis in Osteosarcoma Cells Compared with Flow Cytometry Kuan Liu, Pengcheng Liu, Liu R et al. · Medical science monitor basic research/Medical science monitor. Basic research Open access 9 Feb 2015 777
30 E-CELL: software environment for whole-cell simulation. Masaru Tomita, Kazuaki Hashimoto, Kazutoshi Takahashi et al. · Bioinformatics 1999 772
31 Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. I Magnusson, Douglas L. Rothman, Lee D. Katz et al. · Journal of Clinical Investigation Open access Oct 1992 768
32 THE RETICULAR FORMATION REVISITED I. CALMA. M.D. Milan. · Developmental Medicine & Child Neurology Jun 1959 743
33 Human cytomegalovirus infection and expression in human malignant glioma. Charles Cobbs, Lualhati E. Harkins, Minu Samanta et al. · PubMed 15 Jun 2002 721
34 Molecular Testing for Mutations in Improving the Fine-Needle Aspiration Diagnosis of Thyroid Nodules Yuri E. Nikiforov, David L. Steward, Toni M. Robinson-Smith et al. · The Journal of Clinical Endocrinology & Metabolism 24 Mar 2009 718
35 Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Ralf Gold, Mascha C. Schmied, Gerhard Giegerich et al. · PubMed Aug 1994 685
36 Fine-needle aspiration of thyroid nodules: A study of 4703 patients with histologic and clinical correlations Jack Z. Yang, Vicki J. Schnadig, Roberto Logroño et al. · Cancer Open access 6 Aug 2007 683
37 bcl-2 Protein in Non-Small-Cell Lung Carcinoma Francesco Pezzella, Helen Turley, Işınsu Kuzu et al. · New England Journal of Medicine Open access 2 Sep 1993 677
38 The Chemical Kinetics of Enzyme Action Claude A. Villee, Keith J. Laidler · AIBS Bulletin 1959 643
39 Molecular Biology of Neuroblastoma John M. Maris, Katherine K. Matthay · Journal of Clinical Oncology Jul 1999 643
40 Natural History of Dysplasia of the Uterine Cervix Philippa H. Holowaty, A. B. Miller, Thomas E. Rohan et al. · JNCI Journal of the National Cancer Institute 3 Feb 1999 617
41 Identifying Women With Cervical Neoplasia M. Michele Manos, Walter Kinney, Leo Bartemeier Hurley et al. · JAMA 5 May 1999 585
42 Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee. Hiroyuki Shimada, I.M. Ambros, Louis P. Dehner et al. · PubMed 15 Jul 1999 576
43 Biochemistry (4th edn) David S. Latchman · Trends in Biochemical Sciences Nov 1995 571
44 Extramedullary plasmacytoma Christoph Alexiou, Reinhardt J. Kau, Hermann Dietzfelbinger et al. · Cancer Open access Jun 1999 571
45 International Union Against Cancer. Classification of isolated tumor cells and micrometastasis. Paul Hermanek, Robert V. P. Hutter, Leslie H. Sobin et al. · PubMed 15 Dec 1999 551
46 Combinatorial generation of variable fusion proteins in the Ewing family of tumours. Jessica Zucman‐Rossi, Thomas Melot, Chantal Desmaze et al. · The EMBO Journal Open access Dec 1993 541
47 Biochemistry of the Amino Acids Kendall Willard. King, Alton Meister · AIBS Bulletin Nov 1957 538
48 Computerized Quantitation of Synergism and Antagonism of Taxol, Topotecan, and Cisplatin Against Human Teratocarcinoma Cell Growth: a Rational Approach to Clinical Protocol Design Ting‐Chao Chou, Robert John Motzer, Yanli Tong et al. · JNCI Journal of the National Cancer Institute 19 Oct 1994 528
49 Combination Therapy With Thalidomide Plus Dexamethasone for Newly Diagnosed Myeloma S. Vincent Rajkumar, Suzanne R. Hayman, Morie Abraham Gertz et al. · Journal of Clinical Oncology 30 Oct 2002 518
50 Differential Expression of Proliferation-Associated Molecules in Individual Micrometastatic Carcinoma Cells Klaus Pantel, Günter Schlimok, Stephan Braun et al. · JNCI Journal of the National Cancer Institute Sep 1993 516

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.