Most cited papers in Cancer-related Molecular Pathways
What are the most cited papers in Cancer-related Molecular Pathways?
The most cited paper in Cancer-related Molecular Pathways is "Hallmarks of Cancer: The Next Generation" (Douglas Hanahan, Robert A. Weinberg, 2011), with 67,836 citations. Next come "The Hallmarks of Cancer" (28,893) and "Stem cells, cancer, and cancer stem cells" (9,797).
Showing 50 of 100 papers. Every paper with more than 2,294 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Hallmarks of Cancer: The Next Generation Douglas Hanahan, Robert A. Weinberg · Cell | Mar 2011 | 67,836 |
| 2 | The Hallmarks of Cancer Douglas Hanahan, Robert A. Weinberg · Cell | 2000 | 28,893 |
| 3 | Stem cells, cancer, and cancer stem cells Tannishtha Reya, Sean J. Morrison, Michael F. Clarke et al. · Nature | Nov 2001 | 9,797 |
| 4 | THE UBIQUITIN SYSTEM Avram Hershko, Aaron J. Ciechanover · Annual Review of Biochemistry | Jun 1998 | 8,852 |
| 5 | WAF1, a potential mediator of p53 tumor suppression Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell | Nov 1993 | 8,417 |
| 6 | p53 Mutations in Human Cancers Monica C. Hollstein, David Sidransky, Bert Vogelstein et al. · Science | 5 Jul 1991 | 8,130 |
| 7 | p53, the Cellular Gatekeeper for Growth and Division Arnold J. Levine · Cell | Feb 1997 | 7,766 |
| 8 | Surfing the p53 network Bert Vogelstein, David Philip Lane, Arnold J. Levine · Nature | Nov 2000 | 6,649 |
| 9 | CDK inhibitors: positive and negative regulators of G1-phase progression Charles J. Sherr, Joanna Roberts · Genes & Development | 15 Jun 1999 | 6,153 |
| 10 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases J. Wade Harper · Cell | 19 Nov 1993 | 5,700 |
| 11 | Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer Manabu Soda, Young Lim Choi, Munehiro Enomoto et al. · Nature | 11 Jul 2007 | 5,494 |
| 12 | Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis Hashem B. El‐Serag, K. Lenhard Rudolph · Gastroenterology | Jun 2007 | 5,483 |
| 13 | Cancer Cell Cycles Charles J. Sherr · Science | 6 Dec 1996 | 5,411 |
| 14 | The Bcl-2 Protein Family: Arbiters of Cell Survival Jerry M. Adams, Suzanne Cory · Science | 28 Aug 1998 | 5,380 |
| 15 | p53, guardian of the genome David Philip Lane · Nature | Jul 1992 | 5,171 |
| 16 | Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell | Mar 1997 | 5,154 |
| 17 | The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains Steven K. Hanks, Anne Marie Quinn, Tony R. Hunter · Science | Jul 1988 | 5,150 |
| 18 | The retinoblastoma protein and cell cycle control Robert A. Weinberg · Cell | May 1995 | 4,913 |
| 19 | In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 Lyubomir T. Vassilev, Binh Thanh Vu, Bradford J. Graves et al. · Science | 5 Jan 2004 | 4,741 |
| 20 | The Ki-67 protein: From the known and the unknown Thomas E. Scholzen, Johannes Gerdes · Journal of Cellular Physiology | Mar 2000 | 4,716 |
| 21 | Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature | Mar 1992 | 4,702 |
| 22 | Mdm2 promotes the rapid degradation of p53 Ygal Haupt, Ruth Ben-Yakar Maya, Anat Kazaz et al. · Nature | May 1997 | 4,575 |
| 23 | Cancer genes and the pathways they control Bert Vogelstein, Kenneth W. Kinzler · Nature Medicine | 30 Jul 2004 | 4,303 |
| 24 | Comprehensive genomic characterization of head and neck squamous cell carcinomas The Cancer Genome Atlas Network · Nature | 27 Jan 2015 | 4,183 |
| 25 | New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer Anushka Dongre, Robert A. Weinberg · Nature Reviews Molecular Cell Biology | 20 Nov 2018 | 4,104 |
| 26 | Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Toshiyuki Miyashita, John C. Reed · Cell | 1995 | 4,079 |
| 27 | Papillomaviruses and cancer: from basic studies to clinical application Harald zur Hausen · Nature reviews. Cancer | May 2002 | 4,062 |
| 28 | The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell | Dec 1990 | 4,034 |
| 29 | The Bcl2 family: regulators of the cellular life-or-death switch Suzanne Cory, Jerry M. Adams · Nature reviews. Cancer | Sep 2002 | 4,029 |
| 30 | Cell cycle, CDKs and cancer: a changing paradigm Marcos Malumbres, Mariano Barbacid · Nature reviews. Cancer | 24 Feb 2009 | 4,023 |
| 31 | The p53 tumour suppressor gene Arnold J. Levine, Jamil Antonio Momand, Cathy A. Finlay · Nature | Jun 1991 | 3,842 |
| 32 | Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms David M. Malkin, Frederick P. Li, Louise C. Strong et al. · Science | 30 Nov 1990 | 3,809 |
| 33 | Participation of p53 protein in the cellular response to DNA damage. Michael B. Kastan, Onyinye C. Onyekwere, David Sidransky et al. · PubMed | Dec 1991 | 3,801 |
| 34 | Mechanisms Underlying Ubiquitination Cecile M. Pickart · Annual Review of Biochemistry | Jun 2001 | 3,771 |
| 35 | The Ubiquitin Code David Komander, Michael Rapé · Annual Review of Biochemistry | 22 May 2012 | 3,767 |
| 36 | A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 Manuel Serrano, Gregory James Hannon, David Beach · Nature | Dec 1993 | 3,697 |
| 37 | β-Catenin regulates expression of cyclin D1 in colon carcinoma cells Osamu Tetsu, Frank P. McCormick · Nature | Apr 1999 | 3,621 |
| 38 | The cancer genome Michael R. Stratton, Peter J. Campbell, P. Andrew Futreal · Nature | Apr 2009 | 3,569 |
| 39 | Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed | 15 Sep 1994 | 3,506 |
| 40 | Ferroptosis as a p53-mediated activity during tumour suppression Le Jiang, Ning Kon, Tongyuan Li et al. · Nature | 18 Mar 2015 | 3,475 |
| 41 | DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Christopher J. Bakkenist, Michael B. Kastan · Nature | 2003 | 3,474 |
| 42 | Oncogenic Signaling Pathways in The Cancer Genome Atlas Francisco Sánchez-Vega et al. · Cell | Apr 2018 | 3,452 |
| 43 | Proliferation, cell cycle and apoptosis in cancer Gérard I. Evan, Karen H. Vousden · Nature | May 2001 | 3,427 |
| 44 | p21 is a universal inhibitor of cyclin kinases Yue Xiong, Gregory James Hannon, Hui Zhang et al. · Nature | Dec 1993 | 3,400 |
| 45 | Regulation of p53 stability by Mdm2 Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature | May 1997 | 3,369 |
| 46 | Pan-cancer analysis of whole genomes Lauri A. Aaltonen et al. · Nature | 5 Feb 2020 | 3,360 |
| 47 | Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints Aziz Sancar, Laura A. Lindsey‐Boltz, Keziban Ünsal-Kaçmaz et al. · Annual Review of Biochemistry | Jun 2004 | 3,341 |
| 48 | Apoptosis, oncosis, and necrosis. An overview of cell death. Guido Majno, I Joris · PubMed | 1995 | 3,335 |
| 49 | Principles of CDK regulation David O. Morgan · Nature | Mar 1995 | 3,325 |
| 50 | Disruption of epithelial cell-matrix interactions induces apoptosis SM Frisch, H. Francis · The Journal of Cell Biology | 15 Feb 1994 | 3,286 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.