Most cited papers in Cannabis and Cannabinoid Research
What are the most cited papers in Cannabis and Cannabinoid Research?
The most cited paper in Cannabis and Cannabinoid Research is "Autophagy: Renovation of Cells and Tissues" (Noboru Mizushima, Masaaki Komatsu, 2011), with 6,527 citations. Next come "Autophagy fights disease through cellular self-digestion" (6,507) and "Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor" (5,666).
Showing 50 of 100 papers. Every paper with more than 1,101 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Autophagy: Renovation of Cells and Tissues Noboru Mizushima, Masaaki Komatsu · Cell | Nov 2011 | 6,527 |
| 2 | Autophagy fights disease through cellular self-digestion Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature | Feb 2008 | 6,507 |
| 3 | Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor William A. Devane, Lumir Hanuš, Aviva Breuer et al. · Science | 18 Dec 1992 | 5,666 |
| 4 | Molecular characterization of a peripheral receptor for cannabinoids Sean Munro, Kerrie L. Thomas, Muna Abu-Shaar · Nature | Sep 1993 | 5,110 |
| 5 | Structure of a cannabinoid receptor and functional expression of the cloned cDNA Lisa A. Matsuda, Stephen J. Lolait, Michael Brownstein et al. · Nature | 9 Aug 1990 | 5,040 |
| 6 | Methods in Mammalian Autophagy Research Noboru Mizushima, Tamotsu Yoshimori, Beth Levine · Cell | Feb 2010 | 4,567 |
| 7 | Autophagy: process and function Noboru Mizushima · Genes & Development | 15 Nov 2007 | 4,008 |
| 8 | Development by Self-Digestion Beth Levine, Daniel J. Klionsky · Developmental Cell | Apr 2004 | 3,681 |
| 9 | Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice Catherine A. Ledent, Olga Valverde, G Cossu et al. · Science | 15 Jan 1999 | 3,620 |
| 10 | Autophagy and the Integrated Stress Response Guido Kroemer, Guillermo Mariño, Beth Levine · Molecular Cell | Oct 2010 | 3,556 |
| 11 | Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors Raphael Mechoulam, Shimon Ben‐Shabat, Lumir Ondrej Hanus et al. · Biochemical Pharmacology | Jun 1995 | 2,927 |
| 12 | Mechanism and medical implications of mammalian autophagy Ivan Đikić, Zvulun Elazar · Nature Reviews Molecular Cell Biology | 4 Apr 2018 | 2,842 |
| 13 | International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors Allyn C. Howlett, F. Barth, T.I. Bonner et al. · Pharmacological Reviews | Jun 2002 | 2,839 |
| 14 | Adverse Health Effects of Marijuana Use Nora D. Volkow, Rubén Baler, Wilson M. Compton et al. · New England Journal of Medicine | 4 Jun 2014 | 2,786 |
| 15 | Targeting autophagy in cancer Jean M. Mulcahy Levy, Christina G. Towers, Andrew M. Thorburn · Nature reviews. Cancer | 28 Jul 2017 | 2,635 |
| 16 | Autophagy in Human Health and Disease Augustine M.K. Choi, Stefan W. Ryter, Beth Levine · New England Journal of Medicine | 13 Feb 2013 | 2,600 |
| 17 | Determination and characterization of a cannabinoid receptor in rat brain. William A. Devane, F A Dysarz, M R Johnson et al. · Molecular Pharmacology | Nov 1988 | 2,443 |
| 18 | Cannabinoid receptor localization in brain. Miles A. Herkenham, A B Lynn, M.D. Little et al. · Proceedings of the National Academy of Sciences | Mar 1990 | 2,327 |
| 19 | Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Stefan W. Ryter, Jawed Alam, Augustine M.K. Choi · Physiological Reviews | Apr 2006 | 2,315 |
| 20 | The CAGE Questionnaire: Validation of a New Alcoholism Screening Instrument Demmie G. Mayfield, Gail A McLeod, P. Bradley Hall · American Journal of Psychiatry | Oct 1974 | 2,272 |
| 21 | Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review Theresa HM Moore, Stanley Zammit, Anne R. Lingford-Hughes et al. · The Lancet | Jul 2007 | 2,240 |
| 22 | 2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain Takayuki Sugiura, Shigeru Kondo, Akihiro Sukagawa et al. · Biochemical and Biophysical Research Communications | Oct 1995 | 2,199 |
| 23 | Self-consumption: the interplay of autophagy and apoptosis Guillermo Mariño, Mireia Niso‐Santano, Eric H. Baehrecke et al. · Nature Reviews Molecular Cell Biology | 8 Jan 2014 | 2,197 |
| 24 | Cannabinoids for Medical Use Penny F. Whiting, Robert F. Wolff, Sohan Deshpande et al. · JAMA | 23 Jun 2015 | 2,179 |
| 25 | Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study Miles A. Herkenham, A B Lynn, MR Johnson et al. · Journal of Neuroscience | Feb 1991 | 2,173 |
| 26 | Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide Peter M. Zygmunt, Jesper Petersson, David A. Andersson et al. · Nature | Jul 1999 | 2,160 |
| 27 | Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides Benjamin F. Cravatt, Dan K. Giang, Stephen Patrick Mayfield et al. · Nature | Nov 1996 | 2,140 |
| 28 | Autophagy and Aging David Chaim Rubinsztein, Guillermo Mariño, Guido Kroemer · Cell | Sep 2011 | 2,112 |
| 29 | Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 Ruth Scherz‐Shouval, Elena Shvets, Ephraim Fass et al. · The EMBO Journal | 8 Mar 2007 | 2,106 |
| 30 | The Endocannabinoid System as an Emerging Target of Pharmacotherapy Pál Pacher, Sándor Bátkai, George Kunos · Pharmacological Reviews | Sep 2006 | 2,082 |
| 31 | The molecular logic of endocannabinoid signalling Daniele Piomelli · Nature reviews. Neuroscience | Nov 2003 | 1,961 |
| 32 | Autophagy: from phenomenology to molecular understanding in less than a decade Daniel J. Klionsky · Nature Reviews Molecular Cell Biology | 22 Aug 2007 | 1,953 |
| 33 | The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin Roger G. Pertwee · British Journal of Pharmacology | 10 Sep 2007 | 1,946 |
| 34 | Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 Sven‐Eric Jordt, Diana M. Bautista, Huai-hu Chuang et al. · Nature | 2004 | 1,912 |
| 35 | LC3 and Autophagy Isei Tanida, Takashi Ueno, Eiki Kominami · Methods in molecular biology | 2008 | 1,807 |
| 36 | Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations Sylvaine Galiègue, Sophie Mary, Jean Marchand et al. · European Journal of Biochemistry | Aug 1995 | 1,769 |
| 37 | SR141716A, a potent and selective antagonist of the brain cannabinoid receptor Murielle Rinaldi‐Carmona, Francis Barth, Michel Héaulme et al. · FEBS Letters | 22 Aug 1994 | 1,765 |
| 38 | Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial STEPHEN D. ROSS, Anthony P. Bossis, Jeffrey R. Guss et al. · Journal of Psychopharmacology | 30 Nov 2016 | 1,748 |
| 39 | The endogenous cannabinoid system controls extinction of aversive memories Giovanni Marsicano, Carsten Tobias Wotjak, Shahnaz Christina Azad et al. · Nature | Aug 2002 | 1,735 |
| 40 | Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome Orrin Devinsky, Judith Helen Cross, Linda Laux et al. · New England Journal of Medicine | 24 May 2017 | 1,708 |
| 41 | Induction of autophagy by spermidine promotes longevity Tobias Eisenberg et al. · Nature Cell Biology | 4 Oct 2009 | 1,699 |
| 42 | Molecular definitions of autophagy and related processes Lorenzo Galluzzi et al. · The EMBO Journal | 8 Jun 2017 | 1,670 |
| 43 | Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses Rachel I. Wilson, Roger A. Nicoll · Nature | 29 Mar 2001 | 1,624 |
| 44 | Autophagy in major human diseases Daniel J. Klionsky et al. · The EMBO Journal | 30 Aug 2021 | 1,608 |
| 45 | International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 Roger G. Pertwee, Allyn C. Howlett, Mary E. Abood et al. · Pharmacological Reviews | 15 Nov 2010 | 1,605 |
| 46 | Termination of autophagy and reformation of lysosomes regulated by mTOR Li Yu, Christina K. McPhee, Lixin Zheng et al. · Nature | Jun 2010 | 1,596 |
| 47 | Formation and inactivation of endogenous cannabinoid anandamide in central neurons Vincenzo Di Marzo, Angelo Fontana, Hugues Cadas et al. · Nature | Dec 1994 | 1,589 |
| 48 | Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system K Tsou, Sean M. Brown, M.Clara Sañudo-Peña et al. · Neuroscience | 1998 | 1,586 |
| 49 | The orphan receptor GPR55 is a novel cannabinoid receptor Erik Ryberg, Niklas Larsson, S. Sjögren et al. · British Journal of Pharmacology | 17 Sep 2007 | 1,584 |
| 50 | Role of Endogenous Cannabinoids in Synaptic Signaling Tamás F. Freund, István Katona, Daniele Piomelli · Physiological Reviews | Jul 2003 | 1,575 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.