Most cited papers in Cellular Mechanics and Interactions
What are the most cited papers in Cellular Mechanics and Interactions?
The most cited paper in Cellular Mechanics and Interactions is "Matrix Elasticity Directs Stem Cell Lineage Specification" (Adam Jeffrey Engler, Shamik Sen, Hugh Lee Sweeney et al., 2006), with 13,994 citations. Next come "Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin" (7,308) and "Tissue Cells Feel and Respond to the Stiffness of Their Substrate" (6,452).
Showing 50 of 100 papers. Every paper with more than 1,764 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Matrix Elasticity Directs Stem Cell Lineage Specification Adam Jeffrey Engler, Shamik Sen, Hugh Lee Sweeney et al. · Cell | Aug 2006 | 13,994 |
| 2 | Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin Jazli Aziz, Hafiz Shezali, Zamri Radzi et al. · Skin Pharmacology and Physiology | 2016 | 7,308 |
| 3 | Tissue Cells Feel and Respond to the Stiffness of Their Substrate Dennis E. Discher, Paul A. Janmey, Yu-Li Wang · Science | 18 Nov 2005 | 6,452 |
| 4 | Rho GTPases and the Actin Cytoskeleton Alan K. Hall · Science | 23 Jan 1998 | 6,198 |
| 5 | Role of YAP/TAZ in mechanotransduction Sirio Dupont, Leonardo Morsut, Mariaceleste Aragona et al. · Nature | Jun 2011 | 6,136 |
| 6 | The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells Roland Moll, Werner Wilhelm Franke, Dorothea L. Schiller et al. · Cell | Nov 1982 | 5,315 |
| 7 | Cell Migration: Integrating Signals from Front to Back Anne J. Ridley, Martin Alexander Schwartz, Keith Burridge et al. · Science | 4 Dec 2003 | 5,046 |
| 8 | Rho GTPases in cell biology Sandrine Etienne‐Manneville, Alan K. Hall · Nature | Dec 2002 | 4,844 |
| 9 | In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro Chun-Chi Liang, Ann Y. Park, Jun‐Lin Guan · Nature Protocols | Feb 2007 | 4,789 |
| 10 | Geometric Control of Cell Life and Death Christopher S. Chen, Milan Mrksich, Sui Huang et al. · Science | 30 May 1997 | 4,691 |
| 11 | The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors Anne J. Ridley, Alan Hall · Cell | Aug 1992 | 4,503 |
| 12 | Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia Catherine D. Nobes, Alan K. Hall · Cell | Apr 1995 | 4,456 |
| 13 | Cellular Motility Driven by Assembly and Disassembly of Actin Filaments Thomas Dean Pollard, Gary G. Borisy · Cell | Feb 2003 | 4,257 |
| 14 | Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment Rowena McBeath, Dana M. Pirone, Celeste M. Nelson et al. · Developmental Cell | Apr 2004 | 4,231 |
| 15 | Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling Kandice R. Levental, Hongmei Yu, Laura Kass et al. · Cell | Nov 2009 | 4,155 |
| 16 | Cell Migration: A Physically Integrated Molecular Process Douglas A. Lauffenburger, Alan F. Horwitz · Cell | Feb 1996 | 4,009 |
| 17 | Snakes, shapes, and gradient vector flow Chenyang Xu, Jerry L. Prince · IEEE Transactions on Image Processing | Mar 1998 | 4,002 |
| 18 | Tensional homeostasis and the malignant phenotype Matthew J. Paszek, Nastaran Zahir, Kandice R. Johnson et al. · Cancer Cell | Sep 2005 | 4,000 |
| 19 | Integrin Signaling Filippo G. Giancotti, Erkki I. Ruoslahti · Science | 13 Aug 1999 | 3,870 |
| 20 | The small GTP-binding protein rac regulates growth factor-induced membrane ruffling Anne J. Ridley, Hugh F. Paterson, Caroline L. Johnston et al. · Cell | Aug 1992 | 3,679 |
| 21 | Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis Barry M. Gumbiner · Cell | Feb 1996 | 3,508 |
| 22 | Liquid-Liquid Phase Separation in Biology Anthony A. Hyman, Christoph Andreas Weber, Frank Jülicher · Annual Review of Cell and Developmental Biology | 6 Oct 2014 | 3,414 |
| 23 | Cell Movement Is Guided by the Rigidity of the Substrate Chun‐Min Lo, Hong-Bei Wang, Micah Dembo et al. · Biophysical Journal | Jul 2000 | 3,347 |
| 24 | The Molecular Biology of Axon Guidance Marc Tessier‐Lavigne, Corey S. Goodman · Science | 15 Nov 1996 | 3,329 |
| 25 | Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases Marie Cargnello, Philippe P. Roux · Microbiology and Molecular Biology Reviews | Mar 2011 | 3,321 |
| 26 | Tumour-cell invasion and migration: diversity and escape mechanisms Peter Friedl, Katarina Wolf · Nature reviews. Cancer | May 2003 | 3,265 |
| 27 | A theory of biological pattern formation Alfred Gierer, Hans Meinhardt · Kybernetik | Dec 1972 | 3,251 |
| 28 | Cell mechanics and the cytoskeleton Daniel A. Fletcher, R. Dyche Mullins · Nature | 2010 | 3,116 |
| 29 | Cell locomotion and focal adhesions are regulated by substrate flexibility Robert J. Pelham, Yu‐li Wang · Proceedings of the National Academy of Sciences | 9 Dec 1997 | 3,063 |
| 30 | Taking Cell-Matrix Adhesions to the Third Dimension Edna Cukierman, Roumen G. Pankov, Daron R. Stevens et al. · Science | 23 Nov 2001 | 3,038 |
| 31 | Mechanotransduction Across the Cell Surface and Through the Cytoskeleton Ning Wang, James P. Butler, Donald E. Ingber · Science | 21 May 1993 | 3,011 |
| 32 | Integrins and Signal Transduction Pathways: the Road Taken Edwin A. Clark, Joan S. Brugge · Science | 14 Apr 1995 | 2,983 |
| 33 | The third dimension bridges the gap between cell culture and live tissue Francesco Pampaloni, Emmanuel G. Reynaud, Ernst H. K. Stelzer · Nature Reviews Molecular Cell Biology | 8 Aug 2007 | 2,831 |
| 34 | Collective cell migration in morphogenesis, regeneration and cancer Peter Friedl, Darren T. Gilmour · Nature Reviews Molecular Cell Biology | 23 Jun 2009 | 2,826 |
| 35 | Nature’s hierarchical materials Peter Fratzl, Richard Weinkamer · Progress in Materials Science | 23 Jun 2007 | 2,812 |
| 36 | Phase transitions in the assembly of multivalent signalling proteins Pilong Li, Sudeep Banjade, Hui-Chun Cheng et al. · Nature | Mar 2012 | 2,797 |
| 37 | Hydrogels as extracellular matrix mimics for 3D cell culture Mark W. Tibbitt, Kristi S. Anseth · Biotechnology and Bioengineering | 13 Apr 2009 | 2,743 |
| 38 | Exploring and Engineering the Cell Surface Interface Molly M. Stevens, Julian H. George · Science | 18 Nov 2005 | 2,618 |
| 39 | MICROTUBULE POLYMERIZATION DYNAMICS Arshad B. Desai, Timothy John Mitchison · Annual Review of Cell and Developmental Biology | Nov 1997 | 2,614 |
| 40 | Focal adhesion kinase: in command and control of cell motility Satyajit K. Mitra, Daniel R. Hanson, David D. Schlaepfer · Nature Reviews Molecular Cell Biology | 2005 | 2,599 |
| 41 | RGD modified polymers: biomaterials for stimulated cell adhesion and beyond Ulrich Hersel, Claudia Dahmen, Horst Kessler · Biomaterials | 12 Aug 2003 | 2,592 |
| 42 | Environmental sensing through focal adhesions Benjamin Geiger, Joachim Pius Spatz, Alexander D. Bershadsky · Nature Reviews Molecular Cell Biology | 19 Dec 2008 | 2,571 |
| 43 | Osteoblast adhesion on biomaterials Karine Anselme · Biomaterials | Apr 2000 | 2,494 |
| 44 | Small GTP-Binding Proteins Yoshimi Takai, Takuya Sasaki, Takashi Matozaki · Physiological Reviews | 2001 | 2,488 |
| 45 | Hydrogels with tunable stress relaxation regulate stem cell fate and activity Ovijit Chaudhuri, Luo Gu, Darinka D. Klumpers et al. · Nature Materials | 30 Nov 2015 | 2,484 |
| 46 | The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder Matthew John Dalby, Nikolaj Gadegaard, Rahul S. Tare et al. · Nature Materials | 23 Sep 2007 | 2,419 |
| 47 | Cell-laden microengineered gelatin methacrylate hydrogels Jason William Nichol, Sandeep T. Koshy, Hojae Bae et al. · Biomaterials | 26 Apr 2010 | 2,399 |
| 48 | Concepts of extracellular matrix remodelling in tumour progression and metastasis Juliane Winkler, Abisola Abisoye-Ogunniyan, Kevin James Metcalf et al. · Nature Communications | 9 Oct 2020 | 2,352 |
| 49 | Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion Tony Yeung, Penelope C. Georges, Lisa A. Flanagan et al. · Cell Motility and the Cytoskeleton | 2004 | 2,352 |
| 50 | Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression Asako Sakaue-Sawano, Hiroshi Kurokawa, Toshifumi Morimura et al. · Cell | Feb 2008 | 2,347 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.