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Most cited papers in Chemical Synthesis and Reactions

What are the most cited papers in Chemical Synthesis and Reactions?

The most cited paper in Chemical Synthesis and Reactions is "Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2" (Jason Patrick Hallett, Tom Welton, 2011), with 12,587 citations. Next come "Ionic Liquids—New “Solutions” for Transition Metal Catalysis" (5,721) and "A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines" (5,175).

Showing 50 of 100 papers. Every paper with more than 817 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2 Jason Patrick Hallett, Tom Welton · Chemical Reviews Review 6 Apr 2011 12,587
2 Ionic Liquids—New “Solutions” for Transition Metal Catalysis Peter Wasserscheid, Wilhelm Keim · Angewandte Chemie International Edition 3 Nov 2000 5,721
3 A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters 1975 5,175
4 Hydrogen Peroxide Synthesis: An Outlook beyond the Anthraquinone Process José M. Campos‐Martín, Gema Blanco‐Brieva, J.L.G. Fierro · Angewandte Chemie International Edition 13 Oct 2006 3,257
5 Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources Robert‐Jan van Putten, Jan C. van der Waal, E. de Jong et al. · Chemical Reviews ReviewOpen access 11 Feb 2013 2,873
6 Ionic liquids. Green solvents for the future Martyn J. Earle, Kenneth Richard Seddon · Pure and Applied Chemistry Open access 2000 2,798
7 Catalysis by Heteropoly Acids and Multicomponent Polyoxometalates in Liquid-Phase Reactions Ivan V. Kozhevnikov · Chemical Reviews Review Feb 1998 2,765
8 Microwave assisted organic synthesis—a review Pelle Lidström, Jason P. Tierney, Bernard Wathey et al. · Tetrahedron Nov 2001 2,674
9 In the Golden Age of Organocatalysis Peter I. Dalko, Lionel Moisan · Angewandte Chemie International Edition 29 Sep 2004 2,586
10 Tetrahedron report number 163 James T. Lindley · Tetrahedron 1984 2,249
11 Origins, Current Status, and Future Challenges of Green Chemistry Paul T. Anastas, Mary M. Kirchhoff · Accounts of Chemical Research 19 Jun 2002 2,215
12 Recent Advances in Polyoxometalate-Catalyzed Reactions Sasa Wang, Guo‐Yu Yang · Chemical Reviews Review 12 May 2015 2,167
13 Iron-Catalyzed Reactions in Organic Synthesis Carsten Bolm, Julien Legros, Jacques Le Paih et al. · Chemical Reviews Review 19 Nov 2004 2,144
14 Simple Method for the Esterification of Carboxylic Acids Bernhard Neises, Wölfgang Steglich · Angewandte Chemie International Edition in English Jul 1978 2,064
15 Heterogeneous Catalysis Noritaka Mizuno, Makoto Misono · Chemical Reviews Review 8 Jan 1998 2,059
16 Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry Minghao Feng, Bingqing Tang, Steven H. Liang et al. · Current Topics in Medicinal Chemistry Open access 3 Mar 2016 2,023
17 Postsynthetic modification of metal–organic frameworks Zhenqiang Wang, Seth M. Cohen · Chemical Society Reviews Review 2009 1,971
18 Polyoxometalates in Medicine Jeffrey T. Rhule, Craig L. Hill, Deborah A. Judd et al. · Chemical Reviews Review Feb 1998 1,895
19 Green Extraction of Natural Products: Concept and Principles Farid Chemat, Maryline Abert Vian, Giancarlo Cravotto · International Journal of Molecular Sciences Open access 11 Jul 2012 1,888
20 Rational Development of Practical Catalysts for Aromatic Carbon−Nitrogen Bond Formation John P. Wolfe, Seble H. Wagaw, Jean-François Marcoux et al. · Accounts of Chemical Research 21 Oct 1998 1,786
21 Pyridinium chlorochromate. An efficient reagent for oxidation of primary and secondary alcohols to carbonyl compounds Elias James Corey, J. William Suggs · Tetrahedron Letters 1975 1,776
22 Green solvents for sustainable organic synthesis: state of the art Roger A. Sheldon · Green Chemistry 2005 1,706
23 Electrochemical Properties of Polyoxometalates as Electrocatalysts Masahiro Sadakane, Eberhard Steckhan · Chemical Reviews Review Feb 1998 1,699
24 Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions I. P. Beletskaya, Valentine P. Ananikov · Chemical Reviews Review 9 Mar 2011 1,679
25 Asymmetric Multicomponent Reactions (AMCRs): The New Frontier Diego J. Ramón, Miguel Yus · Angewandte Chemie International Edition 18 Feb 2005 1,668
26 5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications Andreia A. Rosatella, Svilen P. Simeonov, Raquel F. M. Frade et al. · Green Chemistry 2011 1,647
27 Catalytic Chemistry of Heteropoly Compounds Toshio Okuhara, Noritaka Mizuno, Makoto Misono · Advances in catalysis Book chapter 1996 1,644
28 Stereoselective Organic Reactions in Water Ulf M. Lindström · Chemical Reviews Review 19 Jun 2002 1,643
29 Ionic liquids in catalysis Tom Welton · Coordination Chemistry Reviews 6 Jul 2004 1,606
30 A greatly improved procedure for ruthenium tetroxide catalyzed oxidations of organic compounds Per H. J. Carlsen, Tsutomu Katsuki, Victor S. Martı́n et al. · The Journal of Organic Chemistry Sep 1981 1,593
31 Applications of Acceptorless Dehydrogenation and Related Transformations in Chemical Synthesis Chidambaram Gunanathan, David Milstein · Science 18 Jul 2013 1,550
32 Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures 1 Ahmed F. Abdel‐Magid, Kenneth G. Carson, Bruce D. Harris et al. · The Journal of Organic Chemistry 1996 1,504
33 Metal–Organic Frameworks for Heterogeneous Basic Catalysis Zhu Li, Xiao‐Qin Liu, Hai‐Long Jiang et al. · Chemical Reviews Review 25 May 2017 1,483
34 Microwave assisted organic reactions Stephen Caddick · Tetrahedron Sep 1995 1,434
35 Metal-Catalyzed Carbon−Sulfur Bond Formation Teruyuki Kondo, Take‐aki Mitsudo · Chemical Reviews Review 11 Jul 2000 1,425
36 Metal–organic frameworks: versatile heterogeneous catalysts for efficient catalytic organic transformations Adeel Hussain Chughtai, Nazir Ahmad, Hussein A. Younus et al. · Chemical Society Reviews Review 2015 1,392
37 Transesterification of vegetable oils: a review Ulf Friedrich Schuchardt, Ricardo Sercheli, Rogério Matheus Vargas · Journal of the Brazilian Chemical Society Open access May 1998 1,333
38 Multicomponent reactions: advanced tools for sustainable organic synthesis Răzvan C. Cioc, Eelco Ruijter, Romano V. A. Orrù · Green Chemistry 2014 1,332
39 Organic chemistry in water Chao‐Jun Li, Liang Chen · Chemical Society Reviews Review 21 Nov 2005 1,329
40 Organocatalysis—after the gold rush Søren Bertelsen, Karl Anker Jørgensen · Chemical Society Reviews Review 2009 1,289
41 Diphenylprolinol Silyl Ethers as Efficient Organocatalysts for the Asymmetric Michael Reaction of Aldehydes and Nitroalkenes Yujiro Hayashi, Hiroaki Gotoh, Takaaki Hayashi et al. · Angewandte Chemie International Edition Jun 2005 1,263
42 Lewis Base Catalysis in Organic Synthesis Scott E. Denmark, Gregory L. Beutner · Angewandte Chemie International Edition 31 Jan 2008 1,258
43 Asymmetric Catalysis of Epoxide Ring-Opening Reactions Eric N. Jacobsen · Accounts of Chemical Research 16 May 2000 1,256
44 A Survey of Applications of Polyoxometalates Dimitris E. Katsoulis · Chemical Reviews Review 17 Jan 1998 1,249
45 Metal–Organic Framework-Based Catalysts with Single Metal Sites Yong‐Sheng Wei, Mei Zhang, Ruqiang Zou et al. · Chemical Reviews Review May 2020 1,246
46 Tetrapropylammonium Perruthenate, Pr4N+RuO4 -, TPAP: A Catalytic Oxidant for Organic Synthesis Steven V. Ley, Joanne Norman, William P. Griffith et al. · Synthesis 1994 1,237
47 Oxidation of alcohols by “activated” dimethyl sulfoxide. a preparative, steric and mechanistic study Kanji Omura, Daniel Swern · Tetrahedron 1978 1,227
48 4‐Dialkylaminopyridines as Highly Active Acylation Catalysts. [New synthetic method (25)] Gerhard Höfle, Wölfgang Steglich, Helmut Vorbrüggen · Angewandte Chemie International Edition in English Aug 1978 1,202
49 Novel Brønsted Acidic Ionic Liquids and Their Use as Dual Solvent−Catalysts Amanda C. Cole, Jessica L. Jensen, Ioanna Ntai et al. · Journal of the American Chemical Society May 2002 1,199
50 Recent Developments in the Synthesis and Utilization of Chiral Sulfoxides Inmaculada Fernández, Noureddine Khiar · Chemical Reviews Review Aug 2003 1,185

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.