Topic · Chronic Lymphocytic Leukemia Research

Most cited papers in Chronic Lymphocytic Leukemia Research

Chronic Lymphocytic Leukemia Research

What are the most cited papers in Chronic Lymphocytic Leukemia Research?

The most cited paper in Chronic Lymphocytic Leukemia Research is "The 2016 revision of the World Health Organization classification of lymphoid neoplasms" (Steven H. Swerdlow, Elı́as Campo, Stefano Aldo Pileri et al., 2016), with 7,935 citations. Next come "Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia" (5,063) and "The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" (4,010).

Published TypeAccessCitations

Showing 50 of 99 papers. Every paper with more than 1,220 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	The 2016 revision of the World Health Organization classification of lymphoid neoplasms Steven H. Swerdlow, Elı́as Campo, Stefano Aldo Pileri et al. · Blood Open access	15 Mar 2016	7,935
2	Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia George Adrian Calin, Calin Dan Dumitru, Masayoshi Shimizu et al. · Proceedings of the National Academy of Sciences Open access	14 Nov 2002	5,063
3	The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms Rita Alaggio et al. · Leukemia Open access	22 Jun 2022	4,010
4	Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines Michael J. Hallek, Bruce D. Cheson, Daniel Catovsky et al. · Blood Open access	23 Jan 2008	3,806
5	Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells Brian J. Druker, Shu Tamura, Elisabeth Buchdunger et al. · Nature Medicine	May 1996	3,681
6	Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia David L. Porter, Bruce L. Levine, Michael D. Kalos et al. · New England Journal of Medicine Open access	10 Aug 2011	3,584
7	Report of an International Workshop to Standardize Response Criteria for Non-Hodgkin's Lymphomas Bruce D. Cheson, Sandra J. Horning, Bertr Coiffier et al. · Journal of Clinical Oncology	Apr 1999	3,495
8	High Frequency of Mutations of the PIK3CA Gene in Human Cancers Yardena Samuels, Zhenghe Wang, Alberto Bardelli et al. · Science	15 Mar 2004	3,473
9	Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia Hartmut Döhner, Stephan Stilgenbauer, Axel Benner et al. · New England Journal of Medicine	28 Dec 2000	3,318
10	Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification Mercedes E. Gorre, Mansoor Mohammed, Katharine B. Ellwood et al. · Science	3 Aug 2001	3,120
11	ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets Andrew James Souers et al. · Nature Medicine	6 Jan 2013	3,089
12	Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 Jacques J. M. van Dongen et al. · Leukemia Open access	Dec 2003	3,072
13	The PI3K Pathway in Human Disease David A. Fruman, Honyin Chiu, Benjamin David Hopkins et al. · Cell Open access	Aug 2017	2,806
14	Targeting the phosphoinositide 3-kinase pathway in cancer Pixu Liu, Hai-Ling Margaret Cheng, Thomas M. Roberts et al. · Nature Reviews Drug Discovery ReviewOpen access	31 Jul 2009	2,779
15	Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia Terry John Hamblin, Zadie A. Davis, Anne Catherine Gardiner et al. · Blood	15 Sep 1999	2,724
16	International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an International workshop Wendell A. Wilson, Azzudin E. Gharavi, Takao Koike et al. · Arthritis & Rheumatism	Jul 1999	2,695
17	Clinical staging of chronic lymphocytic leukemia KR Rai, A Sawitsky, Cronkite Ep et al. · Blood	Aug 1975	2,684
18	Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia Rajendra N. Damle, Tarun Wasil, Franco Fais et al. · Blood	15 Sep 1999	2,607
19	Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update Antonio C. Wolff, M. Elizabeth Hammond, Kimberly H. Allison et al. · Journal of Clinical Oncology Open access	30 May 2018	2,537
20	Genetics of rheumatoid arthritis contributes to biology and drug discovery Yukinori Okada et al. · Nature Open access	24 Dec 2013	2,501
21	T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia Michael D. Kalos, Bruce L. Levine, David L. Porter et al. · Science Translational Medicine Open access	10 Aug 2011	2,431
22	A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia George Adrian Calin et al. · New England Journal of Medicine	26 Oct 2005	2,425
23	Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma Stephan Wade Morris, Mark N. Kirstein, Marcus B. Valentine et al. · Science	4 Mar 1994	2,424
24	Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection Ira M. Jacobson et al. · New England Journal of Medicine Open access	22 Jun 2011	2,394
25	Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia John C. Byrd et al. · New England Journal of Medicine Open access	19 Jun 2013	2,283
26	Strategies and challenges for the next generation of antibody–drug conjugates Alain Beck, Liliane Goetsch, Charles Dumontet et al. · Nature Reviews Drug Discovery Review	17 Mar 2017	2,280
27	Protein kinases — the major drug targets of the twenty-first century? Philip Cohen · Nature Reviews Drug Discovery Review	Apr 2002	2,203
28	Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery Bryan T. Hennessy, Debra L. Smith, Prahlad T. Ram et al. · Nature Reviews Drug Discovery Review	Dec 2005	2,188
29	Antibody therapy of cancer Andrew Mark Scott, Jedd D. Wolchok, Lloyd J. Old · Nature reviews. Cancer Review	22 Mar 2012	2,177
30	Comparison of a Standard Regimen (CHOP) with Three Intensive Chemotherapy Regimens for Advanced Non-Hodgkin's Lymphoma Richard I. Fisher, Ellen R. Gaynor, Steve Dahlberg et al. · New England Journal of Medicine Open access	8 Apr 1993	2,167
31	Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes Bjoern Chapuy et al. · Nature Medicine Open access	27 Apr 2018	2,023
32	The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications Elı́as Campo, Steven H. Swerdlow, Nancy L. Harris et al. · Blood Open access	7 Feb 2011	2,011
33	European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013 Michele Baccarani et al. · Blood Open access	27 Jun 2013	2,005
34	A History of Cancer Chemotherapy Vincent T. DeVita, Edward Chu · Cancer Research Open access	30 Oct 2008	1,978
35	Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia Andrew Warwick Roberts, Matthew Steven Davids, John M. Pagel et al. · New England Journal of Medicine Open access	6 Dec 2015	1,929
36	A small molecule–kinase interaction map for clinical kinase inhibitors Miles A. Fabian et al. · Nature Biotechnology Open access	13 Feb 2005	1,927
37	Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene Guillaume Cartron, Laurent Dacheux, Gilles Salles et al. · Blood	Feb 2002	1,888
38	Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial Michael J. Hallek et al. · The Lancet	Oct 2010	1,886
39	PI3K pathway alterations in cancer: variations on a theme T L Yuan, Lewis C. Cantley · Oncogene Open access	15 Sep 2008	1,862
40	National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment Cheson Bd, J M Bennett, Michael R. Grever et al. · Blood	15 Jun 1996	1,831
41	Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor Neil P. Shah, Chris Tran, Francis Y. Lee et al. · Science	15 Jul 2004	1,811
42	2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease‐modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis Jasvinder A. Singh et al. · Arthritis Care & Research Open access	2 Apr 2012	1,806
43	Involvement of the bcl -2 Gene in Human Follicular Lymphoma Yoshihide Tsujimoto, Jeffrey Cossman, Elaine S. Jaffe et al. · Science	21 Jun 1985	1,800
44	Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies Qiang Guo, Yuxiang Wang, Dan Xu et al. · Bone Research Open access	25 Apr 2018	1,794
45	Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation Yoshihide Tsujimoto, L R Finger, Jorge J. Yunis et al. · Science	30 Nov 1984	1,793
46	A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis J L Binet, Ariane Auquier, Guillaume Dighiero et al. · Cancer	Jul 1981	1,784
47	Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Daniel R. Knighton, Jianhua Zheng, Lynn F. Ten Eyck et al. · Science	26 Jul 1991	1,781
48	The emerging mechanisms of isoform-specific PI3K signalling Bart Vanhaesebroeck, Julie Guillermet‐Guibert, Mariona Graupera et al. · Nature Reviews Molecular Cell Biology Review	9 Apr 2010	1,773
49	PI3K and cancer: lessons, challenges and opportunities David A. Fruman, Christian Rommel · Nature Reviews Drug Discovery ReviewOpen access	31 Jan 2014	1,760
50	Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia David Porter, Wei‐Ting Hwang, Noelle V. Frey et al. · Science Translational Medicine Open access	2 Sep 2015	1,754

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.