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Most cited papers in Coenzyme Q10 studies and effects

What are the most cited papers in Coenzyme Q10 studies and effects?

The most cited paper in Coenzyme Q10 studies and effects is "Oxidative Stress: Harms and Benefits for Human Health" (Gabriele Pizzino, Natasha Irrera, Mariapaola Cucinotta et al., 2017), with 4,835 citations. Next come "Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism" (4,713) and "Mitochondrial formation of reactive oxygen species" (4,379).

Showing 50 of 100 papers. Every paper with more than 672 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Oxidative Stress: Harms and Benefits for Human Health Gabriele Pizzino, Natasha Irrera, Mariapaola Cucinotta et al. · Oxidative Medicine and Cellular Longevity Open access 2017 4,835
2 Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism Peter D. Mitchell · Nature Jul 1961 4,713
3 Mitochondrial formation of reactive oxygen species Julio F. Turrens · The Journal of Physiology Open access 25 Aug 2003 4,379
4 Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue C. De Duve, Berton C. Pressman, R. Gianetto et al. · Biochemical Journal Open access Aug 1955 4,175
5 Oxidative stress, aging, and diseases Ilaria Liguori, Gennaro Russo, Francesco Curcio et al. · Clinical Interventions in Aging Open access Apr 2018 4,013
6 Mitochondrial free radical generation, oxidative stress, and aging Enrique Cadenas, Kelvin J.A. Davies · Free Radical Biology and Medicine Aug 2000 3,002
7 Dietary Carcinogens and Anticarcinogens Bruce N. Ames · Science 23 Sep 1983 2,987
8 Protein Oxidation and Aging Earl R. Stadtman · Science 28 Aug 1992 2,701
9 The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis Masayuki P. Yamamoto, Thomas W. Kensler, Hozumi Motohashi · Physiological Reviews ReviewOpen access 2 May 2018 1,982
10 Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase Yibing Li, Ting‐Ting Huang, Elaine J. Carlson et al. · Nature Genetics Dec 1995 1,791
11 A novel automated method to measure total antioxidant response against potent free radical reactions Özcan Erel · Clinical Biochemistry 2 Dec 2003 1,772
12 Free radicals and tissue damage produced by exercise Kelvin J.A. Davies, Alexandre T. Quintanilha, George A. Brooks et al. · Biochemical and Biophysical Research Communications Aug 1982 1,743
13 Role of ROS and RNS Sources in Physiological and Pathological Conditions Sergio Di Meo, Tanea T. Reed, Paola Venditti et al. · Oxidative Medicine and Cellular Longevity Open access 2016 1,626
14 Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria Julio F. Turrens, Alejandro D. Boveris · Biochemical Journal Open access Nov 1980 1,602
15 Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain Julie St‐Pierre, Julie A. Buckingham, Stephen J. Roebuck et al. · Journal of Biological Chemistry Open access Nov 2002 1,546
16 Role of Free Radicals in the Neurodegenerative Diseases Barry B. Halliwell · Drugs & Aging 2001 1,505
17 Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement Deirdre Nolfi‐Donegan, Andrea Braganza, Sruti S. Shiva · Redox Biology Open access 6 Aug 2020 1,491
18 Role of oxidative stress in cardiovascular diseases Naranjan S. Dhalla, Rana M. Temsah, Thomas Netticadan · Journal of Hypertension Jun 2000 1,469
19 The Role of Oxidative Stress in Neurodegenerative Diseases Geon Ha Kim, Jieun E. Kim, Sandy Jeong Rhie et al. · Experimental Neurobiology Open access 21 Dec 2015 1,364
20 Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives Sara Mostafalou, Mohammad Reza Abdollahi · Toxicology and Applied Pharmacology 9 Feb 2013 1,259
21 Generation of reactive oxygen species by the mitochondrial electron transport chain Yuanbin Liu, Gary M. Fiskum, David A. Schubert · Journal of Neurochemistry Mar 2002 1,253
22 Biochemical, physiological and medical aspects of ubiquinone function Lars Ernster, Gustav Dallner · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Open access May 1995 1,232
23 The sites and topology of mitochondrial superoxide production Martin D. Brand · Experimental Gerontology Open access 12 Jan 2010 1,214
24 Mechanisms of free radical oxidation of unsaturated lipids Ned A. Porter, Sarah E. Caldwell, Karen A. Mills · Lipids Apr 1995 1,212
25 Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations Michael P. Murphy, Robin A.J. Smith · The Annual Review of Pharmacology and Toxicology Review 2 Oct 2006 1,180
26 A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension Richard P. Lifton, Robert G. Dluhy, Michael D. Powers et al. · Nature 1992 1,169
27 A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness Michael H. J. Maes, Piotr Gałecki, Yong Seun Chang et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry 13 May 2010 1,153
28 Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation Roger C. Harris, Karin Söderlund, E. Hultman · Clinical Science Sep 1992 1,141
29 Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents Dongryeol Ryu, Laurent Mouchiroud, Pénélope A. Andreux et al. · Nature Medicine Open access 11 Jul 2016 1,116
30 Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells Geoffrey F. Kelso, Carolyn M. Porteous, Carolyn V. Coulter et al. · Journal of Biological Chemistry Open access Feb 2001 1,114
31 Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response Charles Edwin Myers, William Patrick McGuire, Robert H. Liss et al. · Science 8 Jul 1977 1,112
32 Mechanism of Toxicity in Rotenone Models of Parkinson's Disease Todd Sherer, Ranjita S. Betarbet, Claudia M. Testa et al. · Journal of Neuroscience Open access 26 Nov 2003 1,097
33 The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin · Cell Open access 2011 1,091
34 Hydrogen peroxide in the human body Barry B. Halliwell, Marie Véronique Clément, Lee Hua Long · FEBS Letters 30 Nov 2000 1,084
35 Mitonuclear protein imbalance as a conserved longevity mechanism Riekelt H. Houtkooper, Laurent Mouchiroud, Dongryeol Ryu et al. · Nature Open access 21 May 2013 1,081
36 Oxidative stress, exercise, and antioxidant supplementation Maria L. Urso, Priscilla M. Clarkson · Toxicology 28 May 2003 1,078
37 Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling Martin D. Brand · Free Radical Biology and Medicine 13 Apr 2016 1,074
38 ER stress and the unfolded protein response in neurodegeneration Claudio A. Hetz, Smita Saxena · Nature Reviews Neurology ReviewOpen access 21 Jul 2017 1,073
39 Role of Oxidants in Ischemic Brain Damage Pak Hoo Chan · Stroke Jun 1996 1,039
40 Metabolism and function of coenzyme Q Mikael J. Turunen, Jerker M. Olsson, Gustav Dallner · Biochimica et Biophysica Acta (BBA) - Biomembranes Open access 6 Dec 2003 1,035
41 Oxidative Stress, Mitochondrial Dysfunction, and Aging Hang Cui, Yahui Kong, Hong Zhang · Journal of Signal Transduction Open access 2 Oct 2011 1,034
42 Neurodegenerative diseases and oxidative stress Jacques Emerit, Marvin A. Edeas, François Bricaire · Biomedicine & Pharmacotherapy 13 Dec 2003 1,033
43 Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Russell M. Lebovitz, Henggui Zhang, Hannes Vogel et al. · Proceedings of the National Academy of Sciences Open access 3 Sep 1996 1,032
44 Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future John M.C. Gutteridge, Barry B. Halliwell · Annals of the New York Academy of Sciences 2000 1,015
45 Measurement of F2-isoprostanes as an index of oxidative stress in vivo L.Jackson Roberts, Jason D. Morrow · Free Radical Biology and Medicine Feb 2000 1,000
46 Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Asako Yoritaka, Nobutaka Hattori, Kôji Uchida et al. · Proceedings of the National Academy of Sciences Open access 2 Apr 1996 988
47 A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity Siu Sylvia Lee, Raymond Lee, Andrew G. Fraser et al. · Nature Genetics 25 Nov 2002 986
48 Effects of Coenzyme Q10 in Early Parkinson Disease Clifford W. Shults · Archives of Neurology Oct 2002 982
49 Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential Kate Petersen Shay, Régis F. Moreau, Eric J.T. Smith et al. · Biochimica et Biophysica Acta (BBA) - General Subjects Open access 5 Aug 2009 982
50 Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation James A. Joseph, Barbara Shukitt‐Hale, Natalia A. Denisova et al. · Journal of Neuroscience Open access 15 Sep 1999 981

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.