Most cited papers in Colorectal and Anal Carcinomas

Colorectal and Anal Carcinomas

What are the most cited papers in Colorectal and Anal Carcinomas?

The most cited paper in Colorectal and Anal Carcinomas is "Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer" (Rolf Sauer, Heinz Becker, Werner Hohenberger et al., 2004), with 6,117 citations. Next come "Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature" (5,277) and "Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer" (5,071).

Published TypeAccessAuthorsCitations

Showing 50 of 100 papers. Every paper with more than 949 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer Rolf Sauer, Heinz Becker, Werner Hohenberger et al. · New England Journal of Medicine	20 Oct 2004	6,117
2	Signet-Ring Cell Carcinoma of the Colon: A Case Report and Review of the Literature Peter Y. Park, Teresa A. Goldin, John C. S. Chang et al. · Case Reports in Oncology Open access	3 Nov 2015	5,277
3	Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer David Cunningham, Yves Humblet, Salvatore Siena et al. · New England Journal of Medicine Open access	21 Jul 2004	5,071
4	Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer Ellen Kapiteijn, Corrie A.M. Marijnen, Irıs D. Nagtegaal et al. · New England Journal of Medicine Open access	30 Aug 2001	4,238
5	First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial Yelena Yuriy Janjigian et al. · The Lancet Open access	5 Jun 2021	3,110
6	Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer Leonard B. Saltz, John Vernon Cox, Charles David Blanke et al. · New England Journal of Medicine Open access	28 Sep 2000	3,022
7	Clues to the Pathogenesis of Familial Colorectal Cancer Lauri A. Aaltonen, Païvi Peltomäki, Fredrick S. Leach et al. · Science	7 May 1993	2,736
8	RECURRENCE AND SURVIVAL AFTER TOTAL MESORECTAL EXCISION FOR RECTAL CANCER Richard J. Heald, R. D. H. Ryall · The Lancet	Jun 1986	2,735
9	Chemotherapy with Preoperative Radiotherapy in Rectal Cancer Jean-François Bosset, Laurence Collette, G. Calais et al. · New England Journal of Medicine Open access	13 Sep 2006	2,734
10	Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial Joël Shapiro et al. · The Lancet Oncology	6 Aug 2015	2,615
11	Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study Aurélien Marabelle et al. · The Lancet Oncology Open access	10 Sep 2020	2,600
12	Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer Swedish Rectal Cancer Trial · New England Journal of Medicine Open access	3 Apr 1997	2,535
13	Cervical cancer Paul Andrew Cohen, Anjua Jhingran, Ana Oaknin et al. · The Lancet	2019	2,514
14	Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer Japanese Society for Cancer of the Colon and Rectum et al. · International Journal of Clinical Oncology Open access	27 Mar 2017	2,496
15	Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy Janis Marie Taube, Alison Klein, Julie Renee Brahmer et al. · Clinical Cancer Research Open access	9 Apr 2014	2,362
16	Pelvic Radiation with Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer Mitchell Morris, Patricia J. Eifel, Jiandong Lu et al. · New England Journal of Medicine	15 Apr 1999	2,341
17	Concurrent Chemotherapy and Pelvic Radiation Therapy Compared With Pelvic Radiation Therapy Alone as Adjuvant Therapy After Radical Surgery in High-Risk Early-Stage Cancer of the Cervix William A. Peters, P.Y. Liu, Rolland J. Barrett et al. · Journal of Clinical Oncology Open access	8 Apr 2000	2,338
18	Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial Yoon‐Koo Kang et al. · The Lancet Open access	12 Oct 2017	2,317
19	Occurrence and prognosis of extranodal lymphomas C.R. Freeman, John W. Berg, Sidney J. Cutler · Cancer	1972	2,304
20	Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer Christine M. Ribic, Daniel J. Sargent, Malcolm J. Moore et al. · New England Journal of Medicine Open access	16 Jul 2003	2,180
21	Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years Rolf Sauer, Torsten Liersch, Susanne Merkel et al. · Journal of Clinical Oncology Open access	24 Apr 2012	2,153
22	Combined Chemotherapy and Radiotherapy Compared with Radiotherapy Alone in Patients with Cancer of the Esophagus Arnold M. Herskovic, Karen L Martz, Muhyi Al‐Sarraf et al. · New England Journal of Medicine	11 Jun 1992	2,134
23	Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer Michael James Overman, Sara Lonardi, Ka Yeung Mark Wong et al. · Journal of Clinical Oncology Open access	20 Jan 2018	2,121
24	Immunotherapy in colorectal cancer: rationale, challenges and potential Karuna Ganesh, Zsofia Kinga Stadler, Andrea Cercek et al. · Nature Reviews Gastroenterology & Hepatology ReviewOpen access	18 Mar 2019	2,087
25	Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlations A.M. Mandard, Frédéric Dalibard, J.-C. Mandard et al. · Cancer Open access	Jun 1994	2,072
26	Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data Monique Maas, Patty J. Nelemans, Vincenzo Valentini et al. · The Lancet Oncology	8 Aug 2010	1,983
27	LOCAL RECURRENCE OF RECTAL ADENOCARCINOMA DUE TO INADEQUATE SURGICAL RESECTION Philip Quirke, Michael F. Dixon, Paul Durdey et al. · The Lancet	Nov 1986	1,983
28	Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial W. van Gijn, Corrie A.M. Marijnen, Irıs D. Nagtegaal et al. · The Lancet Oncology	22 May 2011	1,930
29	Operative Versus Nonoperative Treatment for Stage 0 Distal Rectal Cancer Following Chemoradiation Therapy Angelita Habr‐Gama, Rodrigo Oliva Perez, Wladimir Nadalin et al. · Annals of Surgery Open access	21 Sep 2004	1,923
30	Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma James Edward Krook, C G Moertel, Leonard L. Gunderson et al. · New England Journal of Medicine	14 Mar 1991	1,905
31	Development and Validation of a Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Colorectal Cancer Yanqi Huang, Changhong Liang, Lan He et al. · Journal of Clinical Oncology	3 May 2016	1,898
32	Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Bengt L. G. Glimelius, Emmanuel Tiret, Andrés Cervantes et al. · Annals of Oncology Open access	27 Sep 2013	1,787
33	Mesorectal excision for rectal cancer John K. MacFarlane, R. D. H. Ryall, Richard J. Heald · The Lancet	Feb 1993	1,773
34	Current treatment and recent progress in gastric cancer Smita Suhas Joshi, Brian D. Badgwell · CA A Cancer Journal for Clinicians Open access	16 Feb 2021	1,766
35	Preoperative Radiotherapy With or Without Concurrent Fluorouracil and Leucovorin in T3-4 Rectal Cancers: Results of FFCD 9203 Jean‐Pierre Gérard, Thierry Conroy, Franck Bonnetain et al. · Journal of Clinical Oncology	28 Sep 2006	1,748
36	Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial Martijn HGM van der Pas, Eva Haglind, Miguel Angel Cuesta et al. · The Lancet Oncology	5 Feb 2013	1,730
37	Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial Renu R. Bahadoer et al. · The Lancet Oncology Open access147 authors	7 Dec 2020	1,715
38	Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study Jong‐Mu Sun et al. · The Lancet Open access	Aug 2021	1,679
39	Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer Nuh N. Rahbari, Jürgen Weitz, Werner Hohenberger et al. · Surgery	12 Dec 2009	1,574
40	Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study Charles W. Whitney, William T. Sause, Brian N. Bundy et al. · Journal of Clinical Oncology Open access	May 1999	1,544
41	Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial David Sebag‐Montefiore, Richard J. Stephens, Robert JC Steele et al. · The Lancet Open access	Mar 2009	1,518
42	Gastric cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up Florian Lordick, Fátima Carneiro, Stefano Cascinu et al. · Annals of Oncology Open access	30 Jul 2022	1,516
43	Randomized Trial of Laparoscopic-Assisted Resection of Colorectal Carcinoma: 3-Year Results of the UK MRC CLASICC Trial Group David George Jayne, P J Guillou, Helen C. Thorpe et al. · Journal of Clinical Oncology Open access	18 Jul 2007	1,516
44	Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer Jakob Nikolas Kather, Alexander T. Pearson, Niels Halama et al. · Nature Medicine Open access	3 Jun 2019	1,500
45	A Randomized Trial of Laparoscopic versus Open Surgery for Rectal Cancer Hendrik Jaap Bonjer, Charlotte Leonore Deijen, Gabor A. Abis et al. · New England Journal of Medicine Open access	2 Apr 2015	1,465
46	A Randomized Trial Comparing Postoperative Adjuvant Chemotherapy with Cisplatin and 5-Fluorouracil Versus Preoperative Chemotherapy for Localized Advanced Squamous Cell Carcinoma of the Thoracic Esophagus (JCOG9907) Nobutoshi Ando, Hoichi Kato, Hiroyasu Igaki et al. · Annals of Surgical Oncology Open access	30 Aug 2011	1,459
47	Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers Myriam Chalabi et al. · Nature Medicine Open access	Apr 2020	1,437
48	Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial Naiyer A. Rizvi et al. · The Lancet Oncology Open access	19 Feb 2015	1,436
49	Rectal Cancer Richard J. Heald, Brendan John Moran, R. D. H. Ryall et al. · Archives of Surgery	Aug 1998	1,405
50	Addition of Aflibercept to Fluorouracil, Leucovorin, and Irinotecan Improves Survival in a Phase III Randomized Trial in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen Eric Van Cutsem, Josep M. Tabernero, Radek Lakomý et al. · Journal of Clinical Oncology	4 Sep 2012	1,403

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.