Science Explorer Back to mapMap

Most cited papers in COVID-19 Clinical Research Studies

COVID-19 Clinical Research Studies

What are the most cited papers in COVID-19 Clinical Research Studies?

The most cited paper in COVID-19 Clinical Research Studies is "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China" (Chaolin Huang et al., 2020), with 52,028 citations. Next come "Clinical Characteristics of Coronavirus Disease 2019 in China" (31,256) and "A Novel Coronavirus from Patients with Pneumonia in China, 2019" (30,499).

Showing 50 of 98 papers. Every paper with more than 3,060 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Chaolin Huang et al. · The Lancet Open access 24 Jan 2020 52,028
2 Clinical Characteristics of Coronavirus Disease 2019 in China Wei‐jie Guan et al. · New England Journal of Medicine Open access 28 Feb 2020 31,256
3 A Novel Coronavirus from Patients with Pneumonia in China, 2019 Na Zhu, Dingyu Zhang, Wenling Wang et al. · New England Journal of Medicine Open access 24 Jan 2020 30,499
4 Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Fei Zhou, Ting Yu, Ronghui Du et al. · The Lancet Open access Mar 2020 29,236
5 A pneumonia outbreak associated with a new coronavirus of probable bat origin Peng Zhou et al. · Nature Open access 3 Feb 2020 23,429
6 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Markus Hoffmann, Hannah Kleine‐Weber, Simon Schroeder et al. · Cell Open access 8 Mar 2020 21,493
7 Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China Dawei Wang, Bo Hu, Chang Hu et al. · JAMA Open access 7 Feb 2020 21,261
8 La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19 Martínez González, Marina · DSPACE System - Metalibrary (University of the Coast) Open access 2020 19,306
9 Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Zunyou Wu, Jennifer M. McGoogan · JAMA Open access 24 Feb 2020 18,071
10 Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Fernando P. Polack et al. · New England Journal of Medicine Open access 10 Dec 2020 15,741
11 Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Xiaobo Yang, Yu Lai Yuan, Jiqian Xu et al. · The Lancet Respiratory Medicine Open access 24 Feb 2020 10,739
12 Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Safiya I. Richardson et al. · JAMA Open access 22 Apr 2020 9,915
13 A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Jasper Fuk‐Woo Chan et al. · The Lancet Open access 24 Jan 2020 9,628
14 Pathological findings of COVID-19 associated with acute respiratory distress syndrome Zhe Xu, Lei Shi, Yijin Wang et al. · The Lancet Respiratory Medicine Open access 18 Feb 2020 8,909
15 Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China Chaomin Wu et al. · JAMA Internal Medicine Open access 13 Mar 2020 8,770
16 Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR Victor M. Corman et al. · Eurosurveillance Open access 23 Jan 2020 8,218
17 A novel coronavirus outbreak of global health concern Chen Wang, Peter Horby, Frederick G. Hayden et al. · The Lancet Open access 24 Jan 2020 8,144
18 Remdesivir for the Treatment of Covid-19 — Final Report John H. Beigel et al. · New England Journal of Medicine Open access 22 May 2020 7,759
19 Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China Ling Mao, Huijuan Jin, Mengdie Wang et al. · JAMA Neurology Open access 10 Apr 2020 7,427
20 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Manli Wang, Ruiyuan Cao, Leike Zhang et al. · Cell Research Open access 4 Feb 2020 7,401
21 Virological assessment of hospitalized patients with COVID-2019 Roman Wölfel, Victor M. Corman, Wolfgang Guggemos et al. · Nature Open access Apr 2020 7,240
22 Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus Peter A. Banks, Thomas L. Bollen, Christos Dervenis et al. · Gut Open access 25 Oct 2012 7,229
23 Factors associated with COVID-19-related death using OpenSAFELY Elizabeth Williamson et al. · Nature Open access 8 Jul 2020 6,783
24 Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor Jun Lan, Jiwan Ge, Jinfang Yu et al. · Nature Open access 30 Mar 2020 6,769
25 Endothelial cell infection and endotheliitis in COVID-19 Zsuzsanna Varga, Andreas J. Flammer, Peter Steiger et al. · The Lancet Open access 21 Apr 2020 6,667
26 The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application Stephen A. Lauer, Kyra H. Grantz, Qifang Bi et al. · Annals of Internal Medicine Open access 9 Mar 2020 6,618
27 First Case of 2019 Novel Coronavirus in the United States Michelle L. Holshue et al. · New England Journal of Medicine Open access 31 Jan 2020 6,413
28 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges Chih‐Cheng Lai, Tzu-Ping Shih, Wen‐Chien Ko et al. · International Journal of Antimicrobial Agents Open access 17 Feb 2020 6,402
29 World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19) Catrin Sohrabi, Zaid Alsafi, Niamh O’Neill et al. · International Journal of Surgery Open access 26 Feb 2020 6,329
30 Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Wenhui Li, Michael John Moore, Natalya Yu. Vasilieva et al. · Nature Open access 26 Nov 2003 6,301
31 The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak Hussin Alwan Rothan, Siddappa N. Byrareddy · Journal of Autoimmunity Open access 26 Feb 2020 6,056
32 Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases Tao Ai, Zhenlu Yang, Hongyan Hou et al. · Radiology Open access 26 Feb 2020 6,035
33 Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 Maximilian Ackermann, Stijn E. Verleden, Mark Philipp Kuehnel et al. · New England Journal of Medicine Open access 21 May 2020 5,915
34 Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy Giacomo Grasselli et al. · JAMA Open access114 authors 6 Apr 2020 5,912
35 Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Ning Tang, Dengju Li, Xiong Wang et al. · Journal of Thrombosis and Haemostasis Open access 19 Feb 2020 5,896
36 Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 Renhong Yan, Yuanyuan Zhang, Yaning Li et al. · Science Open access 4 Mar 2020 5,612
37 A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 Bin Cao et al. · New England Journal of Medicine Open access 18 Mar 2020 5,526
38 The proximal origin of SARS-CoV-2 Kristian G. Andersen, Andrew Rambaut, Walter Ian Lipkin et al. · Nature Medicine Open access 17 Mar 2020 5,518
39 Characteristics of SARS-CoV-2 and COVID-19 Ben Hu, Hua Guo, Peng Zhou et al. · Nature Reviews Microbiology ReviewOpen access 6 Oct 2020 5,514
40 Detection of SARS-CoV-2 in Different Types of Clinical Specimens Wenling Wang, Yanli Xu, Ruqin Gao et al. · JAMA Open access 11 Mar 2020 5,352
41 Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Frederikus Albertus Klok, Marieke J.H.A. Kruip, Nardo J. M. van der Meer et al. · Thrombosis Research Open access 10 Apr 2020 5,252
42 Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Qiurong Ruan, KUN YU YANG, Wenxia Wang et al. · Intensive Care Medicine Open access 3 Mar 2020 5,179
43 Post-acute COVID-19 syndrome Ani Nalbandian et al. · Nature Medicine Open access 22 Mar 2021 5,134
44 Clinical and immunological features of severe and moderate coronavirus disease 2019 Guang Chen, Di Wu, Wei Guo et al. · Journal of Clinical Investigation Open access 27 Mar 2020 5,083
45 Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China Chuan Qin, Luo‐Qi Zhou, Ziwei Hu et al. · Clinical Infectious Diseases Open access 6 Mar 2020 5,047
46 Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK Merryn Voysey et al. · The Lancet Open access765 authors 8 Dec 2020 5,030
47 The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status Yan-Rong Guo, Qing-Dong Cao, Zhong-Si Hong et al. · Military Medical Research Open access 13 Mar 2020 4,923
48 Presumed Asymptomatic Carrier Transmission of COVID-19 Yan Bai, Lingsheng Yao, Tao Wei et al. · JAMA Open access 21 Feb 2020 4,866
49 Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) Willem Joost Wiersinga, Andrew Rhodes, ALLEN C. CHENG et al. · JAMA Open access 10 Jul 2020 4,842
50 Persistent Symptoms in Patients After Acute COVID-19 Angelo Carfì, Roberto Bernabei, Francesco Landi et al. · JAMA Open access 9 Jul 2020 4,812

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.