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Most cited papers in Environmental Toxicology and Ecotoxicology

Environmental Toxicology and Ecotoxicology

What are the most cited papers in Environmental Toxicology and Ecotoxicology?

The most cited paper in Environmental Toxicology and Ecotoxicology is "Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels" (Charles Beauchamp, Irwin Fridovich, 1971), with 12,959 citations. Next come "Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase" (10,396) and "The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase" (9,109).

Showing 50 of 100 papers. Every paper with more than 917 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels Charles Beauchamp, Irwin Fridovich · Analytical Biochemistry Nov 1971 12,959
2 Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase Stefan L. Marklund, Gudrun MARKLUND · European Journal of Biochemistry Open access Sep 1974 10,396
3 The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase Hara Prasad Misra, Irwin Fridovich · Journal of Biological Chemistry Open access May 1972 9,109
4 Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test Bruce N. Ames, Joyce McCann, Edith F. Yamasaki · Mutation Research/Environmental Mutagenesis and Related Subjects Dec 1975 7,423
5 Oxygen-Derived Free Radicals in Postischemic Tissue Injury Franklin H. Epstein, Joe M. McCord · New England Journal of Medicine 17 Jan 1985 5,459
6 Oxygen toxicity, oxygen radicals, transition metals and disease Barry B. Halliwell, John M.C. Gutteridge · Biochemical Journal Open access Apr 1984 5,351
7 Metals, Toxicity and Oxidative Stress Marián Valko, Harry Morris, M Cronin · Current Medicinal Chemistry 29 Apr 2005 5,027
8 Fish bioaccumulation and biomarkers in environmental risk assessment: a review Ron van der Oost, Jonny Beyer, Nico Vermeulen · Environmental Toxicology and Pharmacology 10 Dec 2002 4,897
9 Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents Brian F. Meyer, N. R. Ferrigni, J. E. Putnam et al. · Planta Medica May 1982 4,843
10 Pharmaceuticals and personal care products in the environment: agents of subtle change? Christian G. Daughton, Thomas A. Ternes · Environmental Health Perspectives Open access Dec 1999 4,496
11 Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuarine sediments Edward R. Long, Donald D. MacDonald, Sherri L. Smith et al. · Environmental Management 1995 4,328
12 The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen Morimitsu Nishikimi, N. Appaji Rao, Kunio Yagi · Biochemical and Biophysical Research Communications 1972 4,097
13 Problems in the assessment of heavy-metal levels in estuaries and the formation of a pollution index D. L. Tomlinson, James G. Wilson, C. R. Harris et al. · Helgoland Marine Research Open access Mar 1980 3,996
14 Sulforhodamine B colorimetric assay for cytotoxicity screening Vanicha Vichai, Kanyawim Kirtikara · Nature Protocols Aug 2006 3,730
15 The Challenge of Micropollutants in Aquatic Systems René P. Schwarzenbach, Beate Isabella Escher, Kathrin Fenner et al. · Science Open access 24 Aug 2006 3,726
16 Development and Evaluation of Consensus-Based Sediment Quality Guidelines for Freshwater Ecosystems Donald D. MacDonald, Christopher G. Ingersoll, Tobias Berger · Archives of Environmental Contamination and Toxicology 30 Jun 2000 3,356
17 Ecotoxicology of human pharmaceuticals Karl Fent, Anna A. Weston, Daniel Caminada · Aquatic Toxicology 28 Oct 2005 3,203
18 Environmental monitoring and assessment Elena Aguilar, Daniel Sousa, Amy V. Uhrin et al. Book chapterOpen access 5 Sep 2011 3,156
19 Oxidative Stress, Caloric Restriction, and Aging Rajindar S. Sohal, Richard H. Weindruch · Science Open access 5 Jul 1996 3,152
20 Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT Bernard M. BABIOR, Ruby S. Kipnes, John T. Curnutte · Journal of Clinical Investigation Open access Mar 1973 2,944
21 Assaying for superoxide dismutase activity: Some large consequences of minor changes in conditions Wayne F. Beyer, Irwin Fridovich · Analytical Biochemistry Mar 1987 2,937
22 Programmed Cell Death in Animal Development Michael D. Jacobson, Miguel Weil, MARTIN C. RAFF · Cell Open access Feb 1997 2,722
23 Environmentally induced oxidative stress in aquatic animals Volodymyr I. Lushchak · Aquatic Toxicology 26 Oct 2010 2,711
24 Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment Gerald T. Ankley, Richard S. Bennett, Russell J. Erickson et al. · Environmental Toxicology and Chemistry Open access 9 Nov 2009 2,710
25 Ascorbate and Glutathione: The Heart of the Redox Hub Christine Helen Foyer, Graham Noctor · PLANT PHYSIOLOGY Open access 2011 2,511
26 Heavy Metals and Pesticides Toxicity in Agricultural Soil and Plants: Ecological Risks and Human Health Implications Ahmed Alengebawy, Sara Taha Abdelkhalek, Sundas Rana Qureshi et al. · Toxics Open access 25 Feb 2021 2,341
27 Ecological and toxicological effects of inorganic nitrogen pollution in aquatic ecosystems: A global assessment Julio A. Camargo, Álvaro Alonso · Environment International 19 Jun 2006 2,269
28 Antifouling technology—past, present and future steps towards efficient and environmentally friendly antifouling coatings Diego Meseguer Yebra, Søren Kiil, Kim Dam‐Johansen · Progress in Organic Coatings 27 Feb 2004 2,244
29 Principles of QSAR models validation: internal and external Paola Gramatica · QSAR & Combinatorial Science Open access 13 Mar 2007 2,207
30 FORWARD SELECTION OF EXPLANATORY VARIABLES F. Guillaume Blanchet, Pierre Legendre, Daniel Borcard · Ecology Sep 2008 2,160
31 Toxicity of heavy metals to microorganisms and microbial processes in agricultural soils: a review K.E. Giller, Ernst Witter, S. P. McGrath · Soil Biology and Biochemistry Sep 1998 1,989
32 Ecological effects, transport, and fate of mercury: a general review Dean W. Boening · Chemosphere Jun 2000 1,852
33 Contaminant-stimulated Reactive Oxygen Species Production and Oxidative Damage in Aquatic Organisms D.R. Livingstone · Marine Pollution Bulletin Aug 2001 1,851
34 OXIDATIVE STRESS IN MARINE ENVIRONMENTS: Biochemistry and Physiological Ecology Michael P. Lesser · Annual Review of Physiology Review 25 Aug 2005 1,842
35 Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants Athanasios Valavanidis, Thomais Vlahogianni, Manos Dassenakis et al. · Ecotoxicology and Environmental Safety 27 Apr 2005 1,812
36 Polychlorinated Biphenyls (PCBs): Environmental Impact, Biochemical and Toxic Responses, and Implications for Risk Assessment Stephen H Safe · Critical Reviews in Toxicology 1994 1,769
37 In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride George Fotakis, John A. Timbrell · Toxicology Letters 19 Aug 2005 1,572
38 The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters Robert Eisenthal, Athel J. Cornish-Bowden · Biochemical Journal Open access Jun 1974 1,565
39 Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment Lúcia H.M.L.M. Santos, Alberto N. Araújo, Adriano Fachini et al. · Journal of Hazardous Materials Open access 31 Oct 2009 1,553
40 Toxicological effects of malachite green Shivaji Srivastava, Ranjana Sinha, Dayalanand Roy · Aquatic Toxicology 9 Dec 2003 1,543
41 Toxicity of nanosized and bulk ZnO, CuO and TiO2 to bacteria Vibrio fischeri and crustaceans Daphnia magna and Thamnocephalus platyurus Margit Heinlaan, Angela Ivask, Irina Blinova et al. · Chemosphere 17 Jan 2008 1,528
42 Bioavailability, accumulation and effects of heavy metals in sediments with special reference to United Kingdom estuaries: a review Geoffrey W. Bryan, W.J. Langston · Environmental Pollution 1992 1,496
43 Energy homeostasis as an integrative tool for assessing limits of environmental stress tolerance in aquatic invertebrates Inna M. Sokolova, Markus Frederich, Rita Bagwe et al. · Marine Environmental Research 30 Apr 2012 1,492
44 Role of the soil matrix and minerals in protecting natural organic materials against biological attack Jeff Baldock, J. O. Skjemstad · Organic Geochemistry Jul 2000 1,461
45 Toxicity of iron and hydrogen peroxide: the Fenton reaction Christine C. Winterbourn · Toxicology Letters Dec 1995 1,420
46 Development and evaluation of sediment quality guidelines for Florida coastal waters Donald D. MacDonald, R. Scott Carr, Fred D. Calder et al. · Ecotoxicology Aug 1996 1,361
47 Prooxidant and antioxidant mechanisms in aquatic organisms Gary W. Winston, Richard T. Di Giulio · Aquatic Toxicology Apr 1991 1,353
48 Aging, Bioavailability, and Overestimation of Risk from Environmental Pollutants Martin J. Alexander · Environmental Science & Technology 8 Sep 2000 1,347
49 Histopathology in fish: proposal for a protocol to assess aquatic pollution Daniel Benjamin Bernet, H. Schmidt, Willy E. Meier et al. · Journal of Fish Diseases 1999 1,339
50 Risk of pesticide pollution at the global scale Fiona H. M. Tang, Manfred Lenzen, Alex B. McBratney et al. · Nature Geoscience Open access 29 Mar 2021 1,323

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.