Topic · Fungal and yeast genetics research

Most cited papers in Fungal and yeast genetics research

Fungal and yeast genetics research

What are the most cited papers in Fungal and yeast genetics research?

The most cited paper in Fungal and yeast genetics research is "A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae." (R Sikorski, Phillip Hieter, 1989), with 8,848 citations. Next come "A novel genetic system to detect protein–protein interactions" (6,181) and "Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae" (5,582).

Published TypeAccessAuthorsCitations

Showing 50 of 100 papers. Every paper with more than 1,456 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. R Sikorski, Phillip Hieter · Genetics Open access	May 1989	8,848
2	A novel genetic system to detect protein–protein interactions Stanley Fields, Ok-Kyu Song · Nature	Jul 1989	6,181
3	Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae Mark S. Longtine, Amos Mckenzie, Douglas James DeMarini et al. · Yeast	4 Dec 1998	5,582
4	Lethality and centrality in protein networks Hawoong Jeong, S. P. Mason, Albert-Ĺaszló Barabási et al. · Nature Open access	May 2001	5,436
5	Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes Audrey P. Gasch, Paul T. Spellman, Camilla M. Kao et al. · Molecular Biology of the Cell Open access	Dec 2000	4,991
6	Functional organization of the yeast proteome by systematic analysis of protein complexes Anne‐Claude Gavin et al. · Nature Open access	2002	4,816
7	Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization Paul T. Spellman, Gavin J. Sherlock, Michael Q. Zhang et al. · Molecular Biology of the Cell Open access	Dec 1998	4,810
8	Large-scale analysis of the yeast proteome by multidimensional protein identification technology Michael P. Washburn, Dirk Andreas Wolters, John R. Yates · Nature Biotechnology	Mar 2001	4,806
9	A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae Peter H Uetz, Loïc Giot, Gerard Cagney et al. · Nature	Feb 2000	4,754
10	Quantitative analysis of complex protein mixtures using isotope-coded affinity tags Steven P. Gygi, Beate Rist, Scott A. Gerber et al. · Nature Biotechnology	Oct 1999	4,680
11	Functional profiling of the Saccharomyces cerevisiae genome Guri N. Giaever et al. · Nature	25 Jul 2002	4,557
12	Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale Joseph L. DeRisi, Vishwanath R. Iyer, Patrick O. Brown · Science	24 Oct 1997	4,526
13	Global analysis of protein localization in budding yeast Won‐Ki Huh, James V. Falvo, Luke C. Gerke et al. · Nature	Oct 2003	4,433
14	Life with 6000 Genes A. Goffeau, B. G. Barrell, Howard Bussey et al. · Science	25 Oct 1996	4,332
15	Signal Transduction by the JNK Group of MAP Kinases Roger J Davis · Cell Open access	Oct 2000	4,242
16	XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor Hiderou Yoshida, Toshie Matsui, Akira Yamamoto et al. · Cell Open access	Dec 2001	4,139
17	Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis Elizabeth A. Winzeler et al. · Science	6 Aug 1999	4,050
18	Global analysis of protein expression in yeast Sina Ghaemmaghami, Won‐Ki Huh, Kiowa Bower et al. · Nature	Oct 2003	3,887
19	A catalogue of splice junction sequences Stephen M. Mount · Nucleic Acids Research Open access	1982	3,879
20	Correlation between Protein and mRNA Abundance in Yeast Steven P. Gygi, Yvan P. Rochon, B. Robert Franza et al. · Molecular and Cellular Biology Open access	Mar 1999	3,858
21	Systematic functional analysis of the Caenorhabditis elegans genome using RNAi Ravi S. Kamath, Andrew G. Fraser, Dong Yan et al. · Nature	2003	3,792
22	SMART, a simple modular architecture research tool: Identification of signaling domains Jörg Schultz, Frank Milpetz, Peer Bork et al. · Proceedings of the National Academy of Sciences Open access	26 May 1998	3,664
23	Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry Yuen Ho et al. · Nature	2002	3,631
24	A comprehensive two-hybrid analysis to explore the yeast protein interactome Takashi Ito, Tomoko Chiba, Ritsuko Ozawa et al. · Proceedings of the National Academy of Sciences Open access	13 Mar 2001	3,602
25	Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications Carrie Baker Brachmann, Adrian Davies, Gregory J. Cost et al. · Yeast	30 Jan 1998	3,586
26	Getting started with yeast Fred Sherman · Methods in enzymology on CD-ROM/Methods in enzymology Book chapter	2002	3,559
27	Improved method for high efficiency transformation of intact yeast cells Daniel Gietz, Andrew St. Jean, Robin A. Woods et al. · Nucleic Acids Research Open access	1992	3,308
28	Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method R. Daniel Gietz, Robin A. Woods · Methods in enzymology on CD-ROM/Methods in enzymology Book chapter	2002	3,028
29	High-efficiency yeast transformation using the LiAc/SS carrier DNA/PEG method R. Daniel Gietz, Robert H. Schiestl · Nature Protocols	2007	3,023
30	Transcriptional Regulatory Networks in Saccharomyces cerevisiae Tong Ihn Lee et al. · Science	24 Oct 2002	3,022
31	Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1 Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti et al. · Science	28 Jan 2000	3,021
32	Global landscape of protein complexes in the yeast Saccharomyces cerevisiae Nevan J. Krogan et al. · Nature	Mar 2006	3,002
33	New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites R. Daniel Gietz, Akio Sugino · Gene	Dec 1988	2,922
34	IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA Marcella A. Calfon, Huiqing Zeng, Fumihiko Urano et al. · Nature	3 Jan 2002	2,916
35	Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis David C. Schwartz, Charles R. Cantor · Cell	May 1984	2,860
36	Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human Christian A. Widmann, Spencer Bruce Gibson, Matthew B. Jarpe et al. · Physiological Reviews Review	1999	2,765
37	A generic protein purification method for protein complex characterization and proteome exploration Guillaume Rigaut, Anna Shevchenko, Berthold Rutz et al. · Nature Biotechnology	Oct 1999	2,728
38	Genomic Libraries and a Host Strain Designed for Highly Efficient Two-Hybrid Selection in Yeast Philip M. James, John T. Halladay, Elizabeth Anne Craig · Genetics Open access	Dec 1996	2,692
39	A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells Jiahuai Han, Jeffrey D. Lee, L. Bibbs et al. · Science	5 Aug 1994	2,670
40	Proteome survey reveals modularity of the yeast cell machinery Anne‐Claude Gavin et al. · Nature	22 Jan 2006	2,601
41	New heterologous modules for classical or PCR‐based gene disruptions in Saccharomyces cerevisiae Achim Wach, Arndt Brachat, Rainer Pöhlmann et al. · Yeast	Dec 1994	2,581
42	The double-strand-break repair model for recombination Jack W. Szostak, Terry L. Orr‐Weaver, Rodney J. Rothstein et al. · Cell	May 1983	2,518
43	Comparative assessment of large-scale data sets of protein–protein interactions Christian von Mering, Roland Krause, ‎Berend Snel et al. · Nature	May 2002	2,394
44	A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance Jef D. Boeke, Francois La Croute, Gerald R. Fink · Molecular and General Genetics MGG	Nov 1984	2,385
45	Identification and phylogeny of ascomycetous yeasts from analysis of nuclear large subunit (26S) ribosomal DNA partial sequences Cletus P. Kurtzman, Christie J. Robnett · Antonie van Leeuwenhoek	May 1998	2,358
46	Heterologous modules for efficient and versatile PCR-based gene targeting inSchizosaccharomyces pombe Jürg Bähler, Jian‐Qiu Wu, Mark S. Longtine et al. · Yeast	Jul 1998	2,343
47	The Genetics of Aspergillus nidulans G. Pontecorvo, J. A. Roper, L.M. Chemmons et al. · Advances in genetics Book chapter	1953	2,339
48	A versatile toolbox for PCR‐based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes Carsten Janke, Maria M. Magiera, Nicole Rathfelder et al. · Yeast	Aug 2004	2,335
49	The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Matt R. Kaeberlein, Mitch McVey, Leonard Guarente · Genes & Development Open access	Oct 1999	2,289
50	Transformation of yeast. A. Hinnen, James B Hicks, Gerald R. Fink · Proceedings of the National Academy of Sciences Open access	Apr 1978	2,234

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.