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Most cited papers in Healthcare and Venom Research

What are the most cited papers in Healthcare and Venom Research?

The most cited paper in Healthcare and Venom Research is "Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs" (C. A. Winter, Edwin A. Risley, George W. Nuss, 1962), with 5,701 citations. Next come "Neuronal Plasticity: Increasing the Gain in Pain" (3,780) and "An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat" (3,067).

Showing 50 of 100 papers. Every paper with more than 354 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine Dec 1962 5,701
2 Neuronal Plasticity: Increasing the Gain in Pain Clifford J. Woolf, Michael W. Salter · Science 9 Jun 2000 3,780
3 An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Sun Ho Kim, Jin Mo Chung · Pain Sep 1992 3,067
4 The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths Anuradhani Kasturiratne, A. Rajitha Wickremasinghe, Nilanthi de Silva et al. · PLoS Medicine Open access 31 Oct 2008 1,950
5 Bee and Wasp Venoms Ernst Habermann · Science 28 Jul 1972 1,571
6 Sequence and specificity of two antibacterial proteins involved in insect immunity H. Steiner, Dan Hultmark, Åke Engström et al. · Nature Jul 1981 1,444
7 Colony Collapse Disorder: A Descriptive Study Dennis vanEngelsdorp, Jay Daniel Evans, Claude Saegerman et al. · PLoS ONE Open access 31 Jul 2009 1,368
8 Cytokine Mechanisms of Central Sensitization: Distinct and Overlapping Role of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α in Regulating Synaptic and Neuronal Activity in the Superficial Spinal Cord Yasuhiko Kawasaki, Ling Zhang, Jen‐Kun Cheng et al. · Journal of Neuroscience Open access 14 May 2008 1,164
9 Structure−Activity Relationship and Classification of Flavonoids as Inhibitors of Xanthine Oxidase and Superoxide Scavengers Paul Cos, Ying Li, Mario R. Calomme et al. · Journal of Natural Products Open access 1998 1,088
10 Role of interleukin 10 in specific immunotherapy. Cezmi A. Akdiş, Thorsten Blesken, Mübeccel Akdiş et al. · Journal of Clinical Investigation Open access Jul 1998 975
11 Propolis: Is there a potential for the development of new drugs? José Maurício Sforcin, Vassya Stefanova Bankova · Journal of Ethnopharmacology 22 Oct 2010 882
12 Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin Thomas J. Lindell, Fanyela Weinberg, Paul W. Morris et al. · Science 23 Oct 1970 872
13 Neurologic Complications of the Reactivation of Varicella–Zoster Virus Donald H. Gilden, Bette Kay Kleinschmidt-DeMasters, James J. LaGuardia et al. · New England Journal of Medicine 2 Mar 2000 856
14 The Antibacterial Activity of Honey Peter C. Molan · Bee World 1992 826
15 Glutamate neurotoxicity in cortical cell culture is calcium dependent Dennis W. Choi · Neuroscience Letters Aug 1985 818
16 Ethanolic Extract of Propolis (EEP) Enhances the Apoptosis- Inducing Potential of TRAIL in Cancer Cells Ewelina Szliszka, Zenon Paweł Czuba, Maciej Domino et al. · Molecules Open access 13 Feb 2009 815
17 Innate and conditioned reactions to threat in rats with amygdaloid lesions. D. Caroline Blanchard, Robert J. Blanchard · Journal of Comparative and Physiological Psychology 1972 758
18 Snake venom variability: methods of study, results and interpretation Jean‐Philippe Chippaux, Vaughan K. Williams, Jennifer A. White · Toxicon 1991 756
19 Varieties of Calcium-Activated Potassium Channels Ramón Latorre, Andrés F. Oberhauser, Pedro P. Labarca et al. · Annual Review of Physiology Mar 1989 741
20 Phenolic Compounds in Honey and Their Associated Health Benefits: A Review Danila Cianciosi, Tamara Yuliett Forbes-Hernández, Sadia Afrin et al. · Molecules Open access 11 Sep 2018 733
21 Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes R. Manjunatha Kini · Toxicon Dec 2003 719
22 Interfacial Catalysis: the Mechanism of Phospholipase A 2 David Lloyd Scott, Steven P. White, Zbyszek Otwinowski et al. · Science Open access 14 Dec 1990 706
23 The evaluation of morphological characteristics of human spermatozoa according to stricter criteria Roelof Menkveld, Frik S.H. Stander, Theunis J. V. W. Kotze et al. · Human Reproduction Jul 1990 685
24 Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins). Tsutomu Higashijima, Sonoko Uzu, Terumi Nakajima et al. · Journal of Biological Chemistry Open access May 1988 680
25 Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception Jeffrey S. Mogil, Sonya G. Wilson, Karine Bon et al. · Pain Mar 1999 658
26 Melittin: a Membrane-active Peptide with Diverse Functions Hariharasundaram Raghuraman, Amitabha Chattopadhyay · Bioscience Reports 30 Nov 2006 656
27 Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention Rhonda G. Kost, Stephen E. Straus · New England Journal of Medicine 4 Jul 1996 650
28 Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds Dain Son, Jang‐Hern Lee, Yong Sun Lee et al. · Pharmacology & Therapeutics 9 May 2007 633
29 Snake Envenoming: A Disease of Poverty Robert A. Harrison, Adam D Hargreaves, Simon C. Wagstaff et al. · PLoS neglected tropical diseases Open access 21 Dec 2009 624
30 Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin Burkhard Bechinger · The Journal of Membrane Biology Apr 1997 605
31 The retrograde axonal transport of nerve growth factor Ian A. Hendry, K. Sto ̈ckel, H. Thoenen et al. · Brain Research Mar 1974 602
32 STUDIES ON THE QUANTITATIVE METHOD FOR DETERMINATION OF HEMORRHAGIC ACTIVITY OF HABU SNAKE VENOM Hisashi Kondo, Satoru Kondo, HIROO IKEZAWA et al. · Japanese Journal of Medical Science and Biology Open access 1960 588
33 Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle Andrew L. Blatz, Karl L. Magleby · Nature Oct 1986 562
34 Diagnosis of Hymenoptera venom allergy Beatrice M Bilò, Franziska Ruëff, Holger Mosbech et al. · Allergy 3 Oct 2005 557
35 The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways Takao Kataoka, Ralph C. Budd, Nils Holler et al. · Current Biology Open access Jun 2000 554
36 Phospholipase A2 myotoxins from Bothrops snake venoms José Marı́a Gutiérrez, Bruno Lomonte · Toxicon Open access Nov 1995 536
37 A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance Zhi‐Ye Zhuang, Yeong‐Ray Wen, De-Ren Zhang et al. · Journal of Neuroscience Open access 29 Mar 2006 535
38 Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy James N. Francis, Stephen J. Till, Stephen R. Durham · Journal of Allergy and Clinical Immunology Open access Jun 2003 530
39 Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia Michael C. Rowbotham, Pamela Stitzlein Davies, Christina Verkempinck et al. · Pain Apr 1996 529
40 On the role of Hsp27 in regulating apoptosis Caoimhín G. Concannon, Adrienne M. Gorman, Afshin Samali · APOPTOSIS 2003 526
41 Venoms as a platform for human drugs: translating toxins into therapeutics Glenn F. King · Expert Opinion on Biological Therapy 23 Sep 2011 524
42 Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. Marek Jutel, Werner J. Pichler, D Skrbic et al. · The Journal of Immunology Apr 1995 524
43 Honey as a topical treatment for wounds Andrew Jull, Nicky A Cullum, Jo C Dumville et al. · Cochrane Database of Systematic Reviews Open access 6 Mar 2015 523
44 Tumor Necrosis Factor-α Induces Mechanical Allodynia after Spinal Nerve Ligation by Activation of p38 MAPK in Primary Sensory Neurons Maria Schäfers, Camilla I. Svensson, Claudia Sommer et al. · Journal of Neuroscience Open access Apr 2003 523
45 On the influence of mechanical surface treatments—deep rolling and laser shock peening—on the fatigue behavior of Ti–6Al–4V at ambient and elevated temperatures Ravi K. Nalla, Igor Altenberger, Ulf Noster et al. · Materials Science and Engineering A 30 Apr 2003 519
46 Lumbar Disc Degeneration Michele Crites Battié, Tapio Videman, Éric Parent · Spine 24 Nov 2004 510
47 Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application Joanna Kocot, Małgorzata Kiełczykowska, Dorota Luchowska-Kocot et al. · Oxidative Medicine and Cellular Longevity Open access 2018 504
48 A pharmacological study of the depression of spinal neurones by glycine and related amino acids D.R. Curtis, L. H�sli, Graham A.R. Johnston · Experimental Brain Research Jul 1968 504
49 The structure of melittin. II. Interpretation of the structure. Thomas C. Terwilliger, David S Eisenberg · Journal of Biological Chemistry Open access Jun 1982 504
50 Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain Huasheng Xiao, Qiuhua Huang, Fang‐Xiong Zhang et al. · Proceedings of the National Academy of Sciences Open access 11 Jun 2002 503

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.